Well-differentiated angiosarcoma of spleen: a teaching case mimicking hemagioma and cytogenetic analysis with array comparative genomic hybridization
Identifieur interne : 000A56 ( Pmc/Curation ); précédent : 000A55; suivant : 000A57Well-differentiated angiosarcoma of spleen: a teaching case mimicking hemagioma and cytogenetic analysis with array comparative genomic hybridization
Auteurs : Lichen Xu [République populaire de Chine] ; Yimin Zhang [République populaire de Chine] ; Hong Zhao [République populaire de Chine] ; Qingxiao Chen [République populaire de Chine] ; Weihang Ma [République populaire de Chine] ; Lanjuan Li [République populaire de Chine]Source :
- World Journal of Surgical Oncology [ 1477-7819 ] ; 2015.
Abstract
Primary splenic angiosarcoma is extremely rare but aggressive malignant vascular neoplasm. Here, we report a case of vascular tumor in spleen that was initially misinterpreted as hemangioma. Two years after splenectomy, the patient admitted again with aggravated abdomen pain and severe anemia. The magnetic resonance imaging (MRI) scan showed widely metastases. The ensuing biopsy for lesion both in liver and in bone marrow showed the similar pathological findings as that in spleen, which supported the final diagnosis of well-differentiated splenic angiosarcoma with extensive metastases. The patient was dead in 3 months after discharge without chemotherapy. The copy number changes for spleen lesion detected by array comparative genome hybridization showed copy number gain at 11q23.2, 11q24.3, 12q24.33, 13q34, copy number loss at 1q24.2-q31.3, 1q41-q42.2, 1 q42.3-q43, 2q36.3-q37.3, 2q37.7, 3q13.33-q26.2, 3q28 - q29, 9p11.2, 13q11, 15q11, homozygous copy loss at 8p11.22, 22q11.23. Less than 200 cases of splenic angiosarcoma have been published in literature of English. To the best of our knowledge, this is the first time analyzed cytogenetic alteration in a well-differentiated primary splenic angiosarcoma.
Url:
DOI: 10.1186/s12957-015-0716-1
PubMed: 26462621
PubMed Central: 4603576
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A57
Links to Exploration step
PMC:4603576Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Well-differentiated angiosarcoma of spleen: a teaching case mimicking hemagioma and cytogenetic analysis with array comparative genomic hybridization</title><author><name sortKey="Xu, Lichen" sort="Xu, Lichen" uniqKey="Xu L" first="Lichen" last="Xu">Lichen Xu</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhang, Yimin" sort="Zhang, Yimin" uniqKey="Zhang Y" first="Yimin" last="Zhang">Yimin Zhang</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhao, Hong" sort="Zhao, Hong" uniqKey="Zhao H" first="Hong" last="Zhao">Hong Zhao</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Chen, Qingxiao" sort="Chen, Qingxiao" uniqKey="Chen Q" first="Qingxiao" last="Chen">Qingxiao Chen</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Bone Marrow Transplantation Center, Department of Hematology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Ma, Weihang" sort="Ma, Weihang" uniqKey="Ma W" first="Weihang" last="Ma">Weihang Ma</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff3">School of Medicine, Zhejiang University, Hangzhou, Zhejiang China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Li, Lanjuan" sort="Li, Lanjuan" uniqKey="Li L" first="Lanjuan" last="Li">Lanjuan Li</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26462621</idno><idno type="pmc">4603576</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603576</idno><idno type="RBID">PMC:4603576</idno><idno type="doi">10.1186/s12957-015-0716-1</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000A57</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A57</idno><idno type="wicri:Area/Pmc/Curation">000A56</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Well-differentiated angiosarcoma of spleen: a teaching case mimicking hemagioma and cytogenetic analysis with array comparative genomic hybridization</title><author><name sortKey="Xu, Lichen" sort="Xu, Lichen" uniqKey="Xu L" first="Lichen" last="Xu">Lichen Xu</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhang, Yimin" sort="Zhang, Yimin" uniqKey="Zhang Y" first="Yimin" last="Zhang">Yimin Zhang</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Zhao, Hong" sort="Zhao, Hong" uniqKey="Zhao H" first="Hong" last="Zhao">Hong Zhao</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Chen, Qingxiao" sort="Chen, Qingxiao" uniqKey="Chen Q" first="Qingxiao" last="Chen">Qingxiao Chen</name><affiliation wicri:level="4"><nlm:aff id="Aff2">Bone Marrow Transplantation Center, Department of Hematology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Ma, Weihang" sort="Ma, Weihang" uniqKey="Ma W" first="Weihang" last="Ma">Weihang Ma</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="Aff3">School of Medicine, Zhejiang University, Hangzhou, Zhejiang China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author><author><name sortKey="Li, Lanjuan" sort="Li, Lanjuan" uniqKey="Li L" first="Lanjuan" last="Li">Lanjuan Li</name><affiliation wicri:level="4"><nlm:aff id="Aff1">State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</nlm:aff><orgName type="university">Université de Zhejiang</orgName><country>République populaire de Chine</country><placeName><settlement type="city">Hangzhou</settlement><region type="province">Zhejiang</region></placeName></affiliation></author></analytic><series><title level="j">World Journal of Surgical Oncology</title><idno type="eISSN">1477-7819</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Primary splenic angiosarcoma is extremely rare but aggressive malignant vascular neoplasm. Here, we report a case of vascular tumor in spleen that was initially misinterpreted as hemangioma. Two years after splenectomy, the patient admitted again with aggravated abdomen pain and severe anemia. The magnetic resonance imaging (MRI) scan showed widely metastases. The ensuing biopsy for lesion both in liver and in bone marrow showed the similar pathological findings as that in spleen, which supported the final diagnosis of well-differentiated splenic angiosarcoma with extensive metastases. The patient was dead in 3 months after discharge without chemotherapy. The copy number changes for spleen lesion detected by array comparative genome hybridization showed copy number gain at 11q23.2, 11q24.3, 12q24.33, 13q34, copy number loss at 1q24.2-q31.3, 1q41-q42.2, 1 q42.3-q43, 2q36.3-q37.3, 2q37.7, 3q13.33-q26.2, 3q28 - q29, 9p11.2, 13q11, 15q11, homozygous copy loss at 8p11.22, 22q11.23. Less than 200 cases of splenic angiosarcoma have been published in literature of English. To the best of our knowledge, this is the first time analyzed cytogenetic alteration in a well-differentiated primary splenic angiosarcoma.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hamid, Ks" uniqKey="Hamid K">KS Hamid</name></author><author><name sortKey="Rodriguez, Ja" uniqKey="Rodriguez J">JA Rodriguez</name></author><author><name sortKey="Lairmore, Tc" uniqKey="Lairmore T">TC Lairmore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Antonescu, C" uniqKey="Antonescu C">C Antonescu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, Rj" uniqKey="Young R">RJ Young</name></author><author><name sortKey="Brown, Nj" uniqKey="Brown N">NJ Brown</name></author><author><name sortKey="Reed, Mw" uniqKey="Reed M">MW Reed</name></author><author><name sortKey="Hughes, D" uniqKey="Hughes D">D Hughes</name></author><author><name sortKey="Woll, Pj" uniqKey="Woll P">PJ Woll</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rouhani, P" uniqKey="Rouhani P">P Rouhani</name></author><author><name sortKey="Fletcher, Cd" uniqKey="Fletcher C">CD Fletcher</name></author><author><name sortKey="Devesa, Ss" uniqKey="Devesa S">SS Devesa</name></author><author><name sortKey="Toro, Jr" uniqKey="Toro J">JR Toro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Jt" uniqKey="Hsu J">JT Hsu</name></author><author><name sortKey="Lin, Cy" uniqKey="Lin C">CY Lin</name></author><author><name sortKey="Wu, Tj" uniqKey="Wu T">TJ Wu</name></author><author><name sortKey="Chen, Hm" uniqKey="Chen H">HM Chen</name></author><author><name sortKey="Hwang, Tl" uniqKey="Hwang T">TL Hwang</name></author><author><name sortKey="Jan, Yy" uniqKey="Jan Y">YY Jan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neuhauser, Ts" uniqKey="Neuhauser T">TS Neuhauser</name></author><author><name sortKey="Derringer, Ga" uniqKey="Derringer G">GA Derringer</name></author><author><name sortKey="Thompson, Ldr" uniqKey="Thompson L">LDR Thompson</name></author><author><name sortKey="Fanburg Smith, Jc" uniqKey="Fanburg Smith J">JC Fanburg-Smith</name></author><author><name sortKey="Miettinen, M" uniqKey="Miettinen M">M Miettinen</name></author><author><name sortKey="Saaristo, A" uniqKey="Saaristo A">A Saaristo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qi, R" uniqKey="Qi R">R Qi</name></author><author><name sortKey="Yu, Jq" uniqKey="Yu J">JQ Yu</name></author><author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name></author><author><name sortKey="Zhou, Xp" uniqKey="Zhou X">XP Zhou</name></author><author><name sortKey="Li, Xm" uniqKey="Li X">XM Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Jt" uniqKey="Hsu J">JT Hsu</name></author><author><name sortKey="Chen, Hm" uniqKey="Chen H">HM Chen</name></author><author><name sortKey="Lin, Cy" uniqKey="Lin C">CY Lin</name></author><author><name sortKey="Yeh, Cn" uniqKey="Yeh C">CN Yeh</name></author><author><name sortKey="Hwang, Tl" uniqKey="Hwang T">TL Hwang</name></author><author><name sortKey="Jan, Yy" uniqKey="Jan Y">YY Jan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falk, S" uniqKey="Falk S">S Falk</name></author><author><name sortKey="Krishnan, J" uniqKey="Krishnan J">J Krishnan</name></author><author><name sortKey="Meis, Jm" uniqKey="Meis J">JM Meis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Zj" uniqKey="Liu Z">ZJ Liu</name></author><author><name sortKey="Du, Xf" uniqKey="Du X">XF Du</name></author><author><name sortKey="Li, Ht" uniqKey="Li H">HT Li</name></author><author><name sortKey="Wang, Zy" uniqKey="Wang Z">ZY Wang</name></author><author><name sortKey="Shen, Z" uniqKey="Shen Z">Z Shen</name></author><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y Yao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez, S" uniqKey="Fernandez S">S Fernandez</name></author><author><name sortKey="Cook, Gw" uniqKey="Cook G">GW Cook</name></author><author><name sortKey="Arber, Da" uniqKey="Arber D">DA Arber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ben Izhak, O" uniqKey="Ben Izhak O">O Ben-Izhak</name></author><author><name sortKey="Bejar, J" uniqKey="Bejar J">J Bejar</name></author><author><name sortKey="Ben Eliezer, S" uniqKey="Ben Eliezer S">S Ben-Eliezer</name></author><author><name sortKey="Vlodavsky, E" uniqKey="Vlodavsky E">E Vlodavsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baumhoer, D" uniqKey="Baumhoer D">D Baumhoer</name></author><author><name sortKey="Gunawan, B" uniqKey="Gunawan B">B Gunawan</name></author><author><name sortKey="Becker, H" uniqKey="Becker H">H Becker</name></author><author><name sortKey="Fuzesi, L" uniqKey="Fuzesi L">L Fuzesi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mertens, F" uniqKey="Mertens F">F Mertens</name></author><author><name sortKey="Panagopoulos, I" uniqKey="Panagopoulos I">I Panagopoulos</name></author><author><name sortKey="Mandahl, N" uniqKey="Mandahl N">N Mandahl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dunlap, Jb" uniqKey="Dunlap J">JB Dunlap</name></author><author><name sortKey="Magenis, Re" uniqKey="Magenis R">RE Magenis</name></author><author><name sortKey="Davis, C" uniqKey="Davis C">C Davis</name></author><author><name sortKey="Himoe, E" uniqKey="Himoe E">E Himoe</name></author><author><name sortKey="Mansoor, A" uniqKey="Mansoor A">A Mansoor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verbeke, Sl" uniqKey="Verbeke S">SL Verbeke</name></author><author><name sortKey="De Jong, D" uniqKey="De Jong D">D de Jong</name></author><author><name sortKey="Bertoni, F" uniqKey="Bertoni F">F Bertoni</name></author><author><name sortKey="Sciot, R" uniqKey="Sciot R">R Sciot</name></author><author><name sortKey="Antonescu, Cr" uniqKey="Antonescu C">CR Antonescu</name></author><author><name sortKey="Szuhai, K" uniqKey="Szuhai K">K Szuhai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manner, J" uniqKey="Manner J">J Manner</name></author><author><name sortKey="Radlwimmer, B" uniqKey="Radlwimmer B">B Radlwimmer</name></author><author><name sortKey="Hohenberger, P" uniqKey="Hohenberger P">P Hohenberger</name></author><author><name sortKey="Mossinger, K" uniqKey="Mossinger K">K Mossinger</name></author><author><name sortKey="Kuffer, S" uniqKey="Kuffer S">S Kuffer</name></author><author><name sortKey="Sauer, C" uniqKey="Sauer C">C Sauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Th" uniqKey="Guo T">TH Guo</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Chang, Ne" uniqKey="Chang N">NE Chang</name></author><author><name sortKey="Singer, S" uniqKey="Singer S">S Singer</name></author><author><name sortKey="Maki, Rg" uniqKey="Maki R">RG Maki</name></author><author><name sortKey="Antonescu, Cr" uniqKey="Antonescu C">CR Antonescu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandez, Ap" uniqKey="Fernandez A">AP Fernandez</name></author><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name></author><author><name sortKey="Tubbs, Rr" uniqKey="Tubbs R">RR Tubbs</name></author><author><name sortKey="Goldblum, Jr" uniqKey="Goldblum J">JR Goldblum</name></author><author><name sortKey="Billings, Sd" uniqKey="Billings S">SD Billings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Domfeh, Ab" uniqKey="Domfeh A">AB Domfeh</name></author><author><name sortKey="Fichera, M" uniqKey="Fichera M">M Fichera</name></author><author><name sortKey="Hunt, Jl" uniqKey="Hunt J">JL Hunt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wen, Vw" uniqKey="Wen V">VW Wen</name></author><author><name sortKey="Mackenzie, Kl" uniqKey="Mackenzie K">KL MacKenzie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Xk" uniqKey="Zhang X">XK Zhang</name></author><author><name sortKey="Gallant, S" uniqKey="Gallant S">S Gallant</name></author><author><name sortKey="Molano, I" uniqKey="Molano I">I Molano</name></author><author><name sortKey="Moussa, Om" uniqKey="Moussa O">OM Moussa</name></author><author><name sortKey="Ruiz, P" uniqKey="Ruiz P">P Ruiz</name></author><author><name sortKey="Spyropoulos, Dd" uniqKey="Spyropoulos D">DD Spyropoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dittmer, J" uniqKey="Dittmer J">J Dittmer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Naito, S" uniqKey="Naito S">S Naito</name></author><author><name sortKey="Shimizu, K" uniqKey="Shimizu K">K Shimizu</name></author><author><name sortKey="Nakashima, M" uniqKey="Nakashima M">M Nakashima</name></author><author><name sortKey="Nakayama, T" uniqKey="Nakayama T">T Nakayama</name></author><author><name sortKey="Ito, T" uniqKey="Ito T">T Ito</name></author><author><name sortKey="Ito, M" uniqKey="Ito M">M Ito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonetti, P" uniqKey="Bonetti P">P Bonetti</name></author><author><name sortKey="Testoni, M" uniqKey="Testoni M">M Testoni</name></author><author><name sortKey="Scandurra, M" uniqKey="Scandurra M">M Scandurra</name></author><author><name sortKey="Ponzoni, M" uniqKey="Ponzoni M">M Ponzoni</name></author><author><name sortKey="Piva, R" uniqKey="Piva R">R Piva</name></author><author><name sortKey="Mensah, Aa" uniqKey="Mensah A">AA Mensah</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Surg Oncol</journal-id><journal-id journal-id-type="iso-abbrev">World J Surg Oncol</journal-id><journal-title-group><journal-title>World Journal of Surgical Oncology</journal-title></journal-title-group><issn pub-type="epub">1477-7819</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26462621</article-id><article-id pub-id-type="pmc">4603576</article-id><article-id pub-id-type="publisher-id">716</article-id><article-id pub-id-type="doi">10.1186/s12957-015-0716-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Well-differentiated angiosarcoma of spleen: a teaching case mimicking hemagioma and cytogenetic analysis with array comparative genomic hybridization</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Xu</surname><given-names>Lichen</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Zhang</surname><given-names>Yimin</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Hong</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Qingxiao</given-names></name><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Ma</surname><given-names>Weihang</given-names></name><address><email>weihangma2014@126.com</email></address><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Lanjuan</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><label></label>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang 310003 China</aff><aff id="Aff2"><label></label>Bone Marrow Transplantation Center, Department of Hematology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang China</aff><aff id="Aff3"><label></label>School of Medicine, Zhejiang University, Hangzhou, Zhejiang China</aff></contrib-group><pub-date pub-type="epub"><day>13</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>13</day><month>10</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>13</volume><elocation-id>300</elocation-id><history><date date-type="received"><day>29</day><month>7</month><year>2015</year></date><date date-type="accepted"><day>5</day><month>10</month><year>2015</year></date></history><permissions><copyright-statement>© Xu et al. 2015</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><p>Primary splenic angiosarcoma is extremely rare but aggressive malignant vascular neoplasm. Here, we report a case of vascular tumor in spleen that was initially misinterpreted as hemangioma. Two years after splenectomy, the patient admitted again with aggravated abdomen pain and severe anemia. The magnetic resonance imaging (MRI) scan showed widely metastases. The ensuing biopsy for lesion both in liver and in bone marrow showed the similar pathological findings as that in spleen, which supported the final diagnosis of well-differentiated splenic angiosarcoma with extensive metastases. The patient was dead in 3 months after discharge without chemotherapy. The copy number changes for spleen lesion detected by array comparative genome hybridization showed copy number gain at 11q23.2, 11q24.3, 12q24.33, 13q34, copy number loss at 1q24.2-q31.3, 1q41-q42.2, 1 q42.3-q43, 2q36.3-q37.3, 2q37.7, 3q13.33-q26.2, 3q28 - q29, 9p11.2, 13q11, 15q11, homozygous copy loss at 8p11.22, 22q11.23. Less than 200 cases of splenic angiosarcoma have been published in literature of English. To the best of our knowledge, this is the first time analyzed cytogenetic alteration in a well-differentiated primary splenic angiosarcoma.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Angiosarcoma</kwd><kwd>Well-differentiation</kwd><kwd>Splenectomy</kwd><kwd>Array comparative genomic hybridization</kwd><kwd>Copy number change</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2015</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A56 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000A56 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4603576
|texte= Well-differentiated angiosarcoma of spleen: a teaching case mimicking hemagioma and cytogenetic analysis with array comparative genomic hybridization
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26462621" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |