The Effect of Simulation on Recurrence after Breast-Conserving Surgery and Radiotherapy: Preliminary Results
Identifieur interne : 002D38 ( Pmc/Curation ); précédent : 002D37; suivant : 002D39The Effect of Simulation on Recurrence after Breast-Conserving Surgery and Radiotherapy: Preliminary Results
Auteurs : Ji-Yoon Kim [Corée du Sud] ; Yeon-Sil Kim [Corée du Sud] ; Mi-Ryung Ryu [Corée du Sud] ; Sung-Whan Kim [Corée du Sud] ; Chul-Seung Kay [Corée du Sud] ; Sei-Chul Yoon [Corée du Sud] ; Woo-Chan Park [Corée du Sud] ; Byung-Joo Song [Corée du Sud] ; Se-Jeong Oh [Corée du Sud] ; Sang-Seol Jung [Corée du Sud] ; Jong-Man Won [Corée du Sud] ; Seung-Nam Kim [Corée du Sud] ; Su-Mi Chung [Corée du Sud]Source :
- Cancer Research and Treatment : Official Journal of Korean Cancer Association [ 1598-2998 ] ; 2006.
Abstract
To evaluate the effect of the simulation method on recurrence among the patients who received radiotherapy after breast-conserving surgery (BCS) for early breast carcinoma.
Between 1995 and 2000, 70 patients with stage I-II breast carcinoma underwent breast-conserving surgery and adjuvant radiotherapy. Twenty nine patients (41.4%) were simulated with the 2D contour-based method (September 1995 to August 1997) and 41 patients (58.6%) were simulated with the 3D CT-based method (September 1997 to February 2000). To analyze the effect of the simulation method, the patient and treatment characteristics were compared.
The characteristics were similar for the patients between the 2D contour-based simulation group and the 3D CT-based simulation group. During a median follow-up period of 75 months, 4 (13.8%) of 29 patients who were treated with 2D simulation and 1 (2.4%) of 41 patients who were treated with 3D simulation group developed treatment failure. The five-year survival rates were 89.2% and 95.1% between the 2D and 3D simulation groups (p=0.196). The five-year disease free survival (
Although our data showed marginal significance for the DFS between the two groups, it is insufficient, due to the small number of patients in our study, to prove whether 3D CT-based simulation might improve the DFS and reduce the risk of recurrence when compared with 2D contour-based simulation. Further study is needed with a larger group of patients.
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DOI: 10.4143/crt.2006.38.1.40
PubMed: 19771258
PubMed Central: 2741657
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Sud</country><wicri:regionArea>Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Su Mi" sort="Chung, Su Mi" uniqKey="Chung S" first="Su-Mi" last="Chung">Su-Mi Chung</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19771258</idno><idno type="pmc">2741657</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741657</idno><idno type="RBID">PMC:2741657</idno><idno type="doi">10.4143/crt.2006.38.1.40</idno><date when="2006">2006</date><idno 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sortKey="Kim, Yeon Sil" sort="Kim, Yeon Sil" uniqKey="Kim Y" first="Yeon-Sil" last="Kim">Yeon-Sil Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Ryu, Mi Ryung" sort="Ryu, Mi Ryung" uniqKey="Ryu M" first="Mi-Ryung" last="Ryu">Mi-Ryung Ryu</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Sung Whan" sort="Kim, Sung Whan" uniqKey="Kim S" first="Sung-Whan" last="Kim">Sung-Whan Kim</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kay, Chul Seung" sort="Kay, Chul Seung" uniqKey="Kay C" first="Chul-Seung" last="Kay">Chul-Seung Kay</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Yoon, Sei Chul" sort="Yoon, Sei Chul" uniqKey="Yoon S" first="Sei-Chul" last="Yoon">Sei-Chul Yoon</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Park, Woo Chan" sort="Park, Woo Chan" uniqKey="Park W" first="Woo-Chan" last="Park">Woo-Chan Park</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Song, Byung Joo" sort="Song, Byung Joo" uniqKey="Song B" first="Byung-Joo" last="Song">Byung-Joo Song</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Oh, Se Jeong" sort="Oh, Se Jeong" uniqKey="Oh S" first="Se-Jeong" last="Oh">Se-Jeong Oh</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Jung, Sang Seol" sort="Jung, Sang Seol" uniqKey="Jung S" first="Sang-Seol" last="Jung">Sang-Seol Jung</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Won, Jong Man" sort="Won, Jong Man" uniqKey="Won J" first="Jong-Man" last="Won">Jong-Man Won</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Kim, Seung Nam" sort="Kim, Seung Nam" uniqKey="Kim S" first="Seung-Nam" last="Kim">Seung-Nam Kim</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Chung, Su Mi" sort="Chung, Su Mi" uniqKey="Chung S" first="Su-Mi" last="Chung">Su-Mi Chung</name><affiliation wicri:level="1"><nlm:aff id="A1">Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Corée du Sud</country><wicri:regionArea>Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cancer Research and Treatment : Official Journal of Korean Cancer Association</title><idno type="ISSN">1598-2998</idno><idno type="eISSN">2005-9256</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To evaluate the effect of the simulation method on recurrence among the patients who received radiotherapy after breast-conserving surgery (BCS) for early breast carcinoma.</p></sec><sec><title>Materials and Methods</title><p>Between 1995 and 2000, 70 patients with stage I-II breast carcinoma underwent breast-conserving surgery and adjuvant radiotherapy. Twenty nine patients (41.4%) were simulated with the 2D contour-based method (September 1995 to August 1997) and 41 patients (58.6%) were simulated with the 3D CT-based method (September 1997 to February 2000). To analyze the effect of the simulation method, the patient and treatment characteristics were compared.</p></sec><sec><title>Results</title><p>The characteristics were similar for the patients between the 2D contour-based simulation group and the 3D CT-based simulation group. During a median follow-up period of 75 months, 4 (13.8%) of 29 patients who were treated with 2D simulation and 1 (2.4%) of 41 patients who were treated with 3D simulation group developed treatment failure. The five-year survival rates were 89.2% and 95.1% between the 2D and 3D simulation groups (p=0.196). The five-year disease free survival (<italic>DFS</italic>) rates were 86.2% and 97.5% between the 2D and 3D simulation groups (p=0.0636). On univariate analysis, age > 40 (p= 0.0226) and the number of dissected axillary lymph node ≥ 10 (p=0.0435) were independent predictors of improved 5-year DFS.</p></sec><sec><title>Conclusions</title><p>Although our data showed marginal significance for the DFS between the two groups, it is insufficient, due to the small number of patients in our study, to prove whether 3D CT-based simulation might improve the DFS and reduce the risk of recurrence when compared with 2D contour-based simulation. Further study is needed with a larger group of patients.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cancer Res Treat</journal-id><journal-id journal-id-type="publisher-id">CRT</journal-id><journal-title-group><journal-title>Cancer Research and Treatment : Official Journal of Korean Cancer Association</journal-title></journal-title-group><issn pub-type="ppub">1598-2998</issn><issn pub-type="epub">2005-9256</issn><publisher><publisher-name>Korean Cancer Association</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19771258</article-id><article-id pub-id-type="pmc">2741657</article-id><article-id pub-id-type="doi">10.4143/crt.2006.38.1.40</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>The Effect of Simulation on Recurrence after Breast-Conserving Surgery and Radiotherapy: Preliminary Results</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Ji-Yoon</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Yeon-Sil</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ryu</surname><given-names>Mi-Ryung</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Sung-Whan</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kay</surname><given-names>Chul-Seung</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yoon</surname><given-names>Sei-Chul</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Park</surname><given-names>Woo-Chan</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Byung-Joo</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Oh</surname><given-names>Se-Jeong</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Jung</surname><given-names>Sang-Seol</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Won</surname><given-names>Jong-Man</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Seung-Nam</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Chung</surname><given-names>Su-Mi</given-names></name><degrees>M.D.</degrees><xref ref-type="aff" rid="A1">1</xref></contrib></contrib-group><aff id="A1"><label>1</label>Department of Radiation Oncology, College of Medicine, The Catholic University of Korea, Seoul, Korea.</aff><aff id="A2"><label>2</label>Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.</aff><author-notes><corresp>Correspondence: Su-Mi Chung, Department of Radiation Oncology, Kangnam St. Mary's Hospital, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea. (Tel) 82-2-590-1566, (Fax) 82-2-3476-1365, <email>sumic@catholic.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2006</year></pub-date><pub-date pub-type="epub"><day>28</day><month>2</month><year>2006</year></pub-date><volume>38</volume><issue>1</issue><fpage>40</fpage><lpage>47</lpage><history><date date-type="received"><day>25</day><month>11</month><year>2005</year></date><date date-type="accepted"><day>10</day><month>1</month><year>2006</year></date></history><permissions><copyright-statement>Copyright © 2006 Korean Cancer Association</copyright-statement><copyright-year>2006</copyright-year></permissions><abstract><sec><title>Purpose</title><p>To evaluate the effect of the simulation method on recurrence among the patients who received radiotherapy after breast-conserving surgery (BCS) for early breast carcinoma.</p></sec><sec><title>Materials and Methods</title><p>Between 1995 and 2000, 70 patients with stage I-II breast carcinoma underwent breast-conserving surgery and adjuvant radiotherapy. Twenty nine patients (41.4%) were simulated with the 2D contour-based method (September 1995 to August 1997) and 41 patients (58.6%) were simulated with the 3D CT-based method (September 1997 to February 2000). To analyze the effect of the simulation method, the patient and treatment characteristics were compared.</p></sec><sec><title>Results</title><p>The characteristics were similar for the patients between the 2D contour-based simulation group and the 3D CT-based simulation group. During a median follow-up period of 75 months, 4 (13.8%) of 29 patients who were treated with 2D simulation and 1 (2.4%) of 41 patients who were treated with 3D simulation group developed treatment failure. The five-year survival rates were 89.2% and 95.1% between the 2D and 3D simulation groups (p=0.196). The five-year disease free survival (<italic>DFS</italic>) rates were 86.2% and 97.5% between the 2D and 3D simulation groups (p=0.0636). On univariate analysis, age > 40 (p= 0.0226) and the number of dissected axillary lymph node ≥ 10 (p=0.0435) were independent predictors of improved 5-year DFS.</p></sec><sec><title>Conclusions</title><p>Although our data showed marginal significance for the DFS between the two groups, it is insufficient, due to the small number of patients in our study, to prove whether 3D CT-based simulation might improve the DFS and reduce the risk of recurrence when compared with 2D contour-based simulation. Further study is needed with a larger group of patients.</p></sec></abstract><kwd-group><kwd>Breast neoplasms</kwd><kwd>Radiotherapy</kwd><kwd>Simulation</kwd><kwd>Recurrence</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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