Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial
Identifieur interne : 002A13 ( Pmc/Curation ); précédent : 002A12; suivant : 002A14Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial
Auteurs : Kerri M. Winters-Stone ; Jessica Dobek ; Lillian Nail ; Jill A. Bennett ; Michael C. Leo ; Arpana Naik ; Anna SchwartzSource :
- Breast cancer research and treatment [ 0167-6806 ] ; 2011.
Abstract
Targeted exercise training could reduce risk factors for fracture and obesity-related diseases that increase from breast cancer treatment, but has not been sufficiently tested. We hypothesized that progressive, moderate-intensity resistance + impact training would increase or maintain hip and spine bone mass, lean mass and fat mass and reduce bone turnover compared to controls who participated in a low-intensity, non-weight bearing stretching program. We conducted a randomized, controlled trial in 106 women with early stage breast cancer who were >1 year post-radiation and/or chemotherapy, ≥50 years of age at diagnosis and postmenopausal, free from osteoporosis and medications for bone loss, resistance and impact exercise naïve, and cleared to exercise by a physician. Women were randomly assigned to participate in 1 year of thrice-weekly progressive, moderate-intensity resistance + impact (jump) exercise or in a similar frequency and length control program of progressive, low-intensity stretching. Primary endpoints were bone mineral density (BMD; g/cm2) of the hip and spine and whole body bone-free lean and fat mass (kg) determined by DXA and biomarkers of bone turnover—serum osteocalcin (ng/ml) and urinary deoxypyrodiniline cross-links (nmol/mmolCr). Women in the resistance + impact training program preserved BMD at the lumbar spine (0.47 vs. −2.13%;
Url:
DOI: 10.1007/s10549-011-1444-z
PubMed: 21424279
PubMed Central: 3124708
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Leo</name></author><author><name sortKey="Naik, Arpana" sort="Naik, Arpana" uniqKey="Naik A" first="Arpana" last="Naik">Arpana Naik</name></author><author><name sortKey="Schwartz, Anna" sort="Schwartz, Anna" uniqKey="Schwartz A" first="Anna" last="Schwartz">Anna Schwartz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21424279</idno><idno type="pmc">3124708</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3124708</idno><idno type="RBID">PMC:3124708</idno><idno type="doi">10.1007/s10549-011-1444-z</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002A14</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A14</idno><idno type="wicri:Area/Pmc/Curation">002A13</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial</title><author><name sortKey="Winters Stone, Kerri M" sort="Winters Stone, Kerri M" uniqKey="Winters Stone K" first="Kerri M." last="Winters-Stone">Kerri M. Winters-Stone</name></author><author><name sortKey="Dobek, Jessica" sort="Dobek, Jessica" uniqKey="Dobek J" first="Jessica" last="Dobek">Jessica Dobek</name></author><author><name sortKey="Nail, Lillian" sort="Nail, Lillian" uniqKey="Nail L" first="Lillian" last="Nail">Lillian Nail</name></author><author><name sortKey="Bennett, Jill A" sort="Bennett, Jill A" uniqKey="Bennett J" first="Jill A." last="Bennett">Jill A. Bennett</name></author><author><name sortKey="Leo, Michael C" sort="Leo, Michael C" uniqKey="Leo M" first="Michael C." last="Leo">Michael C. Leo</name></author><author><name sortKey="Naik, Arpana" sort="Naik, Arpana" uniqKey="Naik A" first="Arpana" last="Naik">Arpana Naik</name></author><author><name sortKey="Schwartz, Anna" sort="Schwartz, Anna" uniqKey="Schwartz A" first="Anna" last="Schwartz">Anna Schwartz</name></author></analytic><series><title level="j">Breast cancer research and treatment</title><idno type="ISSN">0167-6806</idno><idno type="eISSN">1573-7217</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Targeted exercise training could reduce risk factors for fracture and obesity-related diseases that increase from breast cancer treatment, but has not been sufficiently tested. We hypothesized that progressive, moderate-intensity resistance + impact training would increase or maintain hip and spine bone mass, lean mass and fat mass and reduce bone turnover compared to controls who participated in a low-intensity, non-weight bearing stretching program. We conducted a randomized, controlled trial in 106 women with early stage breast cancer who were >1 year post-radiation and/or chemotherapy, ≥50 years of age at diagnosis and postmenopausal, free from osteoporosis and medications for bone loss, resistance and impact exercise naïve, and cleared to exercise by a physician. Women were randomly assigned to participate in 1 year of thrice-weekly progressive, moderate-intensity resistance + impact (jump) exercise or in a similar frequency and length control program of progressive, low-intensity stretching. Primary endpoints were bone mineral density (BMD; g/cm<sup>2</sup>) of the hip and spine and whole body bone-free lean and fat mass (kg) determined by DXA and biomarkers of bone turnover—serum osteocalcin (ng/ml) and urinary deoxypyrodiniline cross-links (nmol/mmolCr). Women in the resistance + impact training program preserved BMD at the lumbar spine (0.47 vs. −2.13%; <italic>P</italic> = 0.001) compared to controls. The resistance + impact group had a smaller increase in osteocalcin (7.0 vs. 27%, <italic>P</italic> = 0.03) and a larger decrease in deoxypyrodinoline (−49.9 vs. −32.6%, <italic>P</italic> = 0.06) than controls. Increases in lean mass from resistance + impact training were greatest among women currently taking aromatase inhibitors compared to controls not on this therapy (<italic>P</italic> = 0.01). Our combined program of resistance + impact exercise reduced risk factors for fracture among postmenopausal breast cancer survivors (BCS) and may be particularly relevant for BCS on aromatase inhibitors (AIs) because of the additional benefit of exercise on muscle mass that could reduce falls.</p></div></front></TEI><pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8111104</journal-id><journal-id journal-id-type="pubmed-jr-id">1254</journal-id><journal-id journal-id-type="nlm-ta">Breast Cancer Res Treat</journal-id><journal-title-group><journal-title>Breast cancer research and treatment</journal-title></journal-title-group><issn pub-type="ppub">0167-6806</issn><issn pub-type="epub">1573-7217</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21424279</article-id><article-id pub-id-type="pmc">3124708</article-id><article-id pub-id-type="doi">10.1007/s10549-011-1444-z</article-id><article-id pub-id-type="manuscript">NIHMS298335</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Strength training stops bone loss and builds muscle in postmenopausal breast cancer survivors: a randomized, controlled trial</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Winters-Stone</surname><given-names>Kerri M.</given-names></name><aff id="A1">School of Nursing, Oregon Health & Science University, 3455 SW US Veteran’s Hospital Rd., Mailcode: SN-ORD, Portland, OR 97239, USA</aff><email>wintersk@ohsu.edu</email></contrib><contrib contrib-type="author"><name><surname>Dobek</surname><given-names>Jessica</given-names></name><aff id="A2">School of Nursing, Oregon Health & Science University, 3455 SW US Veteran’s Hospital Rd., Mailcode: SN-ORD, Portland, OR 97239, USA</aff></contrib><contrib contrib-type="author"><name><surname>Nail</surname><given-names>Lillian</given-names></name><aff id="A3">School of Nursing, Oregon Health & Science University, 3455 SW US Veteran’s Hospital Rd., Mailcode: SN-ORD, Portland, OR 97239, USA</aff></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>Jill A.</given-names></name><aff id="A4">School of Nursing, Oregon Health & Science University, 3455 SW US Veteran’s Hospital Rd., Mailcode: SN-ORD, Portland, OR 97239, USA</aff></contrib><contrib contrib-type="author"><name><surname>Leo</surname><given-names>Michael C.</given-names></name><aff id="A5">School of Nursing, Oregon Health & Science University, 3455 SW US Veteran’s Hospital Rd., Mailcode: SN-ORD, Portland, OR 97239, USA</aff></contrib><contrib contrib-type="author"><name><surname>Naik</surname><given-names>Arpana</given-names></name><aff id="A6">School of Medicine, Oregon Health & Science University, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Schwartz</surname><given-names>Anna</given-names></name><aff id="A7">School of Nursing, University of Washington, Seattle, WA, USA</aff></contrib></contrib-group><pub-date pub-type="nihms-submitted"><day>2</day><month>6</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>19</day><month>3</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>6</month><year>2012</year></pub-date><volume>127</volume><issue>2</issue><fpage>447</fpage><lpage>456</lpage><permissions><copyright-statement>© Springer Science+Business Media, LLC. 2011</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P1">Targeted exercise training could reduce risk factors for fracture and obesity-related diseases that increase from breast cancer treatment, but has not been sufficiently tested. We hypothesized that progressive, moderate-intensity resistance + impact training would increase or maintain hip and spine bone mass, lean mass and fat mass and reduce bone turnover compared to controls who participated in a low-intensity, non-weight bearing stretching program. We conducted a randomized, controlled trial in 106 women with early stage breast cancer who were >1 year post-radiation and/or chemotherapy, ≥50 years of age at diagnosis and postmenopausal, free from osteoporosis and medications for bone loss, resistance and impact exercise naïve, and cleared to exercise by a physician. Women were randomly assigned to participate in 1 year of thrice-weekly progressive, moderate-intensity resistance + impact (jump) exercise or in a similar frequency and length control program of progressive, low-intensity stretching. Primary endpoints were bone mineral density (BMD; g/cm<sup>2</sup>) of the hip and spine and whole body bone-free lean and fat mass (kg) determined by DXA and biomarkers of bone turnover—serum osteocalcin (ng/ml) and urinary deoxypyrodiniline cross-links (nmol/mmolCr). Women in the resistance + impact training program preserved BMD at the lumbar spine (0.47 vs. −2.13%; <italic>P</italic> = 0.001) compared to controls. The resistance + impact group had a smaller increase in osteocalcin (7.0 vs. 27%, <italic>P</italic> = 0.03) and a larger decrease in deoxypyrodinoline (−49.9 vs. −32.6%, <italic>P</italic> = 0.06) than controls. Increases in lean mass from resistance + impact training were greatest among women currently taking aromatase inhibitors compared to controls not on this therapy (<italic>P</italic> = 0.01). Our combined program of resistance + impact exercise reduced risk factors for fracture among postmenopausal breast cancer survivors (BCS) and may be particularly relevant for BCS on aromatase inhibitors (AIs) because of the additional benefit of exercise on muscle mass that could reduce falls.</p></abstract><kwd-group><kwd>Osteoporosis</kwd><kwd>Resistance exercise</kwd><kwd>Body composition</kwd><kwd>Neoplasms</kwd><kwd>Aromatase inhibitors</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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