LymphedemaV1, Pmc, Curation, bibRecord, 000080

Impact of sentinel node biopsy on long-term quality of life in breast cancer patients

Identifieur interne : 000080 ( Pmc/Curation ); précédent : 000079; suivant : 000081

Impact of sentinel node biopsy on long-term quality of life in breast cancer patients

Auteurs : E. De Gournay [France] ; A. Guyomard [France] ; C. Coutant [France] ; S. Boulet [France] ; P. Arveux [France] ; S. Causeret [France] ; S. Gouy [France] ; M-M Padeano [France] ; C. Loustalot [France] ; J-M Sauzedde [France] ; M. Smail [France] ; J-P Combier [France] ; P. Chevillote [France] ; C. Rosburger [France] ; F. Bonnetain [France] ; J. Fraisse [France] ; T. S Dabakuyo-Yonli [France]

Source :

British Journal of Cancer [ 0007-0920 ] ; 2013.

RBID : PMC:3844912

Abstract

Background:

The aim of this study was to assess long-term quality of life (QoL) over a period of 6 years in women with breast cancer (BC) who underwent sentinel lymph node biopsy (SLNB), axillary lymph node dissection (ALND), or SLNB followed by ALND.

Methods:

The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ)-C30 and the EORTC-QLQ-BR-23 questionnaires were used to assess QoL before surgery, just after surgery, 6, 12 and 72 months later. The longitudinal effect of surgical modalities on QoL was assessed with a mixed model analysis of variance for repeated measurements.

Results:

Five hundred and eighteen BC patients were initially included. The median follow-up was 6 years. During the follow-up, 61 patients died. None of the patients of the SLNB group developed lymphedema during follow-up and the relapse rate was similar in the different groups (P=0.62). Before surgery, global health status (P=0.52) and arm symptoms (BRAS) (P=0.99) QoL scores were similar whatever the surgical procedure. The BRAS score (P=0.0001) was better in the SLNB group 72 months after surgery. Moreover, during follow-up, patients treated with SLNB had lower arm symptoms scores than ALND patients and there was no difference for arm symptoms between patients treated with ALND and those treated with SLNB followed by complementary ALND.

Conclusion:

Long-term follow-up showed that SLNB was associated with less morbidity than ALND.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844912

DOI: 10.1038/bjc.2013.658
PubMed: 24169352
PubMed Central: 3844912

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Le document en format XML

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<country xml:lang="fr">France</country>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<country xml:lang="fr">France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact of sentinel node biopsy on long-term quality of life in breast cancer patients</title>
<author><name sortKey="De Gournay, E" sort="De Gournay, E" uniqKey="De Gournay E" first="E" last="De Gournay">E. De Gournay</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of surgery/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion</institution>
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<author><name sortKey="Guyomard, A" sort="Guyomard, A" uniqKey="Guyomard A" first="A" last="Guyomard">A. Guyomard</name>
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, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Coutant, C" sort="Coutant, C" uniqKey="Coutant C" first="C" last="Coutant">C. Coutant</name>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Boulet, S" sort="Boulet, S" uniqKey="Boulet S" first="S" last="Boulet">S. Boulet</name>
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, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Arveux, P" sort="Arveux, P" uniqKey="Arveux P" first="P" last="Arveux">P. Arveux</name>
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, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>EA 4184, Faculty of Medicine, University of Burgundy, 7 boulevard Jeanne d'Arc</institution>
, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Causeret, S" sort="Causeret, S" uniqKey="Causeret S" first="S" last="Causeret">S. Causeret</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of surgery/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion</institution>
, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gouy, S" sort="Gouy, S" uniqKey="Gouy S" first="S" last="Gouy">S. Gouy</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of surgery/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion</institution>
, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Padeano, M M" sort="Padeano, M M" uniqKey="Padeano M" first="M-M" last="Padeano">M-M Padeano</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of surgery/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion</institution>
, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Loustalot, C" sort="Loustalot, C" uniqKey="Loustalot C" first="C" last="Loustalot">C. Loustalot</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of surgery/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion</institution>
, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sauzedde, J M" sort="Sauzedde, J M" uniqKey="Sauzedde J" first="J-M" last="Sauzedde">J-M Sauzedde</name>
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, 71000 Macon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smail, M" sort="Smail, M" uniqKey="Smail M" first="M" last="Smail">M. Smail</name>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Sainte Marie private hospital, 4 all St Jean des Vignes</institution>
, 71100 Chalon sur Saone,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Combier, J P" sort="Combier, J P" uniqKey="Combier J" first="J-P" last="Combier">J-P Combier</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Hotel-Dieu hospital, 175 r Mar Foch</institution>
, 71200 Le Creusot,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chevillote, P" sort="Chevillote, P" uniqKey="Chevillote P" first="P" last="Chevillote">P. Chevillote</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Hotel-Dieu hospital, 175 r Mar Foch</institution>
, 71200 Le Creusot,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rosburger, C" sort="Rosburger, C" uniqKey="Rosburger C" first="C" last="Rosburger">C. Rosburger</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Hotel-Dieu hospital, 175 r Mar Foch</institution>
, 71200 Le Creusot,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bonnetain, F" sort="Bonnetain, F" uniqKey="Bonnetain F" first="F" last="Bonnetain">F. Bonnetain</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Methodology and quality of Life in Oncology unit (EA 3181), University Hospital, 2 place Saint Jacques and national quality of life and cancer clinical research platform</institution>
, 25000 Besançon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fraisse, J" sort="Fraisse, J" uniqKey="Fraisse J" first="J" last="Fraisse">J. Fraisse</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of surgery/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion</institution>
, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="S Dabakuyo Yonli, T" sort="S Dabakuyo Yonli, T" uniqKey="S Dabakuyo Yonli T" first="T" last="S Dabakuyo-Yonli">T. S Dabakuyo-Yonli</name>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Biostatistics and Quality of life Unit/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion, and national quality of life and cancer clinical research platform</institution>
, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>EA 4184, Faculty of Medicine, University of Burgundy, 7 boulevard Jeanne d'Arc</institution>
, 21000 Dijon,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">British Journal of Cancer</title>
<idno type="ISSN">0007-0920</idno>
<idno type="eISSN">1532-1827</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><sec><title>Background:</title>
<p>The aim of this study was to assess long-term quality of life (QoL) over a period of 6 years in women with breast cancer (BC) who underwent sentinel lymph node biopsy (SLNB), axillary lymph node dissection (ALND), or SLNB followed by ALND.</p>
</sec>
<sec><title>Methods:</title>
<p>The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ)-C30 and the EORTC-QLQ-BR-23 questionnaires were used to assess QoL before surgery, just after surgery, 6, 12 and 72 months later. The longitudinal effect of surgical modalities on QoL was assessed with a mixed model analysis of variance for repeated measurements.</p>
</sec>
<sec><title>Results:</title>
<p>Five hundred and eighteen BC patients were initially included. The median follow-up was 6 years. During the follow-up, 61 patients died. None of the patients of the SLNB group developed lymphedema during follow-up and the relapse rate was similar in the different groups (<italic>P</italic>
=0.62). Before surgery, global health status (<italic>P</italic>
=0.52) and arm symptoms (BRAS) (<italic>P</italic>
=0.99) QoL scores were similar whatever the surgical procedure. The BRAS score (<italic>P</italic>
=0.0001) was better in the SLNB group 72 months after surgery. Moreover, during follow-up, patients treated with SLNB had lower arm symptoms scores than ALND patients and there was no difference for arm symptoms between patients treated with ALND and those treated with SLNB followed by complementary ALND.</p>
</sec>
<sec><title>Conclusion:</title>
<p>Long-term follow-up showed that SLNB was associated with less morbidity than ALND.</p>
</sec>
</div>
</front>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id>
<journal-id journal-id-type="iso-abbrev">Br. J. Cancer</journal-id>
<journal-title-group><journal-title>British Journal of Cancer</journal-title>
</journal-title-group>
<issn pub-type="ppub">0007-0920</issn>
<issn pub-type="epub">1532-1827</issn>
<publisher><publisher-name>Nature Publishing Group</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24169352</article-id>
<article-id pub-id-type="pmc">3844912</article-id>
<article-id pub-id-type="pii">bjc2013658</article-id>
<article-id pub-id-type="doi">10.1038/bjc.2013.658</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Clinical Study</subject>
</subj-group>
</article-categories>
<title-group><article-title>Impact of sentinel node biopsy on long-term quality of life in breast cancer patients</article-title>
<alt-title alt-title-type="running">Quality of life after sentinel node biopsy</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>De Gournay</surname>
<given-names>E</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="author-notes" rid="note1"><sup>8</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Guyomard</surname>
<given-names>A</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coutant</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Boulet</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Arveux</surname>
<given-names>P</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Causeret</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gouy</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Padeano</surname>
<given-names>M-M</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Loustalot</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sauzedde</surname>
<given-names>J-M</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smail</surname>
<given-names>M</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Combier</surname>
<given-names>J-P</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chevillote</surname>
<given-names>P</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rosburger</surname>
<given-names>C</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bonnetain</surname>
<given-names>F</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fraisse</surname>
<given-names>J</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>S Dabakuyo-Yonli</surname>
<given-names>T</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="author-notes" rid="note1"><sup>8</sup>
</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
</contrib>
<aff id="aff1"><label>1</label>
<institution>Department of surgery/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion</institution>
, 21000 Dijon,<country>France</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>Biostatistics and Quality of life Unit/Georges François Leclerc Comprehensive Cancer Care Centre-1 rue Professeur Marion, and national quality of life and cancer clinical research platform</institution>
, 21000 Dijon,<country>France</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>EA 4184, Faculty of Medicine, University of Burgundy, 7 boulevard Jeanne d'Arc</institution>
, 21000 Dijon,<country>France</country>
</aff>
<aff id="aff4"><label>4</label>
<institution>Val de Saone private general hospital, 5crs Moreau</institution>
, 71000 Macon,<country>France</country>
</aff>
<aff id="aff5"><label>5</label>
<institution>Sainte Marie private hospital, 4 all St Jean des Vignes</institution>
, 71100 Chalon sur Saone,<country>France</country>
</aff>
<aff id="aff6"><label>6</label>
<institution>Hotel-Dieu hospital, 175 r Mar Foch</institution>
, 71200 Le Creusot,<country>France</country>
</aff>
<aff id="aff7"><label>7</label>
<institution>Methodology and quality of Life in Oncology unit (EA 3181), University Hospital, 2 place Saint Jacques and national quality of life and cancer clinical research platform</institution>
, 25000 Besançon,<country>France</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
E-mail: <email>sdabakuyo@cgfl.fr</email>
</corresp>
<fn fn-type="present-address" id="note1"><label>8</label>
<p>These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>26</day>
<month>11</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>10</month>
<year>2013</year>
</pub-date>
<volume>109</volume>
<issue>11</issue>
<fpage>2783</fpage>
<lpage>2791</lpage>
<history><date date-type="received"><day>05</day>
<month>06</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>20</day>
<month>09</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>01</day>
<month>10</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013 Cancer Research UK</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>Cancer Research UK</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/"><license-p>From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/</license-p>
</license>
</permissions>
<abstract><sec><title>Background:</title>
<p>The aim of this study was to assess long-term quality of life (QoL) over a period of 6 years in women with breast cancer (BC) who underwent sentinel lymph node biopsy (SLNB), axillary lymph node dissection (ALND), or SLNB followed by ALND.</p>
</sec>
<sec><title>Methods:</title>
<p>The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ)-C30 and the EORTC-QLQ-BR-23 questionnaires were used to assess QoL before surgery, just after surgery, 6, 12 and 72 months later. The longitudinal effect of surgical modalities on QoL was assessed with a mixed model analysis of variance for repeated measurements.</p>
</sec>
<sec><title>Results:</title>
<p>Five hundred and eighteen BC patients were initially included. The median follow-up was 6 years. During the follow-up, 61 patients died. None of the patients of the SLNB group developed lymphedema during follow-up and the relapse rate was similar in the different groups (<italic>P</italic>
=0.62). Before surgery, global health status (<italic>P</italic>
=0.52) and arm symptoms (BRAS) (<italic>P</italic>
=0.99) QoL scores were similar whatever the surgical procedure. The BRAS score (<italic>P</italic>
=0.0001) was better in the SLNB group 72 months after surgery. Moreover, during follow-up, patients treated with SLNB had lower arm symptoms scores than ALND patients and there was no difference for arm symptoms between patients treated with ALND and those treated with SLNB followed by complementary ALND.</p>
</sec>
<sec><title>Conclusion:</title>
<p>Long-term follow-up showed that SLNB was associated with less morbidity than ALND.</p>
</sec>
</abstract>
<kwd-group><kwd>breast cancer</kwd>
<kwd>quality of life</kwd>
<kwd>sentinel lymph node biopsy</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="fig1"><label>Figure 1</label>
<caption><p><bold>Mean quality of life scores according to the follow-up time and the type of surgery:</bold>
 (<bold>A</bold>
) global health; (<bold>B</bold>
) arm symptoms; (<bold>C</bold>
) breast symptoms.</p>
</caption>
<graphic xlink:href="bjc2013658f1"></graphic>
</fig>
<table-wrap id="tbl1"><label>Table 1</label>
<caption><title>Clinical and pathological features according to surgery modalities</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> <hr></hr>
</th>
<th colspan="2" align="center" valign="top" charoff="50"><bold>ALND</bold>
<hr></hr>
</th>
<th colspan="2" align="center" valign="top" charoff="50"><bold>SLNB</bold>
<hr></hr>
</th>
<th colspan="2" align="center" valign="top" charoff="50"><bold>SLNB+ALND</bold>
<sup><bold>a</bold>
</sup>
<hr></hr>
</th>
<th align="center" valign="top" char="." charoff="50"> <hr></hr>
</th>
</tr>
<tr><th align="left" valign="top" charoff="50"><bold>Variables</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>%</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>%</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>%</bold>
</th>
<th align="char" valign="top" char="." charoff="50"><italic><bold>P-</bold>
</italic>
<bold>value</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td align="left" valign="top" charoff="50"><bold>Hospital</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">CGFL<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">143<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">86.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">103<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">59.5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">37<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">86.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Private hospital of Dijon<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">17<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">10.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">24<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">13.9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">11.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Le Creusot<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">17<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">9.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Chalon sur Saône<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">14<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">8.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Macon<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">15<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">8.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Hormone status</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.04<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Premenopausal<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">43<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">26.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">26<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">15.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">20.9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Postmenopausal<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">122<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">73.9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">146<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">84.4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">34<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">79.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>HRT</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.08<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Yes<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">34<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">20.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">45<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">26.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">14.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">106<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">64.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">96<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">55.5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">33<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">76.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">25<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">15.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">32<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">18.5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">9.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Tumour histology</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Invasive ductal<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">134<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">81.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">133<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">76.9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">37<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">86.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Invasive lobular<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">17<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">10.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">5.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">7.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><italic>In situ</italic>
<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">23<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">13.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Medullary cancer<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">micro-invasive cancer<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>SBR Grade</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">32<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">19.4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">69<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">39.9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">10<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">23.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">64<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">38.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">56<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">32.4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">21<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">48.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">52<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">31.5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">19<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">11.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">10<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">23.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">17<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">10.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">29<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">16.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>C-erb-2 status</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.34<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Positive<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">25<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">15.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">14<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">8.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">9.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Negative<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">121<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">73.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">104<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">60.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">36<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">83.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">19<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">11.5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">55<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">31.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">7.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Hormone receptor status</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.95<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Positive<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">120<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">72.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">113<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">65.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">33<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">76.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Negative<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">25<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">15.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">22<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">12.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">14.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">20<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">12.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">38<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">22.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">9.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Treatments</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Surgery</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Lumpectomy<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">88<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">53.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">155<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">89.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">42<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">97.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Mastectomy<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">77<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">46.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">17<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">9.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Adjuvant chemotherapy</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Yes<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">111<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">67.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">28<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">16.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">28<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">65.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">54<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">32.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">141<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">81.5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">15<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">34.9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Radiotherapy</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.16<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Yes<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">139<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">84.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">149<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">86.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">41<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">95.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">26<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">15.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">23<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">13.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Hormone therapy</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Yes<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">135<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">81.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">108<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">62.4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">34<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">79.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">29<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">17.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">65<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">37.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">18.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Breast reconstruction</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.07<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Yes<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">22<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">13.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">12<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">6.9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">140<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">84.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">158<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">91.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">40<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">93.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Lymphedema</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Yes<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">17<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">10.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">7.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">143<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">86.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">170<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">98.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">39<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">90.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Type of monitoring</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.91<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Regular<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">154<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">93.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">160<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">92.5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">41<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">95.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Irregular<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">10<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">5.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1.8<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Recurrence</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.62<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Yes<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">10<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">6.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">5.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">4<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">9.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">150<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">90.9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">161<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">93.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">39<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">90.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Tumour size (mm)</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">⩽10 mm<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">35<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">21.2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">91<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">52.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">10<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">23.3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">10–20 mm<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">54<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">32.7<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">71<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">41.0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">28<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">65.1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">>10 mm<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">72<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">43.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2.9<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">5<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">11.6<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Unknown</td>
<td align="char" valign="top" char="." charoff="50">4</td>
<td align="char" valign="top" char="." charoff="50">2.4</td>
<td align="char" valign="top" char="." charoff="50">6</td>
<td align="char" valign="top" char="." charoff="50">3.5</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">0.0</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t1-fn1"><p>Abbreviations: ALND=axillary lymph node dissection; CGFL=Centre Georges François Leclerc; HRT=hormone replacement therapy; SBR=Scarff Bloom and Richardson; SLNB=sentinel lymph node biopsy.</p>
</fn>
<fn id="t1-fn2"><p>Kruskal–Wallis test was used to test the homogeneity of the different groups for quantitative variables; Pearson's <italic>χ</italic>
<sup>2</sup>
-test was used to test the homogeneity of the different groups for qualitative variables.</p>
</fn>
<fn id="t1-fn3"><label>a</label>
<p>Forty patients had SLNB+ALND at the same time.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl2"><label>Table 2</label>
<caption><title>Patient's missing-score profiles according to axillary dissection type</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th>
<th colspan="2" align="center" valign="top" charoff="50"><bold>ALND group (</bold>
<italic><bold>N</bold>
</italic>
<bold>=165)</bold>
<hr></hr>
</th>
<th colspan="2" align="center" valign="top" charoff="50"><bold>SLNB group (</bold>
<italic><bold>N</bold>
</italic>
<bold>=173)</bold>
<hr></hr>
</th>
<th colspan="2" align="center" valign="top" charoff="50"><bold>SLNB+ALND group<sup>a</sup>
 (</bold>
<italic><bold>N</bold>
</italic>
<bold>=43)</bold>
<hr></hr>
</th>
<th align="center" valign="top" char="." charoff="50"><bold>Fisher's exact</bold>
<italic><bold>P-</bold>
</italic>
<bold>value</bold>
<hr></hr>
</th>
</tr>
<tr><th align="left" valign="top" charoff="50"> </th>
<th align="center" valign="top" charoff="50"><italic><bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>%</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>%</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>%</bold>
</th>
<th align="char" valign="top" char="." charoff="50"> </th>
</tr>
</thead>
<tbody valign="top"><tr><td align="left" valign="top" charoff="50"><bold>GHS</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.8<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No missing scores<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">67<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">41<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">76<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">44<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">16<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">37<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Drop-out scores<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">3<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Intermittent missing scores<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">95<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">58<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">95<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">55<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">26<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">60<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No values<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>BRAS</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.81<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No missing scores<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">67<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">41<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">77<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">45<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">16<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">37<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Drop-out scores<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Intermittent missing scores<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">96<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">58<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">94<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">54<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">27<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">63<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No values<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>BRBS</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0.51<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No missing scores<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">85<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">52<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">87<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">50<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">26<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">60<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Drop-out scores<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">2<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">1<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">0<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Intermittent missing scores<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">77<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">47<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">86<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">50<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">17<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50">40<hr></hr>
</td>
<td align="char" valign="top" char="." charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No values</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50"> </td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t2-fn1"><p>Abbreviations: ALND=axillary lymph node dissection; BRAS=BR23 arm symptom; BRBS=BR23 breast symptom; GHS=global health status; SLNB=sentinel lymph node biopsy.</p>
</fn>
<fn id="t2-fn2"><label>a</label>
<p>Forty patients had SLNB+ALND at the same time.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl3"><label>Table 3</label>
<caption><title>QoL scores according to the axillary surgery modalities</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> <hr></hr>
</th>
<th colspan="3" align="center" valign="top" charoff="50"><bold>ALND (</bold>
<italic><bold>N</bold>
</italic>
<bold>=165)</bold>
<hr></hr>
</th>
<th colspan="3" align="center" valign="top" charoff="50"><bold>SLNB (</bold>
<italic><bold>N</bold>
</italic>
<bold>=173)</bold>
<hr></hr>
</th>
<th colspan="3" align="center" valign="top" charoff="50"><bold>SLNB+ALND</bold>
<xref ref-type="fn" rid="t3-fn1">a</xref>
<bold>(</bold>
<italic><bold>N</bold>
</italic>
<bold>=43)</bold>
<hr></hr>
</th>
<th align="center" valign="top" charoff="50"> <hr></hr>
</th>
</tr>
<tr><th align="left" valign="top" charoff="50"><bold>Variables</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>Mean (s.d.)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Median (Min–Max)</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>Mean (s.d.)</bold>
</th>
<th align="center" valign="top" charoff="50"><bold>Median (Min–Max)</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>N</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>Mean (s.d</bold>
.)</th>
<th align="center" valign="top" charoff="50"><bold>Median (Min–Max)</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>P-</bold>
</italic>
<bold>value</bold>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td colspan="11" align="left" valign="top" charoff="50"><bold>GHS</bold>
<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Before surgery</td>
<td align="center" valign="top" charoff="50">93</td>
<td align="char" valign="top" char="(" charoff="50">74 (19)</td>
<td align="center" valign="top" charoff="50">75 (17–100)</td>
<td align="center" valign="top" charoff="50">119</td>
<td align="char" valign="top" char="(" charoff="50">76 (17)</td>
<td align="center" valign="top" charoff="50">83 (33–100)</td>
<td align="center" valign="top" charoff="50">25</td>
<td align="char" valign="top" char="(" charoff="50">79 (19)</td>
<td align="center" valign="top" charoff="50">83 (33–100)</td>
<td align="center" valign="top" charoff="50">0.52</td>
</tr>
<tr><td align="left" valign="top" charoff="50">After surgery</td>
<td align="center" valign="top" charoff="50">114</td>
<td align="char" valign="top" char="(" charoff="50">68 (19)</td>
<td align="center" valign="top" charoff="50">67 (8–100)</td>
<td align="center" valign="top" charoff="50">126</td>
<td align="char" valign="top" char="(" charoff="50">72 (18)</td>
<td align="center" valign="top" charoff="50">71 (17–100)</td>
<td align="center" valign="top" charoff="50">28</td>
<td align="char" valign="top" char="(" charoff="50">65 (23)</td>
<td align="center" valign="top" charoff="50">67 (0–100)</td>
<td align="center" valign="top" charoff="50">0.27</td>
</tr>
<tr><td align="left" valign="top" charoff="50">6 Months after surgery</td>
<td align="center" valign="top" charoff="50">147</td>
<td align="char" valign="top" char="(" charoff="50">72 (18)</td>
<td align="center" valign="top" charoff="50">75 (17–100)</td>
<td align="center" valign="top" charoff="50">137</td>
<td align="char" valign="top" char="(" charoff="50">73 (19)</td>
<td align="center" valign="top" charoff="50">75 (0–100)</td>
<td align="center" valign="top" charoff="50">39</td>
<td align="char" valign="top" char="(" charoff="50">69 (19)</td>
<td align="center" valign="top" charoff="50">67 (33–100)</td>
<td align="center" valign="top" charoff="50">0.36</td>
</tr>
<tr><td align="left" valign="top" charoff="50">12 Months after surgery</td>
<td align="center" valign="top" charoff="50">144</td>
<td align="char" valign="top" char="(" charoff="50">75 (18)</td>
<td align="center" valign="top" charoff="50">83 (25–100)</td>
<td align="center" valign="top" charoff="50">136</td>
<td align="char" valign="top" char="(" charoff="50">77 (18)</td>
<td align="center" valign="top" charoff="50">83 (25–100)</td>
<td align="center" valign="top" charoff="50">36</td>
<td align="char" valign="top" char="(" charoff="50">70 (19)</td>
<td align="center" valign="top" charoff="50">67 (25–100)</td>
<td align="center" valign="top" charoff="50">0.1</td>
</tr>
<tr><td align="left" valign="top" charoff="50">72 Months after surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">160<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">72 (22)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">75 (0–100)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">170<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">70 (20)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">67 (0–100)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">41<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">65 (22)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">67 (17–100)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.15<hr></hr>
</td>
</tr>
<tr><td colspan="11" align="left" valign="top" charoff="50"><bold>BRAS</bold>
<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Before surgery</td>
<td align="center" valign="top" charoff="50">93</td>
<td align="char" valign="top" char="(" charoff="50">6 (9)</td>
<td align="center" valign="top" charoff="50">0 (0–33)</td>
<td align="center" valign="top" charoff="50">120</td>
<td align="char" valign="top" char="(" charoff="50">7 (12)</td>
<td align="center" valign="top" charoff="50">0 (0–67)</td>
<td align="center" valign="top" charoff="50">25</td>
<td align="char" valign="top" char="(" charoff="50">7 (13)</td>
<td align="center" valign="top" charoff="50">0 (0–56)</td>
<td align="center" valign="top" charoff="50">0.99</td>
</tr>
<tr><td align="left" valign="top" charoff="50">After surgery</td>
<td align="center" valign="top" charoff="50">115</td>
<td align="char" valign="top" char="(" charoff="50">19 (18)</td>
<td align="center" valign="top" charoff="50">11 (0–89)</td>
<td align="center" valign="top" charoff="50">125</td>
<td align="char" valign="top" char="(" charoff="50">12 (15)</td>
<td align="center" valign="top" charoff="50">11 (0–67)</td>
<td align="center" valign="top" charoff="50">28</td>
<td align="char" valign="top" char="(" charoff="50">15 (17)</td>
<td align="center" valign="top" charoff="50">11 (0–67)</td>
<td align="center" valign="top" charoff="50">0.004</td>
</tr>
<tr><td align="left" valign="top" charoff="50">6 Months after surgery</td>
<td align="center" valign="top" charoff="50">146</td>
<td align="char" valign="top" char="(" charoff="50">20 (20)</td>
<td align="center" valign="top" charoff="50">11 (0–100)</td>
<td align="center" valign="top" charoff="50">138</td>
<td align="char" valign="top" char="(" charoff="50">13 (16)</td>
<td align="center" valign="top" charoff="50">11 (0–100)</td>
<td align="center" valign="top" charoff="50">39</td>
<td align="char" valign="top" char="(" charoff="50">21 (20)</td>
<td align="center" valign="top" charoff="50">11 (0–78)</td>
<td align="center" valign="top" charoff="50">0.001</td>
</tr>
<tr><td align="left" valign="top" charoff="50">12 Months after surgery</td>
<td align="center" valign="top" charoff="50">145</td>
<td align="char" valign="top" char="(" charoff="50">20 (20)</td>
<td align="center" valign="top" charoff="50">11 (0–100)</td>
<td align="center" valign="top" charoff="50">136</td>
<td align="char" valign="top" char="(" charoff="50">11 (15)</td>
<td align="center" valign="top" charoff="50">0 (0–78)</td>
<td align="center" valign="top" charoff="50">36</td>
<td align="char" valign="top" char="(" charoff="50">19 (17)</td>
<td align="center" valign="top" charoff="50">17 (0–56)</td>
<td align="center" valign="top" charoff="50">0.0001</td>
</tr>
<tr><td align="left" valign="top" charoff="50">72 Months after surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">159<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">23 (26)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">11 (0–100)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">171<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">12 (19)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0 (0–100)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">42<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">17 (24)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">11 (0–100)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.0001<hr></hr>
</td>
</tr>
<tr><td colspan="11" align="left" valign="top" charoff="50"><bold>BRBS</bold>
<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">After surgery</td>
<td align="center" valign="top" charoff="50">102</td>
<td align="char" valign="top" char="(" charoff="50">19 (15)</td>
<td align="center" valign="top" charoff="50">17 (0–67)</td>
<td align="center" valign="top" charoff="50">116</td>
<td align="char" valign="top" char="(" charoff="50">21 (17)</td>
<td align="center" valign="top" charoff="50">17 (0–83)</td>
<td align="center" valign="top" charoff="50">28</td>
<td align="char" valign="top" char="(" charoff="50">17 (17)</td>
<td align="center" valign="top" charoff="50">17 (28–58)</td>
<td align="center" valign="top" charoff="50">0.33</td>
</tr>
<tr><td align="left" valign="top" charoff="50">6 Months after surgery</td>
<td align="center" valign="top" charoff="50">146</td>
<td align="char" valign="top" char="(" charoff="50">22 (20)</td>
<td align="center" valign="top" charoff="50">17 (0–92)</td>
<td align="center" valign="top" charoff="50">138</td>
<td align="char" valign="top" char="(" charoff="50">22 (16)</td>
<td align="center" valign="top" charoff="50">17 (0–89)</td>
<td align="center" valign="top" charoff="50">40</td>
<td align="char" valign="top" char="(" charoff="50">26 (23)</td>
<td align="center" valign="top" charoff="50">17 (0–100)</td>
<td align="center" valign="top" charoff="50">0.64</td>
</tr>
<tr><td align="left" valign="top" charoff="50">12 Months after surgery</td>
<td align="center" valign="top" charoff="50">144</td>
<td align="char" valign="top" char="(" charoff="50">19 (18)</td>
<td align="center" valign="top" charoff="50">17 (0–100)</td>
<td align="center" valign="top" charoff="50">136</td>
<td align="char" valign="top" char="(" charoff="50">19 (16)</td>
<td align="center" valign="top" charoff="50">17 (0–92)</td>
<td align="center" valign="top" charoff="50">37</td>
<td align="char" valign="top" char="(" charoff="50">19 (16)</td>
<td align="center" valign="top" charoff="50">17 (0–58)</td>
<td align="center" valign="top" charoff="50">0.91</td>
</tr>
<tr><td align="left" valign="top" charoff="50">72 Months after surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">160<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">19 (20)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">17 (0–92)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">173<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">16 (18)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">8 (0–92)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">42<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">17 (20)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">17 (0–92)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.63<hr></hr>
</td>
</tr>
<tr><td colspan="11" align="left" valign="top" charoff="50"><bold>Other scores at 72 months</bold>
<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Physical functioning</td>
<td align="center" valign="top" charoff="50">164</td>
<td align="char" valign="top" char="(" charoff="50">83 (17)</td>
<td align="center" valign="top" charoff="50">87 (27–100)</td>
<td align="center" valign="top" charoff="50">172</td>
<td align="char" valign="top" char="(" charoff="50">86 (16)</td>
<td align="center" valign="top" charoff="50">93 (27–100)]</td>
<td align="center" valign="top" charoff="50">43</td>
<td align="char" valign="top" char="(" charoff="50">82 (19)</td>
<td align="center" valign="top" charoff="50">87 (0–100)</td>
<td align="center" valign="top" charoff="50">0.11</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Role functioning</td>
<td align="center" valign="top" charoff="50">164</td>
<td align="char" valign="top" char="(" charoff="50">80 (26)</td>
<td align="center" valign="top" charoff="50">83 (0–100)</td>
<td align="center" valign="top" charoff="50">173</td>
<td align="char" valign="top" char="(" charoff="50">85 (22)</td>
<td align="center" valign="top" charoff="50">100 (0–100)</td>
<td align="center" valign="top" charoff="50">42</td>
<td align="char" valign="top" char="(" charoff="50">82 (22)</td>
<td align="center" valign="top" charoff="50">83 (0–100)</td>
<td align="center" valign="top" charoff="50">0.13</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Emotional functioning</td>
<td align="center" valign="top" charoff="50">161</td>
<td align="char" valign="top" char="(" charoff="50">75(24)</td>
<td align="center" valign="top" charoff="50">75 (0–100)</td>
<td align="center" valign="top" charoff="50">170</td>
<td align="char" valign="top" char="(" charoff="50">76 (23)</td>
<td align="center" valign="top" charoff="50">83 (0–100)</td>
<td align="center" valign="top" charoff="50">42</td>
<td align="char" valign="top" char="(" charoff="50">73 (22)</td>
<td align="center" valign="top" charoff="50">75 (8–100)</td>
<td align="center" valign="top" charoff="50">0.53</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Cognitive functioning</td>
<td align="center" valign="top" charoff="50">161</td>
<td align="char" valign="top" char="(" charoff="50">84 (21)</td>
<td align="center" valign="top" charoff="50">83 (0–100)</td>
<td align="center" valign="top" charoff="50">172</td>
<td align="char" valign="top" char="(" charoff="50">84 (21)</td>
<td align="center" valign="top" charoff="50">100 (0–100)</td>
<td align="center" valign="top" charoff="50">42</td>
<td align="char" valign="top" char="(" charoff="50">77 (26)</td>
<td align="center" valign="top" charoff="50">83 (0–100)</td>
<td align="center" valign="top" charoff="50">0.27</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Social functioning</td>
<td align="center" valign="top" charoff="50">159</td>
<td align="char" valign="top" char="(" charoff="50">85 (26)</td>
<td align="center" valign="top" charoff="50">100 (0–100)</td>
<td align="center" valign="top" charoff="50">170</td>
<td align="char" valign="top" char="(" charoff="50">89 (21)</td>
<td align="center" valign="top" charoff="50">100 (0–100)</td>
<td align="center" valign="top" charoff="50">42</td>
<td align="char" valign="top" char="(" charoff="50">83 (24)</td>
<td align="center" valign="top" charoff="50">100 (17–100)</td>
<td align="center" valign="top" charoff="50">0.33</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Fatigue</td>
<td align="center" valign="top" charoff="50">162</td>
<td align="char" valign="top" char="(" charoff="50">28 (25)</td>
<td align="center" valign="top" charoff="50">22 (0–100)</td>
<td align="center" valign="top" charoff="50">172</td>
<td align="char" valign="top" char="(" charoff="50">27 (23)</td>
<td align="center" valign="top" charoff="50">22 (0–100)</td>
<td align="center" valign="top" charoff="50">42</td>
<td align="char" valign="top" char="(" charoff="50">31 (24)</td>
<td align="center" valign="top" charoff="50">33 (0–100)</td>
<td align="center" valign="top" charoff="50">0.51</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Nausea and vomiting</td>
<td align="center" valign="top" charoff="50">162</td>
<td align="char" valign="top" char="(" charoff="50">6 (15)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">171</td>
<td align="char" valign="top" char="(" charoff="50">3 (10)</td>
<td align="center" valign="top" charoff="50">0 (0–67)</td>
<td align="center" valign="top" charoff="50">42</td>
<td align="char" valign="top" char="(" charoff="50">3 (16)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">0.51</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Pain</td>
<td align="center" valign="top" charoff="50">164</td>
<td align="char" valign="top" char="(" charoff="50">21 (26)</td>
<td align="center" valign="top" charoff="50">17 (0–100)</td>
<td align="center" valign="top" charoff="50">172</td>
<td align="char" valign="top" char="(" charoff="50">18 (24)</td>
<td align="center" valign="top" charoff="50">33 (0–100)</td>
<td align="center" valign="top" charoff="50">42</td>
<td align="char" valign="top" char="(" charoff="50">20 (22)</td>
<td align="center" valign="top" charoff="50">17 (0–67)</td>
<td align="center" valign="top" charoff="50">0.5</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Dyspnoea</td>
<td align="center" valign="top" charoff="50">160</td>
<td align="char" valign="top" char="(" charoff="50">19 (26)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">171</td>
<td align="char" valign="top" char="(" charoff="50">20 (27)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">41</td>
<td align="char" valign="top" char="(" charoff="50">21 (29)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">0.96</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Insomnia</td>
<td align="center" valign="top" charoff="50">158</td>
<td align="char" valign="top" char="(" charoff="50">28 (29)</td>
<td align="center" valign="top" charoff="50">33 (0–100)</td>
<td align="center" valign="top" charoff="50">169</td>
<td align="char" valign="top" char="(" charoff="50">31 (33)</td>
<td align="center" valign="top" charoff="50">33 (0–100)</td>
<td align="center" valign="top" charoff="50">41</td>
<td align="char" valign="top" char="(" charoff="50">41 (33)</td>
<td align="center" valign="top" charoff="50">33 (0–100)</td>
<td align="center" valign="top" charoff="50">0.12</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Appetite loss</td>
<td align="center" valign="top" charoff="50">160</td>
<td align="char" valign="top" char="(" charoff="50">10 (23)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">171</td>
<td align="char" valign="top" char="(" charoff="50">6 (17)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">40</td>
<td align="char" valign="top" char="(" charoff="50">5 (16)</td>
<td align="center" valign="top" charoff="50">0 (0–67)</td>
<td align="center" valign="top" charoff="50">0.38</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Constipation</td>
<td align="center" valign="top" charoff="50">162</td>
<td align="char" valign="top" char="(" charoff="50">17 (28)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">170</td>
<td align="char" valign="top" char="(" charoff="50">16 (25)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">42</td>
<td align="char" valign="top" char="(" charoff="50">13 (21)</td>
<td align="center" valign="top" charoff="50">0 (0–67)</td>
<td align="center" valign="top" charoff="50">0.96</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Diarrhoea</td>
<td align="center" valign="top" charoff="50">159</td>
<td align="char" valign="top" char="(" charoff="50">8 (16)</td>
<td align="center" valign="top" charoff="50">0 (0–67)</td>
<td align="center" valign="top" charoff="50">169</td>
<td align="char" valign="top" char="(" charoff="50">7 (15)</td>
<td align="center" valign="top" charoff="50">0 (0–67)</td>
<td align="center" valign="top" charoff="50">40</td>
<td align="char" valign="top" char="(" charoff="50">9 (18)</td>
<td align="center" valign="top" charoff="50">0 (0–67)</td>
<td align="center" valign="top" charoff="50">0.95</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Financial difficulties<hr></hr>
</td>
<td align="center" valign="top" charoff="50">159<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">7 (20)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0 (0–100)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">169<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">7 (18)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0 (0–100)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">42<hr></hr>
</td>
<td align="char" valign="top" char="(" charoff="50">6 (15)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0 (0–67)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.97<hr></hr>
</td>
</tr>
<tr><td colspan="11" align="left" valign="top" charoff="50"><bold>QLQ-BR23</bold>
<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Body image</td>
<td align="center" valign="top" charoff="50">159</td>
<td align="char" valign="top" char="(" charoff="50">71 (32)</td>
<td align="center" valign="top" charoff="50">83 (0–100)</td>
<td align="center" valign="top" charoff="50">168</td>
<td align="char" valign="top" char="(" charoff="50">83 (25)</td>
<td align="center" valign="top" charoff="50">92 (0–100)</td>
<td align="center" valign="top" charoff="50">40</td>
<td align="char" valign="top" char="(" charoff="50">76 (27)</td>
<td align="center" valign="top" charoff="50">83 (0–100)</td>
<td align="center" valign="top" charoff="50">0.0005</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Sexual functioning</td>
<td align="center" valign="top" charoff="50">145</td>
<td align="char" valign="top" char="(" charoff="50">19 (24)</td>
<td align="center" valign="top" charoff="50">0 (0–100)</td>
<td align="center" valign="top" charoff="50">152</td>
<td align="char" valign="top" char="(" charoff="50">18 (23)</td>
<td align="center" valign="top" charoff="50">0 (0–83)</td>
<td align="center" valign="top" charoff="50">38</td>
<td align="char" valign="top" char="(" charoff="50">16 (20)</td>
<td align="center" valign="top" charoff="50">0 (0–67)</td>
<td align="center" valign="top" charoff="50">0.77</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Sexual enjoyment</td>
<td align="center" valign="top" charoff="50">68</td>
<td align="char" valign="top" char="(" charoff="50">46(33)</td>
<td align="center" valign="top" charoff="50">33 (0–100)</td>
<td align="center" valign="top" charoff="50">65</td>
<td align="char" valign="top" char="(" charoff="50">53 (33)</td>
<td align="center" valign="top" charoff="50">67 (0–100)</td>
<td align="center" valign="top" charoff="50">17</td>
<td align="char" valign="top" char="(" charoff="50">45 (29)</td>
<td align="center" valign="top" charoff="50">33 (0–100)</td>
<td align="center" valign="top" charoff="50">0.44</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Future perspectives</td>
<td align="center" valign="top" charoff="50">156</td>
<td align="char" valign="top" char="(" charoff="50">57 (35)</td>
<td align="center" valign="top" charoff="50">67 (0–100)</td>
<td align="center" valign="top" charoff="50">166</td>
<td align="char" valign="top" char="(" charoff="50">67 (30)</td>
<td align="center" valign="top" charoff="50">67 (0–100)</td>
<td align="center" valign="top" charoff="50">37</td>
<td align="char" valign="top" char="(" charoff="50">66 (33)</td>
<td align="center" valign="top" charoff="50">67 (0–100)</td>
<td align="center" valign="top" charoff="50">0.04</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Systemic therapy side effects</td>
<td align="center" valign="top" charoff="50">162</td>
<td align="char" valign="top" char="(" charoff="50">19 (20)</td>
<td align="center" valign="top" charoff="50">14 (0–95)</td>
<td align="center" valign="top" charoff="50">170</td>
<td align="char" valign="top" char="(" charoff="50">13 (14)</td>
<td align="center" valign="top" charoff="50">10 (0–81)</td>
<td align="center" valign="top" charoff="50">41</td>
<td align="char" valign="top" char="(" charoff="50">18 (15)</td>
<td align="center" valign="top" charoff="50">14 (0–81)</td>
<td align="center" valign="top" charoff="50">0.01</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Upset by hair loss</td>
<td align="center" valign="top" charoff="50">63</td>
<td align="char" valign="top" char="(" charoff="50">56 (41)</td>
<td align="center" valign="top" charoff="50">67 (0–100)</td>
<td align="center" valign="top" charoff="50">45</td>
<td align="char" valign="top" char="(" charoff="50">30 (34)</td>
<td align="center" valign="top" charoff="50">33 (0–100)</td>
<td align="center" valign="top" charoff="50">21</td>
<td align="char" valign="top" char="(" charoff="50">38 (41)</td>
<td align="center" valign="top" charoff="50">33 (0–100)</td>
<td align="center" valign="top" charoff="50">0.004</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t3-fn1"><p>Abbreviations: ALND=axillary lymph node dissection; BRAS=BR23 arm symptom; BRBS=BR23 breast symptom; GHS=global health status; QoL=quality of life; SLNB=sentinel lymph node biopsy.</p>
</fn>
<fn id="t3-fn2"><label>a</label>
<p>Forty patients had SLNB+ALND at the same time.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl4"><label>Table 4</label>
<caption><title>Long-term effect of surgical procedure and factors affecting global health and breast symptoms in breast cancer patient</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th>
<th colspan="2" align="center" valign="top" charoff="50"><bold>Global health</bold>
<hr></hr>
</th>
<th colspan="2" align="center" valign="top" charoff="50"><bold>Breast symptoms</bold>
<hr></hr>
</th>
</tr>
<tr><th align="left" valign="top" charoff="50"> </th>
<th align="center" valign="top" charoff="50"><bold>Beta (s.e.)</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>P</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50"><bold>Beta (s.e.)</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>P</bold>
</italic>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td align="left" valign="top" charoff="50"><bold>Constant</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50">74 (6.4)<hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<hr></hr>
</td>
<td align="center" valign="top" charoff="50">19.8 (6.4)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.002<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Follow-up</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<xref ref-type="fn" rid="t4-fn1">a</xref>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<xref ref-type="fn" rid="t4-fn1">a</xref>
<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Before surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">After surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−6.7 (1.5)<hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">6 Months after surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−4 (1.4)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.005<hr></hr>
</td>
<td align="center" valign="top" charoff="50">4.4 (1.4)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.0012<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">12 Months after surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−1.2 (1.4)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.4<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.9 (1.4)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.52<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">72 Months after surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−5.3 (1.4)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.0002<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−1.1 (1.3)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.41<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Axillary dissection type</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.0726<xref ref-type="fn" rid="t4-fn1">a</xref>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.84<xref ref-type="fn" rid="t4-fn1">a</xref>
<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">ALND<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">SLNB<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−1.8 (2.5)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.48<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−1.1 (2.4)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.6323<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">SLNB+ALND<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−6.4 (2.8)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.02<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.3 (2.7)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.9075<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Tumour size</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.0371<xref ref-type="fn" rid="t4-fn1">a</xref>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">>20 mm<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">10–20 mm<hr></hr>
</td>
<td align="center" valign="top" charoff="50">3.4 (2.4)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.16<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">⩽0 mm<hr></hr>
</td>
<td align="center" valign="top" charoff="50">7.2 (2.8)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.01<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Hormone status</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.03<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Postmenopausal<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Premenopausal</td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50"> </td>
<td align="center" valign="top" charoff="50">4.4 (2)</td>
<td align="center" valign="top" charoff="50"> </td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t4-fn1"><p>Abbreviations: ALND=axillary lymph node dissection; SLNB=sentinel lymph node biopsy; s.e.=standard error.</p>
</fn>
<fn id="t4-fn2"><p>NB: Multivariable analyses were adjusted for hospitals, hormonal status, the Scarff Bloom and Richardson grade, treaments: the type of surgery, adjuvant chemotherapy, hormone therapy, the occurrence of lymphedema and tumour size.</p>
</fn>
<fn id="t4-fn3"><label>a</label>
<p>Overall effect.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl5"><label>Table 5</label>
<caption><title>Long-term effect of surgical procedure and factors affecting arm symptoms in breast cancer patients</title>
</caption>
<table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col>
<col align="center"></col>
<col align="center"></col>
</colgroup>
<thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> <hr></hr>
</th>
<th colspan="2" align="center" valign="top" charoff="50"><bold>Arm symptoms</bold>
</th>
</tr>
<tr><th align="left" valign="top" charoff="50"> </th>
<th align="center" valign="top" charoff="50"><bold>Beta (s.e.)</bold>
</th>
<th align="center" valign="top" charoff="50"><italic><bold>P</bold>
</italic>
</th>
</tr>
</thead>
<tbody valign="top"><tr><td align="left" valign="top" charoff="50"><bold>Constant</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50">19.8 (6)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.0011<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Follow-up</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Before surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">After surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">12.6 (2.2)<hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">6 Months after surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">12.6 (2.1)<hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">12 Months after surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">13.2 (2.1)<hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">72 Months after surgery<hr></hr>
</td>
<td align="center" valign="top" charoff="50">15.5 (2.1)<hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Axillary dissection type</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.22<xref ref-type="fn" rid="t5-fn1">a</xref>
<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">ALND<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">SLNB<hr></hr>
</td>
<td align="center" valign="top" charoff="50">3.1 (3.1)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.32<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">SLNB+ALND<hr></hr>
</td>
<td align="center" valign="top" charoff="50">2.4 (4.2)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.56<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Interaction follow-up time</bold>
<bold>and</bold>
<bold>surgical procedure</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.04<xref ref-type="fn" rid="t5-fn1">a</xref>
<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">After surgery and SLNB<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−7.6 (3.1)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.01<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">After surgery and (SLNB+ALND)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−5.1 (4.9)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.29<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">After surgery and ALND<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">6 Months after surgery and SLNB<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−6.1 (3)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.04<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">6 Months after surgery and (SLNB+ALND)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−2.2 (4.6)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.63<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">6 Months after surgery and ALND<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">12 Months after surgery and SLNB<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−9 (3)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.003<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">12 Months after surgery and (SLNB+ALND)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−0.7 (4.6)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.88<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">12 Months after surgery and ALND<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">72 Months after surgery and SLND<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−10.8 (2.9)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.0002<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">72 Months after surgery and (SLNB+ALND)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−5.3 (4.5)<hr></hr>
</td>
<td align="center" valign="top" charoff="50">0.24<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">72 Months after surgery and ALND<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Lymphedema</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Yes<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No<hr></hr>
</td>
<td align="center" valign="top" charoff="50">−13.4 (3.2)<hr></hr>
</td>
<td align="center" valign="top" charoff="50"><0.0001<hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50"><bold>Hormone therapy</bold>
<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">Yes<hr></hr>
</td>
<td align="center" valign="top" charoff="50">Reference<hr></hr>
</td>
<td align="center" valign="top" charoff="50"> <hr></hr>
</td>
</tr>
<tr><td align="left" valign="top" charoff="50">No</td>
<td align="center" valign="top" charoff="50">−3.9 (2)</td>
<td align="center" valign="top" charoff="50">0.049</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn id="t5-fn1"><p>Abbreviations: ALND=axillary lymph node dissection; SLNB=sentinel lymph node biopsy.</p>
</fn>
<fn id="t5-fn2"><p>NB: Multivariable analyses were adjusted for hospitals, hormone status, the Scarff Bloom and Richardson grade, treaments (the type of surgery, adjuvant chemotherapy, hormone therapy), the occurrence of lymphedema and tumour size.</p>
</fn>
<fn id="t5-fn3"><label>a</label>
<p>Overall effect.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
</record>

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Impact of sentinel node biopsy on long-term quality of life in breast cancer patients

Impact of sentinel node biopsy on long-term quality of life in breast cancer patients

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