PULMONARY EDEMA IN INFLUENZAL PNEUMONIA OF THE MOUSE AND THE RELATION OF FLUID IN THE LUNG TO THE INCEPTION OF PNEUMOCOCCAL PNEUMONIA
Identifieur interne : 001B98 ( Pmc/Curation ); précédent : 001B97; suivant : 001B99PULMONARY EDEMA IN INFLUENZAL PNEUMONIA OF THE MOUSE AND THE RELATION OF FLUID IN THE LUNG TO THE INCEPTION OF PNEUMOCOCCAL PNEUMONIA
Auteurs : Carl G. Harford ; Mary HaraSource :
- The Journal of Experimental Medicine [ 0022-1007 ] ; 1950.
Abstract
Pulmonary edema is a component of the fully developed influenza viral lesion in the mouse. Mice with experimental pulmonary fluid have an increased susceptibility to inhaled pneumococci and under these circumstances the organisms grow in the lung and produce the lesion of bacterial pneumonia. The presence of pulmonary edema in the lesion due to the influenza virus in the lung of the mouse appears to account adequately for the previous observation that inhaled pneumococci grow in the influenza viral lesion. Mice dying of pneumococcal septicemia after inhaling fine droplets containing this organism do not have pneumonia. The delay in migration of polymorphonuclear leucocytes into the lung after injection of pneumococci suspended in serum is an important factor in susceptibility to infection since it allows ample time for pneumococci to grow in the pulmonary fluid. The slow phagocytic action of pulmonary macrophages likewise permits growth of pneumococci. Conditions in human beings that are known to be complicated by pulmonary edema are also known to be associated with increased susceptibility to secondary bacterial pneumonia.
Url:
PubMed: 19871702
PubMed Central: 2135962
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<author><name sortKey="Harford, Carl G" sort="Harford, Carl G" uniqKey="Harford C" first="Carl G." last="Harford">Carl G. Harford</name>
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<author><name sortKey="Hara, Mary" sort="Hara, Mary" uniqKey="Hara M" first="Mary" last="Hara">Mary Hara</name>
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<author><name sortKey="Harford, Carl G" sort="Harford, Carl G" uniqKey="Harford C" first="Carl G." last="Harford">Carl G. Harford</name>
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<author><name sortKey="Hara, Mary" sort="Hara, Mary" uniqKey="Hara M" first="Mary" last="Hara">Mary Hara</name>
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<series><title level="j">The Journal of Experimental Medicine</title>
<idno type="ISSN">0022-1007</idno>
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<front><div type="abstract" xml:lang="en"><p>Pulmonary edema is a component of the fully developed influenza viral lesion in the mouse. Mice with experimental pulmonary fluid have an increased susceptibility to inhaled pneumococci and under these circumstances the organisms grow in the lung and produce the lesion of bacterial pneumonia. The presence of pulmonary edema in the lesion due to the influenza virus in the lung of the mouse appears to account adequately for the previous observation that inhaled pneumococci grow in the influenza viral lesion. Mice dying of pneumococcal septicemia after inhaling fine droplets containing this organism do not have pneumonia. The delay in migration of polymorphonuclear leucocytes into the lung after injection of pneumococci suspended in serum is an important factor in susceptibility to infection since it allows ample time for pneumococci to grow in the pulmonary fluid. The slow phagocytic action of pulmonary macrophages likewise permits growth of pneumococci. Conditions in human beings that are known to be complicated by pulmonary edema are also known to be associated with increased susceptibility to secondary bacterial pneumonia.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Exp Med</journal-id>
<journal-title>The Journal of Experimental Medicine</journal-title>
<issn pub-type="ppub">0022-1007</issn>
<issn pub-type="epub">1540-9538</issn>
<publisher><publisher-name>The Rockefeller University Press</publisher-name>
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<article-meta><article-id pub-id-type="pmid">19871702</article-id>
<article-id pub-id-type="pmc">2135962</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>PULMONARY EDEMA IN INFLUENZAL PNEUMONIA OF THE MOUSE AND THE RELATION OF FLUID IN THE LUNG TO THE INCEPTION OF PNEUMOCOCCAL PNEUMONIA</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Harford</surname>
<given-names>Carl G.</given-names>
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<contrib contrib-type="author"><name><surname>Hara</surname>
<given-names>Mary</given-names>
</name>
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<contrib contrib-type="author"><collab>With the Technical Assistance of Alice Hamlin</collab>
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<aff id="N0x3b57a50N0x36366f0">From the Department of Medicine and the Oscar Johnson Institute for Medical Research, Washington University School of Medicine, St. Louis</aff>
<pub-date pub-type="ppub"><day>28</day>
<month>2</month>
<year>1950</year>
</pub-date>
<volume>91</volume>
<issue>3</issue>
<fpage>245</fpage>
<lpage>260</lpage>
<history><date date-type="received"><day>11</day>
<month>11</month>
<year>1949</year>
</date>
</history>
<permissions><copyright-statement>Copyright © Copyright, 1950, by The Rockefeller Institute for Medical Research New York</copyright-statement>
</permissions>
<abstract><p>Pulmonary edema is a component of the fully developed influenza viral lesion in the mouse. Mice with experimental pulmonary fluid have an increased susceptibility to inhaled pneumococci and under these circumstances the organisms grow in the lung and produce the lesion of bacterial pneumonia. The presence of pulmonary edema in the lesion due to the influenza virus in the lung of the mouse appears to account adequately for the previous observation that inhaled pneumococci grow in the influenza viral lesion. Mice dying of pneumococcal septicemia after inhaling fine droplets containing this organism do not have pneumonia. The delay in migration of polymorphonuclear leucocytes into the lung after injection of pneumococci suspended in serum is an important factor in susceptibility to infection since it allows ample time for pneumococci to grow in the pulmonary fluid. The slow phagocytic action of pulmonary macrophages likewise permits growth of pneumococci. Conditions in human beings that are known to be complicated by pulmonary edema are also known to be associated with increased susceptibility to secondary bacterial pneumonia.</p>
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