Efficacy of multimodal exercise-based rehabilitation on physical activity, cardiorespiratory fitness, and patient-reported outcomes in cancer survivors: a randomized, controlled trial
Identifieur interne : 002C17 ( Pmc/Curation ); précédent : 002C16; suivant : 002C18Efficacy of multimodal exercise-based rehabilitation on physical activity, cardiorespiratory fitness, and patient-reported outcomes in cancer survivors: a randomized, controlled trial
Auteurs : J. Midtgaard ; J. F. Christensen ; A. Tolver [Danemark] ; L. W. Jones [États-Unis] ; J. Uth ; B. Rasmussen ; L. Tang ; L. Adamsen ; M. R RthSource :
- Annals of Oncology [ 0923-7534 ] ; 2013.
Abstract
Sedentary behavior and impaired cardiovascular reserve capacity are common late effects of cancer therapy emphasizing the need for effective strategies to increase physical activity (PA) in cancer survivors. We examined the efficacy of a 12-month exercise-based rehabilitation program on self-reported PA, cardiorespiratory fitness (VO2peak), strength, and patient-reported outcomes.
Two hundred fourteen post-treatment cancer survivors were randomly assigned to a 12-month rehabilitation program consisting of individual (
After 12 months, the percentage of patients reporting meeting PA goal behavior (≥3 h/week) was significantly increased in the PACT group versus the HE group (70.4% versus 43.4%,
A 12-month exercise-based rehabilitation program is an effective strategy to promote PA and improve VO2peak in cancer survivors.
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DOI: 10.1093/annonc/mdt185
PubMed: 23704198
PubMed Central: 3755327
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Christensen</name><affiliation><nlm:aff id="mdt185_af3"><addr-line>Department of Oncology</addr-line>,<institution>Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tolver, A" sort="Tolver, A" uniqKey="Tolver A" first="A." last="Tolver">A. Tolver</name><affiliation wicri:level="1"><nlm:aff id="mdt185_af4"><addr-line>Department of Mathematical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jones, L W" sort="Jones, L W" uniqKey="Jones L" first="L. W." last="Jones">L. W. Jones</name><affiliation wicri:level="1"><nlm:aff id="mdt185_af5"><addr-line>Department of Radiation Oncology</addr-line>,<institution>Duke Cancer Institute</institution>,<addr-line>Durham</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uth, J" sort="Uth, J" uniqKey="Uth J" first="J." last="Uth">J. Uth</name><affiliation><nlm:aff id="mdt185_af1"><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rasmussen, B" sort="Rasmussen, B" uniqKey="Rasmussen B" first="B." last="Rasmussen">B. Rasmussen</name><affiliation><nlm:aff id="mdt185_af1"><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tang, L" sort="Tang, L" uniqKey="Tang L" first="L." last="Tang">L. Tang</name><affiliation><nlm:aff id="mdt185_af1"><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="Adamsen, L" sort="Adamsen, L" uniqKey="Adamsen L" first="L." last="Adamsen">L. Adamsen</name><affiliation><nlm:aff id="mdt185_af1"><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdt185_af2"><addr-line>Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="R Rth, M" sort="R Rth, M" uniqKey="R Rth M" first="M." last="R Rth">M. R Rth</name><affiliation><nlm:aff id="mdt185_af3"><addr-line>Department of Oncology</addr-line>,<institution>Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23704198</idno><idno type="pmc">3755327</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3755327</idno><idno type="RBID">PMC:3755327</idno><idno type="doi">10.1093/annonc/mdt185</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002C18</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002C18</idno><idno type="wicri:Area/Pmc/Curation">002C17</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C17</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy of multimodal exercise-based rehabilitation on physical activity, cardiorespiratory fitness, and patient-reported outcomes in cancer survivors: a randomized, controlled trial</title><author><name sortKey="Midtgaard, J" sort="Midtgaard, J" uniqKey="Midtgaard J" first="J." last="Midtgaard">J. Midtgaard</name><affiliation><nlm:aff id="mdt185_af1"><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdt185_af2"><addr-line>Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="Christensen, J F" sort="Christensen, J F" uniqKey="Christensen J" first="J. F." last="Christensen">J. F. Christensen</name><affiliation><nlm:aff id="mdt185_af3"><addr-line>Department of Oncology</addr-line>,<institution>Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tolver, A" sort="Tolver, A" uniqKey="Tolver A" first="A." last="Tolver">A. Tolver</name><affiliation wicri:level="1"><nlm:aff id="mdt185_af4"><addr-line>Department of Mathematical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jones, L W" sort="Jones, L W" uniqKey="Jones L" first="L. W." last="Jones">L. W. Jones</name><affiliation wicri:level="1"><nlm:aff id="mdt185_af5"><addr-line>Department of Radiation Oncology</addr-line>,<institution>Duke Cancer Institute</institution>,<addr-line>Durham</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Uth, J" sort="Uth, J" uniqKey="Uth J" first="J." last="Uth">J. Uth</name><affiliation><nlm:aff id="mdt185_af1"><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="Rasmussen, B" sort="Rasmussen, B" uniqKey="Rasmussen B" first="B." last="Rasmussen">B. Rasmussen</name><affiliation><nlm:aff id="mdt185_af1"><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="Tang, L" sort="Tang, L" uniqKey="Tang L" first="L." last="Tang">L. Tang</name><affiliation><nlm:aff id="mdt185_af1"><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="Adamsen, L" sort="Adamsen, L" uniqKey="Adamsen L" first="L." last="Adamsen">L. Adamsen</name><affiliation><nlm:aff id="mdt185_af1"><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation><affiliation><nlm:aff id="mdt185_af2"><addr-line>Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author><author><name sortKey="R Rth, M" sort="R Rth, M" uniqKey="R Rth M" first="M." last="R Rth">M. R Rth</name><affiliation><nlm:aff id="mdt185_af3"><addr-line>Department of Oncology</addr-line>,<institution>Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Annals of Oncology</title><idno type="ISSN">0923-7534</idno><idno type="eISSN">1569-8041</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Sedentary behavior and impaired cardiovascular reserve capacity are common late effects of cancer therapy emphasizing the need for effective strategies to increase physical activity (PA) in cancer survivors. We examined the efficacy of a 12-month exercise-based rehabilitation program on self-reported PA, cardiorespiratory fitness (VO<sub>2peak</sub>), strength, and patient-reported outcomes.</p></sec><sec><title>Patients and methods</title><p>Two hundred fourteen post-treatment cancer survivors were randomly assigned to a 12-month rehabilitation program consisting of individual (<italic>x</italic>3) and group-based (<italic>x</italic>6) counseling in combination with once weekly high-intensity group-based exercise training (the Copenhagen Physical Activity after Cancer Treatment, PACT; <italic>n</italic> = 108) or to a health evaluation program (HE, <italic>n</italic> = 106). Study outcomes were assessed at baseline, 6 months, and 12 months.</p></sec><sec><title>Results</title><p>After 12 months, the percentage of patients reporting meeting PA goal behavior (≥3 h/week) was significantly increased in the PACT group versus the HE group (70.4% versus 43.4%, <italic>P</italic> = 0.001). Repeated measures analyses indicated a statistically significant improvement in VO<sub>2peak</sub> (l min<sup>−1</sup>) in favour of PACT (treatment effect ratio = 1.04; 95% confidence interval 1.00–1.07; <italic>P</italic> = 0.032). Significant between group differences were also observed for strength (<italic>P</italic> < 0.001), depression (<italic>P</italic> = 0.020) and mental health (<italic>P</italic> = 0.040).</p></sec><sec><title>Conclusion</title><p>A 12-month exercise-based rehabilitation program is an effective strategy to promote PA and improve VO<sub>2peak</sub> in cancer survivors.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Ann. Oncol</journal-id><journal-id journal-id-type="publisher-id">annonc</journal-id><journal-id journal-id-type="hwp">annonc</journal-id><journal-title-group><journal-title>Annals of Oncology</journal-title></journal-title-group><issn pub-type="ppub">0923-7534</issn><issn pub-type="epub">1569-8041</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23704198</article-id><article-id pub-id-type="pmc">3755327</article-id><article-id pub-id-type="doi">10.1093/annonc/mdt185</article-id><article-id pub-id-type="publisher-id">mdt185</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject><subj-group subj-group-type="heading"><subject>Quality of Life</subject></subj-group></subj-group></article-categories><title-group><article-title>Efficacy of multimodal exercise-based rehabilitation on physical activity, cardiorespiratory fitness, and patient-reported outcomes in cancer survivors: a randomized, controlled trial</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Midtgaard</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="mdt185_af1">1</xref><xref ref-type="aff" rid="mdt185_af2">2</xref><xref ref-type="corresp" rid="mdt185_cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Christensen</surname><given-names>J. F.</given-names></name><xref ref-type="aff" rid="mdt185_af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Tolver</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="mdt185_af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Jones</surname><given-names>L. W.</given-names></name><xref ref-type="aff" rid="mdt185_af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Uth</surname><given-names>J.</given-names></name><xref ref-type="aff" rid="mdt185_af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rasmussen</surname><given-names>B.</given-names></name><xref ref-type="aff" rid="mdt185_af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tang</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="mdt185_af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Adamsen</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="mdt185_af1">1</xref><xref ref-type="aff" rid="mdt185_af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Rørth</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="mdt185_af3">3</xref></contrib></contrib-group><aff id="mdt185_af1"><label>1</label><institution>The University Hospitals Centre for Health Care Research, Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></aff><aff id="mdt185_af2"><label>2</label><addr-line>Faculty of Health and Medical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line></aff><aff id="mdt185_af3"><label>3</label><addr-line>Department of Oncology</addr-line>,<institution>Rigshospitalet</institution>,<addr-line>Copenhagen</addr-line></aff><aff id="mdt185_af4"><label>4</label><addr-line>Department of Mathematical Sciences</addr-line>,<institution>University of Copenhagen</institution>,<addr-line>Copenhagen</addr-line>,<country>Denmark</country></aff><aff id="mdt185_af5"><label>5</label><addr-line>Department of Radiation Oncology</addr-line>,<institution>Duke Cancer Institute</institution>,<addr-line>Durham</addr-line>,<country>USA</country></aff><author-notes><corresp id="mdt185_cor1"><label>*</label><italic>Correspondence to:</italic> Dr Julie Midtgaard, The University Hospitals Centre for Health Care Research, 9 Blegdamsvej, Rigshospitalet, DK-2100 Copenhagen, Denmark and Faculty of Health and Medical Sciences, University of Copenhagen, 3B Blegdamsvej, DK-2200 Copenhagen, Denmark. Tel: +<phone>45-3545-7336</phone>; Fax: +<fax>45-3545-7399</fax>; E-mail: <email>julie@ucsf.dk</email></corresp></author-notes><pub-date pub-type="ppub"><month>9</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>23</day><month>5</month><year>2013</year></pub-date><volume>24</volume><issue>9</issue><fpage>2267</fpage><lpage>2273</lpage><history><date date-type="received"><day>3</day><month>11</month><year>2012</year></date><date date-type="rev-recd"><day>12</day><month>3</month><year>2013</year></date><date date-type="accepted"><day>10</day><month>4</month><year>2013</year></date></history><permissions><copyright-statement>© The Author 2013. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="mdt185.pdf"></self-uri><abstract><sec><title>Background</title><p>Sedentary behavior and impaired cardiovascular reserve capacity are common late effects of cancer therapy emphasizing the need for effective strategies to increase physical activity (PA) in cancer survivors. We examined the efficacy of a 12-month exercise-based rehabilitation program on self-reported PA, cardiorespiratory fitness (VO<sub>2peak</sub>), strength, and patient-reported outcomes.</p></sec><sec><title>Patients and methods</title><p>Two hundred fourteen post-treatment cancer survivors were randomly assigned to a 12-month rehabilitation program consisting of individual (<italic>x</italic>3) and group-based (<italic>x</italic>6) counseling in combination with once weekly high-intensity group-based exercise training (the Copenhagen Physical Activity after Cancer Treatment, PACT; <italic>n</italic> = 108) or to a health evaluation program (HE, <italic>n</italic> = 106). Study outcomes were assessed at baseline, 6 months, and 12 months.</p></sec><sec><title>Results</title><p>After 12 months, the percentage of patients reporting meeting PA goal behavior (≥3 h/week) was significantly increased in the PACT group versus the HE group (70.4% versus 43.4%, <italic>P</italic> = 0.001). Repeated measures analyses indicated a statistically significant improvement in VO<sub>2peak</sub> (l min<sup>−1</sup>) in favour of PACT (treatment effect ratio = 1.04; 95% confidence interval 1.00–1.07; <italic>P</italic> = 0.032). Significant between group differences were also observed for strength (<italic>P</italic> < 0.001), depression (<italic>P</italic> = 0.020) and mental health (<italic>P</italic> = 0.040).</p></sec><sec><title>Conclusion</title><p>A 12-month exercise-based rehabilitation program is an effective strategy to promote PA and improve VO<sub>2peak</sub> in cancer survivors.</p></sec></abstract><kwd-group><kwd>cancer survivors</kwd><kwd>cardiorespiratory fitness</kwd><kwd>exercise</kwd><kwd>physical activity behavior</kwd><kwd>rct</kwd><kwd>rehabilitation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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