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Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo

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Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo

Auteurs : Andrea Schiefer ; Alexander Schmitz [Allemagne] ; Till F. Sch Berle [Allemagne] ; Sabine Specht ; Christine L Mmer ; Kelly L. Johnston [Royaume-Uni] ; Dmitry G. Vassylyev ; Gabriele M. König [Allemagne] ; Achim Hoerauf ; Kenneth Pfarr

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2012.

RBID : PMC:3490692

Abstract

Doxycycline and rifampicin deplete essential Wolbachia from filarial nematodes that cause lymphatic filariasis or onchocerciasis, resulting in blocked worm development and death. However, doxycycline is contraindicated for children and pregnant/breastfeeding women, as is rifampicin in the latter group with the additional specter of possible resistance development in Mycobacterium spp. Novel antibiotics with a narrower spectrum would aid in eliminating filarial diseases. Corallococcus coralloides synthesizes corallopyronin A, a noncompetitive inhibitor of RNA polymerase ineffective against Mycobacterium spp. Corallopyronin A depleted Wolbachia from infected insect cells (1.89 Thus the antibiotic is effective against intracellular bacteria despite the many intervening surfaces (blood vessels, pleura, worm cuticle) and membranes (worm cell, vesicle, Wolbachia inner and outer membranes). Corallopyronin A is an antibiotic to develop further for filariasis elimination without concern for cross-resistance development in tuberculosis.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3490692

DOI: 10.1093/infdis/jis341
PubMed: 22586066
PubMed Central: 3490692

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 Endobacteria From Filarial Nematodes In Vivo</title>
<author><name sortKey="Schiefer, Andrea" sort="Schiefer, Andrea" uniqKey="Schiefer A" first="Andrea" last="Schiefer">Andrea Schiefer</name>
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,<institution>University Hospital Bonn</institution>
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<author><name sortKey="Schmitz, Alexander" sort="Schmitz, Alexander" uniqKey="Schmitz A" first="Alexander" last="Schmitz">Alexander Schmitz</name>
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 Endobacteria From Filarial Nematodes In Vivo</title>
<author><name sortKey="Schiefer, Andrea" sort="Schiefer, Andrea" uniqKey="Schiefer A" first="Andrea" last="Schiefer">Andrea Schiefer</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="L Mmer, Christine" sort="L Mmer, Christine" uniqKey="L Mmer C" first="Christine" last="L Mmer">Christine L Mmer</name>
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<wicri:regionArea>Institute of Pharmaceutical Biology, University of Bonn</wicri:regionArea>
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<affiliation><nlm:aff id="af1"><addr-line>Institute for Medical Microbiology, Immunology and Parasitology</addr-line>
,<institution>University Hospital Bonn</institution>
</nlm:aff>
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<author><name sortKey="Pfarr, Kenneth" sort="Pfarr, Kenneth" uniqKey="Pfarr K" first="Kenneth" last="Pfarr">Kenneth Pfarr</name>
<affiliation><nlm:aff id="af1"><addr-line>Institute for Medical Microbiology, Immunology and Parasitology</addr-line>
,<institution>University Hospital Bonn</institution>
</nlm:aff>
</affiliation>
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<series><title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
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<front><div type="abstract" xml:lang="en"><p>Doxycycline and rifampicin deplete essential <italic>Wolbachia</italic>
 from filarial nematodes that cause lymphatic filariasis or onchocerciasis, resulting in blocked worm development and death. However, doxycycline is contraindicated for children and pregnant/breastfeeding women, as is rifampicin in the latter group with the additional specter of possible resistance development in <italic>Mycobacterium spp</italic>
. Novel antibiotics with a narrower spectrum would aid in eliminating filarial diseases. <italic>Corallococcus coralloides</italic>
 synthesizes corallopyronin A, a noncompetitive inhibitor of RNA polymerase ineffective against <italic>Mycobacterium spp</italic>
. Corallopyronin A depleted <italic>Wolbachia</italic>
 from infected insect cells (1.89 Thus the antibiotic is effective against intracellular bacteria despite the many intervening surfaces (blood vessels, pleura, worm cuticle) and membranes (worm cell, vesicle, <italic>Wolbachia</italic>
 inner and outer membranes). Corallopyronin A is an antibiotic to develop further for filariasis elimination without concern for cross-resistance development in tuberculosis.</p>
</div>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id>
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<journal-id journal-id-type="hwp">jinfdis</journal-id>
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<article-categories><subj-group subj-group-type="heading"><subject>Major Articles and Brief Reports</subject>
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<title-group><article-title>Corallopyronin A Specifically Targets and Depletes Essential Obligate <italic>Wolbachia</italic>
 Endobacteria From Filarial Nematodes In Vivo</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Schiefer</surname>
<given-names>Andrea</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
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<contrib contrib-type="author"><name><surname>Schmitz</surname>
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<xref ref-type="aff" rid="af2">2</xref>
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<contrib contrib-type="author"><name><surname>Schäberle</surname>
<given-names>Till F.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
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<contrib contrib-type="author"><name><surname>Specht</surname>
<given-names>Sabine</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
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<contrib contrib-type="author"><name><surname>Lämmer</surname>
<given-names>Christine</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Johnston</surname>
<given-names>Kelly L.</given-names>
</name>
<xref ref-type="aff" rid="af3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vassylyev</surname>
<given-names>Dmitry G.</given-names>
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<xref ref-type="aff" rid="af4">4</xref>
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<contrib contrib-type="author"><name><surname>König</surname>
<given-names>Gabriele M.</given-names>
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<given-names>Achim</given-names>
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<contrib contrib-type="author"><name><surname>Pfarr</surname>
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<aff id="af1"><label>1</label>
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<aff id="af2"><label>2</label>
<addr-line>Institute of Pharmaceutical Biology, University of Bonn, Germany</addr-line>
</aff>
<aff id="af3"><label>3</label>
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,<country>United Kingdom</country>
</aff>
<aff id="af4"><label>4</label>
<addr-line>Department of Biochemistry and Molecular Biology, Schools of Medicine and Dentistry</addr-line>
,<institution>University of Alabama at Birmingham</institution>
</aff>
<author-notes><corresp>Correspondence: Achim Hoerauf, MD, Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, 53105, Germany (<email>hoerauf@microbiology-bonn.de</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>7</month>
<year>2012</year>
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<pub-date pub-type="epub"><day>14</day>
<month>5</month>
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<volume>206</volume>
<issue>2</issue>
<fpage>249</fpage>
<lpage>257</lpage>
<history><date date-type="received"><day>17</day>
<month>10</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>6</day>
<month>1</month>
<year>2012</year>
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<permissions><copyright-statement>© The Author 2012. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="jis341.pdf"></self-uri>
<abstract><p>Doxycycline and rifampicin deplete essential <italic>Wolbachia</italic>
 from filarial nematodes that cause lymphatic filariasis or onchocerciasis, resulting in blocked worm development and death. However, doxycycline is contraindicated for children and pregnant/breastfeeding women, as is rifampicin in the latter group with the additional specter of possible resistance development in <italic>Mycobacterium spp</italic>
. Novel antibiotics with a narrower spectrum would aid in eliminating filarial diseases. <italic>Corallococcus coralloides</italic>
 synthesizes corallopyronin A, a noncompetitive inhibitor of RNA polymerase ineffective against <italic>Mycobacterium spp</italic>
. Corallopyronin A depleted <italic>Wolbachia</italic>
 from infected insect cells (1.89 Thus the antibiotic is effective against intracellular bacteria despite the many intervening surfaces (blood vessels, pleura, worm cuticle) and membranes (worm cell, vesicle, <italic>Wolbachia</italic>
 inner and outer membranes). Corallopyronin A is an antibiotic to develop further for filariasis elimination without concern for cross-resistance development in tuberculosis.</p>
</abstract>
<counts><page-count count="23"></page-count>
</counts>
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</front>
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Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo

Corallopyronin A Specifically Targets and Depletes Essential Obligate Wolbachia Endobacteria From Filarial Nematodes In Vivo

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