The Lymphatics and the Inflammatory Response: Lessons Learned from Human Lymphedema
Identifieur interne : 003030 ( Pmc/Curation ); précédent : 003029; suivant : 003031The Lymphatics and the Inflammatory Response: Lessons Learned from Human Lymphedema
Auteurs : Stanley G. RocksonSource :
- Lymphatic Research and Biology [ 1539-6851 ] ; 2013.
Abstract
In lymphedema, there is a profound predisposition to infection with bacterial pathogens. It therefore seems appropriate to reconsider our unique functional definition of the lymphatic structures within a circulatory construct. While the lymphatics unquestionably fulfill a vital circulatory function, it seems more appropriate to view this complex network, comprised both of endothelial-lined vessels and of lymphoid tissue, as the nexus between the circulatory and immune systems. Viewed in this fashion, it becomes evident that the complex biology of regional lymphatic disruption is a manifestation of the interplay between these two vital bodily functions.
Experimental lymph stasis in murine model has been utilized to effectively demonstrate the pathological attributes of human lymphedema, namely, inflammation, fat deposition, and fibrosis. Large-scale transcriptional corroborates the role of inflammatory mechanisms. The murine studies have set the stage for subsequent translational investigation of human lymphedema. Many of the gene expression pathways invoked by lymphedema are relevant to the inflammatory response and have provided a pragmatic approach to the successful identification of potentially relevant circulating biomarkers for human lymphedema.
Url:
DOI: 10.1089/lrb.2013.1132
PubMed: 24024576
PubMed Central: 3780325
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p>In lymphedema, there is a profound predisposition to infection with bacterial pathogens. It therefore seems appropriate to reconsider our unique functional definition of the lymphatic structures within a circulatory construct. While the lymphatics unquestionably fulfill a vital circulatory function, it seems more appropriate to view this complex network, comprised both of endothelial-lined vessels and of lymphoid tissue, as the nexus between the circulatory and immune systems. Viewed in this fashion, it becomes evident that the complex biology of regional lymphatic disruption is a manifestation of the interplay between these two vital bodily functions.</p>
<p>Experimental lymph stasis in murine model has been utilized to effectively demonstrate the pathological attributes of human lymphedema, namely, inflammation, fat deposition, and fibrosis. Large-scale transcriptional corroborates the role of inflammatory mechanisms. The murine studies have set the stage for subsequent translational investigation of human lymphedema. Many of the gene expression pathways invoked by lymphedema are relevant to the inflammatory response and have provided a pragmatic approach to the successful identification of potentially relevant circulating biomarkers for human lymphedema.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Lymphat Res Biol</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject>
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<title-group><article-title>The Lymphatics and the Inflammatory Response: Lessons Learned from Human Lymphedema</article-title>
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<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Rockson</surname>
<given-names>Stanley G.</given-names>
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<degrees>MD</degrees>
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<aff id="aff1"><institution>Stanford University School of Medicine</institution>
, Stanford, California.</aff>
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<author-notes><corresp>Address correspondence to: <italic>Stanley G. Rockson, Allan and Tina Neill Professor of Lymphatic Research and Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA 94305. E-mail:</italic>
<email xlink:href="mailto:rockson@stanford.edu">rockson@stanford.edu</email>
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<pub-date pub-type="ppub"><month>9</month>
<year>2013</year>
<pmc-comment>string-date: September 2013</pmc-comment>
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<volume>11</volume>
<issue>3</issue>
<fpage>117</fpage>
<lpage>120</lpage>
<permissions><copyright-statement>Copyright 2013, Mary Ann Liebert, Inc.</copyright-statement>
<copyright-year>2013</copyright-year>
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<self-uri xlink:type="simple" xlink:href="lrb.2013.1132.pdf"></self-uri>
<abstract><title>Abstract</title>
<p>In lymphedema, there is a profound predisposition to infection with bacterial pathogens. It therefore seems appropriate to reconsider our unique functional definition of the lymphatic structures within a circulatory construct. While the lymphatics unquestionably fulfill a vital circulatory function, it seems more appropriate to view this complex network, comprised both of endothelial-lined vessels and of lymphoid tissue, as the nexus between the circulatory and immune systems. Viewed in this fashion, it becomes evident that the complex biology of regional lymphatic disruption is a manifestation of the interplay between these two vital bodily functions.</p>
<p>Experimental lymph stasis in murine model has been utilized to effectively demonstrate the pathological attributes of human lymphedema, namely, inflammation, fat deposition, and fibrosis. Large-scale transcriptional corroborates the role of inflammatory mechanisms. The murine studies have set the stage for subsequent translational investigation of human lymphedema. Many of the gene expression pathways invoked by lymphedema are relevant to the inflammatory response and have provided a pragmatic approach to the successful identification of potentially relevant circulating biomarkers for human lymphedema.</p>
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