HSV-1 Targets Lymphatic Vessels in the Eye and Draining Lymph Node of Mice Leading to Edema in the Absence of a Functional Type I Interferon Response
Identifieur interne : 002B65 ( Pmc/Curation ); précédent : 002B64; suivant : 002B66HSV-1 Targets Lymphatic Vessels in the Eye and Draining Lymph Node of Mice Leading to Edema in the Absence of a Functional Type I Interferon Response
Auteurs : Katie M. Bryant-Hudson ; Ana J. Chucair-Elliott ; Christopher D. Conrady ; Alex Cohen ; Min Zheng ; Daniel J. J. CarrSource :
- The American Journal of Pathology [ 0002-9440 ] ; 2013.
Abstract
Herpes simplex virus type-1 (HSV-1) induces new lymphatic vessel growth (lymphangiogenesis) in the cornea via expression of vascular endothelial growth factor by virally infected epithelial cells. Here, we extend this observation to demonstrate the selective targeting of corneal lymphatics by HSV-1 in the absence of functional type I interferon (IFN) pathway. Specifically, we examined the impact of HSV-1 replication on angiogenesis using type I IFN receptor deficient (
Url:
DOI: 10.1016/j.ajpath.2013.06.014
PubMed: 23911821
PubMed Central: 3791868
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<author><name sortKey="Bryant Hudson, Katie M" sort="Bryant Hudson, Katie M" uniqKey="Bryant Hudson K" first="Katie M." last="Bryant-Hudson">Katie M. Bryant-Hudson</name>
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<author><name sortKey="Chucair Elliott, Ana J" sort="Chucair Elliott, Ana J" uniqKey="Chucair Elliott A" first="Ana J." last="Chucair-Elliott">Ana J. Chucair-Elliott</name>
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<author><name sortKey="Conrady, Christopher D" sort="Conrady, Christopher D" uniqKey="Conrady C" first="Christopher D." last="Conrady">Christopher D. Conrady</name>
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<author><name sortKey="Cohen, Alex" sort="Cohen, Alex" uniqKey="Cohen A" first="Alex" last="Cohen">Alex Cohen</name>
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<author><name sortKey="Zheng, Min" sort="Zheng, Min" uniqKey="Zheng M" first="Min" last="Zheng">Min Zheng</name>
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<author><name sortKey="Carr, Daniel J J" sort="Carr, Daniel J J" uniqKey="Carr D" first="Daniel J. J." last="Carr">Daniel J. J. Carr</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">HSV-1 Targets Lymphatic Vessels in the Eye and Draining Lymph Node of Mice Leading to Edema in the Absence of a Functional Type I Interferon Response</title>
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<author><name sortKey="Chucair Elliott, Ana J" sort="Chucair Elliott, Ana J" uniqKey="Chucair Elliott A" first="Ana J." last="Chucair-Elliott">Ana J. Chucair-Elliott</name>
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<author><name sortKey="Cohen, Alex" sort="Cohen, Alex" uniqKey="Cohen A" first="Alex" last="Cohen">Alex Cohen</name>
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<author><name sortKey="Zheng, Min" sort="Zheng, Min" uniqKey="Zheng M" first="Min" last="Zheng">Min Zheng</name>
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<author><name sortKey="Carr, Daniel J J" sort="Carr, Daniel J J" uniqKey="Carr D" first="Daniel J. J." last="Carr">Daniel J. J. Carr</name>
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<series><title level="j">The American Journal of Pathology</title>
<idno type="ISSN">0002-9440</idno>
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<front><div type="abstract" xml:lang="en"><p>Herpes simplex virus type-1 (HSV-1) induces new lymphatic vessel growth (lymphangiogenesis) in the cornea via expression of vascular endothelial growth factor by virally infected epithelial cells. Here, we extend this observation to demonstrate the selective targeting of corneal lymphatics by HSV-1 in the absence of functional type I interferon (IFN) pathway. Specifically, we examined the impact of HSV-1 replication on angiogenesis using type I IFN receptor deficient (<italic>CD118</italic>
<sup>−<italic>/</italic>
−</sup>
) mice. HSV-1-induced lymphatic and blood vessel growth into the cornea proper was time-dependent in immunocompetent animals. In contrast, there was an initial robust growth of lymphatic vessels into the cornea of HSV-1-infected <italic>CD118</italic>
<sup>−<italic>/</italic>
−</sup>
mice, but such vessels disappeared by day 5 postinfection. The loss was selective as blood vessel integrity remained intact. Magnetic resonance imaging and confocal microscopy analysis of the draining lymph nodes of <italic>CD118</italic>
<sup>−<italic>/</italic>
−</sup>
mice revealed extensive edema and loss of lymphatics compared with wild-type mice. In addition to a loss of lymphatic vessels in <italic>CD118</italic>
<sup>−<italic>/</italic>
−</sup>
mice, HSV-1 infection resulted in epithelial thinning associated with geographic lesions and edema within the cornea, which is consistent with a loss of lymphatic vasculature. These results underscore the key role functional type I IFN pathway plays in the maintenance of structural integrity within the cornea in addition to the anti-viral characteristics often ascribed to the type I IFN cytokine family.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Pathol</journal-id>
<journal-id journal-id-type="iso-abbrev">Am. J. Pathol</journal-id>
<journal-title-group><journal-title>The American Journal of Pathology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0002-9440</issn>
<issn pub-type="epub">1525-2191</issn>
<publisher><publisher-name>American Society for Investigative Pathology</publisher-name>
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<article-id pub-id-type="publisher-id">S0002-9440(13)00470-7</article-id>
<article-id pub-id-type="doi">10.1016/j.ajpath.2013.06.014</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Regular Article</subject>
<subj-group><subject>Immunopathology and Infectious Diseases</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>HSV-1 Targets Lymphatic Vessels in the Eye and Draining Lymph Node of Mice Leading to Edema in the Absence of a Functional Type I Interferon Response</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Bryant-Hudson</surname>
<given-names>Katie M.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Chucair-Elliott</surname>
<given-names>Ana J.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Conrady</surname>
<given-names>Christopher D.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Cohen</surname>
<given-names>Alex</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Zheng</surname>
<given-names>Min</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Carr</surname>
<given-names>Daniel J.J.</given-names>
</name>
<email>dan-carr@ouhsc.edu</email>
<xref rid="cor1" ref-type="corresp">∗</xref>
</contrib>
</contrib-group>
<aff id="aff1">Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma</aff>
<author-notes><corresp id="cor1"><label>∗</label>
Address correspondence to Daniel J.J. Carr, Ph.D., Department of Ophthalmology, Dean McGee Eye Institute, Room 415, The University of Oklahoma Health Sciences Center, 608 Stanton L Young Boulevard, Oklahoma City, OK 73104. <email>dan-carr@ouhsc.edu</email>
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<pub-date pub-type="pmc-release"><day>1</day>
<month>10</month>
<year>2014</year>
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<pmc-comment> PMC Release delay is 12 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>10</month>
<year>2013</year>
</pub-date>
<volume>183</volume>
<issue>4</issue>
<fpage>1233</fpage>
<lpage>1242</lpage>
<history><date date-type="accepted"><day>20</day>
<month>6</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>© 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>American Society for Investigative Pathology</copyright-holder>
<license><license-p>This document may be redistributed and reused, subject to <ext-link ext-link-type="uri" xlink:href="http://www.elsevier.com/wps/find/authorsview.authors/supplementalterms1.0">certain conditions</ext-link>
.</license-p>
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<abstract><p>Herpes simplex virus type-1 (HSV-1) induces new lymphatic vessel growth (lymphangiogenesis) in the cornea via expression of vascular endothelial growth factor by virally infected epithelial cells. Here, we extend this observation to demonstrate the selective targeting of corneal lymphatics by HSV-1 in the absence of functional type I interferon (IFN) pathway. Specifically, we examined the impact of HSV-1 replication on angiogenesis using type I IFN receptor deficient (<italic>CD118</italic>
<sup>−<italic>/</italic>
−</sup>
) mice. HSV-1-induced lymphatic and blood vessel growth into the cornea proper was time-dependent in immunocompetent animals. In contrast, there was an initial robust growth of lymphatic vessels into the cornea of HSV-1-infected <italic>CD118</italic>
<sup>−<italic>/</italic>
−</sup>
mice, but such vessels disappeared by day 5 postinfection. The loss was selective as blood vessel integrity remained intact. Magnetic resonance imaging and confocal microscopy analysis of the draining lymph nodes of <italic>CD118</italic>
<sup>−<italic>/</italic>
−</sup>
mice revealed extensive edema and loss of lymphatics compared with wild-type mice. In addition to a loss of lymphatic vessels in <italic>CD118</italic>
<sup>−<italic>/</italic>
−</sup>
mice, HSV-1 infection resulted in epithelial thinning associated with geographic lesions and edema within the cornea, which is consistent with a loss of lymphatic vasculature. These results underscore the key role functional type I IFN pathway plays in the maintenance of structural integrity within the cornea in addition to the anti-viral characteristics often ascribed to the type I IFN cytokine family.</p>
</abstract>
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</front>
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