Breast cancer metastasis and the lymphatic system
Identifieur interne : 000305 ( Pmc/Curation ); précédent : 000304; suivant : 000306Breast cancer metastasis and the lymphatic system
Auteurs : Munazzah Rahman [États-Unis] ; Sulma Mohammed [États-Unis]Source :
- Oncology Letters [ 1792-1074 ] ; 2015.
Abstract
Breast cancer remains the leading cause of cancer mortality worldwide, despite a significant decline in death rates due to early detection. The majority of cancer mortalities are due to the metastasis of tumor cells to other organs. Metastasis or tumor cell dissemination occurs via the hematogenous and lymphatic systems. For many carcinomas, the dissemination of tumor cells via lymphatic drainage of the tumor is the most common metastatic route. Such lymphatic drainage collects at the regional lymph nodes and the dissection and pathological examination of these nodes for lodged cancer cells is the gold standard procedure to detect metastasis. The present report provides an overview of the lymphatic system and its clinical significance as a prognostic factor, in addition to the interactions between the primary tumor and its microenvironment, and the influence of genomic subtypes on the resulting organ-specific pattern of tumor cell dissemination. It also examines the seemingly protracted asymptomatic period, during which the disseminated cells remain dormant, leading to the manifestation of metastasis decades after the successful treatment of the primary tumor.
Url:
DOI: 10.3892/ol.2015.3486
PubMed: 26622656
PubMed Central: 4533217
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PMC:4533217Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Breast cancer remains the leading cause of cancer mortality worldwide, despite a significant decline in death rates due to early detection. The majority of cancer mortalities are due to the metastasis of tumor cells to other organs. Metastasis or tumor cell dissemination occurs via the hematogenous and lymphatic systems. For many carcinomas, the dissemination of tumor cells via lymphatic drainage of the tumor is the most common metastatic route. Such lymphatic drainage collects at the regional lymph nodes and the dissection and pathological examination of these nodes for lodged cancer cells is the gold standard procedure to detect metastasis. The present report provides an overview of the lymphatic system and its clinical significance as a prognostic factor, in addition to the interactions between the primary tumor and its microenvironment, and the influence of genomic subtypes on the resulting organ-specific pattern of tumor cell dissemination. It also examines the seemingly protracted asymptomatic period, during which the disseminated cells remain dormant, leading to the manifestation of metastasis decades after the successful treatment of the primary tumor.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Oncol Lett</journal-id>
<journal-id journal-id-type="iso-abbrev">Oncol Lett</journal-id>
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<title-group><article-title>Breast cancer metastasis and the lymphatic system</article-title>
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Department of Comparative Pathobiology, Purdue University, West Lafayette, IN 47907, USA</aff>
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Purdue Center for Cancer Research, West Lafayette, IN 47907, USA</aff>
<aff id="af3-ol-0-0-3486"><label>3</label>
Bindley Bioscience, Purdue Discovery Park, West Lafayette, IN 47907, USA</aff>
<author-notes><corresp id="c1-ol-0-0-3486"><italic>Correspondence to</italic>
: Dr Sulma Mohammed, Department of Comparative Pathobiology, Purdue University, 725 Harrison Street, West Lafayette, IN 47907, USA, E-mail: <email>mohammes@purdue.edu</email>
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<volume>10</volume>
<issue>3</issue>
<fpage>1233</fpage>
<lpage>1239</lpage>
<history><date date-type="received"><day>22</day>
<month>7</month>
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<permissions><copyright-statement>Copyright © 2015, Spandidos Publications</copyright-statement>
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<abstract><p>Breast cancer remains the leading cause of cancer mortality worldwide, despite a significant decline in death rates due to early detection. The majority of cancer mortalities are due to the metastasis of tumor cells to other organs. Metastasis or tumor cell dissemination occurs via the hematogenous and lymphatic systems. For many carcinomas, the dissemination of tumor cells via lymphatic drainage of the tumor is the most common metastatic route. Such lymphatic drainage collects at the regional lymph nodes and the dissection and pathological examination of these nodes for lodged cancer cells is the gold standard procedure to detect metastasis. The present report provides an overview of the lymphatic system and its clinical significance as a prognostic factor, in addition to the interactions between the primary tumor and its microenvironment, and the influence of genomic subtypes on the resulting organ-specific pattern of tumor cell dissemination. It also examines the seemingly protracted asymptomatic period, during which the disseminated cells remain dormant, leading to the manifestation of metastasis decades after the successful treatment of the primary tumor.</p>
</abstract>
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