Immune reactions in human filariasis.
Identifieur interne : 001834 ( Pmc/Curation ); précédent : 001833; suivant : 001835Immune reactions in human filariasis.
Auteurs : D. Subrahmanyam ; K. Mehta ; D S Nelson ; Y V Rao ; C K RaoSource :
- Journal of Clinical Microbiology [ 0095-1137 ] ; 1978.
Abstract
Sera from cases of elephantiasis due to Wuchereria bancrofti infection promoted an intense adhesion of peripheral blood leukocytes to W. bancrofti microfilariae in vitro. A similar adhesion was also seen using sera from some normal persons living for several years in areas where filariasis is endemic. No such adhesion was evident with sera from microfilaria carriers or from normal subjects from nonendemic areas. The adhesion was complement independent and was associated with the immunoglobulin G fraction of serum. 51Cr release studies suggested the occurrence of cell-mediated cytotoxicity to W. bancrofti microfilariae in the presence of elephantiasis serum. Microfilariae of Litomosoides carinii could be isolated free of blood cells, from the blood of infected rats. In the presence of serum, or its immunoglobulin G fraction, from patients with elephantiasis, L. carinii microfilariae adhered to human peripheral blood leukocytes or rat spleen cells.
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PubMed: 359589
PubMed Central: 275191
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Microbiol</journal-id><journal-title>Journal of Clinical Microbiology</journal-title><issn pub-type="ppub">0095-1137</issn><issn pub-type="epub">1098-660X</issn></journal-meta><article-meta><article-id pub-id-type="pmid">359589</article-id><article-id pub-id-type="pmc">275191</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Immune reactions in human filariasis.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Subrahmanyam</surname><given-names>D</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mehta</surname><given-names>K</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nelson</surname><given-names>D S</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rao</surname><given-names>Y V</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rao</surname><given-names>C K</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>8</month><year>1978</year></pub-date><volume>8</volume><issue>2</issue><fpage>228</fpage><lpage>232</lpage><abstract><p>Sera from cases of elephantiasis due to Wuchereria bancrofti infection promoted an intense adhesion of peripheral blood leukocytes to W. bancrofti microfilariae in vitro. A similar adhesion was also seen using sera from some normal persons living for several years in areas where filariasis is endemic. No such adhesion was evident with sera from microfilaria carriers or from normal subjects from nonendemic areas. The adhesion was complement independent and was associated with the immunoglobulin G fraction of serum. 51Cr release studies suggested the occurrence of cell-mediated cytotoxicity to W. bancrofti microfilariae in the presence of elephantiasis serum. Microfilariae of Litomosoides carinii could be isolated free of blood cells, from the blood of infected rats. In the presence of serum, or its immunoglobulin G fraction, from patients with elephantiasis, L. carinii microfilariae adhered to human peripheral blood leukocytes or rat spleen cells.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><graphic xlink:href="jcm00193-0130-a" xlink:role="229"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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