A rare cause of hemoptysis
Identifieur interne : 002695 ( Pmc/Curation ); précédent : 002694; suivant : 002696A rare cause of hemoptysis
Auteurs : Meghan Aversa ; Sacha Bhinder ; Jeffrey Tanguay ; John ThenganattSource :
- Respiratory Medicine Case Reports [ 2213-0071 ] ; 2014.
Abstract
Angiosarcomas are rare, malignant, endothelial-cell tumors of vascular origin that can arise at any body site. They frequently metastasize to the lung, heralded by dyspnea, hemoptysis, chest pain, pneumothoraces, and diffuse pulmonary hemorrhage. However, in most cases lung metastases are discovered after the diagnosis of a primary angiosarcoma has already been established. Very rarely will an undiagnosed metastatic angiosarcoma present as diffuse pulmonary hemorrhage. We describe the case of a 59-year-old male who presented to hospital with dyspnea and hemoptysis. CT chest revealed rapidly progressing nodular changes and broncho-alveolar lavage returns were progressively bloody. Open lung wedge biopsy ultimately revealed metastatic angiosarcoma and extensive pulmonary hemorrhage. Our case highlights the key clinical, radiological, and pathological features of this rare malignancy that frequently metastasizes to the lung and reminds clinicians to consider it as a cause of hemoptysis and pulmonary hemorrhage.
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DOI: 10.1016/j.rmcr.2014.08.001
PubMed: 26029560
PubMed Central: 4246356
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A rare cause of hemoptysis</title><author><name sortKey="Aversa, Meghan" sort="Aversa, Meghan" uniqKey="Aversa M" first="Meghan" last="Aversa">Meghan Aversa</name></author><author><name sortKey="Bhinder, Sacha" sort="Bhinder, Sacha" uniqKey="Bhinder S" first="Sacha" last="Bhinder">Sacha Bhinder</name></author><author><name sortKey="Tanguay, Jeffrey" sort="Tanguay, Jeffrey" uniqKey="Tanguay J" first="Jeffrey" last="Tanguay">Jeffrey Tanguay</name></author><author><name sortKey="Thenganatt, John" sort="Thenganatt, John" uniqKey="Thenganatt J" first="John" last="Thenganatt">John Thenganatt</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26029560</idno><idno type="pmc">4246356</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246356</idno><idno type="RBID">PMC:4246356</idno><idno type="doi">10.1016/j.rmcr.2014.08.001</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">002696</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002696</idno><idno type="wicri:Area/Pmc/Curation">002695</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002695</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A rare cause of hemoptysis</title><author><name sortKey="Aversa, Meghan" sort="Aversa, Meghan" uniqKey="Aversa M" first="Meghan" last="Aversa">Meghan Aversa</name></author><author><name sortKey="Bhinder, Sacha" sort="Bhinder, Sacha" uniqKey="Bhinder S" first="Sacha" last="Bhinder">Sacha Bhinder</name></author><author><name sortKey="Tanguay, Jeffrey" sort="Tanguay, Jeffrey" uniqKey="Tanguay J" first="Jeffrey" last="Tanguay">Jeffrey Tanguay</name></author><author><name sortKey="Thenganatt, John" sort="Thenganatt, John" uniqKey="Thenganatt J" first="John" last="Thenganatt">John Thenganatt</name></author></analytic><series><title level="j">Respiratory Medicine Case Reports</title><idno type="eISSN">2213-0071</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Angiosarcomas are rare, malignant, endothelial-cell tumors of vascular origin that can arise at any body site. They frequently metastasize to the lung, heralded by dyspnea, hemoptysis, chest pain, pneumothoraces, and diffuse pulmonary hemorrhage. However, in most cases lung metastases are discovered after the diagnosis of a primary angiosarcoma has already been established. Very rarely will an undiagnosed metastatic angiosarcoma present as diffuse pulmonary hemorrhage. We describe the case of a 59-year-old male who presented to hospital with dyspnea and hemoptysis. CT chest revealed rapidly progressing nodular changes and broncho-alveolar lavage returns were progressively bloody. Open lung wedge biopsy ultimately revealed metastatic angiosarcoma and extensive pulmonary hemorrhage. Our case highlights the key clinical, radiological, and pathological features of this rare malignancy that frequently metastasizes to the lung and reminds clinicians to consider it as a cause of hemoptysis and pulmonary hemorrhage.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Patel, A M" uniqKey="Patel A">A.M. Patel</name></author><author><name sortKey="Ryu, J H" uniqKey="Ryu J">J.H. Ryu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ravi, V" uniqKey="Ravi V">V. Ravi</name></author><author><name sortKey="Patel, S" uniqKey="Patel S">S. Patel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adem, C" uniqKey="Adem C">C. Adem</name></author><author><name sortKey="Aubry, M C" uniqKey="Aubry M">M.C. Aubry</name></author><author><name sortKey="Tazelaar, H D" uniqKey="Tazelaar H">H.D. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Respir Med Case Rep</journal-id><journal-id journal-id-type="iso-abbrev">Respir Med Case Rep</journal-id><journal-title-group><journal-title>Respiratory Medicine Case Reports</journal-title></journal-title-group><issn pub-type="epub">2213-0071</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26029560</article-id><article-id pub-id-type="pmc">4246356</article-id><article-id pub-id-type="publisher-id">S2213-0071(14)00041-0</article-id><article-id pub-id-type="doi">10.1016/j.rmcr.2014.08.001</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>A rare cause of hemoptysis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Aversa</surname><given-names>Meghan</given-names></name></contrib><contrib contrib-type="author"><name><surname>Bhinder</surname><given-names>Sacha</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tanguay</surname><given-names>Jeffrey</given-names></name></contrib><contrib contrib-type="author"><name><surname>Thenganatt</surname><given-names>John</given-names></name><email>john.thenganatt@uhn.ca</email><xref rid="cor1" ref-type="corresp">∗</xref></contrib></contrib-group><aff id="aff1">Division of Respirology, Department of Medicine, Toronto General Hospital, 585 University Avenue, 9N-965, Toronto ON, M5G 2N2, Canada</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author. Tel.: +1 (416) 340 4800x4591; fax: +1 (416) 340 3109. <email>john.thenganatt@uhn.ca</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>28</day><month>9</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>28</day><month>9</month><year>2014</year></pub-date><volume>13</volume><fpage>48</fpage><lpage>50</lpage><permissions><copyright-statement>© 2014 The Authors</copyright-statement><copyright-year>2014</copyright-year><license license-type="CC BY-NC-ND" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><license-p>This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).</license-p></license></permissions><abstract><p>Angiosarcomas are rare, malignant, endothelial-cell tumors of vascular origin that can arise at any body site. They frequently metastasize to the lung, heralded by dyspnea, hemoptysis, chest pain, pneumothoraces, and diffuse pulmonary hemorrhage. However, in most cases lung metastases are discovered after the diagnosis of a primary angiosarcoma has already been established. Very rarely will an undiagnosed metastatic angiosarcoma present as diffuse pulmonary hemorrhage. We describe the case of a 59-year-old male who presented to hospital with dyspnea and hemoptysis. CT chest revealed rapidly progressing nodular changes and broncho-alveolar lavage returns were progressively bloody. Open lung wedge biopsy ultimately revealed metastatic angiosarcoma and extensive pulmonary hemorrhage. Our case highlights the key clinical, radiological, and pathological features of this rare malignancy that frequently metastasizes to the lung and reminds clinicians to consider it as a cause of hemoptysis and pulmonary hemorrhage.</p></abstract><kwd-group><title>Keywords</title><kwd>Metastatic angiosarcoma</kwd><kwd>Diffuse pulmonary hemorrhage</kwd></kwd-group></article-meta></front><floats-group><fig id="fig1"><label>Fig. 1</label><caption><p>CT chest showing bilateral, multifocal, nodulor changes with surrounding ground-glass attenuation and consolidation (A). CT chest obtained two weeks later showing interval worsening of the nodular changes, ground-glass attenuation, and consolidation bilaterally (B).</p></caption><graphic xlink:href="gr1"></graphic></fig><fig id="fig2"><label>Fig. 2</label><caption><p>A low-magnification photomicrograph illustrating several pulmonary vessels containing the highly mitotically active spindle cells with enlarged nuclei (A,arrows). A high-magnification view illustrating a single branching pulmonary vessels containing the spindle cell lesion (B,arrows).</p></caption><graphic xlink:href="gr2"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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