Lymph-node staining with activated carbon CH40: a new method for axillary lymph-node dissection in breast cancer
Identifieur interne : 002D25 ( Pmc/Curation ); précédent : 002D24; suivant : 002D26Lymph-node staining with activated carbon CH40: a new method for axillary lymph-node dissection in breast cancer
Auteurs : Takashi Yokota ; Toshihiro Saito ; Yoichi Narushima ; Kazutsugu Iwamoto ; Masashi Iizuka ; Akeo Hagiwara ; Kiyoshi Sawai ; Shu Kikuchi ; Yasuo Kunii ; Hidemi YamauchiSource :
- Canadian Journal of Surgery [ 0008-428X ] ; 2000.
Abstract
To demonstrate the usefulness of activated carbon particles (CH40) as a vital staining dye for visualizing lymphatic vessels and lymph nodes in breast cancer.
A retrospective evaluation.
Department of Surgery in Sendai National Hospital, Japan, a 716-bed teaching hospital.
To identify as many lymph nodes as possible in the axillary fat, by which we might decrease the possibility of the presence of undetected metastatic nodes, an emulsion of activated carbon particles (CH40) was injected into the centre of the mammary gland, close to the tumour site, 3 days before radical surgery.
The number of lymph nodes found by the traditional method and by the CH40-injection method were recorded.
After injection, the CH40 was readily adsorbed into regional lymphatics and streamed along with the lymph flow to blacken regional lymph nodes. The CH40-guided method increased the mean number of nodes per case found in the axilla from 8.4, by the traditional method, to 14.0 nodes per case.
The use of the CH40 technique has two technical advantages; one is that it allows surgeons to locate the blackened lymph nodes at the time of surgery and the other is that it allows pathologists to look for the nodes in fatty tissue. Lymph-node dissection with the aid of activated carbon particles is inexpensive, easy to perform and enables the smallest lymph nodes to be easily recognized. CH40 is the technique of choice for the detection of axillary lymph nodes in cases where the number of lymph nodes detected by the traditional method is too small for accurate surgery. In conclusion, the present study demonstrates that CH40 could be an appropriate tool for more accurate staging of breast cancer axillary specimens.
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PubMed: 10851412
PubMed Central: 3695160
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymph-node staining with activated carbon CH40: a new method for axillary lymph-node dissection in breast cancer</title><author><name sortKey="Yokota, Takashi" sort="Yokota, Takashi" uniqKey="Yokota T" first="Takashi" last="Yokota">Takashi Yokota</name></author><author><name sortKey="Saito, Toshihiro" sort="Saito, Toshihiro" uniqKey="Saito T" first="Toshihiro" last="Saito">Toshihiro Saito</name></author><author><name sortKey="Narushima, Yoichi" sort="Narushima, Yoichi" uniqKey="Narushima Y" first="Yoichi" last="Narushima">Yoichi Narushima</name></author><author><name sortKey="Iwamoto, Kazutsugu" sort="Iwamoto, Kazutsugu" uniqKey="Iwamoto K" first="Kazutsugu" last="Iwamoto">Kazutsugu Iwamoto</name></author><author><name sortKey="Iizuka, Masashi" sort="Iizuka, Masashi" uniqKey="Iizuka M" first="Masashi" last="Iizuka">Masashi Iizuka</name></author><author><name sortKey="Hagiwara, Akeo" sort="Hagiwara, Akeo" uniqKey="Hagiwara A" first="Akeo" last="Hagiwara">Akeo Hagiwara</name></author><author><name sortKey="Sawai, Kiyoshi" sort="Sawai, Kiyoshi" uniqKey="Sawai K" first="Kiyoshi" last="Sawai">Kiyoshi Sawai</name></author><author><name sortKey="Kikuchi, Shu" sort="Kikuchi, Shu" uniqKey="Kikuchi S" first="Shu" last="Kikuchi">Shu Kikuchi</name></author><author><name sortKey="Kunii, Yasuo" sort="Kunii, Yasuo" uniqKey="Kunii Y" first="Yasuo" last="Kunii">Yasuo Kunii</name></author><author><name sortKey="Yamauchi, Hidemi" sort="Yamauchi, Hidemi" uniqKey="Yamauchi H" first="Hidemi" last="Yamauchi">Hidemi Yamauchi</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10851412</idno><idno type="pmc">3695160</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695160</idno><idno type="RBID">PMC:3695160</idno><date when="2000">2000</date><idno type="wicri:Area/Pmc/Corpus">002D26</idno><idno type="wicri:explorRef" wicri:stream="Pmc" 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Iwamoto</name></author><author><name sortKey="Iizuka, Masashi" sort="Iizuka, Masashi" uniqKey="Iizuka M" first="Masashi" last="Iizuka">Masashi Iizuka</name></author><author><name sortKey="Hagiwara, Akeo" sort="Hagiwara, Akeo" uniqKey="Hagiwara A" first="Akeo" last="Hagiwara">Akeo Hagiwara</name></author><author><name sortKey="Sawai, Kiyoshi" sort="Sawai, Kiyoshi" uniqKey="Sawai K" first="Kiyoshi" last="Sawai">Kiyoshi Sawai</name></author><author><name sortKey="Kikuchi, Shu" sort="Kikuchi, Shu" uniqKey="Kikuchi S" first="Shu" last="Kikuchi">Shu Kikuchi</name></author><author><name sortKey="Kunii, Yasuo" sort="Kunii, Yasuo" uniqKey="Kunii Y" first="Yasuo" last="Kunii">Yasuo Kunii</name></author><author><name sortKey="Yamauchi, Hidemi" sort="Yamauchi, Hidemi" uniqKey="Yamauchi H" first="Hidemi" last="Yamauchi">Hidemi Yamauchi</name></author></analytic><series><title level="j">Canadian Journal of Surgery</title><idno type="ISSN">0008-428X</idno><idno type="eISSN">1488-2310</idno><imprint><date when="2000">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To demonstrate the usefulness of activated carbon particles (CH40) as a vital staining dye for visualizing lymphatic vessels and lymph nodes in breast cancer.</p></sec><sec><title>Design</title><p>A retrospective evaluation.</p></sec><sec><title>Setting</title><p>Department of Surgery in Sendai National Hospital, Japan, a 716-bed teaching hospital.</p></sec><sec><title>Methods</title><p>To identify as many lymph nodes as possible in the axillary fat, by which we might decrease the possibility of the presence of undetected metastatic nodes, an emulsion of activated carbon particles (CH40) was injected into the centre of the mammary gland, close to the tumour site, 3 days before radical surgery.</p></sec><sec><title>Main outcome measure</title><p>The number of lymph nodes found by the traditional method and by the CH40-injection method were recorded.</p></sec><sec><title>Results</title><p>After injection, the CH40 was readily adsorbed into regional lymphatics and streamed along with the lymph flow to blacken regional lymph nodes. The CH40-guided method increased the mean number of nodes per case found in the axilla from 8.4, by the traditional method, to 14.0 nodes per case.</p></sec><sec><title>Conclusions</title><p>The use of the CH40 technique has two technical advantages; one is that it allows surgeons to locate the blackened lymph nodes at the time of surgery and the other is that it allows pathologists to look for the nodes in fatty tissue. Lymph-node dissection with the aid of activated carbon particles is inexpensive, easy to perform and enables the smallest lymph nodes to be easily recognized. CH40 is the technique of choice for the detection of axillary lymph nodes in cases where the number of lymph nodes detected by the traditional method is too small for accurate surgery. In conclusion, the present study demonstrates that CH40 could be an appropriate tool for more accurate staging of breast cancer axillary specimens.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Can J Surg</journal-id><journal-id journal-id-type="iso-abbrev">Can J Surg</journal-id><journal-id journal-id-type="publisher-id">0372715</journal-id><journal-title-group><journal-title>Canadian Journal of Surgery</journal-title></journal-title-group><issn pub-type="ppub">0008-428X</issn><issn pub-type="epub">1488-2310</issn><publisher><publisher-name>Canadian Medical Association</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">10851412</article-id><article-id pub-id-type="pmc">3695160</article-id><article-id pub-id-type="publisher-id">0430191</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Lymph-node staining with activated carbon CH40: a new method for axillary lymph-node dissection in breast cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yokota</surname><given-names>Takashi</given-names></name><degrees>MD</degrees><xref ref-type="corresp" rid="c1-0430191"></xref></contrib><contrib contrib-type="author"><name><surname>Saito</surname><given-names>Toshihiro</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Narushima</surname><given-names>Yoichi</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Iwamoto</surname><given-names>Kazutsugu</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Iizuka</surname><given-names>Masashi</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Hagiwara</surname><given-names>Akeo</given-names></name><degrees>MD</degrees><xref ref-type="author-notes" rid="fn1-0430191">*</xref></contrib><contrib contrib-type="author"><name><surname>Sawai</surname><given-names>Kiyoshi</given-names></name><degrees>MD</degrees><xref ref-type="author-notes" rid="fn1-0430191">*</xref></contrib><contrib contrib-type="author"><name><surname>Kikuchi</surname><given-names>Shu</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Kunii</surname><given-names>Yasuo</given-names></name><degrees>MD</degrees></contrib><contrib contrib-type="author"><name><surname>Yamauchi</surname><given-names>Hidemi</given-names></name><degrees>MD</degrees></contrib><aff id="af1-0430191">Department of Surgery, Sendai National Hospital, Sendai, 983-8520, Japan</aff></contrib-group><author-notes><corresp id="c1-0430191">Correspondence to: Dr. Takashi Yokota, Department of Surgery, Sendai National Hospital, Miyagino-ku, Sendai 983-8520, Japan; fax 022-291-8114, <email>yokoyoko@jun.ncvc.go.jp</email></corresp><fn id="fn1-0430191"><label>*</label><p>First Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, 602, Japan</p></fn></author-notes><pub-date pub-type="ppub"><month>6</month><year>2000</year></pub-date><volume>43</volume><issue>3</issue><fpage>191</fpage><lpage>196</lpage><history><date date-type="accepted"><day>04</day><month>7</month><year>1999</year></date></history><permissions><copyright-statement>© 2000 Canadian Medical Association</copyright-statement><copyright-year>2000</copyright-year></permissions><abstract><sec><title>Objective</title><p>To demonstrate the usefulness of activated carbon particles (CH40) as a vital staining dye for visualizing lymphatic vessels and lymph nodes in breast cancer.</p></sec><sec><title>Design</title><p>A retrospective evaluation.</p></sec><sec><title>Setting</title><p>Department of Surgery in Sendai National Hospital, Japan, a 716-bed teaching hospital.</p></sec><sec><title>Methods</title><p>To identify as many lymph nodes as possible in the axillary fat, by which we might decrease the possibility of the presence of undetected metastatic nodes, an emulsion of activated carbon particles (CH40) was injected into the centre of the mammary gland, close to the tumour site, 3 days before radical surgery.</p></sec><sec><title>Main outcome measure</title><p>The number of lymph nodes found by the traditional method and by the CH40-injection method were recorded.</p></sec><sec><title>Results</title><p>After injection, the CH40 was readily adsorbed into regional lymphatics and streamed along with the lymph flow to blacken regional lymph nodes. The CH40-guided method increased the mean number of nodes per case found in the axilla from 8.4, by the traditional method, to 14.0 nodes per case.</p></sec><sec><title>Conclusions</title><p>The use of the CH40 technique has two technical advantages; one is that it allows surgeons to locate the blackened lymph nodes at the time of surgery and the other is that it allows pathologists to look for the nodes in fatty tissue. Lymph-node dissection with the aid of activated carbon particles is inexpensive, easy to perform and enables the smallest lymph nodes to be easily recognized. CH40 is the technique of choice for the detection of axillary lymph nodes in cases where the number of lymph nodes detected by the traditional method is too small for accurate surgery. In conclusion, the present study demonstrates that CH40 could be an appropriate tool for more accurate staging of breast cancer axillary specimens.</p></sec></abstract><trans-abstract xml:lang="fr"><sec><title>Objectif</title><p>Démontrer l’utilité des particules de carbone activé (CH40) comme colorant vital pour visualiser les vaisseaux lymphatiques et les ganglions lymphatiques dans les cas de cancer du sein.</p></sec><sec><title>Conception</title><p>Évaluation rétrospective.</p></sec><sec><title>Contexte</title><p>Département de chirurgie de l’Hôpital Sendai National, Japon, hôpital d’enseignement de 716 lits.</p></sec><sec><title>Méthodes</title><p>Afin d’identifier, dans le gras axillaire, le plus grand nombre possible de ganglions lymphatiques, ce qui permettrait de réduire la possibilité qu’il y ait des métastases non détectées dans les ganglions, on a injecté une émulsion de particules de carbone activé (CH40) dans le centre de la glande mammaire, à proximité du site de la tumeur, trois jours avant une intervention chirurgicale radicale.</p></sec><sec><title>Principale mesure de résultats</title><p>On a consigné le nombre de ganglions lymphatiques découverts au moyen de la méthode classique et de la méthode à l’injection de CH40.</p></sec><sec><title>Résultats</title><p>Après l’injection, le CH40 a été rapidement absorbé dans le système lymphatique régional qu’il a suivi pour noircir les ganglions lymphatiques régionaux. La méthode guidée par le CH40 a augmenté le nombre moyen de ganglions par cas découverts dans la région axillaire pour porter les 8,4 ganglions découverts par la méthode traditionnelle à 14,0 ganglions par cas.</p></sec><sec><title>Conclusions</title><p>L’utilisation de la méthode au CH40 offre deux avantages techniques : elle permet au chirurgien de localiser les ganglions lymphatiques noircis au moment de l’intervention chirurgicale et au pathologiste de chercher des ganglions présents dans le tissu gras. L’exérèse de ganglions lymphatiques au moyen de particules de carbone activé est peu coûteuse, facile à pratiquer et permet de reconnaître facilement les ganglions lymphatiques les plus petits. La méthode au CH40 est la technique de choix pour détecter les ganglions lymphatiques axillaires lorsque le nombre de ganglions lymphatiques détectés par la méthode classique est trop limité pour permettre une intervention chirurgicale précise. En conclusion, l’é-tude démontre que le CH40 pourrait constituer un outil approprié qui aiderait à déterminer avec plus de précision le stade de spécimens axillaires dans les cas de cancer du sein.</p></sec></trans-abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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