Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer
Identifieur interne : 003119 ( Pmc/Curation ); précédent : 003118; suivant : 003120Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer
Auteurs : Lívio Portela Cardoso-Coelho [Brésil] ; Rafael Soares Borges [Brésil] ; Airlane Pereira Alencar [Brésil] ; Larysse Maira Cardoso-Campos-Verdes [Brésil] ; João Paulo Da Silva-Sampaio [Brésil] ; Umbelina Soares Borges [Brésil] ; Luiz Henrique Gebrim [Brésil] ; Benedito Borges Da Silva [Brésil]Source :
- Oncology Letters [ 1792-1074 ] ; 2017.
Abstract
The replacement of sentinel lymph node biopsy (SNB) by ultrasound-guided fine-needle aspiration (US-guided FNA) cytology of axillary lymph nodes is controversial, despite the simplicity and reduced cost of the latter. In the present study, US-guided FNA was performed in 27 patients with early-stage breast cancer for comparison with SNB. Data were analyzed by calculation of sample proportions. Tumor subtypes included invasive ductal carcinoma (85%), invasive lobular carcinoma (7%), and tubular and metaplastic carcinoma (4%). FNA had a sensitivity of 45%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 73%. Axillary lymph node cytology obtained by US guided-FNA in patients with breast cancer had a specificity similar to that of sentinel lymph node histopathology in the presence of axillary node metastases. However, when lymph node cytology is negative, it does not exclude the existence of metastatic implants, due to its low sensitivity in comparison to sentinel lymph node histopathology.
Url:
DOI: 10.3892/ol.2017.5817
PubMed: 28521436
PubMed Central: 5431261
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<front><div type="abstract" xml:lang="en"><p>The replacement of sentinel lymph node biopsy (SNB) by ultrasound-guided fine-needle aspiration (US-guided FNA) cytology of axillary lymph nodes is controversial, despite the simplicity and reduced cost of the latter. In the present study, US-guided FNA was performed in 27 patients with early-stage breast cancer for comparison with SNB. Data were analyzed by calculation of sample proportions. Tumor subtypes included invasive ductal carcinoma (85%), invasive lobular carcinoma (7%), and tubular and metaplastic carcinoma (4%). FNA had a sensitivity of 45%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 73%. Axillary lymph node cytology obtained by US guided-FNA in patients with breast cancer had a specificity similar to that of sentinel lymph node histopathology in the presence of axillary node metastases. However, when lymph node cytology is negative, it does not exclude the existence of metastatic implants, due to its low sensitivity in comparison to sentinel lymph node histopathology.</p>
</div>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Oncol Lett</journal-id>
<journal-id journal-id-type="iso-abbrev">Oncol Lett</journal-id>
<journal-id journal-id-type="publisher-id">OL</journal-id>
<journal-title-group><journal-title>Oncology Letters</journal-title>
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<title-group><article-title>Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Cardoso-Coelho</surname>
<given-names>Lívio Portela</given-names>
</name>
<xref ref-type="aff" rid="af1-ol-0-0-5817">1</xref>
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<contrib contrib-type="author"><name><surname>Borges</surname>
<given-names>Rafael Soares</given-names>
</name>
<xref ref-type="aff" rid="af2-ol-0-0-5817">2</xref>
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<contrib contrib-type="author"><name><surname>Alencar</surname>
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<given-names>Larysse Maira</given-names>
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<contrib contrib-type="author"><name><surname>da Silva-Sampaio</surname>
<given-names>João Paulo</given-names>
</name>
<xref ref-type="aff" rid="af1-ol-0-0-5817">1</xref>
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<contrib contrib-type="author"><name><surname>Borges</surname>
<given-names>Umbelina Soares</given-names>
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<xref ref-type="aff" rid="af1-ol-0-0-5817">1</xref>
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<contrib contrib-type="author"><name><surname>Gebrim</surname>
<given-names>Luiz Henrique</given-names>
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<xref ref-type="aff" rid="af4-ol-0-0-5817">4</xref>
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<contrib contrib-type="author"><name><surname>da Silva</surname>
<given-names>Benedito Borges</given-names>
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<xref ref-type="aff" rid="af1-ol-0-0-5817">1</xref>
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<aff id="af1-ol-0-0-5817"><label>1</label>
Postgraduate Science and Health Program, Federal University of Piauí, Teresina, PI 64001-020, Brazil</aff>
<aff id="af2-ol-0-0-5817"><label>2</label>
Breast Disorder Unit, Getulio Vargas Hospital, Teresina, PI 64001-020, Brazil</aff>
<aff id="af3-ol-0-0-5817"><label>3</label>
Department of Statistics, Sao Paulo University, Sao Paulo, SP 05508-220, Brazil</aff>
<aff id="af4-ol-0-0-5817"><label>4</label>
Department of Mastology, Federal University of Sao Paulo, Sao Paulo, SP 04024-002, Brazil</aff>
<author-notes><corresp id="c1-ol-0-0-5817"><italic>Correspondence to</italic>
: Professor Benedito Borges da Silva, Postgraduate Science and Health Program, Federal University of Piauí and Breast Disorder Unit, Getulio Vargas Hospital, 2280 Avenida Frei Serafim, Teresina, PI 64001-020, Brazil, E-mail: <email>beneditoborges@globo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>5</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub"><day>07</day>
<month>3</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>07</day>
<month>3</month>
<year>2017</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the . </pmc-comment>
<volume>13</volume>
<issue>5</issue>
<fpage>3299</fpage>
<lpage>3302</lpage>
<history><date date-type="received"><day>24</day>
<month>8</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>31</day>
<month>1</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2017, Spandidos Publications</copyright-statement>
<copyright-year>2017</copyright-year>
</permissions>
<abstract><p>The replacement of sentinel lymph node biopsy (SNB) by ultrasound-guided fine-needle aspiration (US-guided FNA) cytology of axillary lymph nodes is controversial, despite the simplicity and reduced cost of the latter. In the present study, US-guided FNA was performed in 27 patients with early-stage breast cancer for comparison with SNB. Data were analyzed by calculation of sample proportions. Tumor subtypes included invasive ductal carcinoma (85%), invasive lobular carcinoma (7%), and tubular and metaplastic carcinoma (4%). FNA had a sensitivity of 45%, specificity of 100%, positive predictive value of 100% and a negative predictive value of 73%. Axillary lymph node cytology obtained by US guided-FNA in patients with breast cancer had a specificity similar to that of sentinel lymph node histopathology in the presence of axillary node metastases. However, when lymph node cytology is negative, it does not exclude the existence of metastatic implants, due to its low sensitivity in comparison to sentinel lymph node histopathology.</p>
</abstract>
<kwd-group><kwd>breast cancer</kwd>
<kwd>axillary lymph node</kwd>
<kwd>sentinel lymph node</kwd>
<kwd>fine-needle aspiration biopsy</kwd>
</kwd-group>
</article-meta>
</front>
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