Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells
Identifieur interne : 000458 ( Pmc/Curation ); précédent : 000457; suivant : 000459Molecular and Cellular Effects of In Vitro Shockwave Treatment on Lymphatic Endothelial Cells
Auteurs : Sabrina Rohringer [Autriche] ; Wolfgang Holnthoner [Autriche] ; Matthias Hackl [Autriche] ; Anna M. Weihs [Autriche] ; Dominik Rünzler [Autriche] ; Susanna Skalicky [Autriche] ; Michael Karbiener [Autriche] ; Marcel Scheideler [Autriche] ; Johannes Pröll [Autriche] ; Christian Gabriel [Autriche] ; Bernhard Schweighofer [Autriche] ; Marion Gröger [Autriche] ; Andreas Spittler [Autriche] ; Johannes Grillari [Autriche] ; Heinz Redl [Autriche]Source :
- PLoS ONE [ 1932-6203 ] ; 2014.
Abstract
Extracorporeal shockwave treatment was shown to improve orthopaedic diseases and wound healing and to stimulate lymphangiogenesis
Url:
DOI: 10.1371/journal.pone.0114806
PubMed: 25502694
PubMed Central: 4263473
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PMC:4263473Le document en format XML
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Shockwave Treatment on Lymphatic Endothelial Cells</title>
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Shockwave Treatment on Lymphatic Endothelial Cells</title>
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</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, Vienna</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Austrian Cluster for Tissue Regeneration, Vienna, Austria</addr-line>
</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Austrian Cluster for Tissue Regeneration, Vienna</wicri:regionArea>
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</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>Extracorporeal shockwave treatment was shown to improve orthopaedic diseases and wound healing and to stimulate lymphangiogenesis <italic>in vivo</italic>
. The aim of this study was to investigate <italic>in vitro</italic>
shockwave treatment (IVSWT) effects on lymphatic endothelial cell (LEC) behavior and lymphangiogenesis. We analyzed migration, proliferation, vascular tube forming capability and marker expression changes of LECs after IVSWT compared with HUVECs. Finally, transcriptome- and miRNA analyses were conducted to gain deeper insight into the IVSWT-induced molecular mechanisms in LECs. The results indicate that IVSWT-mediated proliferation changes of LECs are highly energy flux density-dependent and LEC 2D as well as 3D migration was enhanced through IVSWT. IVSWT suppressed HUVEC 3D migration but enhanced vasculogenesis. Furthermore, we identified podoplanin<sup>high</sup>
and podoplanin<sup>low</sup>
cell subpopulations, whose ratios changed upon IVSWT treatment. Transcriptome- and miRNA analyses on these populations showed differences in genes specific for signaling and vascular tissue. Our findings help to understand the cellular and molecular mechanisms underlying shockwave-induced lymphangiogenesis <italic>in vivo</italic>
.</p>
</div>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25502694</article-id>
<article-id pub-id-type="pmc">4263473</article-id>
<article-id pub-id-type="publisher-id">PONE-D-14-41122</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0114806</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Biochemistry</subject>
<subj-group><subject>Biochemical Activity</subject>
</subj-group>
</subj-group>
<subj-group><subject>Biotechnology</subject>
<subj-group><subject>Medical Devices and Equipment</subject>
</subj-group>
</subj-group>
<subj-group><subject>Cell Biology</subject>
<subj-group><subject>Cell Adhesion</subject>
<subject>Cell Motility</subject>
<subject>Cell Physiology</subject>
<subject>Cell Processes</subject>
<subject>Cytometry</subject>
<subject>Molecular Cell Biology</subject>
<subject>Signal Transduction</subject>
</subj-group>
</subj-group>
<subj-group><subject>Computational Biology</subject>
</subj-group>
<subj-group><subject>Molecular Biology</subject>
<subj-group><subject>Molecular Biology Techniques</subject>
</subj-group>
</subj-group>
<subj-group><subject>Physiology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Molecular and Cellular Effects of <italic>In Vitro</italic>
Shockwave Treatment on Lymphatic Endothelial Cells</article-title>
<alt-title alt-title-type="running-head">Shockwave Treatment of Lymphatic Endothelial Cells</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Rohringer</surname>
<given-names>Sabrina</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Holnthoner</surname>
<given-names>Wolfgang</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hackl</surname>
<given-names>Matthias</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weihs</surname>
<given-names>Anna M.</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rünzler</surname>
<given-names>Dominik</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Skalicky</surname>
<given-names>Susanna</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Karbiener</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Scheideler</surname>
<given-names>Marcel</given-names>
</name>
<xref ref-type="aff" rid="aff5"><sup>5</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pröll</surname>
<given-names>Johannes</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gabriel</surname>
<given-names>Christian</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff6"><sup>6</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schweighofer</surname>
<given-names>Bernhard</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gröger</surname>
<given-names>Marion</given-names>
</name>
<xref ref-type="aff" rid="aff7"><sup>7</sup>
</xref>
<xref ref-type="aff" rid="aff8"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Spittler</surname>
<given-names>Andreas</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff9"><sup>9</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Grillari</surname>
<given-names>Johannes</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff10"><sup>10</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Redl</surname>
<given-names>Heinz</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Donaueschingenstrasse 13, Vienna, Austria</addr-line>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>Austrian Cluster for Tissue Regeneration, Vienna, Austria</addr-line>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>Department of Biochemical Engineering, University of Applied Sciences Technikum Wien, Hoechstaedtplatz 6, Vienna, Austria</addr-line>
</aff>
<aff id="aff4"><label>4</label>
<addr-line>TAmiRNA GmbH, Muthgasse 11, Vienna, Austria</addr-line>
</aff>
<aff id="aff5"><label>5</label>
<addr-line>Institute for Molecular Biotechnology, Graz University of Technology, Petersgasse 14, Graz, Austria</addr-line>
</aff>
<aff id="aff6"><label>6</label>
<addr-line>Red Cross Blood Transfusion Service, Krankenhausstrasse 7, Linz, Austria</addr-line>
</aff>
<aff id="aff7"><label>7</label>
<addr-line>Skin and Endothelium Research Division, Department of Dermatology, Medical University of Vienna, Vienna, Austria</addr-line>
</aff>
<aff id="aff8"><label>8</label>
<addr-line>Core Facility Imaging, Medical University of Vienna, Vienna, Austria</addr-line>
</aff>
<aff id="aff9"><label>9</label>
<addr-line>Core Facility Flow Cytometry & Surgical Research Laboratories, Medical University of Vienna, Vienna, Austria</addr-line>
</aff>
<aff id="aff10"><label>10</label>
<addr-line>Department of Biotechnology, University of Natural Resources and Life Sciences Vienna, Muthgasse 18, Vienna, Austria</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Dulak</surname>
<given-names>Jozef</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Faculty of Biochemistry, Poland</addr-line>
</aff>
<author-notes><corresp id="cor1">* E-mail: <email>Wolfgang.Holnthoner@trauma.lbg.ac.at</email>
</corresp>
<fn fn-type="conflict"><p><bold>Competing Interests: </bold>
MH and SS are employed by TAmiRNA GmbH. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.</p>
</fn>
<fn fn-type="con"><p>Conceived and designed the experiments: WH SR HR AMW BS MH. Performed the experiments: SR MH JP BS SS AS MK MS. Analyzed the data: SR WH MH BS SS. Contributed reagents/materials/analysis tools: MG AS DR CG JG. Wrote the paper: SR WH MH BS.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>12</month>
<year>2014</year>
</pub-date>
<volume>9</volume>
<issue>12</issue>
<elocation-id>e114806</elocation-id>
<history><date date-type="received"><day>15</day>
<month>9</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>11</day>
<month>11</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-year>2014</copyright-year>
<copyright-holder>Rohringer et al</copyright-holder>
<license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<abstract><p>Extracorporeal shockwave treatment was shown to improve orthopaedic diseases and wound healing and to stimulate lymphangiogenesis <italic>in vivo</italic>
. The aim of this study was to investigate <italic>in vitro</italic>
shockwave treatment (IVSWT) effects on lymphatic endothelial cell (LEC) behavior and lymphangiogenesis. We analyzed migration, proliferation, vascular tube forming capability and marker expression changes of LECs after IVSWT compared with HUVECs. Finally, transcriptome- and miRNA analyses were conducted to gain deeper insight into the IVSWT-induced molecular mechanisms in LECs. The results indicate that IVSWT-mediated proliferation changes of LECs are highly energy flux density-dependent and LEC 2D as well as 3D migration was enhanced through IVSWT. IVSWT suppressed HUVEC 3D migration but enhanced vasculogenesis. Furthermore, we identified podoplanin<sup>high</sup>
and podoplanin<sup>low</sup>
cell subpopulations, whose ratios changed upon IVSWT treatment. Transcriptome- and miRNA analyses on these populations showed differences in genes specific for signaling and vascular tissue. Our findings help to understand the cellular and molecular mechanisms underlying shockwave-induced lymphangiogenesis <italic>in vivo</italic>
.</p>
</abstract>
<funding-group><funding-statement>This study was funded by: EU Biodesign Program (262948) (<ext-link ext-link-type="uri" xlink:href="http://www.biodesign.eu">www.biodesign.eu</ext-link>
) to HR and WH, a Femtech student fellowship from the Austrian research promotion agency FFG (<ext-link ext-link-type="uri" xlink:href="http://www.ffg.at">www.ffg.at</ext-link>
) to SR, the NewTissue Project (CFFG 818412) from the Austrian research promotion agency and City of Vienna (MA27 #06-06) and the City of Vienna Competence team reacTissue Project (MA27 #12-06) to DR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. MH and SS are employed by TAmiRNA GmbH. TAmiRNA GmbH provided support in the form of salaries for authors MH and SS, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><page-count count="23"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>The authors confirm that all data underlying the findings are fully available without restriction. All raw files from mRNA analyses are available in the gene expression omnibus (GEO) under accession number GSE62510. The Accession Number for the miRNA data is GSE62748 and can be accessed by the Link: <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE62748">http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE62748</ext-link>
.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>The authors confirm that all data underlying the findings are fully available without restriction. All raw files from mRNA analyses are available in the gene expression omnibus (GEO) under accession number GSE62510. The Accession Number for the miRNA data is GSE62748 and can be accessed by the Link: <ext-link ext-link-type="uri" xlink:href="http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE62748">http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE62748</ext-link>
.</p>
</notes>
</front>
</pmc>
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