Targeting amino acid metabolism in cancer growth and anti-tumor immune response
Identifieur interne : 000496 ( Pmc/Curation ); précédent : 000495; suivant : 000497Targeting amino acid metabolism in cancer growth and anti-tumor immune response
Auteurs : Elitsa AnanievaSource :
- World Journal of Biological Chemistry [ 1949-8454 ] ; 2015.
Abstract
Recent advances in amino acid metabolism have revealed that targeting amino acid metabolic enzymes in cancer therapy is a promising strategy for the development of novel therapeutic agents. There are currently several drugs in clinical trials that specifically target amino acid metabolic pathways in tumor cells. In the context of the tumor microenvironment, however, tumor cells form metabolic relationships with immune cells, and they often compete for common nutrients. Many tumors evolved to escape immune surveillance by taking advantage of their metabolic flexibility and redirecting nutrients for their own advantage. This review outlines the most recent advances in targeting amino acid metabolic pathways in cancer therapy while giving consideration to the impact these pathways may have on the anti-tumor immune response.
Url:
DOI: 10.4331/wjbc.v6.i4.281
PubMed: 26629311
PubMed Central: 4657121
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000496
Links to Exploration step
PMC:4657121Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Targeting amino acid metabolism in cancer growth and anti-tumor immune response</title><author><name sortKey="Ananieva, Elitsa" sort="Ananieva, Elitsa" uniqKey="Ananieva E" first="Elitsa" last="Ananieva">Elitsa Ananieva</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26629311</idno><idno type="pmc">4657121</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657121</idno><idno type="RBID">PMC:4657121</idno><idno type="doi">10.4331/wjbc.v6.i4.281</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000496</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000496</idno><idno type="wicri:Area/Pmc/Curation">000496</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000496</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Targeting amino acid metabolism in cancer growth and anti-tumor immune response</title><author><name sortKey="Ananieva, Elitsa" sort="Ananieva, Elitsa" uniqKey="Ananieva E" first="Elitsa" last="Ananieva">Elitsa Ananieva</name></author></analytic><series><title level="j">World Journal of Biological Chemistry</title><idno type="ISSN">1949-8454</idno><idno type="eISSN">1949-8454</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Recent advances in amino acid metabolism have revealed that targeting amino acid metabolic enzymes in cancer therapy is a promising strategy for the development of novel therapeutic agents. There are currently several drugs in clinical trials that specifically target amino acid metabolic pathways in tumor cells. In the context of the tumor microenvironment, however, tumor cells form metabolic relationships with immune cells, and they often compete for common nutrients. Many tumors evolved to escape immune surveillance by taking advantage of their metabolic flexibility and redirecting nutrients for their own advantage. This review outlines the most recent advances in targeting amino acid metabolic pathways in cancer therapy while giving consideration to the impact these pathways may have on the anti-tumor immune response.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Biol Chem</journal-id><journal-id journal-id-type="publisher-id">WJBC</journal-id><journal-title-group><journal-title>World Journal of Biological Chemistry</journal-title></journal-title-group><issn pub-type="ppub">1949-8454</issn><issn pub-type="epub">1949-8454</issn><publisher><publisher-name>Baishideng Publishing Group Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26629311</article-id><article-id pub-id-type="pmc">4657121</article-id><article-id pub-id-type="other">jWJBC.v6.i4.pg281</article-id><article-id pub-id-type="doi">10.4331/wjbc.v6.i4.281</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Targeting amino acid metabolism in cancer growth and anti-tumor immune response</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Ananieva</surname><given-names>Elitsa</given-names></name></contrib><aff>Elitsa Ananieva, Biochemistry and Nutrition, Des Moines University, Des Moines, IA 50312, United States</aff></contrib-group><author-notes><fn><p>Author contributions: Ananieva E entirely contributed to this article.</p><p>Correspondence to: Elitsa Ananieva, PhD, Assistant Professor of Biochemistry, Biochemistry and Nutrition, Des Moines University, 3200 Grand Avenue, Des Moines, IA 50312, United States. <email>elitsa.ananieva-stoyanova@dmu.edu</email></p><p>Telephone: +1-515-2711529 Fax: +1-515-2714215</p></fn></author-notes><pub-date pub-type="ppub"><day>26</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>26</day><month>11</month><year>2015</year></pub-date><volume>6</volume><issue>4</issue><fpage>281</fpage><lpage>289</lpage><history><date date-type="received"><day>27</day><month>5</month><year>2015</year></date><date date-type="rev-recd"><day>7</day><month>7</month><year>2015</year></date><date date-type="accepted"><day>29</day><month>9</month><year>2015</year></date></history><permissions><copyright-statement>©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p>Recent advances in amino acid metabolism have revealed that targeting amino acid metabolic enzymes in cancer therapy is a promising strategy for the development of novel therapeutic agents. There are currently several drugs in clinical trials that specifically target amino acid metabolic pathways in tumor cells. In the context of the tumor microenvironment, however, tumor cells form metabolic relationships with immune cells, and they often compete for common nutrients. Many tumors evolved to escape immune surveillance by taking advantage of their metabolic flexibility and redirecting nutrients for their own advantage. This review outlines the most recent advances in targeting amino acid metabolic pathways in cancer therapy while giving consideration to the impact these pathways may have on the anti-tumor immune response.</p></abstract><kwd-group><kwd>Amino acid metabolism</kwd><kwd>T cells</kwd><kwd>Anti-tumor immune response</kwd><kwd>Tumor microenvironment</kwd><kwd>Cancer therapy</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000496 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000496 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4657121
|texte= Targeting amino acid metabolism in cancer growth and anti-tumor immune response
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26629311" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |