Use of High-Dose, Twice-Yearly Albendazole and Ivermectin to Suppress Wuchereria bancrofti Microfilarial Levels
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Auteurs : Benoit Dembele ; Yaya I. Coulibaly ; Housseini Dolo ; Siaka Konate ; Siaka Y. Coulibaly ; Dramane Sanogo ; Lamine Soumaoro ; Michel E. Coulibaly ; Salif Seriba Doumbia ; Abdallah A. Diallo ; Sekou F. Traore ; Adama Diaman Keita ; Michael P. Fay ; Thomas B. Nutman ; Amy D. KlionSource :
- Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America [ 1058-4838 ] ; 2010.
Abstract
Url:
DOI: 10.1086/657063
PubMed: 21039220
PubMed Central: 3106228
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Use of High-Dose, Twice-Yearly Albendazole and Ivermectin to Suppress <italic>Wuchereria bancrofti</italic>
Microfilarial Levels</title>
<author><name sortKey="Dembele, Benoit" sort="Dembele, Benoit" uniqKey="Dembele B" first="Benoit" last="Dembele">Benoit Dembele</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coulibaly, Yaya I" sort="Coulibaly, Yaya I" uniqKey="Coulibaly Y" first="Yaya I." last="Coulibaly">Yaya I. Coulibaly</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dolo, Housseini" sort="Dolo, Housseini" uniqKey="Dolo H" first="Housseini" last="Dolo">Housseini Dolo</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Konate, Siaka" sort="Konate, Siaka" uniqKey="Konate S" first="Siaka" last="Konate">Siaka Konate</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coulibaly, Siaka Y" sort="Coulibaly, Siaka Y" uniqKey="Coulibaly S" first="Siaka Y." last="Coulibaly">Siaka Y. Coulibaly</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sanogo, Dramane" sort="Sanogo, Dramane" uniqKey="Sanogo D" first="Dramane" last="Sanogo">Dramane Sanogo</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Soumaoro, Lamine" sort="Soumaoro, Lamine" uniqKey="Soumaoro L" first="Lamine" last="Soumaoro">Lamine Soumaoro</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coulibaly, Michel E" sort="Coulibaly, Michel E" uniqKey="Coulibaly M" first="Michel E." last="Coulibaly">Michel E. Coulibaly</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Doumbia, Salif Seriba" sort="Doumbia, Salif Seriba" uniqKey="Doumbia S" first="Salif Seriba" last="Doumbia">Salif Seriba Doumbia</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diallo, Abdallah A" sort="Diallo, Abdallah A" uniqKey="Diallo A" first="Abdallah A." last="Diallo">Abdallah A. Diallo</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Traore, Sekou F" sort="Traore, Sekou F" uniqKey="Traore S" first="Sekou F." last="Traore">Sekou F. Traore</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keita, Adama Diaman" sort="Keita, Adama Diaman" uniqKey="Keita A" first="Adama Diaman" last="Keita">Adama Diaman Keita</name>
<affiliation><nlm:aff id="a2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fay, Michael P" sort="Fay, Michael P" uniqKey="Fay M" first="Michael P." last="Fay">Michael P. Fay</name>
<affiliation><nlm:aff id="a3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
<affiliation><nlm:aff id="a4"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name>
<affiliation><nlm:aff id="a4"></nlm:aff>
</affiliation>
</author>
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<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106228</idno>
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<idno type="doi">10.1086/657063</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Use of High-Dose, Twice-Yearly Albendazole and Ivermectin to Suppress <italic>Wuchereria bancrofti</italic>
Microfilarial Levels</title>
<author><name sortKey="Dembele, Benoit" sort="Dembele, Benoit" uniqKey="Dembele B" first="Benoit" last="Dembele">Benoit Dembele</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coulibaly, Yaya I" sort="Coulibaly, Yaya I" uniqKey="Coulibaly Y" first="Yaya I." last="Coulibaly">Yaya I. Coulibaly</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dolo, Housseini" sort="Dolo, Housseini" uniqKey="Dolo H" first="Housseini" last="Dolo">Housseini Dolo</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Konate, Siaka" sort="Konate, Siaka" uniqKey="Konate S" first="Siaka" last="Konate">Siaka Konate</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coulibaly, Siaka Y" sort="Coulibaly, Siaka Y" uniqKey="Coulibaly S" first="Siaka Y." last="Coulibaly">Siaka Y. Coulibaly</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sanogo, Dramane" sort="Sanogo, Dramane" uniqKey="Sanogo D" first="Dramane" last="Sanogo">Dramane Sanogo</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Soumaoro, Lamine" sort="Soumaoro, Lamine" uniqKey="Soumaoro L" first="Lamine" last="Soumaoro">Lamine Soumaoro</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coulibaly, Michel E" sort="Coulibaly, Michel E" uniqKey="Coulibaly M" first="Michel E." last="Coulibaly">Michel E. Coulibaly</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Doumbia, Salif Seriba" sort="Doumbia, Salif Seriba" uniqKey="Doumbia S" first="Salif Seriba" last="Doumbia">Salif Seriba Doumbia</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Diallo, Abdallah A" sort="Diallo, Abdallah A" uniqKey="Diallo A" first="Abdallah A." last="Diallo">Abdallah A. Diallo</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Traore, Sekou F" sort="Traore, Sekou F" uniqKey="Traore S" first="Sekou F." last="Traore">Sekou F. Traore</name>
<affiliation><nlm:aff id="a1"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Keita, Adama Diaman" sort="Keita, Adama Diaman" uniqKey="Keita A" first="Adama Diaman" last="Keita">Adama Diaman Keita</name>
<affiliation><nlm:aff id="a2"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fay, Michael P" sort="Fay, Michael P" uniqKey="Fay M" first="Michael P." last="Fay">Michael P. Fay</name>
<affiliation><nlm:aff id="a3"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nutman, Thomas B" sort="Nutman, Thomas B" uniqKey="Nutman T" first="Thomas B." last="Nutman">Thomas B. Nutman</name>
<affiliation><nlm:aff id="a4"></nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klion, Amy D" sort="Klion, Amy D" uniqKey="Klion A" first="Amy D." last="Klion">Amy D. Klion</name>
<affiliation><nlm:aff id="a4"></nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</title>
<idno type="ISSN">1058-4838</idno>
<idno type="eISSN">1537-6591</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold><italic>Background.</italic>
</bold>
Annual mass treatment with albendazole and ivermectin is the mainstay of current strategies to interrupt transmission of <italic>Wuchereria bancrofti</italic>
in Africa. More-effective microfilarial suppression could potentially reduce the time necessary to interrupt transmission, easing the economic burden of mass treatment programs in countries with limited resources.</p>
<p><bold><italic>Methods.</italic>
</bold>
To determine the effect of increased dose and frequency of albendazole-ivermectin treatment on microfilarial clearance, 51 <italic>W. bancrofti</italic>
microfilaremic residents of an area of <italic>W. bancrofti</italic>
endemicity in Mali were randomized to receive 2 doses of annual, standard-dose albendazole-ivermectin therapy (400 mg and 150 µg/kg; <italic>n</italic>
= 26) or 4 doses of twice-yearly, increased-dose albendazole-ivermectin therapy (800 mg and 400 µg/kg; <italic>n</italic>
= 25).</p>
<p><bold><italic>Results.</italic>
</bold>
Although microfilarial levels decreased significantly after therapy in both groups, levels were significantly lower in the high-dose, twice-yearly group at 12, 18, and 24 months. Furthermore, there was complete clearance of detectable microfilariae at 12 months in the 19 patients in the twice-yearly therapy group with data available at 12 months, compared with 9 of 21 patients in the annual therapy group (<italic>P</italic>
<.001 , by Fisher's exact test). This difference between the 2 groups was sustained at 18 and 24 months, with no detectable microfilariae in the patients receiving twice-yearly treatment. Worm nests detectable by ultrasonography and <italic>W. bancrofti</italic>
circulating antigen levels, as measured by enzyme-linked immunosorbent assay, were decreased to the same degree in both groups at 24 months, compared with baseline.</p>
<p><bold><italic>Conclusions.</italic>
</bold>
These findings suggest that increasing the dosage and frequency of albendazole-ivermectin treatment enhances suppression of microfilariae but that this effect may not be attributable to improved adulticidal activity.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Infect Dis</journal-id>
<journal-id journal-id-type="hwp">cid</journal-id>
<journal-id journal-id-type="publisher-id">clinids</journal-id>
<journal-title-group><journal-title>Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America</journal-title>
</journal-title-group>
<issn pub-type="ppub">1058-4838</issn>
<issn pub-type="epub">1537-6591</issn>
<publisher><publisher-name>The University of Chicago Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21039220</article-id>
<article-id pub-id-type="pmc">3106228</article-id>
<article-id pub-id-type="doi">10.1086/657063</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles and Commentaries</subject>
<subj-group subj-group-type="heading"><subject>Major Articles</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Use of High-Dose, Twice-Yearly Albendazole and Ivermectin to Suppress <italic>Wuchereria bancrofti</italic>
Microfilarial Levels</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Dembele</surname>
<given-names>Benoit</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coulibaly</surname>
<given-names>Yaya I.</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Dolo</surname>
<given-names>Housseini</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Konate</surname>
<given-names>Siaka</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coulibaly</surname>
<given-names>Siaka Y.</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sanogo</surname>
<given-names>Dramane</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Soumaoro</surname>
<given-names>Lamine</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coulibaly</surname>
<given-names>Michel E.</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Doumbia</surname>
<given-names>Salif Seriba</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Diallo</surname>
<given-names>Abdallah A.</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Traore</surname>
<given-names>Sekou F.</given-names>
</name>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Keita</surname>
<given-names>Adama Diaman</given-names>
</name>
<xref ref-type="aff" rid="a2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fay</surname>
<given-names>Michael P.</given-names>
</name>
<xref ref-type="aff" rid="a3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nutman</surname>
<given-names>Thomas B.</given-names>
</name>
<xref ref-type="aff" rid="a4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Klion</surname>
<given-names>Amy D.</given-names>
</name>
<xref ref-type="aff" rid="a4">4</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<aff id="a1"><label><sup>1</sup>
</label>
<institution>Faculty of Medicine, Pharmacy and Dentistry, Filariasis Unit, University of Bamako</institution>
,<addr-line>Bamako, Mali</addr-line>
</aff>
<aff id="a2"><label><sup>2</sup>
</label>
<institution>Department of Radiology, Hospital of Point G</institution>
,<addr-line>Bamako, Mali</addr-line>
</aff>
<aff id="a3"><label><sup>3</sup>
</label>
<institution>Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases</institution>
,<addr-line>Bethesda, Maryland</addr-line>
</aff>
<aff id="a4"><label><sup>4</sup>
</label>
<institution>Laboratory of Parasitic Diseases, National Institutes of Health</institution>
,<addr-line>Bethesda, Maryland</addr-line>
</aff>
</contrib-group>
<author-notes><corresp id="cor1">Reprints or correspondence: Dr. Amy D. Klion Laboratory of Parasitic Diseases Bldg 50 Rm 6351 National Institutes of Health Bethesda MD 20892 (<email>aklion@nih.gov</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>1</day>
<month>12</month>
<year>2010</year>
</pub-date>
<volume>51</volume>
<issue>11</issue>
<fpage>1229</fpage>
<lpage>1235</lpage>
<history><date date-type="received"><day>9</day>
<month>3</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>13</day>
<month>5</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>© 2010 by the Infectious Diseases Society of America</copyright-statement>
<copyright-year>2010</copyright-year>
</permissions>
<abstract><p><bold><italic>Background.</italic>
</bold>
Annual mass treatment with albendazole and ivermectin is the mainstay of current strategies to interrupt transmission of <italic>Wuchereria bancrofti</italic>
in Africa. More-effective microfilarial suppression could potentially reduce the time necessary to interrupt transmission, easing the economic burden of mass treatment programs in countries with limited resources.</p>
<p><bold><italic>Methods.</italic>
</bold>
To determine the effect of increased dose and frequency of albendazole-ivermectin treatment on microfilarial clearance, 51 <italic>W. bancrofti</italic>
microfilaremic residents of an area of <italic>W. bancrofti</italic>
endemicity in Mali were randomized to receive 2 doses of annual, standard-dose albendazole-ivermectin therapy (400 mg and 150 µg/kg; <italic>n</italic>
= 26) or 4 doses of twice-yearly, increased-dose albendazole-ivermectin therapy (800 mg and 400 µg/kg; <italic>n</italic>
= 25).</p>
<p><bold><italic>Results.</italic>
</bold>
Although microfilarial levels decreased significantly after therapy in both groups, levels were significantly lower in the high-dose, twice-yearly group at 12, 18, and 24 months. Furthermore, there was complete clearance of detectable microfilariae at 12 months in the 19 patients in the twice-yearly therapy group with data available at 12 months, compared with 9 of 21 patients in the annual therapy group (<italic>P</italic>
<.001 , by Fisher's exact test). This difference between the 2 groups was sustained at 18 and 24 months, with no detectable microfilariae in the patients receiving twice-yearly treatment. Worm nests detectable by ultrasonography and <italic>W. bancrofti</italic>
circulating antigen levels, as measured by enzyme-linked immunosorbent assay, were decreased to the same degree in both groups at 24 months, compared with baseline.</p>
<p><bold><italic>Conclusions.</italic>
</bold>
These findings suggest that increasing the dosage and frequency of albendazole-ivermectin treatment enhances suppression of microfilariae but that this effect may not be attributable to improved adulticidal activity.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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