Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort
Identifieur interne : 000D57 ( Pmc/Curation ); précédent : 000D56; suivant : 000D58Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort
Auteurs : Steffen E. Petersen ; Nay Aung ; Mihir M. Sanghvi ; Filip Zemrak ; Kenneth Fung ; Jose Miguel Paiva ; Jane M. Francis ; Mohammed Y. Khanji ; Elena Lukaschuk ; Aaron M. Lee ; Valentina Carapella ; Young Jin Kim [Corée du Sud] ; Paul Leeson ; Stefan K. Piechnik ; Stefan NeubauerSource :
- Journal of Cardiovascular Magnetic Resonance [ 1097-6647 ] ; 2017.
Abstract
Cardiovascular magnetic resonance (CMR) is the gold standard method for the assessment of cardiac structure and function. Reference ranges permit differentiation between normal and pathological states. To date, this study is the largest to provide CMR specific reference ranges for left ventricular, right ventricular, left atrial and right atrial structure and function derived from truly healthy Caucasian adults aged 45–74.
Five thousand sixty-five UK Biobank participants underwent CMR using steady-state free precession imaging at 1.5 Tesla. Manual analysis was performed for all four cardiac chambers. Participants with non-Caucasian ethnicity, known cardiovascular disease and other conditions known to affect cardiac chamber size and function were excluded. Remaining participants formed the healthy reference cohort; reference ranges were calculated and were stratified by gender and age (45–54, 55–64, 65–74).
After applying exclusion criteria, 804 (16.2%) participants were available for analysis. Left ventricular (LV) volumes were larger in males compared to females for absolute and indexed values. With advancing age, LV volumes were mostly smaller in both sexes. LV ejection fraction was significantly greater in females compared to males (mean ± standard deviation [SD] of 61 ± 5% vs 58 ± 5%) and remained static with age for both genders. In older age groups, LV mass was lower in men, but remained virtually unchanged in women. LV mass was significantly higher in males compared to females (mean ± SD of 53 ± 9 g/m2 vs 42 ± 7 g/m2). Right ventricular (RV) volumes were significantly larger in males compared to females for absolute and indexed values and were smaller with advancing age. RV ejection fraction was higher with increasing age in females only. Left atrial (LA) maximal volume and stroke volume were significantly larger in males compared to females for absolute values but not for indexed values. LA ejection fraction was similar for both sexes. Right atrial (RA) maximal volume was significantly larger in males for both absolute and indexed values, while RA ejection fraction was significantly higher in females.
We describe age- and sex-specific reference ranges for the left ventricle, right ventricle and atria in the largest validated normal Caucasian population.
The online version of this article (doi:10.1186/s12968-017-0327-9) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12968-017-0327-9
PubMed: 28178995
PubMed Central: 5304550
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000D58
Links to Exploration step
PMC:5304550Curation
No country items
Steffen E. Petersen<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5454</institution-id>
<institution-id institution-id-type="GRID">grid.15444.30</institution-id>
<institution>Department of Radiology, Severance Hospital,</institution>
<institution>Yonsei University College of Medicine,</institution>
</institution-wrap>
50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>50-1 Yonsei-ro, Seodaemun-gu, Seoul</wicri:regionArea>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort</title>
<author><name sortKey="Petersen, Steffen E" sort="Petersen, Steffen E" uniqKey="Petersen S" first="Steffen E." last="Petersen">Steffen E. Petersen</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aung, Nay" sort="Aung, Nay" uniqKey="Aung N" first="Nay" last="Aung">Nay Aung</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sanghvi, Mihir M" sort="Sanghvi, Mihir M" uniqKey="Sanghvi M" first="Mihir M." last="Sanghvi">Mihir M. Sanghvi</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zemrak, Filip" sort="Zemrak, Filip" uniqKey="Zemrak F" first="Filip" last="Zemrak">Filip Zemrak</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Fung, Kenneth" sort="Fung, Kenneth" uniqKey="Fung K" first="Kenneth" last="Fung">Kenneth Fung</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Paiva, Jose Miguel" sort="Paiva, Jose Miguel" uniqKey="Paiva J" first="Jose Miguel" last="Paiva">Jose Miguel Paiva</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Francis, Jane M" sort="Francis, Jane M" uniqKey="Francis J" first="Jane M." last="Francis">Jane M. Francis</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Khanji, Mohammed Y" sort="Khanji, Mohammed Y" uniqKey="Khanji M" first="Mohammed Y." last="Khanji">Mohammed Y. Khanji</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lukaschuk, Elena" sort="Lukaschuk, Elena" uniqKey="Lukaschuk E" first="Elena" last="Lukaschuk">Elena Lukaschuk</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lee, Aaron M" sort="Lee, Aaron M" uniqKey="Lee A" first="Aaron M." last="Lee">Aaron M. Lee</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Carapella, Valentina" sort="Carapella, Valentina" uniqKey="Carapella V" first="Valentina" last="Carapella">Valentina Carapella</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kim, Young Jin" sort="Kim, Young Jin" uniqKey="Kim Y" first="Young Jin" last="Kim">Young Jin Kim</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5454</institution-id>
<institution-id institution-id-type="GRID">grid.15444.30</institution-id>
<institution>Department of Radiology, Severance Hospital,</institution>
<institution>Yonsei University College of Medicine,</institution>
</institution-wrap>
50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>50-1 Yonsei-ro, Seodaemun-gu, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leeson, Paul" sort="Leeson, Paul" uniqKey="Leeson P" first="Paul" last="Leeson">Paul Leeson</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Piechnik, Stefan K" sort="Piechnik, Stefan K" uniqKey="Piechnik S" first="Stefan K." last="Piechnik">Stefan K. Piechnik</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Neubauer, Stefan" sort="Neubauer, Stefan" uniqKey="Neubauer S" first="Stefan" last="Neubauer">Stefan Neubauer</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">28178995</idno>
<idno type="pmc">5304550</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304550</idno>
<idno type="RBID">PMC:5304550</idno>
<idno type="doi">10.1186/s12968-017-0327-9</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">000D58</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D58</idno>
<idno type="wicri:Area/Pmc/Curation">000D57</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D57</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort</title>
<author><name sortKey="Petersen, Steffen E" sort="Petersen, Steffen E" uniqKey="Petersen S" first="Steffen E." last="Petersen">Steffen E. Petersen</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aung, Nay" sort="Aung, Nay" uniqKey="Aung N" first="Nay" last="Aung">Nay Aung</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sanghvi, Mihir M" sort="Sanghvi, Mihir M" uniqKey="Sanghvi M" first="Mihir M." last="Sanghvi">Mihir M. Sanghvi</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zemrak, Filip" sort="Zemrak, Filip" uniqKey="Zemrak F" first="Filip" last="Zemrak">Filip Zemrak</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Fung, Kenneth" sort="Fung, Kenneth" uniqKey="Fung K" first="Kenneth" last="Fung">Kenneth Fung</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Paiva, Jose Miguel" sort="Paiva, Jose Miguel" uniqKey="Paiva J" first="Jose Miguel" last="Paiva">Jose Miguel Paiva</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Francis, Jane M" sort="Francis, Jane M" uniqKey="Francis J" first="Jane M." last="Francis">Jane M. Francis</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Khanji, Mohammed Y" sort="Khanji, Mohammed Y" uniqKey="Khanji M" first="Mohammed Y." last="Khanji">Mohammed Y. Khanji</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lukaschuk, Elena" sort="Lukaschuk, Elena" uniqKey="Lukaschuk E" first="Elena" last="Lukaschuk">Elena Lukaschuk</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Lee, Aaron M" sort="Lee, Aaron M" uniqKey="Lee A" first="Aaron M." last="Lee">Aaron M. Lee</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</nlm:aff>
<wicri:noCountry code="subfield">EC1M 6BQ UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Carapella, Valentina" sort="Carapella, Valentina" uniqKey="Carapella V" first="Valentina" last="Carapella">Valentina Carapella</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kim, Young Jin" sort="Kim, Young Jin" uniqKey="Kim Y" first="Young Jin" last="Kim">Young Jin Kim</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5454</institution-id>
<institution-id institution-id-type="GRID">grid.15444.30</institution-id>
<institution>Department of Radiology, Severance Hospital,</institution>
<institution>Yonsei University College of Medicine,</institution>
</institution-wrap>
50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 South Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>50-1 Yonsei-ro, Seodaemun-gu, Seoul</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Leeson, Paul" sort="Leeson, Paul" uniqKey="Leeson P" first="Paul" last="Leeson">Paul Leeson</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Piechnik, Stefan K" sort="Piechnik, Stefan K" uniqKey="Piechnik S" first="Stefan K." last="Piechnik">Stefan K. Piechnik</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Neubauer, Stefan" sort="Neubauer, Stefan" uniqKey="Neubauer S" first="Stefan" last="Neubauer">Stefan Neubauer</name>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</nlm:aff>
<wicri:noCountry code="subfield">OX3 9DU UK</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Cardiovascular Magnetic Resonance</title>
<idno type="ISSN">1097-6647</idno>
<idno type="eISSN">1532-429X</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Cardiovascular magnetic resonance (CMR) is the gold standard method for the assessment of cardiac structure and function. Reference ranges permit differentiation between normal and pathological states. To date, this study is the largest to provide CMR specific reference ranges for left ventricular, right ventricular, left atrial and right atrial structure and function derived from truly healthy Caucasian adults aged 45–74.</p>
</sec>
<sec><title>Methods</title>
<p>Five thousand sixty-five UK Biobank participants underwent CMR using steady-state free precession imaging at 1.5 Tesla. Manual analysis was performed for all four cardiac chambers. Participants with non-Caucasian ethnicity, known cardiovascular disease and other conditions known to affect cardiac chamber size and function were excluded. Remaining participants formed the healthy reference cohort; reference ranges were calculated and were stratified by gender and age (45–54, 55–64, 65–74).</p>
</sec>
<sec><title>Results</title>
<p>After applying exclusion criteria, 804 (16.2%) participants were available for analysis. Left ventricular (LV) volumes were larger in males compared to females for absolute and indexed values. With advancing age, LV volumes were mostly smaller in both sexes. LV ejection fraction was significantly greater in females compared to males (mean ± standard deviation [SD] of 61 ± 5% vs 58 ± 5%) and remained static with age for both genders. In older age groups, LV mass was lower in men, but remained virtually unchanged in women. LV mass was significantly higher in males compared to females (mean ± SD of 53 ± 9 g/m<sup>2</sup>
vs 42 ± 7 g/m<sup>2</sup>
). Right ventricular (RV) volumes were significantly larger in males compared to females for absolute and indexed values and were smaller with advancing age. RV ejection fraction was higher with increasing age in females only. Left atrial (LA) maximal volume and stroke volume were significantly larger in males compared to females for absolute values but not for indexed values. LA ejection fraction was similar for both sexes. Right atrial (RA) maximal volume was significantly larger in males for both absolute and indexed values, while RA ejection fraction was significantly higher in females.</p>
</sec>
<sec><title>Conclusions</title>
<p>We describe age- and sex-specific reference ranges for the left ventricle, right ventricle and atria in the largest validated normal Caucasian population.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s12968-017-0327-9) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Maceira, Am" uniqKey="Maceira A">AM Maceira</name>
</author>
<author><name sortKey="Prasad, Sk" uniqKey="Prasad S">SK Prasad</name>
</author>
<author><name sortKey="Khan, M" uniqKey="Khan M">M Khan</name>
</author>
<author><name sortKey="Pennell, Dj" uniqKey="Pennell D">DJ Pennell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hudsmith, L" uniqKey="Hudsmith L">L Hudsmith</name>
</author>
<author><name sortKey="Petersen, S" uniqKey="Petersen S">S Petersen</name>
</author>
<author><name sortKey="Francis, J" uniqKey="Francis J">J Francis</name>
</author>
<author><name sortKey="Robson, M" uniqKey="Robson M">M Robson</name>
</author>
<author><name sortKey="Neubauer, S" uniqKey="Neubauer S">S Neubauer</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kawel Boehm, N" uniqKey="Kawel Boehm N">N Kawel-Boehm</name>
</author>
<author><name sortKey="Maceira, A" uniqKey="Maceira A">A Maceira</name>
</author>
<author><name sortKey="Valsangiacomo Buechel, Er" uniqKey="Valsangiacomo Buechel E">ER Valsangiacomo-Buechel</name>
</author>
<author><name sortKey="Vogel Claussen, J" uniqKey="Vogel Claussen J">J Vogel-Claussen</name>
</author>
<author><name sortKey="Turkbey, Eb" uniqKey="Turkbey E">EB Turkbey</name>
</author>
<author><name sortKey="Williams, R" uniqKey="Williams R">R Williams</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yeon, Sb" uniqKey="Yeon S">SB Yeon</name>
</author>
<author><name sortKey="Salton, Cj" uniqKey="Salton C">CJ Salton</name>
</author>
<author><name sortKey="Gona, P" uniqKey="Gona P">P Gona</name>
</author>
<author><name sortKey="Chuang, Ml" uniqKey="Chuang M">ML Chuang</name>
</author>
<author><name sortKey="Blease, Sj" uniqKey="Blease S">SJ Blease</name>
</author>
<author><name sortKey="Han, Y" uniqKey="Han Y">Y Han</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Foppa, M" uniqKey="Foppa M">M Foppa</name>
</author>
<author><name sortKey="Arora, G" uniqKey="Arora G">G Arora</name>
</author>
<author><name sortKey="Gona, P" uniqKey="Gona P">P Gona</name>
</author>
<author><name sortKey="Ashrafi, A" uniqKey="Ashrafi A">A Ashrafi</name>
</author>
<author><name sortKey="Salton, Cj" uniqKey="Salton C">CJ Salton</name>
</author>
<author><name sortKey="Yeon, Sb" uniqKey="Yeon S">SB Yeon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sudlow, C" uniqKey="Sudlow C">C Sudlow</name>
</author>
<author><name sortKey="Gallacher, J" uniqKey="Gallacher J">J Gallacher</name>
</author>
<author><name sortKey="Allen, N" uniqKey="Allen N">N Allen</name>
</author>
<author><name sortKey="Beral, V" uniqKey="Beral V">V Beral</name>
</author>
<author><name sortKey="Burton, P" uniqKey="Burton P">P Burton</name>
</author>
<author><name sortKey="Danesh, J" uniqKey="Danesh J">J Danesh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petersen, Se" uniqKey="Petersen S">SE Petersen</name>
</author>
<author><name sortKey="Matthews, Pm" uniqKey="Matthews P">PM Matthews</name>
</author>
<author><name sortKey="Bamberg, F" uniqKey="Bamberg F">F Bamberg</name>
</author>
<author><name sortKey="Bluemke, Da" uniqKey="Bluemke D">DA Bluemke</name>
</author>
<author><name sortKey="Francis, Jm" uniqKey="Francis J">JM Francis</name>
</author>
<author><name sortKey="Friedrich, Mg" uniqKey="Friedrich M">MG Friedrich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petersen, Se" uniqKey="Petersen S">SE Petersen</name>
</author>
<author><name sortKey="Matthews, Pm" uniqKey="Matthews P">PM Matthews</name>
</author>
<author><name sortKey="Francis, Jm" uniqKey="Francis J">JM Francis</name>
</author>
<author><name sortKey="Robson, Md" uniqKey="Robson M">MD Robson</name>
</author>
<author><name sortKey="Zemrak, F" uniqKey="Zemrak F">F Zemrak</name>
</author>
<author><name sortKey="Boubertakh, R" uniqKey="Boubertakh R">R Boubertakh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lang, Rm" uniqKey="Lang R">RM Lang</name>
</author>
<author><name sortKey="Badano, Lp" uniqKey="Badano L">LP Badano</name>
</author>
<author><name sortKey="Mor Avi, V" uniqKey="Mor Avi V">V Mor-Avi</name>
</author>
<author><name sortKey="Afilalo, J" uniqKey="Afilalo J">J Afilalo</name>
</author>
<author><name sortKey="Armstrong, A" uniqKey="Armstrong A">A Armstrong</name>
</author>
<author><name sortKey="Ernande, L" uniqKey="Ernande L">L Ernande</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Solberg, He" uniqKey="Solberg H">HE Solberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Du Bois, D" uniqKey="Du Bois D">D Du Bois</name>
</author>
<author><name sortKey="Du Bois, Ef" uniqKey="Du Bois E">EF Du Bois</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bland, Jm" uniqKey="Bland J">JM Bland</name>
</author>
<author><name sortKey="Altman, Dg" uniqKey="Altman D">DG Altman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hallgren, Ka" uniqKey="Hallgren K">KA Hallgren</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Dweck, Mr" uniqKey="Dweck M">MR Dweck</name>
</author>
<author><name sortKey="Joshi, S" uniqKey="Joshi S">S Joshi</name>
</author>
<author><name sortKey="Murigu, T" uniqKey="Murigu T">T Murigu</name>
</author>
<author><name sortKey="Gulati, A" uniqKey="Gulati A">A Gulati</name>
</author>
<author><name sortKey="Alpendurada, F" uniqKey="Alpendurada F">F Alpendurada</name>
</author>
<author><name sortKey="Jabbour, A" uniqKey="Jabbour A">A Jabbour</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sievers, B" uniqKey="Sievers B">B Sievers</name>
</author>
<author><name sortKey="Kirchberg, S" uniqKey="Kirchberg S">S Kirchberg</name>
</author>
<author><name sortKey="Franken, U" uniqKey="Franken U">U Franken</name>
</author>
<author><name sortKey="Bakan, A" uniqKey="Bakan A">A Bakan</name>
</author>
<author><name sortKey="Addo, M" uniqKey="Addo M">M Addo</name>
</author>
<author><name sortKey="John Puthenveettil, B" uniqKey="John Puthenveettil B">B John-Puthenveettil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maceira, Am" uniqKey="Maceira A">AM Maceira</name>
</author>
<author><name sortKey="Cosin Sales, J" uniqKey="Cosin Sales J">J Cosín-Sales</name>
</author>
<author><name sortKey="Roughton, M" uniqKey="Roughton M">M Roughton</name>
</author>
<author><name sortKey="Prasad, Sk" uniqKey="Prasad S">SK Prasad</name>
</author>
<author><name sortKey="Pennell, Dj" uniqKey="Pennell D">DJ Pennell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Maceira, Am" uniqKey="Maceira A">AM Maceira</name>
</author>
<author><name sortKey="Cosin Sales, J" uniqKey="Cosin Sales J">J Cosín-Sales</name>
</author>
<author><name sortKey="Roughton, M" uniqKey="Roughton M">M Roughton</name>
</author>
<author><name sortKey="Prasad, Sk" uniqKey="Prasad S">SK Prasad</name>
</author>
<author><name sortKey="Pennell, Dj" uniqKey="Pennell D">DJ Pennell</name>
</author>
<author><name sortKey="Sanfilippo, A" uniqKey="Sanfilippo A">A Sanfilippo</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Helge Erik Solberg, Ds" uniqKey="Helge Erik Solberg D">DS Helge Erik Solberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lieb, W" uniqKey="Lieb W">W Lieb</name>
</author>
<author><name sortKey="Xanthakis, V" uniqKey="Xanthakis V">V Xanthakis</name>
</author>
<author><name sortKey="Sullivan, Lm" uniqKey="Sullivan L">LM Sullivan</name>
</author>
<author><name sortKey="Aragam, J" uniqKey="Aragam J">J Aragam</name>
</author>
<author><name sortKey="Pencina, Mj" uniqKey="Pencina M">MJ Pencina</name>
</author>
<author><name sortKey="Larson, Mg" uniqKey="Larson M">MG Larson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fuchs, A" uniqKey="Fuchs A">A Fuchs</name>
</author>
<author><name sortKey="Mejdahl, Mr" uniqKey="Mejdahl M">MR Mejdahl</name>
</author>
<author><name sortKey="Kuhl, Jt" uniqKey="Kuhl J">JT Kühl</name>
</author>
<author><name sortKey="Stisen, Zr" uniqKey="Stisen Z">ZR Stisen</name>
</author>
<author><name sortKey="Nilsson, Ejp" uniqKey="Nilsson E">EJP Nilsson</name>
</author>
<author><name sortKey="K Ber, Lv" uniqKey="K Ber L">LV Køber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chung, Ak" uniqKey="Chung A">AK Chung</name>
</author>
<author><name sortKey="Das, Sr" uniqKey="Das S">SR Das</name>
</author>
<author><name sortKey="Leonard, D" uniqKey="Leonard D">D Leonard</name>
</author>
<author><name sortKey="Peshock, Rm" uniqKey="Peshock R">RM Peshock</name>
</author>
<author><name sortKey="Kazi, F" uniqKey="Kazi F">F Kazi</name>
</author>
<author><name sortKey="Abdullah, Sm" uniqKey="Abdullah S">SM Abdullah</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Strait, Jb" uniqKey="Strait J">JB Strait</name>
</author>
<author><name sortKey="Lakatta, Eg" uniqKey="Lakatta E">EG Lakatta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schulman, Sp" uniqKey="Schulman S">SP Schulman</name>
</author>
<author><name sortKey="Lakatta, Eg" uniqKey="Lakatta E">EG Lakatta</name>
</author>
<author><name sortKey="Fleg, Jl" uniqKey="Fleg J">JL Fleg</name>
</author>
<author><name sortKey="Lakatta, L" uniqKey="Lakatta L">L Lakatta</name>
</author>
<author><name sortKey="Becker, Lc" uniqKey="Becker L">LC Becker</name>
</author>
<author><name sortKey="Gerstenblith, G" uniqKey="Gerstenblith G">G Gerstenblith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kitzman, Dw" uniqKey="Kitzman D">DW Kitzman</name>
</author>
<author><name sortKey="Scholz, Dg" uniqKey="Scholz D">DG Scholz</name>
</author>
<author><name sortKey="Hagen, Pt" uniqKey="Hagen P">PT Hagen</name>
</author>
<author><name sortKey="Ilstrup, Dm" uniqKey="Ilstrup D">DM Ilstrup</name>
</author>
<author><name sortKey="Edwards, Wd" uniqKey="Edwards W">WD Edwards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Margossian, R" uniqKey="Margossian R">R Margossian</name>
</author>
<author><name sortKey="Schwartz, Ml" uniqKey="Schwartz M">ML Schwartz</name>
</author>
<author><name sortKey="Prakash, A" uniqKey="Prakash A">A Prakash</name>
</author>
<author><name sortKey="Wruck, L" uniqKey="Wruck L">L Wruck</name>
</author>
<author><name sortKey="Hurwitz, Lm" uniqKey="Hurwitz L">LM Hurwitz</name>
</author>
<author><name sortKey="Marcus, E" uniqKey="Marcus E">E Marcus</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Teo, Ksl" uniqKey="Teo K">KSL Teo</name>
</author>
<author><name sortKey="Carbone, A" uniqKey="Carbone A">A Carbone</name>
</author>
<author><name sortKey="Piantadosi, C" uniqKey="Piantadosi C">C Piantadosi</name>
</author>
<author><name sortKey="Chew, Dp" uniqKey="Chew D">DP Chew</name>
</author>
<author><name sortKey="Hammett, Cjk" uniqKey="Hammett C">CJK Hammett</name>
</author>
<author><name sortKey="Brown, Ma" uniqKey="Brown M">MA Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rider, Oj" uniqKey="Rider O">OJ Rider</name>
</author>
<author><name sortKey="Francis, Jm" uniqKey="Francis J">JM Francis</name>
</author>
<author><name sortKey="Ali, Mk" uniqKey="Ali M">MK Ali</name>
</author>
<author><name sortKey="Byrne, J" uniqKey="Byrne J">J Byrne</name>
</author>
<author><name sortKey="Clarke, K" uniqKey="Clarke K">K Clarke</name>
</author>
<author><name sortKey="Neubauer, S" uniqKey="Neubauer S">S Neubauer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rider, Oj" uniqKey="Rider O">OJ Rider</name>
</author>
<author><name sortKey="Petersen, Se" uniqKey="Petersen S">SE Petersen</name>
</author>
<author><name sortKey="Francis, Jm" uniqKey="Francis J">JM Francis</name>
</author>
<author><name sortKey="Ali, Mk" uniqKey="Ali M">MK Ali</name>
</author>
<author><name sortKey="Hudsmith, Le" uniqKey="Hudsmith L">LE Hudsmith</name>
</author>
<author><name sortKey="Robinson, Mr" uniqKey="Robinson M">MR Robinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Cardiovasc Magn Reson</journal-id>
<journal-id journal-id-type="iso-abbrev">J Cardiovasc Magn Reson</journal-id>
<journal-title-group><journal-title>Journal of Cardiovascular Magnetic Resonance</journal-title>
</journal-title-group>
<issn pub-type="ppub">1097-6647</issn>
<issn pub-type="epub">1532-429X</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28178995</article-id>
<article-id pub-id-type="pmc">5304550</article-id>
<article-id pub-id-type="publisher-id">327</article-id>
<article-id pub-id-type="doi">10.1186/s12968-017-0327-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Petersen</surname>
<given-names>Steffen E.</given-names>
</name>
<address><email>s.e.petersen@qmul.ac.uk</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aung</surname>
<given-names>Nay</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sanghvi</surname>
<given-names>Mihir M.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zemrak</surname>
<given-names>Filip</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fung</surname>
<given-names>Kenneth</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Paiva</surname>
<given-names>Jose Miguel</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Francis</surname>
<given-names>Jane M.</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khanji</surname>
<given-names>Mohammed Y.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lukaschuk</surname>
<given-names>Elena</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Aaron M.</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Carapella</surname>
<given-names>Valentina</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Young Jin</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leeson</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Piechnik</surname>
<given-names>Stefan K.</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Neubauer</surname>
<given-names>Stefan</given-names>
</name>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2171 1133</institution-id>
<institution-id institution-id-type="GRID">grid.4868.2</institution-id>
<institution>William Harvey Research Institute, NIHR Cardiovascular Biomedical Research Unit at Barts,</institution>
<institution>Queen Mary University of London,</institution>
</institution-wrap>
Charterhouse Square, London, EC1M 6BQ UK</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Division of Cardiovascular Medicine, Radcliffe Department of Medicine,</institution>
<institution>University of Oxford,</institution>
</institution-wrap>
Level 6, West Wing, John Radcliffe Hospital, Headington, Oxford, OX3 9DU UK</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0470 5454</institution-id>
<institution-id institution-id-type="GRID">grid.15444.30</institution-id>
<institution>Department of Radiology, Severance Hospital,</institution>
<institution>Yonsei University College of Medicine,</institution>
</institution-wrap>
50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 South Korea</aff>
</contrib-group>
<pub-date pub-type="epub"><day>3</day>
<month>2</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>3</day>
<month>2</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><year>2017</year>
</pub-date>
<volume>19</volume>
<elocation-id>18</elocation-id>
<history><date date-type="received"><day>8</day>
<month>10</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>14</day>
<month>1</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2017</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p>Cardiovascular magnetic resonance (CMR) is the gold standard method for the assessment of cardiac structure and function. Reference ranges permit differentiation between normal and pathological states. To date, this study is the largest to provide CMR specific reference ranges for left ventricular, right ventricular, left atrial and right atrial structure and function derived from truly healthy Caucasian adults aged 45–74.</p>
</sec>
<sec><title>Methods</title>
<p>Five thousand sixty-five UK Biobank participants underwent CMR using steady-state free precession imaging at 1.5 Tesla. Manual analysis was performed for all four cardiac chambers. Participants with non-Caucasian ethnicity, known cardiovascular disease and other conditions known to affect cardiac chamber size and function were excluded. Remaining participants formed the healthy reference cohort; reference ranges were calculated and were stratified by gender and age (45–54, 55–64, 65–74).</p>
</sec>
<sec><title>Results</title>
<p>After applying exclusion criteria, 804 (16.2%) participants were available for analysis. Left ventricular (LV) volumes were larger in males compared to females for absolute and indexed values. With advancing age, LV volumes were mostly smaller in both sexes. LV ejection fraction was significantly greater in females compared to males (mean ± standard deviation [SD] of 61 ± 5% vs 58 ± 5%) and remained static with age for both genders. In older age groups, LV mass was lower in men, but remained virtually unchanged in women. LV mass was significantly higher in males compared to females (mean ± SD of 53 ± 9 g/m<sup>2</sup>
vs 42 ± 7 g/m<sup>2</sup>
). Right ventricular (RV) volumes were significantly larger in males compared to females for absolute and indexed values and were smaller with advancing age. RV ejection fraction was higher with increasing age in females only. Left atrial (LA) maximal volume and stroke volume were significantly larger in males compared to females for absolute values but not for indexed values. LA ejection fraction was similar for both sexes. Right atrial (RA) maximal volume was significantly larger in males for both absolute and indexed values, while RA ejection fraction was significantly higher in females.</p>
</sec>
<sec><title>Conclusions</title>
<p>We describe age- and sex-specific reference ranges for the left ventricle, right ventricle and atria in the largest validated normal Caucasian population.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s12968-017-0327-9) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Cardiovascular magnetic resonance</kwd>
<kwd>Reference values</kwd>
<kwd>Ventricular function</kwd>
<kwd>Atrial function</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100000274</institution-id>
<institution>British Heart Foundation</institution>
</institution-wrap>
</funding-source>
<award-id>PG/14/89/31194</award-id>
<principal-award-recipient><name><surname>Petersen</surname>
<given-names>Steffen E.</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2017</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D57 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000D57 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:5304550 |texte= Reference ranges for cardiac structure and function using cardiovascular magnetic resonance (CMR) in Caucasians from the UK Biobank population cohort }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:28178995" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
![]() | This area was generated with Dilib version V0.6.31. | ![]() |