Adrenomedullin delivery in microsphere-scaffold composite for remodeling of the alveolar bone following tooth extraction: an experimental study in the rat
Identifieur interne : 002A89 ( Pmc/Curation ); précédent : 002A88; suivant : 002A90Adrenomedullin delivery in microsphere-scaffold composite for remodeling of the alveolar bone following tooth extraction: an experimental study in the rat
Auteurs : Lin Wang [République populaire de Chine] ; Ling Zheng [République populaire de Chine] ; Chunyan Li [République populaire de Chine] ; Shujun Dong [République populaire de Chine] ; Lan A [République populaire de Chine] ; Yanmin Zhou [République populaire de Chine]Source :
- BioMedical Engineering OnLine [ 1475-925X ] ; 2013.
Abstract
Alveolar ridge resorption, as a significant problem in implant and restorative dentistry, has long been considered as an inevitable outcome following tooth extraction. Recently, adrenomedullin (ADM) is reported to be able to stimulate the proliferation and migration of various cells including osteoblasts. The purpose of this study was to investigate the influence of local ADM application in the tooth extraction socket
Chitosan micropheres were developed by an emulsion-ionic cross-linking method for ADM delivery. Poly (L -lactic-co-glycolic) acid (PLGA) and nano-hydroxyapatite (nHA) were used to prepare scaffolds to contain the micrspheres with ADM.
The microspheres had a spherical structure and a relative rough and uniform surface, and the particle size was under a normal distribution, with the average diameter of 38.59 μm. The scaffolds had open and interconnected pores. In addition, the high porosity of the composite was 88.93%. Radiographic and histological examination revealed that the PLGA/nHA/CMs/ADM composite could accelerate the alveolar bone remodeling and reduce the residual ridge resorption compared with the PLGA/nHA/CMs scaffold.
The results of this study suggest that local application of ADM has the potential to preserve the residual alveolar ridge and accelerate the alveolar bone remodeling.
Url:
DOI: 10.1186/1475-925X-12-99
PubMed: 24099554
PubMed Central: 4124888
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populaire de Chine</country><wicri:regionArea>Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun</wicri:regionArea></affiliation></author><author><name sortKey="Li, Chunyan" sort="Li, Chunyan" uniqKey="Li C" first="Chunyan" last="Li">Chunyan Li</name><affiliation wicri:level="1"><nlm:aff id="I2">Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun</wicri:regionArea></affiliation></author><author><name sortKey="Dong, Shujun" sort="Dong, Shujun" uniqKey="Dong S" first="Shujun" last="Dong">Shujun Dong</name><affiliation wicri:level="1"><nlm:aff id="I1">VIP integrated department, Stomatological hospital, Jilin University, Changchun, China</nlm:aff><country 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xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24099554</idno><idno type="pmc">4124888</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124888</idno><idno type="RBID">PMC:4124888</idno><idno type="doi">10.1186/1475-925X-12-99</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002A90</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A90</idno><idno type="wicri:Area/Pmc/Curation">002A89</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A89</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Adrenomedullin delivery in microsphere-scaffold composite for remodeling of the alveolar bone following tooth extraction: an experimental study in the rat</title><author><name sortKey="Wang, Lin" sort="Wang, Lin" uniqKey="Wang L" first="Lin" last="Wang">Lin Wang</name><affiliation wicri:level="1"><nlm:aff id="I1">VIP integrated department, Stomatological hospital, Jilin University, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>VIP integrated department, Stomatological hospital, Jilin University, Changchun</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Ling" sort="Zheng, Ling" uniqKey="Zheng L" first="Ling" last="Zheng">Ling Zheng</name><affiliation wicri:level="1"><nlm:aff id="I2">Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun</wicri:regionArea></affiliation></author><author><name sortKey="Li, Chunyan" sort="Li, Chunyan" uniqKey="Li C" first="Chunyan" last="Li">Chunyan Li</name><affiliation wicri:level="1"><nlm:aff id="I2">Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun</wicri:regionArea></affiliation></author><author><name sortKey="Dong, Shujun" sort="Dong, Shujun" uniqKey="Dong S" first="Shujun" last="Dong">Shujun Dong</name><affiliation wicri:level="1"><nlm:aff id="I1">VIP integrated department, Stomatological hospital, Jilin University, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>VIP integrated department, Stomatological hospital, Jilin University, Changchun</wicri:regionArea></affiliation></author><author><name sortKey="A, Lan" sort="A, Lan" uniqKey="A L" first="Lan" last="A">Lan A</name><affiliation wicri:level="1"><nlm:aff id="I2">Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Yanmin" sort="Zhou, Yanmin" uniqKey="Zhou Y" first="Yanmin" last="Zhou">Yanmin Zhou</name><affiliation wicri:level="1"><nlm:aff id="I2">Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun</wicri:regionArea></affiliation></author></analytic><series><title level="j">BioMedical Engineering OnLine</title><idno type="eISSN">1475-925X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Alveolar ridge resorption, as a significant problem in implant and restorative dentistry, has long been considered as an inevitable outcome following tooth extraction. Recently, adrenomedullin (ADM) is reported to be able to stimulate the proliferation and migration of various cells including osteoblasts. The purpose of this study was to investigate the influence of local ADM application in the tooth extraction socket <italic>in vivo</italic>.</p></sec><sec><title>Methods</title><p>Chitosan micropheres were developed by an emulsion-ionic cross-linking method for ADM delivery. Poly (L -lactic-co-glycolic) acid (PLGA) and nano-hydroxyapatite (nHA) were used to prepare scaffolds to contain the micrspheres with ADM. <italic>In vivo</italic> experiment was evaluated by transplanting the composite into the rat socket right after the incisor extraction. After 4, 8, 12 weeks implantation, radiographic and histological tests were carried out to evaluate the effect of released ADM on the alveolar bone.</p></sec><sec><title>Results</title><p>The microspheres had a spherical structure and a relative rough and uniform surface, and the particle size was under a normal distribution, with the average diameter of 38.59 μm. The scaffolds had open and interconnected pores. In addition, the high porosity of the composite was 88.93%. Radiographic and histological examination revealed that the PLGA/nHA/CMs/ADM composite could accelerate the alveolar bone remodeling and reduce the residual ridge resorption compared with the PLGA/nHA/CMs scaffold.</p></sec><sec><title>Conclusions</title><p>The results of this study suggest that local application of ADM has the potential to preserve the residual alveolar ridge and accelerate the alveolar bone remodeling.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mardas, N" uniqKey="Mardas N">N Mardas</name></author><author><name sortKey="Chadha, V" uniqKey="Chadha V">V Chadha</name></author><author><name sortKey="Donos, N" uniqKey="Donos N">N Donos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kutkut, A" uniqKey="Kutkut A">A Kutkut</name></author><author><name sortKey="Andreana, S" uniqKey="Andreana S">S Andreana</name></author><author><name sortKey="Kim, Hl" uniqKey="Kim H">HL 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Eng Online</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Eng Online</journal-id><journal-title-group><journal-title>BioMedical Engineering OnLine</journal-title></journal-title-group><issn pub-type="epub">1475-925X</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24099554</article-id><article-id pub-id-type="pmc">4124888</article-id><article-id pub-id-type="publisher-id">1475-925X-12-99</article-id><article-id pub-id-type="doi">10.1186/1475-925X-12-99</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Adrenomedullin delivery in microsphere-scaffold composite for remodeling of the alveolar bone following tooth extraction: an experimental study in the rat</article-title></title-group><contrib-group><contrib contrib-type="author" id="A1"><name><surname>Wang</surname><given-names>Lin</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>wanglin1982@jlu.edu.cn</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Zheng</surname><given-names>Ling</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>zl19870123@126.com</email></contrib><contrib contrib-type="author" id="A3"><name><surname>Li</surname><given-names>Chunyan</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>cyli@jlu.edu.cn</email></contrib><contrib contrib-type="author" id="A4"><name><surname>Dong</surname><given-names>Shujun</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>dsj@jlu.edu.cn</email></contrib><contrib contrib-type="author" id="A5"><name><surname>A</surname><given-names>Lan</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>hialan1983_2001@163.com</email></contrib><contrib contrib-type="author" corresp="yes" id="A6"><name><surname>Zhou</surname><given-names>Yanmin</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>zhouym@jlu.edu.cn</email></contrib></contrib-group><aff id="I1"><label>1</label>VIP integrated department, Stomatological hospital, Jilin University, Changchun, China</aff><aff id="I2"><label>2</label>Implant center, Stomatological hospital, Jilin University, 1500# Qinghua Road, Chaoyang District, Changchun, China</aff><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>8</day><month>10</month><year>2013</year></pub-date><volume>12</volume><fpage>99</fpage><lpage>99</lpage><history><date date-type="received"><day>11</day><month>5</month><year>2013</year></date><date date-type="accepted"><day>18</day><month>9</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 Wang et al.; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Wang et al.; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:href="http://www.biomedical-engineering-online.com/content/12/1/99"></self-uri><abstract><sec><title>Background</title><p>Alveolar ridge resorption, as a significant problem in implant and restorative dentistry, has long been considered as an inevitable outcome following tooth extraction. Recently, adrenomedullin (ADM) is reported to be able to stimulate the proliferation and migration of various cells including osteoblasts. The purpose of this study was to investigate the influence of local ADM application in the tooth extraction socket <italic>in vivo</italic>.</p></sec><sec><title>Methods</title><p>Chitosan micropheres were developed by an emulsion-ionic cross-linking method for ADM delivery. Poly (L -lactic-co-glycolic) acid (PLGA) and nano-hydroxyapatite (nHA) were used to prepare scaffolds to contain the micrspheres with ADM. <italic>In vivo</italic> experiment was evaluated by transplanting the composite into the rat socket right after the incisor extraction. After 4, 8, 12 weeks implantation, radiographic and histological tests were carried out to evaluate the effect of released ADM on the alveolar bone.</p></sec><sec><title>Results</title><p>The microspheres had a spherical structure and a relative rough and uniform surface, and the particle size was under a normal distribution, with the average diameter of 38.59 μm. The scaffolds had open and interconnected pores. In addition, the high porosity of the composite was 88.93%. Radiographic and histological examination revealed that the PLGA/nHA/CMs/ADM composite could accelerate the alveolar bone remodeling and reduce the residual ridge resorption compared with the PLGA/nHA/CMs scaffold.</p></sec><sec><title>Conclusions</title><p>The results of this study suggest that local application of ADM has the potential to preserve the residual alveolar ridge and accelerate the alveolar bone remodeling.</p></sec></abstract><kwd-group><kwd>Poly (lactic-co-glycolic) acid</kwd><kwd>Microsphere</kwd><kwd>Adrenomedullin</kwd><kwd>Alveolar bone loss</kwd><kwd>Bone regeneration</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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