Outcome of chromosomally normal livebirths with increased fetal nuchal translucency at 10-14 weeks' gestation.
Identifieur interne : 001901 ( Pmc/Curation ); précédent : 001900; suivant : 001902Outcome of chromosomally normal livebirths with increased fetal nuchal translucency at 10-14 weeks' gestation.
Auteurs : A F Brady ; P P Pandya ; B. Yuksel ; A. Greenough ; M A Patton ; K H NicolaidesSource :
- Journal of Medical Genetics [ 0022-2593 ] ; 1998.
Abstract
The aim of this study was to determine the outcome of chromosomally normal livebirths with increased fetal nuchal translucency at 10-14 weeks' gestation. Clinical follow up of 89 chromosomally normal livebirths that in fetal life had a minimum nuchal translucency thickness of 3.5 mm and a comparison group of 302 infants whose fetal nuchal translucency thickness at 10-14 weeks of gestation was less than 3.5 mm was performed. Major abnormalities, mainly structural defects of the cardiovascular or skeletal systems, were found in 10.1% (nine of 89) of the group with increased translucency, compared to 2% (five of 302) in those with translucency of less than 3.5 mm (chi2=11.9, p<0.001). Delay in achievement of developmental milestones was observed in one of the infants with increased translucency and in one of the comparison group. The findings of this study show that in chromosomally normal fetuses increased nuchal translucency thickness at 10-14 weeks of gestation is a marker for fetal abnormalities including structural defects and genetic syndromes.
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PubMed: 9541107
PubMed Central: 1051246
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Med Genet</journal-id><journal-title>Journal of Medical Genetics</journal-title><issn pub-type="ppub">0022-2593</issn><issn pub-type="epub">1468-6244</issn></journal-meta><article-meta><article-id pub-id-type="pmid">9541107</article-id><article-id pub-id-type="pmc">1051246</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Outcome of chromosomally normal livebirths with increased fetal nuchal translucency at 10-14 weeks' gestation.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Brady</surname><given-names>A F</given-names></name></contrib><contrib contrib-type="author"><name><surname>Pandya</surname><given-names>P P</given-names></name></contrib><contrib contrib-type="author"><name><surname>Yuksel</surname><given-names>B</given-names></name></contrib><contrib contrib-type="author"><name><surname>Greenough</surname><given-names>A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Patton</surname><given-names>M A</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nicolaides</surname><given-names>K H</given-names></name></contrib></contrib-group><aff>Medical Genetics Unit, St George's Hospital Medical School, London, UK.</aff><pub-date pub-type="ppub"><month>3</month><year>1998</year></pub-date><volume>35</volume><issue>3</issue><fpage>222</fpage><lpage>224</lpage><abstract><p>The aim of this study was to determine the outcome of chromosomally normal livebirths with increased fetal nuchal translucency at 10-14 weeks' gestation. Clinical follow up of 89 chromosomally normal livebirths that in fetal life had a minimum nuchal translucency thickness of 3.5 mm and a comparison group of 302 infants whose fetal nuchal translucency thickness at 10-14 weeks of gestation was less than 3.5 mm was performed. Major abnormalities, mainly structural defects of the cardiovascular or skeletal systems, were found in 10.1% (nine of 89) of the group with increased translucency, compared to 2% (five of 302) in those with translucency of less than 3.5 mm (chi2=11.9, p<0.001). Delay in achievement of developmental milestones was observed in one of the infants with increased translucency and in one of the comparison group. The findings of this study show that in chromosomally normal fetuses increased nuchal translucency thickness at 10-14 weeks of gestation is a marker for fetal abnormalities including structural defects and genetic syndromes.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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