Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors
Identifieur interne : 000676 ( Pmc/Curation ); précédent : 000675; suivant : 000677Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors
Auteurs : Melinda L. Irwin ; Brenda Cartmel ; Cary P. Gross ; Elizabeth Ercolano ; Fangyong Li ; Xiaopan Yao ; Martha Fiellin ; Scott Capozza ; Marianna Rothbard ; Yang Zhou ; Maura Harrigan ; Tara Sanft ; Kathryn Schmitz ; Tuhina Neogi ; Dawn Hershman ; Jennifer LigibelSource :
- Journal of Clinical Oncology [ 0732-183X ] ; 2014.
Abstract
Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, in 121 breast cancer survivors receiving an AI and reporting arthralgia, a yearlong randomized trial of the impact of exercise versus usual care on arthralgia severity.
Eligibility criteria included receiving an AI for at least 6 months, reporting ≥ 3 of 10 for worst joint pain on the Brief Pain Inventory (BPI), and reporting < 90 minutes per week of aerobic exercise and no strength training. Participants were randomly assigned to exercise (150 minutes per week of aerobic exercise and supervised strength training twice per week) or usual care. The BPI, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, and Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire were completed at baseline and at 3, 6, 9, and 12 months. Intervention effects were evaluated using mixed-model repeated measures analysis, with change at 12 months as the primary end point.
Over 12 months, women randomly assigned to exercise (n = 61) attended 70% (± standard deviation [SD], 28%) of resistance training sessions and increased their exercise by 159 (± SD, 136) minutes per week. Worst joint pain scores decreased by 1.6 points (29%) at 12 months among women randomly assigned to exercise versus a 0.2-point increase (3%) among those receiving usual care (n = 60;
Exercise led to improvement in AI-induced arthralgia in previously inactive breast cancer survivors.
Url:
DOI: 10.1200/JCO.2014.57.1547
PubMed: 25452437
PubMed Central: 4372849
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Melinda L. Irwin<affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors</title><author><name sortKey="Irwin, Melinda L" sort="Irwin, Melinda L" uniqKey="Irwin M" first="Melinda L." last="Irwin">Melinda L. Irwin</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Cartmel, Brenda" sort="Cartmel, Brenda" uniqKey="Cartmel B" first="Brenda" last="Cartmel">Brenda Cartmel</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Gross, Cary P" sort="Gross, Cary P" uniqKey="Gross C" first="Cary P." last="Gross">Cary P. Gross</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Ercolano, Elizabeth" sort="Ercolano, Elizabeth" uniqKey="Ercolano E" first="Elizabeth" last="Ercolano">Elizabeth Ercolano</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Li, Fangyong" sort="Li, Fangyong" uniqKey="Li F" first="Fangyong" last="Li">Fangyong Li</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Yao, Xiaopan" sort="Yao, Xiaopan" uniqKey="Yao X" first="Xiaopan" last="Yao">Xiaopan Yao</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Fiellin, Martha" sort="Fiellin, Martha" uniqKey="Fiellin M" first="Martha" last="Fiellin">Martha Fiellin</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Capozza, Scott" sort="Capozza, Scott" uniqKey="Capozza S" first="Scott" last="Capozza">Scott Capozza</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Rothbard, Marianna" sort="Rothbard, Marianna" uniqKey="Rothbard M" first="Marianna" last="Rothbard">Marianna Rothbard</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Zhou, Yang" sort="Zhou, Yang" uniqKey="Zhou Y" first="Yang" last="Zhou">Yang Zhou</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Harrigan, Maura" sort="Harrigan, Maura" uniqKey="Harrigan M" first="Maura" last="Harrigan">Maura Harrigan</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Sanft, Tara" sort="Sanft, Tara" uniqKey="Sanft T" first="Tara" last="Sanft">Tara Sanft</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Schmitz, Kathryn" sort="Schmitz, Kathryn" uniqKey="Schmitz K" first="Kathryn" last="Schmitz">Kathryn Schmitz</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Neogi, Tuhina" sort="Neogi, Tuhina" uniqKey="Neogi T" first="Tuhina" last="Neogi">Tuhina Neogi</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Hershman, Dawn" sort="Hershman, Dawn" uniqKey="Hershman D" first="Dawn" last="Hershman">Dawn Hershman</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Ligibel, Jennifer" sort="Ligibel, Jennifer" uniqKey="Ligibel J" first="Jennifer" last="Ligibel">Jennifer Ligibel</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25452437</idno><idno type="pmc">4372849</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4372849</idno><idno type="RBID">PMC:4372849</idno><idno type="doi">10.1200/JCO.2014.57.1547</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000676</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000676</idno><idno type="wicri:Area/Pmc/Curation">000676</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000676</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors</title><author><name sortKey="Irwin, Melinda L" sort="Irwin, Melinda L" uniqKey="Irwin M" first="Melinda L." last="Irwin">Melinda L. Irwin</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Cartmel, Brenda" sort="Cartmel, Brenda" uniqKey="Cartmel B" first="Brenda" last="Cartmel">Brenda Cartmel</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Gross, Cary P" sort="Gross, Cary P" uniqKey="Gross C" first="Cary P." last="Gross">Cary P. Gross</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Ercolano, Elizabeth" sort="Ercolano, Elizabeth" uniqKey="Ercolano E" first="Elizabeth" last="Ercolano">Elizabeth Ercolano</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Li, Fangyong" sort="Li, Fangyong" uniqKey="Li F" first="Fangyong" last="Li">Fangyong Li</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Yao, Xiaopan" sort="Yao, Xiaopan" uniqKey="Yao X" first="Xiaopan" last="Yao">Xiaopan Yao</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Fiellin, Martha" sort="Fiellin, Martha" uniqKey="Fiellin M" first="Martha" last="Fiellin">Martha Fiellin</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Capozza, Scott" sort="Capozza, Scott" uniqKey="Capozza S" first="Scott" last="Capozza">Scott Capozza</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Rothbard, Marianna" sort="Rothbard, Marianna" uniqKey="Rothbard M" first="Marianna" last="Rothbard">Marianna Rothbard</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Zhou, Yang" sort="Zhou, Yang" uniqKey="Zhou Y" first="Yang" last="Zhou">Yang Zhou</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Harrigan, Maura" sort="Harrigan, Maura" uniqKey="Harrigan M" first="Maura" last="Harrigan">Maura Harrigan</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Sanft, Tara" sort="Sanft, Tara" uniqKey="Sanft T" first="Tara" last="Sanft">Tara Sanft</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Schmitz, Kathryn" sort="Schmitz, Kathryn" uniqKey="Schmitz K" first="Kathryn" last="Schmitz">Kathryn Schmitz</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Neogi, Tuhina" sort="Neogi, Tuhina" uniqKey="Neogi T" first="Tuhina" last="Neogi">Tuhina Neogi</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Hershman, Dawn" sort="Hershman, Dawn" uniqKey="Hershman D" first="Dawn" last="Hershman">Dawn Hershman</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author><author><name sortKey="Ligibel, Jennifer" sort="Ligibel, Jennifer" uniqKey="Ligibel J" first="Jennifer" last="Ligibel">Jennifer Ligibel</name><affiliation><nlm:aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</nlm:aff><wicri:noCountry code="subfield">NY.</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of Clinical Oncology</title><idno type="ISSN">0732-183X</idno><idno type="eISSN">1527-7755</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, in 121 breast cancer survivors receiving an AI and reporting arthralgia, a yearlong randomized trial of the impact of exercise versus usual care on arthralgia severity.</p></sec><sec><title>Patients and Methods</title><p>Eligibility criteria included receiving an AI for at least 6 months, reporting ≥ 3 of 10 for worst joint pain on the Brief Pain Inventory (BPI), and reporting < 90 minutes per week of aerobic exercise and no strength training. Participants were randomly assigned to exercise (150 minutes per week of aerobic exercise and supervised strength training twice per week) or usual care. The BPI, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, and Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire were completed at baseline and at 3, 6, 9, and 12 months. Intervention effects were evaluated using mixed-model repeated measures analysis, with change at 12 months as the primary end point.</p></sec><sec><title>Results</title><p>Over 12 months, women randomly assigned to exercise (n = 61) attended 70% (± standard deviation [SD], 28%) of resistance training sessions and increased their exercise by 159 (± SD, 136) minutes per week. Worst joint pain scores decreased by 1.6 points (29%) at 12 months among women randomly assigned to exercise versus a 0.2-point increase (3%) among those receiving usual care (n = 60; <italic>P</italic> < .001). Pain severity and interference, as well as DASH and WOMAC pain scores, also decreased significantly at 12 months in women randomly assigned to exercise, compared with increases for those receiving usual care (all <italic>P</italic> < .001).</p></sec><sec><title>Conclusion</title><p>Exercise led to improvement in AI-induced arthralgia in previously inactive breast cancer survivors.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Oncol</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Oncol</journal-id><journal-id journal-id-type="hwp">jco</journal-id><journal-id journal-id-type="pmc">jco</journal-id><journal-id journal-id-type="publisher-id">JCO</journal-id><journal-title-group><journal-title>Journal of Clinical Oncology</journal-title></journal-title-group><issn pub-type="ppub">0732-183X</issn><issn pub-type="epub">1527-7755</issn><publisher><publisher-name>American Society of Clinical Oncology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25452437</article-id><article-id pub-id-type="pmc">4372849</article-id><article-id pub-id-type="publisher-id">71547</article-id><article-id pub-id-type="doi">10.1200/JCO.2014.57.1547</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>Bc1</subject><subject>Bc7</subject><subject>Psc2</subject></subj-group><subj-group subj-group-type="heading"><subject>ORIGINAL REPORTS</subject><subj-group><subject>Rapid Communications</subject></subj-group></subj-group></article-categories><title-group><article-title>Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors</article-title><alt-title alt-title-type="short">Exercise, AIs, and Arthralgia</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Irwin</surname><given-names>Melinda L.</given-names></name><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Cartmel</surname><given-names>Brenda</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Gross</surname><given-names>Cary P.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Ercolano</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Fangyong</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Yao</surname><given-names>Xiaopan</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Fiellin</surname><given-names>Martha</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Capozza</surname><given-names>Scott</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Rothbard</surname><given-names>Marianna</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Yang</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Harrigan</surname><given-names>Maura</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Sanft</surname><given-names>Tara</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Schmitz</surname><given-names>Kathryn</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Neogi</surname><given-names>Tuhina</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Hershman</surname><given-names>Dawn</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Ligibel</surname><given-names>Jennifer</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><aff id="aff1">Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Martha Fiellin, Scott Capozza, Marianna Rothbard, Yang Zhou, Maura Harrigan, and Tara Sanft, Yale University; Melinda L. Irwin, Brenda Cartmel, Cary P. Gross, Elizabeth Ercolano, Fangyong Li, Xiaopan Yao, Yang Zhou, and Tara Sanft, Yale Cancer Center, New Haven, CT; Kathryn Schmitz, University of Pennsylvania, Philadelphia, PA; Tuhina Neogi, Boston University School of Medicine; Jennifer Ligibel, Dana-Farber Cancer Institute, Boston, MA; and Dawn Hershman, Columbia University, New York, NY.</aff></contrib-group><author-notes><corresp id="cor1">Corresponding author: Melinda L. Irwin, PhD, MPH, Department of Chronic Disease Epidemiology, Yale School of Public Health, P.O. Box 208034, New Haven, CT 06520-8034; e-mail: <email>melinda.irwin@yale.edu</email>.</corresp></author-notes><pub-date pub-type="ppub"><day>1</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>1</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>33</volume><issue>10</issue><fpage>1104</fpage><lpage>1111</lpage><permissions><copyright-statement>© 2014 by American Society of Clinical Oncology</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>American Society of Clinical Oncology</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zlj01015001104.pdf"></self-uri><abstract><sec><title>Purpose</title><p>Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, in 121 breast cancer survivors receiving an AI and reporting arthralgia, a yearlong randomized trial of the impact of exercise versus usual care on arthralgia severity.</p></sec><sec><title>Patients and Methods</title><p>Eligibility criteria included receiving an AI for at least 6 months, reporting ≥ 3 of 10 for worst joint pain on the Brief Pain Inventory (BPI), and reporting < 90 minutes per week of aerobic exercise and no strength training. Participants were randomly assigned to exercise (150 minutes per week of aerobic exercise and supervised strength training twice per week) or usual care. The BPI, Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, and Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire were completed at baseline and at 3, 6, 9, and 12 months. Intervention effects were evaluated using mixed-model repeated measures analysis, with change at 12 months as the primary end point.</p></sec><sec><title>Results</title><p>Over 12 months, women randomly assigned to exercise (n = 61) attended 70% (± standard deviation [SD], 28%) of resistance training sessions and increased their exercise by 159 (± SD, 136) minutes per week. Worst joint pain scores decreased by 1.6 points (29%) at 12 months among women randomly assigned to exercise versus a 0.2-point increase (3%) among those receiving usual care (n = 60; <italic>P</italic> < .001). Pain severity and interference, as well as DASH and WOMAC pain scores, also decreased significantly at 12 months in women randomly assigned to exercise, compared with increases for those receiving usual care (all <italic>P</italic> < .001).</p></sec><sec><title>Conclusion</title><p>Exercise led to improvement in AI-induced arthralgia in previously inactive breast cancer survivors.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:25452437" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |