Validation of Six Nomograms for Predicting Non-sentinel Lymph Node Metastases in a Dutch Breast Cancer Population
Identifieur interne : 000C04 ( Pmc/Curation ); précédent : 000C03; suivant : 000C05Validation of Six Nomograms for Predicting Non-sentinel Lymph Node Metastases in a Dutch Breast Cancer Population
Auteurs : Siem A. Dingemans [Pays-Bas] ; Peter D. De Rooij [Pays-Bas] ; Roos M. Van Der Vuurst De Vries [Pays-Bas] ; Leo M. Budel [Pays-Bas] ; Caroline M. Contant [Pays-Bas] ; Anne E. M. Van Der Pool [Pays-Bas]Source :
- Annals of Surgical Oncology [ 1068-9265 ] ; 2015.
Abstract
The usefulness of axillary lymph node dissection (ALND) in patients with positive sentinel nodes (SN) is still an ongoing debate. Several nomograms have been developed for predicting non-sentinel lymph node metastases (NSLNM). We validated six nomograms using data from 10 years of breast cancer surgery in our hospital.
We retrospectively analyzed all patients with a proven breast malignancy and a SN procedure between 2001 and 2011 in our hospital.
Data from 1084 patients were reviewed; 260 (24 %) had a positive SN. No patients with isolated tumor cells, 6 patients (8 %) with micrometastases, and 65 patients (41 %) with macrometastases had additional axillary NSLNM. In 2 patients (3 %) with micrometastases, the ALND influenced postoperative treatment. In the group of patients with macrometastases tumor size >2 cm, extranodal growth and having no negative SNs were predictors of NSLNM. The revised MD Anderson Cancer Center and Helsinki nomograms performed the best, with an area under the curve value of 0.78.
ALND could probably be safely omitted in most patients with micrometastases but is still indicated in patients with macrometastases, especially in patients with tumor size >2 cm, extranodal growth, and no negative SNs. The revised MD Anderson Cancer Center and Helsinki nomograms were the most predictive in our patient group.
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DOI: 10.1245/s10434-015-4858-8
PubMed: 26369528
PubMed Central: 4718954
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De Rooij</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Vuurst De Vries, Roos M" sort="Van Der Vuurst De Vries, Roos M" uniqKey="Van Der Vuurst De Vries R" first="Roos M." last="Van Der Vuurst De Vries">Roos M. Van Der Vuurst De Vries</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Budel, Leo M" sort="Budel, Leo M" uniqKey="Budel L" first="Leo M." last="Budel">Leo M. Budel</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Pathology, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Contant, Caroline M" sort="Contant, Caroline M" uniqKey="Contant C" first="Caroline M." last="Contant">Caroline M. Contant</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Pool, Anne E M" sort="Van Der Pool, Anne E M" uniqKey="Van Der Pool A" first="Anne E. M." last="Van Der Pool">Anne E. M. Van Der Pool</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26369528</idno><idno type="pmc">4718954</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718954</idno><idno type="RBID">PMC:4718954</idno><idno type="doi">10.1245/s10434-015-4858-8</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000C05</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C05</idno><idno type="wicri:Area/Pmc/Curation">000C04</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Validation of Six Nomograms for Predicting Non-sentinel Lymph Node Metastases in a Dutch Breast Cancer Population</title><author><name sortKey="Dingemans, Siem A" sort="Dingemans, Siem A" uniqKey="Dingemans S" first="Siem A." last="Dingemans">Siem A. Dingemans</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="De Rooij, Peter D" sort="De Rooij, Peter D" uniqKey="De Rooij P" first="Peter D." last="De Rooij">Peter D. De Rooij</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Vuurst De Vries, Roos M" sort="Van Der Vuurst De Vries, Roos M" uniqKey="Van Der Vuurst De Vries R" first="Roos M." last="Van Der Vuurst De Vries">Roos M. Van Der Vuurst De Vries</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Budel, Leo M" sort="Budel, Leo M" uniqKey="Budel L" first="Leo M." last="Budel">Leo M. Budel</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Pathology, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Contant, Caroline M" sort="Contant, Caroline M" uniqKey="Contant C" first="Caroline M." last="Contant">Caroline M. Contant</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Pool, Anne E M" sort="Van Der Pool, Anne E M" uniqKey="Van Der Pool A" first="Anne E. M." last="Van Der Pool">Anne E. M. Van Der Pool</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of Surgical Oncology</title><idno type="ISSN">1068-9265</idno><idno type="eISSN">1534-4681</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The usefulness of axillary lymph node dissection (ALND) in patients with positive sentinel nodes (SN) is still an ongoing debate. Several nomograms have been developed for predicting non-sentinel lymph node metastases (NSLNM). We validated six nomograms using data from 10 years of breast cancer surgery in our hospital.</p></sec><sec><title>Methods</title><p>We retrospectively analyzed all patients with a proven breast malignancy and a SN procedure between 2001 and 2011 in our hospital.</p></sec><sec><title>Results</title><p>Data from 1084 patients were reviewed; 260 (24 %) had a positive SN. No patients with isolated tumor cells, 6 patients (8 %) with micrometastases, and 65 patients (41 %) with macrometastases had additional axillary NSLNM. In 2 patients (3 %) with micrometastases, the ALND influenced postoperative treatment. In the group of patients with macrometastases tumor size >2 cm, extranodal growth and having no negative SNs were predictors of NSLNM. The revised MD Anderson Cancer Center and Helsinki nomograms performed the best, with an area under the curve value of 0.78.</p></sec><sec><title>Conclusions</title><p>ALND could probably be safely omitted in most patients with micrometastases but is still indicated in patients with macrometastases, especially in patients with tumor size >2 cm, extranodal growth, and no negative SNs. The revised MD Anderson Cancer Center and Helsinki nomograms were the most predictive in our patient group.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Van Der Waal, D" uniqKey="Van Der Waal D">D Van der Waal</name></author><author><name sortKey="Verbeek, Al" uniqKey="Verbeek A">AL Verbeek</name></author><author><name sortKey="Den Heeten, Gj" uniqKey="Den Heeten G">GJ den Heeten</name></author><author><name sortKey="Ripping, Tm" uniqKey="Ripping T">TM Ripping</name></author><author><name sortKey="Tjan Heijnen, Vc" uniqKey="Tjan Heijnen V">VC Tjan-Heijnen</name></author><author><name sortKey="Broeders, Mj" uniqKey="Broeders M">MJ Broeders</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Giuliano, Ae" uniqKey="Giuliano A">AE Giuliano</name></author><author><name sortKey="Hunt, Kk" uniqKey="Hunt K">KK Hunt</name></author><author><name sortKey="Ballman, Kv" uniqKey="Ballman K">KV Ballman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hwang, Rf" uniqKey="Hwang R">RF Hwang</name></author><author><name sortKey="Krishnamurthy, S" uniqKey="Krishnamurthy S">S Krishnamurthy</name></author><author><name sortKey="Hunt, Kk" uniqKey="Hunt K">KK Hunt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hessman, Cj" uniqKey="Hessman C">CJ Hessman</name></author><author><name sortKey="Naik, Am" uniqKey="Naik A">AM Naik</name></author><author><name sortKey="Kearney, Nm" uniqKey="Kearney N">NM Kearney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van La Parra, Rfd" uniqKey="Van La Parra R">RFD Van la Parra</name></author><author><name sortKey="Francissen, Cmtp" uniqKey="Francissen C">CMTP Francissen</name></author><author><name sortKey="Peer, Pgm" uniqKey="Peer P">PGM Peer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Zee, Kj" uniqKey="Van Zee K">KJ Van Zee</name></author><author><name sortKey="Manasseh, D Me" uniqKey="Manasseh D">D-ME Manasseh</name></author><author><name sortKey="Bevilacqua, Jlb" uniqKey="Bevilacqua J">JLB Bevilacqua</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galimberti, V" uniqKey="Galimberti V">V Galimberti</name></author><author><name sortKey="Botteri, E" uniqKey="Botteri E">E Botteri</name></author><author><name sortKey="Chifu, C" uniqKey="Chifu C">C Chifu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sola, M" uniqKey="Sola M">M Solá</name></author><author><name sortKey="Alberro, Ja" uniqKey="Alberro J">JA Alberro</name></author><author><name sortKey="Fraile, M" uniqKey="Fraile M">M Fraile</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donker, M" uniqKey="Donker M">M Donker</name></author><author><name sortKey="Van Tienhoven, G" uniqKey="Van Tienhoven G">G van Tienhoven</name></author><author><name sortKey="Straver, Me" uniqKey="Straver M">ME Straver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galimberti, V" uniqKey="Galimberti V">V Galimberti</name></author><author><name sortKey="Cole, Bf" uniqKey="Cole B">BF Cole</name></author><author><name sortKey="Zurrida, S" uniqKey="Zurrida S">S Zurrida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Unal, B" uniqKey="Unal B">B Unal</name></author><author><name sortKey="Gur, As" uniqKey="Gur A">AS Gur</name></author><author><name sortKey="Kayiran, O" uniqKey="Kayiran O">O Kayiran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Degnim, Ac" uniqKey="Degnim A">AC Degnim</name></author><author><name sortKey="Reynolds, C" uniqKey="Reynolds C">C Reynolds</name></author><author><name sortKey="Pantvaidya, G" uniqKey="Pantvaidya G">G Pantvaidya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barranger, E" uniqKey="Barranger E">E Barranger</name></author><author><name sortKey="Coutant, C" uniqKey="Coutant C">C Coutant</name></author><author><name sortKey="Flahault, A" uniqKey="Flahault A">A Flahault</name></author><author><name sortKey="Delpech, Y" uniqKey="Delpech Y">Y Delpech</name></author><author><name sortKey="Darai, E" uniqKey="Darai E">E Darai</name></author><author><name sortKey="Uzan, S" uniqKey="Uzan S">S Uzan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pal, A" uniqKey="Pal A">A Pal</name></author><author><name sortKey="Provenzano, E" uniqKey="Provenzano E">E Provenzano</name></author><author><name sortKey="Duffy, Sw" uniqKey="Duffy S">SW Duffy</name></author><author><name sortKey="Pinder, Se" uniqKey="Pinder S">SE Pinder</name></author><author><name sortKey="Purushotham, Ad" uniqKey="Purushotham A">AD Purushotham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kohrt, He" uniqKey="Kohrt H">HE Kohrt</name></author><author><name sortKey="Olshen, Ra" uniqKey="Olshen R">RA Olshen</name></author><author><name sortKey="Bermas, Hr" uniqKey="Bermas H">HR Bermas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meretoja, Tj" uniqKey="Meretoja T">TJ Meretoja</name></author><author><name sortKey="Leidenius, Mhk" uniqKey="Leidenius M">MHK Leidenius</name></author><author><name sortKey="Heikkil, Ps" uniqKey="Heikkil P">PS Heikkilä</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mittendorf, Ea" uniqKey="Mittendorf E">EA Mittendorf</name></author><author><name sortKey="Hunt, Kk" uniqKey="Hunt K">KK Hunt</name></author><author><name sortKey="Boughey, Jc" uniqKey="Boughey J">JC Boughey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Wessem, Kjp" uniqKey="Van Wessem K">KJP Van Wessem</name></author><author><name sortKey="Meijer, Ws" uniqKey="Meijer W">WS Meijer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sobin, Lh" uniqKey="Sobin L">LH Sobin</name></author><author><name sortKey="Gospodarowicz, Mk" uniqKey="Gospodarowicz M">MK Gospodarowicz</name></author><author><name sortKey="Wittekind, Cw" uniqKey="Wittekind C">CW Wittekind</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, L" uniqKey="Zhu L">L Zhu</name></author><author><name sortKey="Jin, L" uniqKey="Jin L">L Jin</name></author><author><name sortKey="Li, S" uniqKey="Li S">S Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanley, Ja" uniqKey="Hanley J">JA Hanley</name></author><author><name sortKey="Mcneil, Bj" uniqKey="Mcneil B">BJ McNeil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tvedskov, Tf" uniqKey="Tvedskov T">TF Tvedskov</name></author><author><name sortKey="Jensen, Mb" uniqKey="Jensen M">MB Jensen</name></author><author><name sortKey="Lisse, Im" uniqKey="Lisse I">IM Lisse</name></author><author><name sortKey="Ejlertsen, B" uniqKey="Ejlertsen B">B Ejlertsen</name></author><author><name sortKey="Balslev, E" uniqKey="Balslev E">E Balslev</name></author><author><name sortKey="Kroman, N" uniqKey="Kroman N">N Kroman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Surg Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Ann. Surg. Oncol</journal-id><journal-title-group><journal-title>Annals of Surgical Oncology</journal-title></journal-title-group><issn pub-type="ppub">1068-9265</issn><issn pub-type="epub">1534-4681</issn><publisher><publisher-name>Springer US</publisher-name><publisher-loc>New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26369528</article-id><article-id pub-id-type="pmc">4718954</article-id><article-id pub-id-type="publisher-id">4858</article-id><article-id pub-id-type="doi">10.1245/s10434-015-4858-8</article-id><article-categories><subj-group subj-group-type="heading"><subject>Breast Oncology</subject></subj-group></article-categories><title-group><article-title>Validation of Six Nomograms for Predicting Non-sentinel Lymph Node Metastases in a Dutch Breast Cancer Population</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Dingemans</surname><given-names>Siem A.</given-names></name><degrees>MD</degrees><address><email>s.a.dingemans@amc.nl</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>de Rooij</surname><given-names>Peter D.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>van der Vuurst de Vries</surname><given-names>Roos M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Budel</surname><given-names>Leo M.</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Contant</surname><given-names>Caroline M.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>van der Pool</surname><given-names>Anne E. M.</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><label></label>Department of Surgery, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</aff><aff id="Aff2"><label></label>Department of Pathology, Maasstad Hospital Rotterdam, Rotterdam, The Netherlands</aff></contrib-group><pub-date pub-type="epub"><day>14</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>14</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="ppub"><year>2016</year></pub-date><volume>23</volume><fpage>477</fpage><lpage>481</lpage><history><date date-type="received"><day>8</day><month>6</month><year>2015</year></date></history><permissions><copyright-statement>© The Author(s) 2015</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>The usefulness of axillary lymph node dissection (ALND) in patients with positive sentinel nodes (SN) is still an ongoing debate. Several nomograms have been developed for predicting non-sentinel lymph node metastases (NSLNM). We validated six nomograms using data from 10 years of breast cancer surgery in our hospital.</p></sec><sec><title>Methods</title><p>We retrospectively analyzed all patients with a proven breast malignancy and a SN procedure between 2001 and 2011 in our hospital.</p></sec><sec><title>Results</title><p>Data from 1084 patients were reviewed; 260 (24 %) had a positive SN. No patients with isolated tumor cells, 6 patients (8 %) with micrometastases, and 65 patients (41 %) with macrometastases had additional axillary NSLNM. In 2 patients (3 %) with micrometastases, the ALND influenced postoperative treatment. In the group of patients with macrometastases tumor size >2 cm, extranodal growth and having no negative SNs were predictors of NSLNM. The revised MD Anderson Cancer Center and Helsinki nomograms performed the best, with an area under the curve value of 0.78.</p></sec><sec><title>Conclusions</title><p>ALND could probably be safely omitted in most patients with micrometastases but is still indicated in patients with macrometastases, especially in patients with tumor size >2 cm, extranodal growth, and no negative SNs. The revised MD Anderson Cancer Center and Helsinki nomograms were the most predictive in our patient group.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Society of Surgical Oncology 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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