Regional radiotherapy versus an axillary lymph node dissection after lumpectomy: a safe alternative for an axillary lymph node dissection in a clinically uninvolved axilla in breast cancer. A case control study with 10 years follow up
Identifieur interne : 001C16 ( Pmc/Curation ); précédent : 001C15; suivant : 001C17Regional radiotherapy versus an axillary lymph node dissection after lumpectomy: a safe alternative for an axillary lymph node dissection in a clinically uninvolved axilla in breast cancer. A case control study with 10 years follow up
Auteurs : Patty H. Spruit [Pays-Bas] ; Sabine Siesling [Pays-Bas] ; Marloes Ag Elferink [Pays-Bas] ; Ernest Ja Vonk [Pays-Bas] ; Carel Jm Hoekstra [Pays-Bas]Source :
- Radiation Oncology (London, England) [ 1748-717X ] ; 2007.
Abstract
The standard treatment of the axilla in breast cancer used to be an axillary lymph node dissection. An axillary lymph node dissection is known to give substantial risks of morbidity. In recent years the sentinel node biopsy has become common practice. Future randomized study results will determine whether the expected decrease in morbidity can be proven.
Before the introduction of the sentinel node biopsy, we conducted a study in which 180 women of 50 years and older with T1/T2 cN0 breast cancer were treated with breast conserving therapy. Instead of an axillary lymph node dissection regional radiotherapy was given in combination with tamoxifen (RT-group). The study group was compared with 341 patients, with the same patient and tumour characteristics, treated with an axillary lymph node dissection (S-group).
The treatment groups were comparable, except for age. The RT-group was significantly older than the S-group. The median follow up was 7.2 years. The regional relapse rates were low and equal in both treatment groups, 1.1% in RT-group versus 1.5% in S-group at 5 years. The overall survival was similar; the disease free survival was significant better in the RT-group.
Regional recurrence rates after regional radiotherapy are very low and equal to an axillary lymphnode dissection.
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DOI: 10.1186/1748-717X-2-40
PubMed: 17971196
PubMed Central: 2173900
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Regional radiotherapy versus an axillary lymph node dissection after lumpectomy: a safe alternative for an axillary lymph node dissection in a clinically uninvolved axilla in breast cancer. A case control study with 10 years follow up</title><author><name sortKey="Spruit, Patty H" sort="Spruit, Patty H" uniqKey="Spruit P" first="Patty H" last="Spruit">Patty H. Spruit</name><affiliation wicri:level="1"><nlm:aff id="I1">Radiotherapeutic Institute RISO, Deventer, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radiotherapeutic Institute RISO, Deventer</wicri:regionArea></affiliation></author><author><name sortKey="Siesling, Sabine" sort="Siesling, Sabine" uniqKey="Siesling S" first="Sabine" last="Siesling">Sabine Siesling</name><affiliation wicri:level="1"><nlm:aff id="I2">Comprehensive Cancer Centre Stedendriehoek Twente, Enschede, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Comprehensive Cancer Centre Stedendriehoek Twente, Enschede</wicri:regionArea></affiliation></author><author><name sortKey="Elferink, Marloes Ag" sort="Elferink, Marloes Ag" uniqKey="Elferink M" first="Marloes Ag" last="Elferink">Marloes Ag Elferink</name><affiliation wicri:level="1"><nlm:aff id="I2">Comprehensive Cancer Centre Stedendriehoek Twente, Enschede, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Comprehensive Cancer Centre Stedendriehoek Twente, Enschede</wicri:regionArea></affiliation></author><author><name sortKey="Vonk, Ernest Ja" sort="Vonk, Ernest Ja" uniqKey="Vonk E" first="Ernest Ja" last="Vonk">Ernest Ja Vonk</name><affiliation wicri:level="1"><nlm:aff id="I1">Radiotherapeutic Institute RISO, Deventer, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radiotherapeutic Institute RISO, Deventer</wicri:regionArea></affiliation></author><author><name sortKey="Hoekstra, Carel Jm" sort="Hoekstra, Carel Jm" uniqKey="Hoekstra C" first="Carel Jm" last="Hoekstra">Carel Jm Hoekstra</name><affiliation wicri:level="1"><nlm:aff id="I1">Radiotherapeutic Institute RISO, Deventer, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radiotherapeutic Institute RISO, Deventer</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">17971196</idno><idno type="pmc">2173900</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173900</idno><idno type="RBID">PMC:2173900</idno><idno type="doi">10.1186/1748-717X-2-40</idno><date when="2007">2007</date><idno type="wicri:Area/Pmc/Corpus">001C17</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001C17</idno><idno type="wicri:Area/Pmc/Curation">001C16</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Regional radiotherapy versus an axillary lymph node dissection after lumpectomy: a safe alternative for an axillary lymph node dissection in a clinically uninvolved axilla in breast cancer. A case control study with 10 years follow up</title><author><name sortKey="Spruit, Patty H" sort="Spruit, Patty H" uniqKey="Spruit P" first="Patty H" last="Spruit">Patty H. Spruit</name><affiliation wicri:level="1"><nlm:aff id="I1">Radiotherapeutic Institute RISO, Deventer, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radiotherapeutic Institute RISO, Deventer</wicri:regionArea></affiliation></author><author><name sortKey="Siesling, Sabine" sort="Siesling, Sabine" uniqKey="Siesling S" first="Sabine" last="Siesling">Sabine Siesling</name><affiliation wicri:level="1"><nlm:aff id="I2">Comprehensive Cancer Centre Stedendriehoek Twente, Enschede, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Comprehensive Cancer Centre Stedendriehoek Twente, Enschede</wicri:regionArea></affiliation></author><author><name sortKey="Elferink, Marloes Ag" sort="Elferink, Marloes Ag" uniqKey="Elferink M" first="Marloes Ag" last="Elferink">Marloes Ag Elferink</name><affiliation wicri:level="1"><nlm:aff id="I2">Comprehensive Cancer Centre Stedendriehoek Twente, Enschede, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Comprehensive Cancer Centre Stedendriehoek Twente, Enschede</wicri:regionArea></affiliation></author><author><name sortKey="Vonk, Ernest Ja" sort="Vonk, Ernest Ja" uniqKey="Vonk E" first="Ernest Ja" last="Vonk">Ernest Ja Vonk</name><affiliation wicri:level="1"><nlm:aff id="I1">Radiotherapeutic Institute RISO, Deventer, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radiotherapeutic Institute RISO, Deventer</wicri:regionArea></affiliation></author><author><name sortKey="Hoekstra, Carel Jm" sort="Hoekstra, Carel Jm" uniqKey="Hoekstra C" first="Carel Jm" last="Hoekstra">Carel Jm Hoekstra</name><affiliation wicri:level="1"><nlm:aff id="I1">Radiotherapeutic Institute RISO, Deventer, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radiotherapeutic Institute RISO, Deventer</wicri:regionArea></affiliation></author></analytic><series><title level="j">Radiation Oncology (London, England)</title><idno type="eISSN">1748-717X</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The standard treatment of the axilla in breast cancer used to be an axillary lymph node dissection. An axillary lymph node dissection is known to give substantial risks of morbidity. In recent years the sentinel node biopsy has become common practice. Future randomized study results will determine whether the expected decrease in morbidity can be proven.</p></sec><sec sec-type="methods"><title>Methods</title><p>Before the introduction of the sentinel node biopsy, we conducted a study in which 180 women of 50 years and older with T1/T2 cN0 breast cancer were treated with breast conserving therapy. Instead of an axillary lymph node dissection regional radiotherapy was given in combination with tamoxifen (RT-group). The study group was compared with 341 patients, with the same patient and tumour characteristics, treated with an axillary lymph node dissection (S-group).</p></sec><sec><title>Results</title><p>The treatment groups were comparable, except for age. The RT-group was significantly older than the S-group. The median follow up was 7.2 years. The regional relapse rates were low and equal in both treatment groups, 1.1% in RT-group versus 1.5% in S-group at 5 years. The overall survival was similar; the disease free survival was significant better in the RT-group.</p></sec><sec><title>Conclusion</title><p>Regional recurrence rates after regional radiotherapy are very low and equal to an axillary lymphnode dissection.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Radiat Oncol</journal-id><journal-title>Radiation Oncology (London, England)</journal-title><issn pub-type="epub">1748-717X</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">17971196</article-id><article-id pub-id-type="pmc">2173900</article-id><article-id pub-id-type="publisher-id">1748-717X-2-40</article-id><article-id pub-id-type="doi">10.1186/1748-717X-2-40</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Regional radiotherapy versus an axillary lymph node dissection after lumpectomy: a safe alternative for an axillary lymph node dissection in a clinically uninvolved axilla in breast cancer. A case control study with 10 years follow up</article-title></title-group><contrib-group><contrib id="A1" contrib-type="author"><name><surname>Spruit</surname><given-names>Patty H</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>p.spruit@risomail.nl</email></contrib><contrib id="A2" contrib-type="author"><name><surname>Siesling</surname><given-names>Sabine</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>s.siesling@ikst.nl</email></contrib><contrib id="A3" contrib-type="author"><name><surname>Elferink</surname><given-names>Marloes AG</given-names></name><xref ref-type="aff" rid="I2">2</xref><email>m.elferink@ikst.nl</email></contrib><contrib id="A4" contrib-type="author"><name><surname>Vonk</surname><given-names>Ernest JA</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>e.vonk@risomail.nl</email></contrib><contrib id="A5" corresp="yes" contrib-type="author"><name><surname>Hoekstra</surname><given-names>Carel JM</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>c.hoekstra@risomail.nl</email></contrib></contrib-group><aff id="I1"><label>1</label>Radiotherapeutic Institute RISO, Deventer, The Netherlands</aff><aff id="I2"><label>2</label>Comprehensive Cancer Centre Stedendriehoek Twente, Enschede, The Netherlands</aff><pub-date pub-type="collection"><year>2007</year></pub-date><pub-date pub-type="epub"><day>30</day><month>10</month><year>2007</year></pub-date><volume>2</volume><fpage>40</fpage><lpage>40</lpage><ext-link ext-link-type="uri" xlink:href="http://www.ro-journal.com/content/2/1/40"></ext-link><history><date date-type="received"><day>19</day><month>6</month><year>2007</year></date><date date-type="accepted"><day>30</day><month>10</month><year>2007</year></date></history><permissions><copyright-statement>Copyright © 2007 Spruit et al; licensee BioMed Central Ltd.</copyright-statement><copyright-year>2007</copyright-year><copyright-holder>Spruit et al; licensee BioMed Central Ltd.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.0"><p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0"></ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p><pmc-comment>
Spruit
H
Patty
p.spruit@risomail.nl
Regional radiotherapy versus an axillary lymph node dissection after lumpectomy: a safe alternative for an axillary lymph node dissection in a clinically uninvolved axilla in breast cancer. A case control study with 10 years follow up
2007 Radiation Oncology 2(1): 40-. (2007) 1748-717X(2007)2:1<40> urn:ISSN:1748-717X
</license></permissions><abstract><sec><title>Background</title><p>The standard treatment of the axilla in breast cancer used to be an axillary lymph node dissection. An axillary lymph node dissection is known to give substantial risks of morbidity. In recent years the sentinel node biopsy has become common practice. Future randomized study results will determine whether the expected decrease in morbidity can be proven.</p></sec><sec sec-type="methods"><title>Methods</title><p>Before the introduction of the sentinel node biopsy, we conducted a study in which 180 women of 50 years and older with T1/T2 cN0 breast cancer were treated with breast conserving therapy. Instead of an axillary lymph node dissection regional radiotherapy was given in combination with tamoxifen (RT-group). The study group was compared with 341 patients, with the same patient and tumour characteristics, treated with an axillary lymph node dissection (S-group).</p></sec><sec><title>Results</title><p>The treatment groups were comparable, except for age. The RT-group was significantly older than the S-group. The median follow up was 7.2 years. The regional relapse rates were low and equal in both treatment groups, 1.1% in RT-group versus 1.5% in S-group at 5 years. The overall survival was similar; the disease free survival was significant better in the RT-group.</p></sec><sec><title>Conclusion</title><p>Regional recurrence rates after regional radiotherapy are very low and equal to an axillary lymphnode dissection.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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