Squamous cell carcinoma arising from congenital lymphedema
Identifieur interne : 000852 ( Pmc/Curation ); précédent : 000851; suivant : 000853Squamous cell carcinoma arising from congenital lymphedema
Auteurs : Raja Parthiban [Inde] ; Amrit Kaur Kaler [Inde] ; Shameem Shariff [Inde] ; M. Sangeeta [Inde]Source :
- SAGE Open Medical Case Reports [ 2050-313X ] ; 2013.
Abstract
Congenital lymphedema is a rare type of primary lymphedema occurring at birth or developing shortly later. Primary lymphedema can be classified according to whether it is familial or sporadic. The primary congenital familial lymphedema is also known as Milroy’s disease. Majority of primary cases are sporadic type. Chronic lymphedema can be secondary to infections, surgery with lymph node excision, trauma, lymphadenectomy, radiotherapy, filarial infection, and so on. It is recognized that a variety of malignant tumors can arise in chronic congenital or acquired lymphedema; the most documented associations are lymphangiosarcoma, basal cell carcinoma, lymphoma, malignant melanoma, and Kaposi’s sarcoma. A total of 13 cases of squamous cell carcinoma arising from chronic (primary or acquired) lymphedema have been reported, and only 3 cases of congenital lymphedema presented with squamous cell carcinoma as reported. A 32-year-old young male presented with chronic unilateral left lower limb lymphedema of 28 years duration. In addition, he had a 3-month history of a fungating cutaneous lesion on the lateral side measuring 2 cm × 1 cm in size. Fine-needle aspiration cytology was performed on the later mass, and a diagnosis of angiosarcoma was made. At histopathology, the appearances did not confirm angiosarcoma. However, an impression of carcinoma was made as squamous cells were observed in sheets. Immunohistochemistry was performed using markers for CD31, factor VIII (FVIII), and MiB. The epithelial marker cytokeratin was positive for squamoid cells and MiB index of 75%. The vascular markers FVIII and CD31 were negative, thus ruling out angiosarcoma. The final diagnosis was given as infiltrating squamous cell carcinoma in chronic lymphedema.
Url:
DOI: 10.1177/2050313X13496507
PubMed: 27489627
PubMed Central: 4857268
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<front><div type="abstract" xml:lang="en"><p>Congenital lymphedema is a rare type of primary lymphedema occurring at birth or developing shortly later. Primary lymphedema can be classified according to whether it is familial or sporadic. The primary congenital familial lymphedema is also known as Milroy’s disease. Majority of primary cases are sporadic type. Chronic lymphedema can be secondary to infections, surgery with lymph node excision, trauma, lymphadenectomy, radiotherapy, filarial infection, and so on. It is recognized that a variety of malignant tumors can arise in chronic congenital or acquired lymphedema; the most documented associations are lymphangiosarcoma, basal cell carcinoma, lymphoma, malignant melanoma, and Kaposi’s sarcoma. A total of 13 cases of squamous cell carcinoma arising from chronic (primary or acquired) lymphedema have been reported, and only 3 cases of congenital lymphedema presented with squamous cell carcinoma as reported. A 32-year-old young male presented with chronic unilateral left lower limb lymphedema of 28 years duration. In addition, he had a 3-month history of a fungating cutaneous lesion on the lateral side measuring 2 cm × 1 cm in size. Fine-needle aspiration cytology was performed on the later mass, and a diagnosis of angiosarcoma was made. At histopathology, the appearances did not confirm angiosarcoma. However, an impression of carcinoma was made as squamous cells were observed in sheets. Immunohistochemistry was performed using markers for CD31, factor VIII (FVIII), and MiB. The epithelial marker cytokeratin was positive for squamoid cells and MiB index of 75%. The vascular markers FVIII and CD31 were negative, thus ruling out angiosarcoma. The final diagnosis was given as infiltrating squamous cell carcinoma in chronic lymphedema.</p>
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</author>
<author><name sortKey="Mortimer, Ps" uniqKey="Mortimer P">PS Mortimer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brostrom, La" uniqKey="Brostrom L">LA Brostrom</name>
</author>
<author><name sortKey="Nilsonne, U" uniqKey="Nilsonne U">U Nilsonne</name>
</author>
<author><name sortKey="Kronberg, M" uniqKey="Kronberg M">M Kronberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Clark, B" uniqKey="Clark B">B Clark</name>
</author>
<author><name sortKey="Sitzia, J" uniqKey="Sitzia J">J Sitzia</name>
</author>
<author><name sortKey="Harlow, W" uniqKey="Harlow W">W Harlow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azurdia, Rm" uniqKey="Azurdia R">RM Azurdia</name>
</author>
<author><name sortKey="Guerin, Dm" uniqKey="Guerin D">DM Guerin</name>
</author>
<author><name sortKey="Verbov, Jl" uniqKey="Verbov J">JL Verbov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ruocco, V" uniqKey="Ruocco V">V Ruocco</name>
</author>
<author><name sortKey="Astarita, C" uniqKey="Astarita C">C Astarita</name>
</author>
<author><name sortKey="Guerrera, V" uniqKey="Guerrera V">V Guerrera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartal, Ah" uniqKey="Bartal A">AH Bartal</name>
</author>
<author><name sortKey="Pinsky, Cm" uniqKey="Pinsky C">CM Pinsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paydas, S" uniqKey="Paydas S">S Paydas</name>
</author>
<author><name sortKey="Sahin, B" uniqKey="Sahin B">B Sahin</name>
</author>
<author><name sortKey="Yavuz, S" uniqKey="Yavuz S">S Yavuz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Epstein, Ji" uniqKey="Epstein J">JI Epstein</name>
</author>
<author><name sortKey="Mendelsohn, G" uniqKey="Mendelsohn G">G Mendelsohn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Echenique Elizondo, M" uniqKey="Echenique Elizondo M">M Echenique-Elizondo</name>
</author>
<author><name sortKey="Elorza, J" uniqKey="Elorza J">J Elorza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ostrow, Rs" uniqKey="Ostrow R">RS Ostrow</name>
</author>
<author><name sortKey="Manias, D" uniqKey="Manias D">D Manias</name>
</author>
<author><name sortKey="Mitchell, Aj" uniqKey="Mitchell A">AJ Mitchell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name>
</author>
<author><name sortKey="Haiko, P" uniqKey="Haiko P">P Haiko</name>
</author>
<author><name sortKey="Sainio, K" uniqKey="Sainio K">K Sainio</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Magalhaes, Cbs" uniqKey="Magalhaes C">CBS Magalhães</name>
</author>
<author><name sortKey="Soares, C" uniqKey="Soares C">C Soares</name>
</author>
</analytic>
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</author>
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</author>
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</author>
<author><name sortKey="Treves, N" uniqKey="Treves N">N Treves</name>
</author>
</analytic>
</biblStruct>
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</author>
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</author>
<author><name sortKey="Porock, D" uniqKey="Porock D">D Porock</name>
</author>
</analytic>
</biblStruct>
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</author>
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</author>
<author><name sortKey="Stanley, Mw" uniqKey="Stanley M">MW Stanley</name>
</author>
</analytic>
</biblStruct>
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</author>
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</author>
<author><name sortKey="Pettinato, G" uniqKey="Pettinato G">G Pettinato</name>
</author>
</analytic>
</biblStruct>
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</author>
<author><name sortKey="Myint, F" uniqKey="Myint F">F Myint</name>
</author>
<author><name sortKey="Hamilton, G" uniqKey="Hamilton G">G Hamilton</name>
</author>
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<title-group><article-title>Squamous cell carcinoma arising from congenital lymphedema</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Parthiban</surname>
<given-names>Raja</given-names>
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<xref ref-type="aff" rid="aff1-2050313X13496507">1</xref>
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<contrib contrib-type="author" corresp="yes"><name><surname>Kaler</surname>
<given-names>Amrit Kaur</given-names>
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<given-names>Shameem</given-names>
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<contrib contrib-type="author"><name><surname>Sangeeta</surname>
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<aff id="aff1-2050313X13496507"><label>1</label>
Department of Pathology, MVJ Medical College & Research Hospital, Bangalore, Karnataka, India</aff>
<aff id="aff2-2050313X13496507"><label>2</label>
Sri Devraj Urs Medical College, Kolar, Karnataka, India</aff>
<author-notes><corresp id="corresp1-2050313X13496507">Amrit Kaur Kaler, Assistant Professor, Department of Pathology, MVJ Medical College & Research Hospital, Dandupalya, 30th KM Milestone, National Highway 4, Kolathur Post, Hoskote, Bangalore, Karnataka, India. Email: <email>amrit_kaler@yahoo.co.in</email>
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<pub-date pub-type="epub"><day>19</day>
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<year>2013</year>
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<volume>1</volume>
<elocation-id>2050313X13496507</elocation-id>
<permissions><copyright-statement>© The Author(s) 2013</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder content-type="sage">SAGE Publications</copyright-holder>
<license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (<ext-link ext-link-type="uri" xlink:href="http://www.creativecommons.org/licenses/by-nc/3.0/">http://www.creativecommons.org/licenses/by-nc/3.0/</ext-link>
) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(<ext-link ext-link-type="uri" xlink:href="http://www.uk.sagepub.com/aboutus/openaccess.htm">http://www.uk.sagepub.com/aboutus/openaccess.htm</ext-link>
).</license-p>
</license>
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<abstract><p>Congenital lymphedema is a rare type of primary lymphedema occurring at birth or developing shortly later. Primary lymphedema can be classified according to whether it is familial or sporadic. The primary congenital familial lymphedema is also known as Milroy’s disease. Majority of primary cases are sporadic type. Chronic lymphedema can be secondary to infections, surgery with lymph node excision, trauma, lymphadenectomy, radiotherapy, filarial infection, and so on. It is recognized that a variety of malignant tumors can arise in chronic congenital or acquired lymphedema; the most documented associations are lymphangiosarcoma, basal cell carcinoma, lymphoma, malignant melanoma, and Kaposi’s sarcoma. A total of 13 cases of squamous cell carcinoma arising from chronic (primary or acquired) lymphedema have been reported, and only 3 cases of congenital lymphedema presented with squamous cell carcinoma as reported. A 32-year-old young male presented with chronic unilateral left lower limb lymphedema of 28 years duration. In addition, he had a 3-month history of a fungating cutaneous lesion on the lateral side measuring 2 cm × 1 cm in size. Fine-needle aspiration cytology was performed on the later mass, and a diagnosis of angiosarcoma was made. At histopathology, the appearances did not confirm angiosarcoma. However, an impression of carcinoma was made as squamous cells were observed in sheets. Immunohistochemistry was performed using markers for CD31, factor VIII (FVIII), and MiB. The epithelial marker cytokeratin was positive for squamoid cells and MiB index of 75%. The vascular markers FVIII and CD31 were negative, thus ruling out angiosarcoma. The final diagnosis was given as infiltrating squamous cell carcinoma in chronic lymphedema.</p>
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