LymphedemaV1, Pmc, Curation, bibRecord, 002728

Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy

Identifieur interne : 002728 ( Pmc/Curation ); précédent : 002727; suivant : 002729

Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy

Auteurs : S. Modi [Royaume-Uni] ; A W B. Stanton [Royaume-Uni] ; W E Svensson [Royaume-Uni] ; A M Peters [Royaume-Uni] ; P S Mortimer [Royaume-Uni] ; J R Levick [Royaume-Uni]

Source :

The Journal of Physiology [ 0022-3751 ] ; 2007.

RBID : PMC:2277237

Abstract

Axillary surgery for breast cancer partially obstructs lymph outflow from the arm, chronically raising the lymphatic smooth muscle afterload. This may lead to pump failure, as in hypertensive cardiac failure, and could explain features of breast cancer treatment-related lymphoedema (BCRL) such as its delayed onset. A new method was developed to measure human lymphatic contractility non-invasively and test the hypothesis of contractile impairment. ^99mTc-human IgG (Tc-HIG), injected into the hand dermis, drained into the arm lymphatic system which was imaged using a gamma-camera. Lymph transit time from hand to axilla, t_transit, was 9.6 ± 7.2 min (mean ±s.d.) (velocity 8.9 cm min⁻¹) in seven normal subjects. To assess lymphatic contractility, a sphygmomanometer cuff around the upper arm was inflated to 60 mmHg (P_cuff) before ^99mTc-HIG injection and maintained for >> t_transit. When P_cuff exceeded the maximum pressure generated by the lymphatic pump (P_pump), radiolabelled lymph was held up at the distal cuff border. P_cuff was then lowered in 10 mmHg steps until ^99mTc-HIG began to flow under the cuff to the axilla, indicating P_pump≥P_cuff. In 16 normal subjects P_pump was 39 ± 14 mmHg. P_pump was 38% lower in 16 women with BCRL, namely 24 ± 19 mmHg (P = 0.014, Student's unpaired t test), and correlated negatively with the degree of swelling (12–56%). Blood radiolabel accumulation proved an unreliable measure of lymphatic pump function. Lymphatic congestion lymphoscintigraphy thus provided a quantitative measure of human lymphatic contractility without surgical cut-down, and the results supported the hypothesis of lymphatic pump failure in BCRL.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277237

DOI: 10.1113/jphysiol.2007.130401
PubMed: 17569739
PubMed Central: 2277237

Links toward previous steps (curation, corpus...)

to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002729

Links to Exploration step

PMC:2277237

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy</title>
<author><name sortKey="Modi, S" sort="Modi, S" uniqKey="Modi S" first="S" last="Modi">S. Modi</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Cardiac and Vascular Sciences (Dermatology), University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London SW17 0RE</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Nuclear Medicine, Hammersmith Hospital</institution>
<addr-line>London W12 0HS, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London W12 0HS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Cardiac and Vascular Sciences (Dermatology), University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London SW17 0RE</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Nuclear Medicine, Hammersmith Hospital</institution>
<addr-line>London W12 0HS, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London W12 0HS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Svensson, W E" sort="Svensson, W E" uniqKey="Svensson W" first="W E" last="Svensson">W E Svensson</name>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Nuclear Medicine, Hammersmith Hospital</institution>
<addr-line>London W12 0HS, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London W12 0HS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peters, A M" sort="Peters, A M" uniqKey="Peters A" first="A M" last="Peters">A M Peters</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Nuclear Medicine, Royal Sussex County Hospital</institution>
<addr-line>Brighton BN2 5BE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Brighton BN2 5BE</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">P S Mortimer</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Cardiac and Vascular Sciences (Dermatology), University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London SW17 0RE</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Basic Medical Sciences (Physiology), St George's Hospital Medical School, University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London SW17 0RE</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">17569739</idno>
<idno type="pmc">2277237</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2277237</idno>
<idno type="RBID">PMC:2277237</idno>
<idno type="doi">10.1113/jphysiol.2007.130401</idno>
<date when="2007">2007</date>
<idno type="wicri:Area/Pmc/Corpus">002729</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002729</idno>
<idno type="wicri:Area/Pmc/Curation">002728</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002728</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy</title>
<author><name sortKey="Modi, S" sort="Modi, S" uniqKey="Modi S" first="S" last="Modi">S. Modi</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Cardiac and Vascular Sciences (Dermatology), University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London SW17 0RE</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Nuclear Medicine, Hammersmith Hospital</institution>
<addr-line>London W12 0HS, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London W12 0HS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stanton, A W B" sort="Stanton, A W B" uniqKey="Stanton A" first="A W B" last="Stanton">A W B. Stanton</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Cardiac and Vascular Sciences (Dermatology), University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London SW17 0RE</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Nuclear Medicine, Hammersmith Hospital</institution>
<addr-line>London W12 0HS, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London W12 0HS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Svensson, W E" sort="Svensson, W E" uniqKey="Svensson W" first="W E" last="Svensson">W E Svensson</name>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>Nuclear Medicine, Hammersmith Hospital</institution>
<addr-line>London W12 0HS, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London W12 0HS</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Peters, A M" sort="Peters, A M" uniqKey="Peters A" first="A M" last="Peters">A M Peters</name>
<affiliation wicri:level="1"><nlm:aff id="au4"><institution>Nuclear Medicine, Royal Sussex County Hospital</institution>
<addr-line>Brighton BN2 5BE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Brighton BN2 5BE</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mortimer, P S" sort="Mortimer, P S" uniqKey="Mortimer P" first="P S" last="Mortimer">P S Mortimer</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Cardiac and Vascular Sciences (Dermatology), University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London SW17 0RE</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Levick, J R" sort="Levick, J R" uniqKey="Levick J" first="J R" last="Levick">J R Levick</name>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Basic Medical Sciences (Physiology), St George's Hospital Medical School, University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London SW17 0RE</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Physiology</title>
<idno type="ISSN">0022-3751</idno>
<idno type="eISSN">1469-7793</idno>
<imprint><date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Axillary surgery for breast cancer partially obstructs lymph outflow from the arm, chronically raising the lymphatic smooth muscle afterload. This may lead to pump failure, as in hypertensive cardiac failure, and could explain features of breast cancer treatment-related lymphoedema (BCRL) such as its delayed onset. A new method was developed to measure human lymphatic contractility non-invasively and test the hypothesis of contractile impairment. <sup>99m</sup>
Tc-human IgG (Tc-HIG), injected into the hand dermis, drained into the arm lymphatic system which was imaged using a gamma-camera. Lymph transit time from hand to axilla, <italic>t</italic>
<sub>transit</sub>
, was 9.6 ± 7.2 min (mean ±<sc>s.d.</sc>
) (velocity 8.9 cm min<sup>−1</sup>
) in seven normal subjects. To assess lymphatic contractility, a sphygmomanometer cuff around the upper arm was inflated to 60 mmHg (<italic>P</italic>
<sub>cuff</sub>
) before <sup>99m</sup>
Tc-HIG injection and maintained for >> <italic>t</italic>
<sub>transit</sub>
. When <italic>P</italic>
<sub>cuff</sub>
 exceeded the maximum pressure generated by the lymphatic pump (<italic>P</italic>
<sub>pump</sub>
), radiolabelled lymph was held up at the distal cuff border. <italic>P</italic>
<sub>cuff</sub>
 was then lowered in 10 mmHg steps until <sup>99m</sup>
Tc-HIG began to flow under the cuff to the axilla, indicating <italic>P</italic>
<sub>pump</sub>
≥<italic>P</italic>
<sub>cuff</sub>
. In 16 normal subjects <italic>P</italic>
<sub>pump</sub>
 was 39 ± 14 mmHg. <italic>P</italic>
<sub>pump</sub>
 was 38% lower in 16 women with BCRL, namely 24 ± 19 mmHg (<italic>P</italic>
 = 0.014, Student's unpaired <italic>t</italic>
 test), and correlated negatively with the degree of swelling (12–56%). Blood radiolabel accumulation proved an unreliable measure of lymphatic pump function. Lymphatic congestion lymphoscintigraphy thus provided a quantitative measure of human lymphatic contractility without surgical cut-down, and the results supported the hypothesis of lymphatic pump failure in BCRL.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">J Physiol</journal-id>
<journal-id journal-id-type="publisher-id">tjp</journal-id>
<journal-title>The Journal of Physiology</journal-title>
<issn pub-type="ppub">0022-3751</issn>
<issn pub-type="epub">1469-7793</issn>
<publisher><publisher-name>Blackwell Science Inc</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">17569739</article-id>
<article-id pub-id-type="pmc">2277237</article-id>
<article-id pub-id-type="doi">10.1113/jphysiol.2007.130401</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Cardiovascular</subject>
</subj-group>
</article-categories>
<title-group><article-title>Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Modi</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stanton</surname>
<given-names>A W B</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Svensson</surname>
<given-names>W E</given-names>
</name>
<xref ref-type="aff" rid="au3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Peters</surname>
<given-names>A M</given-names>
</name>
<xref ref-type="aff" rid="au4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mortimer</surname>
<given-names>P S</given-names>
</name>
<xref ref-type="aff" rid="au1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Levick</surname>
<given-names>J R</given-names>
</name>
<xref ref-type="aff" rid="au2">2</xref>
</contrib>
<aff id="au1"><label>1</label>
<institution>Cardiac and Vascular Sciences (Dermatology), University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</aff>
<aff id="au2"><label>2</label>
<institution>Basic Medical Sciences (Physiology), St George's Hospital Medical School, University of London</institution>
<addr-line>London SW17 0RE, UK</addr-line>
</aff>
<aff id="au3"><label>3</label>
<institution>Nuclear Medicine, Hammersmith Hospital</institution>
<addr-line>London W12 0HS, UK</addr-line>
</aff>
<aff id="au4"><label>4</label>
<institution>Nuclear Medicine, Royal Sussex County Hospital</institution>
<addr-line>Brighton BN2 5BE, UK</addr-line>
</aff>
</contrib-group>
<author-notes><corresp id="cor1"><bold>Corresponding author</bold>
 A. W. B. Stanton: St George's Hospital Medical School, University of London, Cranmer Terrace, London SW17 0RE, UK. Email: <email>astanton@sgul.ac.uk</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>8</month>
<year>2007</year>
</pub-date>
<pub-date pub-type="epub"><day>14</day>
<month>6</month>
<year>2007</year>
</pub-date>
<volume>583</volume>
<issue>Pt 1</issue>
<fpage>271</fpage>
<lpage>285</lpage>
<history><date date-type="received"><day>13</day>
<month>2</month>
<year>2007</year>
</date>
<date date-type="accepted"><day>10</day>
<month>6</month>
<year>2007</year>
</date>
</history>
<copyright-statement>© 2007 The Authors. Journal compilation © 2007 The Physiological Society</copyright-statement>
<copyright-year>2007</copyright-year>
<abstract><p>Axillary surgery for breast cancer partially obstructs lymph outflow from the arm, chronically raising the lymphatic smooth muscle afterload. This may lead to pump failure, as in hypertensive cardiac failure, and could explain features of breast cancer treatment-related lymphoedema (BCRL) such as its delayed onset. A new method was developed to measure human lymphatic contractility non-invasively and test the hypothesis of contractile impairment. <sup>99m</sup>
Tc-human IgG (Tc-HIG), injected into the hand dermis, drained into the arm lymphatic system which was imaged using a gamma-camera. Lymph transit time from hand to axilla, <italic>t</italic>
<sub>transit</sub>
, was 9.6 ± 7.2 min (mean ±<sc>s.d.</sc>
) (velocity 8.9 cm min<sup>−1</sup>
) in seven normal subjects. To assess lymphatic contractility, a sphygmomanometer cuff around the upper arm was inflated to 60 mmHg (<italic>P</italic>
<sub>cuff</sub>
) before <sup>99m</sup>
Tc-HIG injection and maintained for >> <italic>t</italic>
<sub>transit</sub>
. When <italic>P</italic>
<sub>cuff</sub>
 exceeded the maximum pressure generated by the lymphatic pump (<italic>P</italic>
<sub>pump</sub>
), radiolabelled lymph was held up at the distal cuff border. <italic>P</italic>
<sub>cuff</sub>
 was then lowered in 10 mmHg steps until <sup>99m</sup>
Tc-HIG began to flow under the cuff to the axilla, indicating <italic>P</italic>
<sub>pump</sub>
≥<italic>P</italic>
<sub>cuff</sub>
. In 16 normal subjects <italic>P</italic>
<sub>pump</sub>
 was 39 ± 14 mmHg. <italic>P</italic>
<sub>pump</sub>
 was 38% lower in 16 women with BCRL, namely 24 ± 19 mmHg (<italic>P</italic>
 = 0.014, Student's unpaired <italic>t</italic>
 test), and correlated negatively with the degree of swelling (12–56%). Blood radiolabel accumulation proved an unreliable measure of lymphatic pump function. Lymphatic congestion lymphoscintigraphy thus provided a quantitative measure of human lymphatic contractility without surgical cut-down, and the results supported the hypothesis of lymphatic pump failure in BCRL.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002728 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 002728 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    LymphedemaV1
   |flux=    Pmc
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:2277237
   |texte=   Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i   -Sk "pubmed:17569739" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd   \
       | NlmPubMed2Wicri -a LymphedemaV1

This area was generated with Dilib version V0.6.31.
Data generation: Sat Nov 4 17:40:35 2017. Site generation: Tue Feb 13 16:42:16 2024

	Serveur d'exploration sur le lymphœdème
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le lymphœdème

Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy

Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki