BREAST CANCER METASTASIS IN THE STOMACH: WHEN THE GASTRECTOMY IS INDICATED ?
Identifieur interne : 000712 ( Pmc/Curation ); précédent : 000711; suivant : 000713BREAST CANCER METASTASIS IN THE STOMACH: WHEN THE GASTRECTOMY IS INDICATED ?
Auteurs : Marcus Vinicius Rozo Rodrigues ; Valdir Tercioti-Junior ; Luiz Roberto Lopes ; João De Souza Coelho-Neto ; Nelson Adami AndreolloSource :
- Arquivos Brasileiros de Cirurgia Digestiva : ABCD [ 0102-6720 ] ; 2016.
Abstract
Breast cancer is the most common malignant neoplasm in the female population. However, stomach is a rare site for metastasis, and can show up many years after initial diagnosis and treatment of the primary tumor.
Analyze a case series of this tumor and propose measures that can diagnose it with more precocity.
Were analyzed 12 patients with secondary gastric tumors. Immunohistochemistry has demonstrated that primary tumor was breast cancer. We retrieved information of age, histological type, interval between diagnosis of the primary breast cancer and its metastases, immunohistochemistry results, treatment and survival.
The mean age was 71.3 years (ranging 40-86). Ten cases had already been underwent mastectomy in the moment of the diagnosis of gastric metastasis. Two patients had diagnosis of both primary and secondary tumors concomitantly. At average, diagnosis of gastric metastasis was seven years after diagnosis of primary breast cancer (ranging 0-13). Besides, nine cases had also metastases in other organs, being bones the most affected ones. Immunohistochemistry of the metastases has shown positivity for CK7 antibody in 83.34%, estrogen receptor in 91.67%, progesterone receptor in 66.67% and AE1AE3 antibody in 75%, considering all 12 cases. Moreover, CK20 was absent significantly (66.67%). The positivity of BRST2 marker did not present statistical significance (41.67%). Eight cases were treated with chemotherapy associated or not with hormonal blockade. Surgical treatment of gastric metastasis was performed in four cases: three of them with total gastrectomy and one with distal gastrectomy. Follow-up has shown a mean survival of 14.58 months after diagnosis of metastasis, with only two patients still alive.
Patients with a history of breast cancer presenting endoscopic diagnosis of gastric cancer it is necessary to consider the possibility of gastric metastasis of breast cancer. The confirmation is by immunohistochemistry and gastrectomy should be oriented in the absence of other secondary involvement and control of the primary lesion.
Url:
DOI: 10.1590/0102-6720201600020005
PubMed: 27438032
PubMed Central: 4944741
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">BREAST CANCER METASTASIS IN THE STOMACH: WHEN THE GASTRECTOMY IS
INDICATED ?</title><author><name sortKey="Rodrigues, Marcus Vinicius Rozo" sort="Rodrigues, Marcus Vinicius Rozo" uniqKey="Rodrigues M" first="Marcus Vinicius Rozo" last="Rodrigues">Marcus Vinicius Rozo Rodrigues</name></author><author><name sortKey="Tercioti Junior, Valdir" sort="Tercioti Junior, Valdir" uniqKey="Tercioti Junior V" first="Valdir" last="Tercioti-Junior">Valdir Tercioti-Junior</name></author><author><name sortKey="Lopes, Luiz Roberto" sort="Lopes, Luiz Roberto" uniqKey="Lopes L" first="Luiz Roberto" last="Lopes">Luiz Roberto Lopes</name></author><author><name sortKey="Coelho Neto, Joao De Souza" sort="Coelho Neto, Joao De Souza" uniqKey="Coelho Neto J" first="João De Souza" last="Coelho-Neto">João De Souza Coelho-Neto</name></author><author><name sortKey="Andreollo, Nelson Adami" sort="Andreollo, Nelson Adami" uniqKey="Andreollo N" first="Nelson Adami" last="Andreollo">Nelson Adami Andreollo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27438032</idno><idno type="pmc">4944741</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4944741</idno><idno type="RBID">PMC:4944741</idno><idno type="doi">10.1590/0102-6720201600020005</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000712</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000712</idno><idno type="wicri:Area/Pmc/Curation">000712</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000712</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">BREAST CANCER METASTASIS IN THE STOMACH: WHEN THE GASTRECTOMY IS
INDICATED ?</title><author><name sortKey="Rodrigues, Marcus Vinicius Rozo" sort="Rodrigues, Marcus Vinicius Rozo" uniqKey="Rodrigues M" first="Marcus Vinicius Rozo" last="Rodrigues">Marcus Vinicius Rozo Rodrigues</name></author><author><name sortKey="Tercioti Junior, Valdir" sort="Tercioti Junior, Valdir" uniqKey="Tercioti Junior V" first="Valdir" last="Tercioti-Junior">Valdir Tercioti-Junior</name></author><author><name sortKey="Lopes, Luiz Roberto" sort="Lopes, Luiz Roberto" uniqKey="Lopes L" first="Luiz Roberto" last="Lopes">Luiz Roberto Lopes</name></author><author><name sortKey="Coelho Neto, Joao De Souza" sort="Coelho Neto, Joao De Souza" uniqKey="Coelho Neto J" first="João De Souza" last="Coelho-Neto">João De Souza Coelho-Neto</name></author><author><name sortKey="Andreollo, Nelson Adami" sort="Andreollo, Nelson Adami" uniqKey="Andreollo N" first="Nelson Adami" last="Andreollo">Nelson Adami Andreollo</name></author></analytic><series><title level="j">Arquivos Brasileiros de Cirurgia Digestiva : ABCD</title><idno type="ISSN">0102-6720</idno><idno type="eISSN">2317-6326</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>ABSTRACT</title><sec><title>Background:</title><p>Breast cancer is the most common malignant neoplasm in the female population.
However, stomach is a rare site for metastasis, and can show up many years after
initial diagnosis and treatment of the primary tumor. </p></sec><sec><title>Aim:</title><p>Analyze a case series of this tumor and propose measures that can diagnose it with
more precocity. </p></sec><sec><title>Methods:</title><p>Were analyzed 12 patients with secondary gastric tumors. Immunohistochemistry has
demonstrated that primary tumor was breast cancer. We retrieved information of
age, histological type, interval between diagnosis of the primary breast cancer
and its metastases, immunohistochemistry results, treatment and survival. </p></sec><sec><title>Results:</title><p>The mean age was 71.3 years (ranging 40-86). Ten cases had already been underwent
mastectomy in the moment of the diagnosis of gastric metastasis. Two patients had
diagnosis of both primary and secondary tumors concomitantly. At average,
diagnosis of gastric metastasis was seven years after diagnosis of primary breast
cancer (ranging 0-13). Besides, nine cases had also metastases in other organs,
being bones the most affected ones. Immunohistochemistry of the metastases has
shown positivity for CK7 antibody in 83.34%, estrogen receptor in 91.67%,
progesterone receptor in 66.67% and AE1AE3 antibody in 75%, considering all 12
cases. Moreover, CK20 was absent significantly (66.67%). The positivity of BRST2
marker did not present statistical significance (41.67%). Eight cases were treated
with chemotherapy associated or not with hormonal blockade. Surgical treatment of
gastric metastasis was performed in four cases: three of them with total
gastrectomy and one with distal gastrectomy. Follow-up has shown a mean survival
of 14.58 months after diagnosis of metastasis, with only two patients still alive.
</p></sec><sec><title>Conclusion:</title><p>Patients with a history of breast cancer presenting endoscopic diagnosis of
gastric cancer it is necessary to consider the possibility of gastric metastasis
of breast cancer. The confirmation is by immunohistochemistry and gastrectomy
should be oriented in the absence of other secondary involvement and control of
the primary lesion.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abid, A" uniqKey="Abid A">A Abid</name></author><author><name sortKey="Moffa, C" uniqKey="Moffa C">C Moffa</name></author><author><name sortKey="Monga, Dk" uniqKey="Monga D">DK Monga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abreu, Gf" uniqKey="Abreu G">GF Abreu</name></author><author><name sortKey="Pitta, Gb" uniqKey="Pitta G">GB Pitta</name></author><author><name sortKey="Araujo, M" uniqKey="Araujo M">M Araújo</name></author><author><name sortKey="Castro Ade, A" uniqKey="Castro Ade A">A Castro Ade</name></author><author><name sortKey="De Azevedo, Wf" uniqKey="De Azevedo W">WF de Azevedo</name></author><author><name sortKey="Miranda, F" uniqKey="Miranda F">F Miranda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ambroggi, M" uniqKey="Ambroggi M">M 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Arq Bras Cir Dig</journal-id><journal-id journal-id-type="iso-abbrev">Arq Bras Cir Dig</journal-id><journal-id journal-id-type="publisher-id">abcd</journal-id><journal-title-group><journal-title>Arquivos Brasileiros de Cirurgia Digestiva : ABCD</journal-title></journal-title-group><issn pub-type="ppub">0102-6720</issn><issn pub-type="epub">2317-6326</issn><publisher><publisher-name>Colégio Brasileiro de Cirurgia Digestiva</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27438032</article-id><article-id pub-id-type="pmc">4944741</article-id><article-id pub-id-type="doi">10.1590/0102-6720201600020005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>BREAST CANCER METASTASIS IN THE STOMACH: WHEN THE GASTRECTOMY IS
INDICATED ?</article-title><trans-title-group xml:lang="pt"><trans-title>Metástases gástricas de câncer de mama: quando a gastrectomia está
indicada?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>RODRIGUES</surname><given-names>Marcus Vinicius Rozo</given-names></name></contrib><contrib contrib-type="author"><name><surname>TERCIOTI-JUNIOR</surname><given-names>Valdir</given-names></name></contrib><contrib contrib-type="author"><name><surname>LOPES</surname><given-names>Luiz Roberto</given-names></name></contrib><contrib contrib-type="author"><name><surname>COELHO-NETO</surname><given-names>João de Souza</given-names></name></contrib><contrib contrib-type="author"><name><surname>ANDREOLLO</surname><given-names>Nelson Adami</given-names></name></contrib><aff>Discipline of Diseases of the Digestive System and Gastrocentro Unit, Department of Surgery, Faculty of Medical Sciences, State University of Campinas - Unicamp, Campinas, SP, Brazil.</aff></contrib-group><author-notes><corresp id="c1">Correspondence: Nelson Adami Andreollo e-mail:
<email>nandreollo@hotmail.com</email></corresp><fn fn-type="conflict" id="fn2"><p>Conflicts of interest: none</p></fn></author-notes><pub-date pub-type="epub-ppub"><season>Apr-Jun</season><year>2016</year></pub-date><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><season>Apr-Jun</season><year>2016</year></pub-date><volume>29</volume><issue>2</issue><fpage>86</fpage><lpage>89</lpage><history><date date-type="received"><day>27</day><month>10</month><year>2015</year></date><date date-type="accepted"><day>26</day><month>1</month><year>2016</year></date></history><permissions><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative
Commons Attribution License</license-p></license></permissions><abstract><title>ABSTRACT</title><sec><title>Background:</title><p>Breast cancer is the most common malignant neoplasm in the female population.
However, stomach is a rare site for metastasis, and can show up many years after
initial diagnosis and treatment of the primary tumor. </p></sec><sec><title>Aim:</title><p>Analyze a case series of this tumor and propose measures that can diagnose it with
more precocity. </p></sec><sec><title>Methods:</title><p>Were analyzed 12 patients with secondary gastric tumors. Immunohistochemistry has
demonstrated that primary tumor was breast cancer. We retrieved information of
age, histological type, interval between diagnosis of the primary breast cancer
and its metastases, immunohistochemistry results, treatment and survival. </p></sec><sec><title>Results:</title><p>The mean age was 71.3 years (ranging 40-86). Ten cases had already been underwent
mastectomy in the moment of the diagnosis of gastric metastasis. Two patients had
diagnosis of both primary and secondary tumors concomitantly. At average,
diagnosis of gastric metastasis was seven years after diagnosis of primary breast
cancer (ranging 0-13). Besides, nine cases had also metastases in other organs,
being bones the most affected ones. Immunohistochemistry of the metastases has
shown positivity for CK7 antibody in 83.34%, estrogen receptor in 91.67%,
progesterone receptor in 66.67% and AE1AE3 antibody in 75%, considering all 12
cases. Moreover, CK20 was absent significantly (66.67%). The positivity of BRST2
marker did not present statistical significance (41.67%). Eight cases were treated
with chemotherapy associated or not with hormonal blockade. Surgical treatment of
gastric metastasis was performed in four cases: three of them with total
gastrectomy and one with distal gastrectomy. Follow-up has shown a mean survival
of 14.58 months after diagnosis of metastasis, with only two patients still alive.
</p></sec><sec><title>Conclusion:</title><p>Patients with a history of breast cancer presenting endoscopic diagnosis of
gastric cancer it is necessary to consider the possibility of gastric metastasis
of breast cancer. The confirmation is by immunohistochemistry and gastrectomy
should be oriented in the absence of other secondary involvement and control of
the primary lesion.</p></sec></abstract><trans-abstract xml:lang="pt"><title>RESUMO</title><sec><title>Racional:</title><p>A neoplasia de mama é o tumor maligno mais comum na população feminina tendo o
trato gastrointestinal, e mais especificamente o estômago, como local incomum para
metástases. </p></sec><sec><title>Objetivo:</title><p>Analisar uma série de casos com esse tumor e propor medidas que possam
diagnosticá-lo com maior precocidade. </p></sec><sec><title>Métodos:</title><p>Foram analisados retrospectivamente 12 pacientes com diagnóstico de neoplasia
gástrica secundária a câncer de mama, confirmado por biópsia e imunoistoquímica.
Foram analisados idade do diagnóstico, tipo histológico do tumor primário,
intervalo de tempo entre o diagnóstico do tumor e a metástase, tratamento e
sobrevida. </p></sec><sec><title>Resultados:</title><p>A idade média foi de 71,3 anos (40-86 anos). Em média, o diagnóstico da metástase
gástrica foi de sete anos após o diagnóstico da lesão primaria (0-13 anos). Nove
casos tiveram metástases em outros órgãos, sendo os ossos os locais mais
acometidos. Evidenciou-se positividade de anticorpo CK7 em 90,9% casos, receptor
de estrógeno em 91,67%, receptor de progesterona em 66,67% e BRST2 em 41,67%. A
ausência de CK20 foi de 88,89%. Oito casos foram tratados com quimioterapia
associada ou não ao bloqueio hormonal e em quatro foi indicada ressecção cirúrgica
sendo em três gastrectomia total e em um caso gastrectomia subtotal. A sobrevida
média foi de 14,58 meses. </p></sec><sec><title>Conclusões:</title><p>Em doentes com história prévia de câncer de mama apresentando diagnóstico
endoscópico de neoplasia gástrica, é necessário considerar a possibilidade de
metástase. A confirmação é feita por estudo imunoistoquímico e a gastrectomia deve
ser orientada diante da ausência de outros locais de acometimento secundário e
controle da lesão primária.</p></sec></trans-abstract><kwd-group><title>HEADINGS:</title><kwd>Breast Neoplasms</kwd><kwd>Neoplasm Metastasis</kwd><kwd>Stomach</kwd><kwd>Drug therapy</kwd><kwd>Gastrectomy</kwd></kwd-group><counts><fig-count count="4"></fig-count><table-count count="0"></table-count><equation-count count="0"></equation-count><ref-count count="27"></ref-count><page-count count="4"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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