Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer
Identifieur interne : 001C19 ( Pmc/Curation ); précédent : 001C18; suivant : 001C20Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer
Auteurs : Masako Takahashi [Japon] ; Mitsunori Sasa [Japon] ; Chieko Hirose [Japon] ; Sonoka Hisaoka [Japon] ; Masako Taki [Japon] ; Toshiyuki Hirose [Japon] ; Yoshimi Bando [Japon]Source :
- World Journal of Surgical Oncology [ 1477-7819 ] ; 2008.
Abstract
Combining a radioisotope with a dye-guided method is the best method for identification of the sentinel lymph nodes (SNs) in breast cancer. However, some institutions are limited to use of a dye-guided method alone. Recently, computed tomographic lymphography (CTLG) employing a nonionic contrast medium has achieved SN identification.
218 patients with primary breast cancer and no clinical evidence of lymph node metastasis were studied. SN identification was performed by CTLG and a dye-guided method. The SN identification rate was analyzed for correlations with the clinicopathological findings.
The SN identification rates were 96% with CTLG, 92% with the dye-guided method and 99% with both methods combined. The identification rates with CTLG and the combined method were significantly lower in node-positive patients compared to node-negative patients, and significantly lower with the combined method in vascular invasion-positive patients compared to negative patients. In addition, the SN identification rate with the dye-guided method was significantly lower in patients with a body mass index (BMI) of ≥ 25, whereas the BMI did not affect the identification rate with CTLG or the combined method. Multiple SNs were detected in approximately 20% of the patients.
Combined performance of CTLG and a dye-guided method enables identification of SNs prior to breast cancer surgery. That SN identification is easier compared with by the dye-guided method alone, and the identification rate is improved compared with either method alone. The combination of methods was especially useful in obese patients. For patients with multiple SNs, the combination has the further advantage of enabling accurate SN biopsy. CTLG may yield false-negative findings in node-positive patients and patients with lymph vessel obstruction.
Url:
DOI: 10.1186/1477-7819-6-57
PubMed: 18549482
PubMed Central: 2492851
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001C20
Links to Exploration step
PMC:2492851Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer</title><author><name sortKey="Takahashi, Masako" sort="Takahashi, Masako" uniqKey="Takahashi M" first="Masako" last="Takahashi">Masako Takahashi</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Radiology, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052</wicri:regionArea></affiliation></author><author><name sortKey="Sasa, Mitsunori" sort="Sasa, Mitsunori" uniqKey="Sasa M" first="Mitsunori" last="Sasa">Mitsunori Sasa</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Surgery, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052</wicri:regionArea></affiliation></author><author><name sortKey="Hirose, Chieko" sort="Hirose, Chieko" uniqKey="Hirose C" first="Chieko" last="Hirose">Chieko Hirose</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Radiology, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193</wicri:regionArea></affiliation></author><author><name sortKey="Hisaoka, Sonoka" sort="Hisaoka, Sonoka" uniqKey="Hisaoka S" first="Sonoka" last="Hisaoka">Sonoka Hisaoka</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Radiology, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193</wicri:regionArea></affiliation></author><author><name sortKey="Taki, Masako" sort="Taki, Masako" uniqKey="Taki M" first="Masako" last="Taki">Masako Taki</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Tokushima Prefecture Hospital, 1-10-3, Kuramoto-cho, Tokushima, 770-8539, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Tokushima Prefecture Hospital, 1-10-3, Kuramoto-cho, Tokushima, 770-8539</wicri:regionArea></affiliation></author><author><name sortKey="Hirose, Toshiyuki" sort="Hirose, Toshiyuki" uniqKey="Hirose T" first="Toshiyuki" last="Hirose">Toshiyuki Hirose</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Surgery, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193</wicri:regionArea></affiliation></author><author><name sortKey="Bando, Yoshimi" sort="Bando, Yoshimi" uniqKey="Bando Y" first="Yoshimi" last="Bando">Yoshimi Bando</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-Cho, Tokushima, 770-8509, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-Cho, Tokushima, 770-8509</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18549482</idno><idno type="pmc">2492851</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2492851</idno><idno type="RBID">PMC:2492851</idno><idno type="doi">10.1186/1477-7819-6-57</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">001C20</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C20</idno><idno type="wicri:Area/Pmc/Curation">001C19</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer</title><author><name sortKey="Takahashi, Masako" sort="Takahashi, Masako" uniqKey="Takahashi M" first="Masako" last="Takahashi">Masako Takahashi</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Radiology, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052</wicri:regionArea></affiliation></author><author><name sortKey="Sasa, Mitsunori" sort="Sasa, Mitsunori" uniqKey="Sasa M" first="Mitsunori" last="Sasa">Mitsunori Sasa</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Surgery, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052</wicri:regionArea></affiliation></author><author><name sortKey="Hirose, Chieko" sort="Hirose, Chieko" uniqKey="Hirose C" first="Chieko" last="Hirose">Chieko Hirose</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Radiology, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193</wicri:regionArea></affiliation></author><author><name sortKey="Hisaoka, Sonoka" sort="Hisaoka, Sonoka" uniqKey="Hisaoka S" first="Sonoka" last="Hisaoka">Sonoka Hisaoka</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Radiology, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193</wicri:regionArea></affiliation></author><author><name sortKey="Taki, Masako" sort="Taki, Masako" uniqKey="Taki M" first="Masako" last="Taki">Masako Taki</name><affiliation wicri:level="1"><nlm:aff id="I4">Department of Radiology, Tokushima Prefecture Hospital, 1-10-3, Kuramoto-cho, Tokushima, 770-8539, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Tokushima Prefecture Hospital, 1-10-3, Kuramoto-cho, Tokushima, 770-8539</wicri:regionArea></affiliation></author><author><name sortKey="Hirose, Toshiyuki" sort="Hirose, Toshiyuki" uniqKey="Hirose T" first="Toshiyuki" last="Hirose">Toshiyuki Hirose</name><affiliation wicri:level="1"><nlm:aff id="I5">Department of Surgery, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Surgery, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193</wicri:regionArea></affiliation></author><author><name sortKey="Bando, Yoshimi" sort="Bando, Yoshimi" uniqKey="Bando Y" first="Yoshimi" last="Bando">Yoshimi Bando</name><affiliation wicri:level="1"><nlm:aff id="I6">Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-Cho, Tokushima, 770-8509, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-Cho, Tokushima, 770-8509</wicri:regionArea></affiliation></author></analytic><series><title level="j">World Journal of Surgical Oncology</title><idno type="eISSN">1477-7819</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Combining a radioisotope with a dye-guided method is the best method for identification of the sentinel lymph nodes (SNs) in breast cancer. However, some institutions are limited to use of a dye-guided method alone. Recently, computed tomographic lymphography (CTLG) employing a nonionic contrast medium has achieved SN identification.</p></sec><sec sec-type="methods"><title>Patients and methods</title><p>218 patients with primary breast cancer and no clinical evidence of lymph node metastasis were studied. SN identification was performed by CTLG and a dye-guided method. The SN identification rate was analyzed for correlations with the clinicopathological findings.</p></sec><sec><title>Results</title><p>The SN identification rates were 96% with CTLG, 92% with the dye-guided method and 99% with both methods combined. The identification rates with CTLG and the combined method were significantly lower in node-positive patients compared to node-negative patients, and significantly lower with the combined method in vascular invasion-positive patients compared to negative patients. In addition, the SN identification rate with the dye-guided method was significantly lower in patients with a body mass index (BMI) of ≥ 25, whereas the BMI did not affect the identification rate with CTLG or the combined method. Multiple SNs were detected in approximately 20% of the patients.</p></sec><sec><title>Conclusion</title><p>Combined performance of CTLG and a dye-guided method enables identification of SNs prior to breast cancer surgery. That SN identification is easier compared with by the dye-guided method alone, and the identification rate is improved compared with either method alone. The combination of methods was especially useful in obese patients. For patients with multiple SNs, the combination has the further advantage of enabling accurate SN biopsy. CTLG may yield false-negative findings in node-positive patients and patients with lymph vessel obstruction.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Surg Oncol</journal-id><journal-title>World Journal of Surgical Oncology</journal-title><issn pub-type="epub">1477-7819</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18549482</article-id><article-id pub-id-type="pmc">2492851</article-id><article-id pub-id-type="publisher-id">1477-7819-6-57</article-id><article-id pub-id-type="doi">10.1186/1477-7819-6-57</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer</article-title></title-group><contrib-group><contrib id="A1" contrib-type="author"><name><surname>Takahashi</surname><given-names>Masako</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>takapy55@tune.ocn.ne.jp</email></contrib><contrib id="A2" corresp="yes" contrib-type="author"><name><surname>Sasa</surname><given-names>Mitsunori</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>breast@mb.tcn.ne.jp</email></contrib><contrib id="A3" contrib-type="author"><name><surname>Hirose</surname><given-names>Chieko</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>hirose@higashitokushima.hosp.go.jp</email></contrib><contrib id="A4" contrib-type="author"><name><surname>Hisaoka</surname><given-names>Sonoka</given-names></name><xref ref-type="aff" rid="I3">3</xref><email>sonoka@mb3.tcn.ne.jp</email></contrib><contrib id="A5" contrib-type="author"><name><surname>Taki</surname><given-names>Masako</given-names></name><xref ref-type="aff" rid="I4">4</xref><email>zaw00407@nifty.ne.jp</email></contrib><contrib id="A6" contrib-type="author"><name><surname>Hirose</surname><given-names>Toshiyuki</given-names></name><xref ref-type="aff" rid="I5">5</xref><email>toshi-hirose@higashitokushima.hosp.go.jp</email></contrib><contrib id="A7" contrib-type="author"><name><surname>Bando</surname><given-names>Yoshimi</given-names></name><xref ref-type="aff" rid="I6">6</xref><email>yoshimi@basic.med.tokushima-u.ac.jp</email></contrib></contrib-group><aff id="I1"><label>1</label>Department of Radiology, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052, Japan</aff><aff id="I2"><label>2</label>Department of Surgery, Tokushima Breast Care Clinic, 4-7-7, Nakashimada-Cho, Tokushima, 770-0052, Japan</aff><aff id="I3"><label>3</label>Department of Radiology, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193, Japan</aff><aff id="I4"><label>4</label>Department of Radiology, Tokushima Prefecture Hospital, 1-10-3, Kuramoto-cho, Tokushima, 770-8539, Japan</aff><aff id="I5"><label>5</label>Department of Surgery, National Higashi Tokushima Hospital, 1-1, Ohmukai-kita, Ootera, Itano, Tokushima, 779-0193, Japan</aff><aff id="I6"><label>6</label>Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15, Kuramoto-Cho, Tokushima, 770-8509, Japan</aff><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>12</day><month>6</month><year>2008</year></pub-date><volume>6</volume><fpage>57</fpage><lpage>57</lpage><ext-link ext-link-type="uri" xlink:href="http://www.wjso.com/content/6/1/57"></ext-link><history><date date-type="received"><day>9</day><month>12</month><year>2007</year></date><date date-type="accepted"><day>12</day><month>6</month><year>2008</year></date></history><permissions><copyright-statement>Copyright © 2008 Takahashi et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2008</copyright-year><copyright-holder>Takahashi et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0"></ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p><pmc-comment>
Takahashi
Masako
takapy55@tune.ocn.ne.jp
Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer
2008 World Journal of Surgical Oncology 6(1): 57-. (2008) 1477-7819(2008)6:1<57> urn:ISSN:1477-7819
</license></permissions><abstract><sec><title>Background</title><p>Combining a radioisotope with a dye-guided method is the best method for identification of the sentinel lymph nodes (SNs) in breast cancer. However, some institutions are limited to use of a dye-guided method alone. Recently, computed tomographic lymphography (CTLG) employing a nonionic contrast medium has achieved SN identification.</p></sec><sec sec-type="methods"><title>Patients and methods</title><p>218 patients with primary breast cancer and no clinical evidence of lymph node metastasis were studied. SN identification was performed by CTLG and a dye-guided method. The SN identification rate was analyzed for correlations with the clinicopathological findings.</p></sec><sec><title>Results</title><p>The SN identification rates were 96% with CTLG, 92% with the dye-guided method and 99% with both methods combined. The identification rates with CTLG and the combined method were significantly lower in node-positive patients compared to node-negative patients, and significantly lower with the combined method in vascular invasion-positive patients compared to negative patients. In addition, the SN identification rate with the dye-guided method was significantly lower in patients with a body mass index (BMI) of ≥ 25, whereas the BMI did not affect the identification rate with CTLG or the combined method. Multiple SNs were detected in approximately 20% of the patients.</p></sec><sec><title>Conclusion</title><p>Combined performance of CTLG and a dye-guided method enables identification of SNs prior to breast cancer surgery. That SN identification is easier compared with by the dye-guided method alone, and the identification rate is improved compared with either method alone. The combination of methods was especially useful in obese patients. For patients with multiple SNs, the combination has the further advantage of enabling accurate SN biopsy. CTLG may yield false-negative findings in node-positive patients and patients with lymph vessel obstruction.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C19 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 001C19 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:2492851
|texte= Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:18549482" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |