Pulmonary hypoplasia and anasarca syndrome in Cika cattle
Identifieur interne : 000A26 ( Pmc/Curation ); précédent : 000A25; suivant : 000A27Pulmonary hypoplasia and anasarca syndrome in Cika cattle
Auteurs : Tanja Švara [Slovénie] ; Vasilij Cociancich [Slovénie] ; Katarina Šest [Slovénie] ; Mitja Gomba [Slovénie] ; Tomislav Paller [Slovénie] ; Jože Stari [Slovénie] ; Cord Drögemüller [Suisse]Source :
- Acta Veterinaria Scandinavica [ 0044-605X ] ; 2016.
Abstract
Hydrops foetalis is defined as excessive fluid accumulation within the foetal extravascular compartments and body cavities. It has been described in human and veterinary medicine, but despite several descriptive studies its aetiology is still not fully clarified. Pulmonary hypoplasia and anasarca (PHA) syndrome is a rare congenital abnormality in cattle that is characterised by hydrops foetalis including extreme subcutaneous oedema (anasarca) and undeveloped or poorly formed lungs (pulmonary hypoplasia). Until now, sporadic cases of PHA were reported in cattle breeds like Australian Dexter, Belted Galloway, Maine-Anjou, and Shorthorn. This report describes the first known cases of PHA syndrome in Slovenian Cika cattle.
A 13-year-old cow aborted a male calf in the seventh month of pregnancy, while a male calf was delivered by caesarean section on the due date from a 14-year-old cow. The pedigree analysis showed that the calves were sired by the same bull, the dams were paternal half-sisters and the second calf was the product of a dam-son mating. Gross lesions were similar in both cases and characterized by severe anasarca, hydrothorax, hydropericardium, ascites, hypoplastic lungs, absence of lymph nodes, and an enlarged heart. The first calf was also athymic. Histopathology of the second affected calf confirmed severe oedema of the subcutis and interstitium of the organs, and pulmonary hypoplasia. The lymph vessels in the subcutis and other organs were severely dilated. Histopathology of the second calf revealed also lack of bronchus associated lymphoid tissue and adrenal gland hypoplasia.
The findings were consistent with known forms of the bovine PHA syndrome. This is the first report of the PHA syndrome occurring in the local endangered breed of Cika cattle. Observed inbreeding practice supports that this lethal defect most likely follows an autosomal recessive mode of inheritance. In the light of the disease phenotype it is assumed that a mutation causing an impaired development of lymph vessels is responsible for the hydrops foetalis associated malformations in bovine PHA.
Url:
DOI: 10.1186/s13028-016-0220-9
PubMed: 27267454
PubMed Central: 4896035
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uniqKey="Cociancich V" first="Vasilij" last="Cociancich">Vasilij Cociancich</name><affiliation wicri:level="1"><nlm:aff id="Aff2">National Veterinary Institute, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>National Veterinary Institute, Veterinary Faculty, University of Ljubljana, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Sest, Katarina" sort="Sest, Katarina" uniqKey="Sest K" first="Katarina" last="Šest">Katarina Šest</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Clinic for Ruminants, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Clinic for Ruminants, Veterinary Faculty, University of Ljubljana, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Gomba, Mitja" sort="Gomba, Mitja" uniqKey="Gomba M" first="Mitja" last="Gomba">Mitja Gomba</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Institute of Pathology, Forensic and Administrative Veterinary Medicine, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Institute of Pathology, Forensic and Administrative Veterinary Medicine, Veterinary Faculty, University of Ljubljana, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Paller, Tomislav" sort="Paller, Tomislav" uniqKey="Paller T" first="Tomislav" last="Paller">Tomislav Paller</name><affiliation wicri:level="1"><nlm:aff id="Aff2">National Veterinary Institute, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>National Veterinary Institute, Veterinary Faculty, University of Ljubljana, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Stari, Joze" sort="Stari, Joze" uniqKey="Stari J" first="Jože" last="Stari">Jože Stari</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Clinic for Ruminants, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia</nlm:aff><country xml:lang="fr">Slovénie</country><wicri:regionArea>Clinic for Ruminants, Veterinary Faculty, University of Ljubljana, Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Drogemuller, Cord" sort="Drogemuller, Cord" uniqKey="Drogemuller C" first="Cord" last="Drögemüller">Cord Drögemüller</name><affiliation wicri:level="1"><nlm:aff id="Aff4">Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern</wicri:regionArea></affiliation></author></analytic><series><title level="j">Acta Veterinaria Scandinavica</title><idno type="ISSN">0044-605X</idno><idno type="eISSN">1751-0147</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Hydrops foetalis is defined as excessive fluid accumulation within the foetal extravascular compartments and body cavities. It has been described in human and veterinary medicine, but despite several descriptive studies its aetiology is still not fully clarified. Pulmonary hypoplasia and anasarca (PHA) syndrome is a rare congenital abnormality in cattle that is characterised by hydrops foetalis including extreme subcutaneous oedema (anasarca) and undeveloped or poorly formed lungs (pulmonary hypoplasia). Until now, sporadic cases of PHA were reported in cattle breeds like Australian Dexter, Belted Galloway, Maine-Anjou, and Shorthorn. This report describes the first known cases of PHA syndrome in Slovenian Cika cattle.</p></sec><sec><title>Case presentation</title><p>A 13-year-old cow aborted a male calf in the seventh month of pregnancy, while a male calf was delivered by caesarean section on the due date from a 14-year-old cow. The pedigree analysis showed that the calves were sired by the same bull, the dams were paternal half-sisters and the second calf was the product of a dam-son mating. Gross lesions were similar in both cases and characterized by severe anasarca, hydrothorax, hydropericardium, ascites, hypoplastic lungs, absence of lymph nodes, and an enlarged heart. The first calf was also athymic. Histopathology of the second affected calf confirmed severe oedema of the subcutis and interstitium of the organs, and pulmonary hypoplasia. The lymph vessels in the subcutis and other organs were severely dilated. Histopathology of the second calf revealed also lack of bronchus associated lymphoid tissue and adrenal gland hypoplasia.</p></sec><sec><title>Conclusions</title><p>The findings were consistent with known forms of the bovine PHA syndrome. This is the first report of the PHA syndrome occurring in the local endangered breed of Cika cattle. Observed inbreeding practice supports that this lethal defect most likely follows an autosomal recessive mode of inheritance. In the light of the disease phenotype it is assumed that a mutation causing an impaired development of lymph vessels is responsible for the hydrops foetalis associated malformations in bovine PHA.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bellini, C" uniqKey="Bellini C">C Bellini</name></author><author><name sortKey="Hennekam, Rc" uniqKey="Hennekam R">RC Hennekam</name></author><author><name sortKey="Fulcheri, E" uniqKey="Fulcheri E">E Fulcheri</name></author><author><name sortKey="Rutigliani, M" uniqKey="Rutigliani M">M Rutigliani</name></author><author><name sortKey="Morcaldi, G" uniqKey="Morcaldi G">G Morcaldi</name></author><author><name sortKey="Boccardo, F" uniqKey="Boccardo F">F Boccardo</name></author><author><name sortKey="Bonioli, E" uniqKey="Bonioli E">E Bonioli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bellini, C" uniqKey="Bellini C">C 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Acta Vet Scand</journal-id><journal-id journal-id-type="iso-abbrev">Acta Vet. Scand</journal-id><journal-title-group><journal-title>Acta Veterinaria Scandinavica</journal-title></journal-title-group><issn pub-type="ppub">0044-605X</issn><issn pub-type="epub">1751-0147</issn><publisher><publisher-name>BioMed Central</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27267454</article-id><article-id pub-id-type="pmc">4896035</article-id><article-id pub-id-type="publisher-id">220</article-id><article-id pub-id-type="doi">10.1186/s13028-016-0220-9</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Pulmonary hypoplasia and anasarca syndrome in Cika cattle</article-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Švara</surname><given-names>Tanja</given-names></name><address><email>tanja.svara@vf.uni-lj.si</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Cociancich</surname><given-names>Vasilij</given-names></name><address><email>vasilij.cociancich@vf.uni-lj.si</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Šest</surname><given-names>Katarina</given-names></name><address><email>katarina.sest@gmail.com</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Gombač</surname><given-names>Mitja</given-names></name><address><email>mitja.gombac@vf.uni-lj.si</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Paller</surname><given-names>Tomislav</given-names></name><address><email>tomislav.paller@vf.uni-lj.si</email></address><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Starič</surname><given-names>Jože</given-names></name><address><email>joze.staric@vf.uni-lj.si</email></address><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes" equal-contrib="yes"><name><surname>Drögemüller</surname><given-names>Cord</given-names></name><address><email>cord.droegemueller@vetsuisse.unibe.ch</email></address><xref ref-type="aff" rid="Aff4">4</xref></contrib><aff id="Aff1"><label>1</label>Institute of Pathology, Forensic and Administrative Veterinary Medicine, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia</aff><aff id="Aff2"><label>2</label>National Veterinary Institute, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia</aff><aff id="Aff3"><label>3</label>Clinic for Ruminants, Veterinary Faculty, University of Ljubljana, Ljubljana, Slovenia</aff><aff id="Aff4"><label>4</label>Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland</aff></contrib-group><pub-date pub-type="epub"><day>6</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>6</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="collection"><year>2016</year></pub-date><volume>58</volume><elocation-id>36</elocation-id><history><date date-type="received"><day>5</day><month>4</month><year>2016</year></date><date date-type="accepted"><day>1</day><month>6</month><year>2016</year></date></history><permissions><copyright-statement>© Švara et al 2016</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background</title><p>Hydrops foetalis is defined as excessive fluid accumulation within the foetal extravascular compartments and body cavities. It has been described in human and veterinary medicine, but despite several descriptive studies its aetiology is still not fully clarified. Pulmonary hypoplasia and anasarca (PHA) syndrome is a rare congenital abnormality in cattle that is characterised by hydrops foetalis including extreme subcutaneous oedema (anasarca) and undeveloped or poorly formed lungs (pulmonary hypoplasia). Until now, sporadic cases of PHA were reported in cattle breeds like Australian Dexter, Belted Galloway, Maine-Anjou, and Shorthorn. This report describes the first known cases of PHA syndrome in Slovenian Cika cattle.</p></sec><sec><title>Case presentation</title><p>A 13-year-old cow aborted a male calf in the seventh month of pregnancy, while a male calf was delivered by caesarean section on the due date from a 14-year-old cow. The pedigree analysis showed that the calves were sired by the same bull, the dams were paternal half-sisters and the second calf was the product of a dam-son mating. Gross lesions were similar in both cases and characterized by severe anasarca, hydrothorax, hydropericardium, ascites, hypoplastic lungs, absence of lymph nodes, and an enlarged heart. The first calf was also athymic. Histopathology of the second affected calf confirmed severe oedema of the subcutis and interstitium of the organs, and pulmonary hypoplasia. The lymph vessels in the subcutis and other organs were severely dilated. Histopathology of the second calf revealed also lack of bronchus associated lymphoid tissue and adrenal gland hypoplasia.</p></sec><sec><title>Conclusions</title><p>The findings were consistent with known forms of the bovine PHA syndrome. This is the first report of the PHA syndrome occurring in the local endangered breed of Cika cattle. Observed inbreeding practice supports that this lethal defect most likely follows an autosomal recessive mode of inheritance. In the light of the disease phenotype it is assumed that a mutation causing an impaired development of lymph vessels is responsible for the hydrops foetalis associated malformations in bovine PHA.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Pulmonary hypoplasia</kwd><kwd>Anasarca</kwd><kwd>Lymphatic system</kwd><kwd>Hydrops foetalis</kwd><kwd>Rare disease</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2016</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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