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Insights into the Pathogenesis of Disease in Human Lymphatic Filariasis

Identifieur interne : 003032 ( Pmc/Curation ); précédent : 003031; suivant : 003033

Insights into the Pathogenesis of Disease in Human Lymphatic Filariasis

Auteurs : Thomas B. Nutman

Source :

RBID : PMC:3780283

Abstract

Abstract

Although two thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ∼40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, lymphedema, and (in its most severe form) elephantiasis. Adult filarial worms reside in the lymphatics and lymph nodes and induce lymphatic dilatation. Progressive lymphatic damage and pathology results primarily from the host inflammatory response to the parasites but also perhaps from the host inflammatory response to the parasite's Wolbachia endosymbiont and as a consequence of superimposed bacterial or fungal infections. This review will attempt to shed light on disease pathogenesis in lymphatic filariasis.


Url:
DOI: 10.1089/lrb.2013.0021
PubMed: 24044755
PubMed Central: 3780283

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PMC:3780283

Le document en format XML

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<p>Although two thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ∼40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, lymphedema, and (in its most severe form) elephantiasis. Adult filarial worms reside in the lymphatics and lymph nodes and induce lymphatic dilatation. Progressive lymphatic damage and pathology results primarily from the host inflammatory response to the parasites but also perhaps from the host inflammatory response to the parasite's Wolbachia endosymbiont and as a consequence of superimposed bacterial or fungal infections. This review will attempt to shed light on disease pathogenesis in lymphatic filariasis.</p>
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<aff id="aff1">Laboratory of Parasitic Diseases,
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<corresp>Address correspondence to:
<italic>Thomas B. Nutman, MD, Building 4, Room B1-03, 4 Center Dr., Bethesda, MD 20892-0425. E-mail:</italic>
<email xlink:href="mailto:tnutman@niaid.nih.gov">tnutman@niaid.nih.gov</email>
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<month>9</month>
<year>2013</year>
<pmc-comment>string-date: September 2013</pmc-comment>
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<volume>11</volume>
<issue>3</issue>
<fpage>144</fpage>
<lpage>148</lpage>
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<copyright-statement>Copyright 2013, Mary Ann Liebert, Inc.</copyright-statement>
<copyright-year>2013</copyright-year>
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<title>Abstract</title>
<p>Although two thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ∼40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, lymphedema, and (in its most severe form) elephantiasis. Adult filarial worms reside in the lymphatics and lymph nodes and induce lymphatic dilatation. Progressive lymphatic damage and pathology results primarily from the host inflammatory response to the parasites but also perhaps from the host inflammatory response to the parasite's Wolbachia endosymbiont and as a consequence of superimposed bacterial or fungal infections. This review will attempt to shed light on disease pathogenesis in lymphatic filariasis.</p>
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