Synchronous Bilateral Breast Cancers
Identifieur interne : 000283 ( Pmc/Curation ); précédent : 000282; suivant : 000284Synchronous Bilateral Breast Cancers
Auteurs : Naveen Padmanabhan ; Annapurneswari Subramanyan ; Selvi RadhakrishnaSource :
- Journal of Clinical and Diagnostic Research : JCDR [ 2249-782X ] ; 2015.
Abstract
Bilateral breast cancer (BBC) is not an uncommon entity in contemporary breast clinics. Improved life expectancy after breast cancer treatment and routine use of contra-lateral breast mammography has led to increased incidence of BBC. Our study objective was to define the epidemiological and tumour characteristics of BBC in India.
A total of 1251 breast cancer patients were treated during the period January 2007 to March 2015 and 30 patients were found to have BBC who constituted the study population (60 tumour samples). Synchronous bilateral breast cancers (SBC) was defined as two tumours diagnosed within an interval of 6 months and a second cancer diagnosed after 6 months was labelled as metachronous breast cancer (MBC). Analyses of patient and tumour characteristics were done in this prospective data base of BBC patients.
Median patient age was 66 years (range 39-85). Majority of the patients had SBC (n=28) and in 12 patients the second tumour was clinically occult and detected only by mammography of the contra-lateral breast. The second tumour was found at lower tumour size compared to the first in 73% of cases and was negative for axillary metastasis in 80% of cases (24/30). Infiltrating ductal carcinoma was the commonest histological type (n=51) and majority of the tumours were ER/PR positive (50/60). Her2 was overexpressed in 13 tumours (21%). Over 70% (22/30) of patients had similar histology in both breasts and amongst them grade concordance was present in about 69% (15/22) of patients. Concordance rates of ER, PR and Her2 statuses were 83%, 80% and 90% respectively. Bilateral mastectomy was the commonest surgery performed in 80% of the patients followed by bilateral breast conservation in 13%. At the end of study period, 26 patients were alive and disease free. Median survival was 29 months (range 3-86 months).
In most patients with BBC, the second tumour is identified at an early stage than index tumours supporting the importance of contralateral breast cancer screening at the time of primary diagnosis and during follow-up. BBC occurs more frequently in old age group and majority of these tumours are estrogen dependent. There is good pathological concordance between the index tumour and the contralateral breast cancer.
Url:
DOI: 10.7860/JCDR/2015/14880.6511
PubMed: 26500995
PubMed Central: 4606324
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Synchronous Bilateral Breast Cancers</title>
<author><name sortKey="Padmanabhan, Naveen" sort="Padmanabhan, Naveen" uniqKey="Padmanabhan N" first="Naveen" last="Padmanabhan">Naveen Padmanabhan</name>
<affiliation><nlm:aff id="aff1"> Registrar, Department of Surgical Oncology,<institution>Apollo Speciality Hospitals</institution>
,<addr-line>Chennai-35, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Subramanyan, Annapurneswari" sort="Subramanyan, Annapurneswari" uniqKey="Subramanyan A" first="Annapurneswari" last="Subramanyan">Annapurneswari Subramanyan</name>
<affiliation><nlm:aff id="aff2"> Chief of Surgical Pathology, Department of Surgical Pathology,<institution>Apollo Speciality Hospitals</institution>
,<addr-line>Chennai-35, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Radhakrishna, Selvi" sort="Radhakrishna, Selvi" uniqKey="Radhakrishna S" first="Selvi" last="Radhakrishna">Selvi Radhakrishna</name>
<affiliation><nlm:aff id="aff3"> Senior Consultant, Department of Breast surgery and Oncoplastic Breast surgeon,<institution>Apollo Speciality Hospitals</institution>
,<addr-line>Chennai-35, India</addr-line>
.</nlm:aff>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Synchronous Bilateral Breast Cancers</title>
<author><name sortKey="Padmanabhan, Naveen" sort="Padmanabhan, Naveen" uniqKey="Padmanabhan N" first="Naveen" last="Padmanabhan">Naveen Padmanabhan</name>
<affiliation><nlm:aff id="aff1"> Registrar, Department of Surgical Oncology,<institution>Apollo Speciality Hospitals</institution>
,<addr-line>Chennai-35, India</addr-line>
.</nlm:aff>
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<author><name sortKey="Subramanyan, Annapurneswari" sort="Subramanyan, Annapurneswari" uniqKey="Subramanyan A" first="Annapurneswari" last="Subramanyan">Annapurneswari Subramanyan</name>
<affiliation><nlm:aff id="aff2"> Chief of Surgical Pathology, Department of Surgical Pathology,<institution>Apollo Speciality Hospitals</institution>
,<addr-line>Chennai-35, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Radhakrishna, Selvi" sort="Radhakrishna, Selvi" uniqKey="Radhakrishna S" first="Selvi" last="Radhakrishna">Selvi Radhakrishna</name>
<affiliation><nlm:aff id="aff3"> Senior Consultant, Department of Breast surgery and Oncoplastic Breast surgeon,<institution>Apollo Speciality Hospitals</institution>
,<addr-line>Chennai-35, India</addr-line>
.</nlm:aff>
</affiliation>
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<series><title level="j">Journal of Clinical and Diagnostic Research : JCDR</title>
<idno type="ISSN">2249-782X</idno>
<idno type="eISSN">0973-709X</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Bilateral breast cancer (BBC) is not an uncommon entity in contemporary breast clinics. Improved life expectancy after breast cancer treatment and routine use of contra-lateral breast mammography has led to increased incidence of BBC. Our study objective was to define the epidemiological and tumour characteristics of BBC in India.</p>
</sec>
<sec><title>Materials and Methods</title>
<p>A total of 1251 breast cancer patients were treated during the period January 2007 to March 2015 and 30 patients were found to have BBC who constituted the study population (60 tumour samples). Synchronous bilateral breast cancers (SBC) was defined as two tumours diagnosed within an interval of 6 months and a second cancer diagnosed after 6 months was labelled as metachronous breast cancer (MBC). Analyses of patient and tumour characteristics were done in this prospective data base of BBC patients.</p>
</sec>
<sec><title>Results</title>
<p>Median patient age was 66 years (range 39-85). Majority of the patients had SBC (n=28) and in 12 patients the second tumour was clinically occult and detected only by mammography of the contra-lateral breast. The second tumour was found at lower tumour size compared to the first in 73% of cases and was negative for axillary metastasis in 80% of cases (24/30). Infiltrating ductal carcinoma was the commonest histological type (n=51) and majority of the tumours were ER/PR positive (50/60). Her2 was overexpressed in 13 tumours (21%). Over 70% (22/30) of patients had similar histology in both breasts and amongst them grade concordance was present in about 69% (15/22) of patients. Concordance rates of ER, PR and Her2 statuses were 83%, 80% and 90% respectively. Bilateral mastectomy was the commonest surgery performed in 80% of the patients followed by bilateral breast conservation in 13%. At the end of study period, 26 patients were alive and disease free. Median survival was 29 months (range 3-86 months).</p>
</sec>
<sec><title>Conclusion</title>
<p>In most patients with BBC, the second tumour is identified at an early stage than index tumours supporting the importance of contralateral breast cancer screening at the time of primary diagnosis and during follow-up. BBC occurs more frequently in old age group and majority of these tumours are estrogen dependent. There is good pathological concordance between the index tumour and the contralateral breast cancer.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Diagn Res</journal-id>
<journal-id journal-id-type="iso-abbrev">J Clin Diagn Res</journal-id>
<journal-id journal-id-type="hwp">Journal of Clinical and Diagnostic Research</journal-id>
<journal-id journal-id-type="publisher-id">JCDR</journal-id>
<journal-title-group><journal-title>Journal of Clinical and Diagnostic Research : JCDR</journal-title>
</journal-title-group>
<issn pub-type="ppub">2249-782X</issn>
<issn pub-type="epub">0973-709X</issn>
<publisher><publisher-name>JCDR Research and Publications (P) Limited</publisher-name>
<publisher-loc>Delhi, India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26500995</article-id>
<article-id pub-id-type="pmc">4606324</article-id>
<article-id pub-id-type="doi">10.7860/JCDR/2015/14880.6511</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Oncology Section</subject>
<subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Synchronous Bilateral Breast Cancers</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Padmanabhan</surname>
<given-names>Naveen</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Subramanyan</surname>
<given-names>Annapurneswari</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Radhakrishna</surname>
<given-names>Selvi</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Registrar, Department of Surgical Oncology,<institution>Apollo Speciality Hospitals</institution>
,<addr-line>Chennai-35, India</addr-line>
.</aff>
<aff id="aff2"><label>2</label>
Chief of Surgical Pathology, Department of Surgical Pathology,<institution>Apollo Speciality Hospitals</institution>
,<addr-line>Chennai-35, India</addr-line>
.</aff>
<aff id="aff3"><label>3</label>
Senior Consultant, Department of Breast surgery and Oncoplastic Breast surgeon,<institution>Apollo Speciality Hospitals</institution>
,<addr-line>Chennai-35, India</addr-line>
.</aff>
<author-notes><corresp id="cor1">NAME, ADDRESS, E-MAIL ID OF THE CORRESPONDING AUTHOR: Dr. Naveen Padmanabhan, W-513, 9<sup>th</sup>
Street, Sector-C, Annanagar West Extension, Chennai-600101, India. E-mail : <email>drnaveenp.in@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>9</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>01</day>
<month>9</month>
<year>2015</year>
</pub-date>
<volume>9</volume>
<issue>9</issue>
<fpage>XC05</fpage>
<lpage>XC08</lpage>
<history><date date-type="received"><day>13</day>
<month>5</month>
<year>2015</year>
</date>
<date date-type="rev-request"><day>23</day>
<month>6</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>20</day>
<month>7</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2015 Journal of Clinical and Diagnostic Research</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<abstract><sec><title>Background</title>
<p>Bilateral breast cancer (BBC) is not an uncommon entity in contemporary breast clinics. Improved life expectancy after breast cancer treatment and routine use of contra-lateral breast mammography has led to increased incidence of BBC. Our study objective was to define the epidemiological and tumour characteristics of BBC in India.</p>
</sec>
<sec><title>Materials and Methods</title>
<p>A total of 1251 breast cancer patients were treated during the period January 2007 to March 2015 and 30 patients were found to have BBC who constituted the study population (60 tumour samples). Synchronous bilateral breast cancers (SBC) was defined as two tumours diagnosed within an interval of 6 months and a second cancer diagnosed after 6 months was labelled as metachronous breast cancer (MBC). Analyses of patient and tumour characteristics were done in this prospective data base of BBC patients.</p>
</sec>
<sec><title>Results</title>
<p>Median patient age was 66 years (range 39-85). Majority of the patients had SBC (n=28) and in 12 patients the second tumour was clinically occult and detected only by mammography of the contra-lateral breast. The second tumour was found at lower tumour size compared to the first in 73% of cases and was negative for axillary metastasis in 80% of cases (24/30). Infiltrating ductal carcinoma was the commonest histological type (n=51) and majority of the tumours were ER/PR positive (50/60). Her2 was overexpressed in 13 tumours (21%). Over 70% (22/30) of patients had similar histology in both breasts and amongst them grade concordance was present in about 69% (15/22) of patients. Concordance rates of ER, PR and Her2 statuses were 83%, 80% and 90% respectively. Bilateral mastectomy was the commonest surgery performed in 80% of the patients followed by bilateral breast conservation in 13%. At the end of study period, 26 patients were alive and disease free. Median survival was 29 months (range 3-86 months).</p>
</sec>
<sec><title>Conclusion</title>
<p>In most patients with BBC, the second tumour is identified at an early stage than index tumours supporting the importance of contralateral breast cancer screening at the time of primary diagnosis and during follow-up. BBC occurs more frequently in old age group and majority of these tumours are estrogen dependent. There is good pathological concordance between the index tumour and the contralateral breast cancer.</p>
</sec>
</abstract>
<kwd-group><kwd>Breast neoplasms</kwd>
<kwd>Estrogen receptor</kwd>
<kwd>Histology</kwd>
<kwd>Mammography</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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