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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Scrotal reconstruction and testicular prosthetics</title><author><name sortKey="Lucas, Jacob W" sort="Lucas, Jacob W" uniqKey="Lucas J" first="Jacob W." last="Lucas">Jacob W. Lucas</name></author><author><name sortKey="Lester, Kyle M" sort="Lester, Kyle M" uniqKey="Lester K" first="Kyle M." last="Lester">Kyle M. Lester</name></author><author><name sortKey="Chen, Andrew" sort="Chen, Andrew" uniqKey="Chen A" first="Andrew" last="Chen">Andrew Chen</name></author><author><name sortKey="Simhan, Jay" sort="Simhan, Jay" uniqKey="Simhan J" first="Jay" last="Simhan">Jay Simhan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">5583055</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583055</idno><idno type="RBID">PMC:5583055</idno><idno type="doi">10.21037/tau.2017.07.06</idno><idno type="pmid">NONE</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">004B84</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004B84</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Scrotal reconstruction and testicular prosthetics</title><author><name sortKey="Lucas, Jacob W" sort="Lucas, Jacob W" uniqKey="Lucas J" first="Jacob W." last="Lucas">Jacob W. Lucas</name></author><author><name sortKey="Lester, Kyle M" sort="Lester, Kyle M" uniqKey="Lester K" first="Kyle M." last="Lester">Kyle M. Lester</name></author><author><name sortKey="Chen, Andrew" sort="Chen, Andrew" uniqKey="Chen A" first="Andrew" last="Chen">Andrew Chen</name></author><author><name sortKey="Simhan, Jay" sort="Simhan, Jay" uniqKey="Simhan J" first="Jay" last="Simhan">Jay Simhan</name></author></analytic><series><title level="j">Translational Andrology and Urology</title><idno type="eISSN">2223-4691</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Scrotal surgery encompasses a wide-variety of surgical techniques for an even wider variety of indications. In this manuscript, we review our indications, techniques, and pit-falls for various reconstructive scrotal surgeries as-well-as surgical tips for placement of testicular prostheses. Penoscrotal webbing (PSW) is an abnormal, often-problematic distal insertion of scrotal skin onto the ventral penile shaft. There are several effective and straightforward techniques used to revise this condition, which include simple scrotoplasty, single- or double-Z-plasty, or the VY-flap scrotoplasty. Reconstruction is also commonly indicated following scrotal skin loss caused by infection, trauma, lymphedema, hidradenitis, and cancer. Although initial management of these conditions often involves scrotal skin removal, repair of expansive scrotal skin loss can be technically difficult and can be accomplished by using one of several skin flaps or skin grafting. Split-thickness skin grafting of scrotal defects can be accomplished easily, and provides durable results.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mihmanli, I" uniqKey="Mihmanli I">I Mihmanli</name></author><author><name sortKey="Kantarci, F" uniqKey="Kantarci F">F Kantarci</name></author><author><name sortKey="Kulaksizoglu, H" uniqKey="Kulaksizoglu H">H Kulaksizoglu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agrawal, Ms" uniqKey="Agrawal M">MS Agrawal</name></author><author><name sortKey="Yadav, H" uniqKey="Yadav H">H Yadav</name></author><author><name sortKey="Upadhyay, A" uniqKey="Upadhyay A">A Upadhyay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lund, L" uniqKey="Lund L">L Lund</name></author><author><name sortKey="Kloster, A" uniqKey="Kloster A">A Kloster</name></author><author><name sortKey="Cao, T" uniqKey="Cao T">T Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jahnson, S" uniqKey="Jahnson S">S Jahnson</name></author><author><name sortKey="Sandblom, D" uniqKey="Sandblom D">D Sandblom</name></author><author><name sortKey="Holmang, S" uniqKey="Holmang S">S. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Transl Androl Urol</journal-id><journal-id journal-id-type="iso-abbrev">Transl Androl Urol</journal-id><journal-id journal-id-type="publisher-id">TAU</journal-id><journal-title-group><journal-title>Translational Andrology and Urology</journal-title></journal-title-group><issn pub-type="epub">2223-4691</issn><publisher><publisher-name>AME Publishing Company</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">5583055</article-id><article-id pub-id-type="publisher-id">tau-06-04-710</article-id><article-id pub-id-type="doi">10.21037/tau.2017.07.06</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Scrotal reconstruction and testicular prosthetics</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lucas</surname><given-names>Jacob W.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lester</surname><given-names>Kyle M.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Andrew</given-names></name></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Simhan</surname><given-names>Jay</given-names></name></contrib><aff id="aff1">Department of Urology,<institution>Einstein Healthcare Network/Fox Chase Cancer Center</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>USA</country></aff></contrib-group><author-notes><fn id="afn1"><p><italic>Contributions:</italic> (I) Conception and design: JW Lucas, J Simhan; (II) Administrative support: J Simhan; (III) Provision of study material or patients: All authors; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.</p></fn><corresp id="cor1"><italic>Correspondence to:</italic> Jay Simhan, MD. Temple Health and the Fox Chase Cancer Center, 1200 Tabor Road, Moss/3 Sley, Philadelphia, PA 19141, USA. Email: <email xlink:href="jsimhan@gmail.com">jsimhan@gmail.com</email>.</corresp></author-notes><pub-date pub-type="epub-ppub"><month>8</month><year>2017</year></pub-date><pmc-comment>Fake ppub date generated by PMC from publisher
pub-date/@pub-type='epub-ppub' </pmc-comment>
<pub-date pub-type="ppub"><month>8</month><year>2017</year></pub-date><volume>6</volume><issue>4</issue><fpage>710</fpage><lpage>721</lpage><history><date date-type="received"><day>10</day><month>4</month><year>2017</year></date><date date-type="accepted"><day>29</day><month>6</month><year>2017</year></date></history><permissions><copyright-statement>2017 Translational Andrology and Urology. All rights reserved.</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>Translational Andrology and Urology.</copyright-holder></permissions><abstract><p>Scrotal surgery encompasses a wide-variety of surgical techniques for an even wider variety of indications. In this manuscript, we review our indications, techniques, and pit-falls for various reconstructive scrotal surgeries as-well-as surgical tips for placement of testicular prostheses. Penoscrotal webbing (PSW) is an abnormal, often-problematic distal insertion of scrotal skin onto the ventral penile shaft. There are several effective and straightforward techniques used to revise this condition, which include simple scrotoplasty, single- or double-Z-plasty, or the VY-flap scrotoplasty. Reconstruction is also commonly indicated following scrotal skin loss caused by infection, trauma, lymphedema, hidradenitis, and cancer. Although initial management of these conditions often involves scrotal skin removal, repair of expansive scrotal skin loss can be technically difficult and can be accomplished by using one of several skin flaps or skin grafting. Split-thickness skin grafting of scrotal defects can be accomplished easily, and provides durable results.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords: </title><kwd>Fournier’s gangrene (FG)</kwd><kwd>hydrocele</kwd><kwd>prosthesis implantation</kwd><kwd>scrotum</kwd><kwd>skin grafting</kwd><kwd>trauma</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>Introduction</title><p>Urologists encounter a wide-variety of conditions affecting the scrotum that require surgical management. These range from simple hydrocelectomy to complex scrotal reconstruction. In this review, we briefly discuss hydrocelectomy, which is amongst the most commonly performed procedures by the general urologist. However, it is our hope that we can provide our indications, surgical techniques, and our complications for more complex scrotal procedures, such as scrotoplasty and split-thickness skin grafting, to provide confidence for the urologist who may not routinely perform these surgeries.</p></sec><sec><title>Hydrocelectomy</title><p>Hydroceles are a commonly encountered urologic condition with an incidence of nearly 1% of adult men (<xref rid="r1" ref-type="bibr">1</xref>). Hydroceles have been classified into communicating or non-communicating types—dependent on whether the processus vaginalis remains patent. In adults, hydroceles tend to be non-communicating, and have a variety of causes: idiopathic and reactive (infection, malignancy, trauma). The diagnosis is most commonly made by physical examination and ultrasonography. On physical exam, hydroceles are manifested by a variable, fluid-filled sac which contains the testis. Classically, the scrotal transillumination test has been used to describe the presence of hydrocele or a solid testicular mass. Ultrasonography can be used to confirm the diagnosis (hydrocele, spermatocele), its volume, and its complexity. Management of hydrocele may involve watchful waiting, sclerotherapy, or hydrocelectomy.</p><p>Sclerotherapy of hydroceles, commonly performed with concomitant aspiration, involves the injection of a sclerosing agent, such as phenol or tetracycline, into the hydrocele sac. The cure rates of sclerotherapy are variable, with most studies reporting anywhere between 50–95% cure (<xref rid="r2" ref-type="bibr">2</xref>-<xref rid="r4" ref-type="bibr">4</xref>). A Cochrane review of aspiration and sclerotherapy versus hydrocelectomy revealed surgical management resulted in fewer long-term recurrences, despite higher rates of complications (<xref rid="r5" ref-type="bibr">5</xref>). At our institution, sclerotherapy is a seldom-used modality, but remains an option for patients with numerus comorbid conditions that may preclude surgical management.</p><p>Hydrocelectomy is one of the most ubiquitous surgical procedures in urologic practice. Although there are numerous techniques for repairing hydrocele (<xref rid="r6" ref-type="bibr">6</xref>-<xref rid="r8" ref-type="bibr">8</xref>), the two most common procedures are the Jaboulay hydrocelectomy and the Lord procedure (<xref rid="r9" ref-type="bibr">9</xref>). At our institution, we prefer the Jaboulay procedure. A small median raphe incision is made and dissected to the level of the hydrocele sac. Once encountered, we use blunt dissection around the tunica to free it from overlying fascia before we deliver it from the incision. It is imperative that the sac is not violated prior, as it makes dissection exceedingly difficult. After the hydrocele sac has been delivered, it is opened with electrocautery, and the fluid is drained in its entirety. We excise as much of the hydrocele sac as possible and evert the remainder without strangulating the cord. The tunical remnant is closed in a running fashion with absorbable suture, and a two-layer closure of the Dartos fascia and scrotal skin is performed. Our dressing consists of triple antibiotic ointment, scrotal fluffs, and tight-fitting underwear for one week following surgery.</p><p>Although hydrocelectomy is a straightforward surgery in most instances, there are several important complications worth discussing—namely hematoma and infection. In a series of 110 scrotal procedures, 55% of which were hydrocelectomy, Swartz and colleagues found a 20% complication rate (22/110), with 5% (5/110) hematoma, and surgical site infections in 3.5% (4/110) (<xref rid="r10" ref-type="bibr">10</xref>). The most common complication in our practice is scrotal hematoma, which can usually be managed with conservative therapy, such as cold compresses and scrotal support. However, we stress early reoperation for scrotal hematomas. Although a difficult decision to make after a purely elective surgery, it can provide quick and definitive therapy with immediate pain relief. One way we have found to obviate the need for early reoperation is to place a closed-suction drain in the scrotum, especially for hydroceles larger than 300 milliliters. We leave closed-suction drains in place for 5–7 days and place the patient on antibiotics for the length of drain placement. Ordinarily, our antibiotic of choice based on our antibiogram is to utilize sulfamethoxazole/trimethoprim.</p></sec><sec><title>Scrotoplasty for penoscrotal web (PSW)</title><p>PSW is an inconspicuous medical condition with no consensus as to an exact definition. However, principally, it is a distal attachment of the scrotum to the ventral penile shaft which reduces the penoscrotal angle. Webbing can be congenital but is most commonly acquired following an over-zealous circumcision. Currently, much of the literature regarding PSW in focused in the pediatric population, where the reported prevalence is 4% (<xref rid="r11" ref-type="bibr">11</xref>). While PSW is not a pathologic condition, it may affect a man’s perception of penile length, alter penetration during intercourse, and can have profound effects on sexual self-esteem (<xref rid="r12" ref-type="bibr">12</xref>). El-Koutby and Amin suggested a tiered classification system of grading PSW: Grade #1 web extends to proximal third of penile shaft; Grade #2 extends to the mid third; and Grade #3 extends to the distal-most third (<xref rid="r11" ref-type="bibr">11</xref>).</p><p>More recently, attention has been turned to adult PSW, specifically in the context of erectile dysfunction and penile prosthetic surgery. Although patients undergoing penile implantation are counseled that stretched penile length is the best predictor of post-implantation erect length, penile shortening following device insertion remains a common complaint (<xref rid="r13" ref-type="bibr">13</xref>,<xref rid="r14" ref-type="bibr">14</xref>). Thus, a number of strategies have been reported in regards to increasing perceived penile length at the time of penile implantation and many of these reconstructive techniques focus on scrotoplasty/ventral phalloplasty performance (<xref rid="r15" ref-type="bibr">15</xref>,<xref rid="r16" ref-type="bibr">16</xref>).</p><p>Perhaps the simplest scrotoplasty technique involves making a horizontal scrotal incision with closure in the longitudinal axis (<xref rid="r17" ref-type="bibr">17</xref>). Additionally, ventral phalloplasty can be completed at the time of penile prosthetic implantation with good results, a practice that we employ frequently at our institution (<xref rid="r18" ref-type="bibr">18</xref>). For more complicated and severe PSW deformities during penile implantation, Carrion and associates described utilizing opposing “checkmarks” to excise redundant scrotal tissue near the penoscrotal junction, with proximal margins one centimeter away from the penile shaft (<xref rid="r19" ref-type="bibr">19</xref>). The curved nature of the incision helps decrease the amount of unopposed tissue that cannot be closed. This technique has been demonstrated to have high patient satisfaction, and the majority (84%, 36/43) of patients in this large series reported increased perception of penile length (<xref rid="r18" ref-type="bibr">18</xref>).</p><p>A single or double Z-plasty can also be utilized as both increase the longitudinal length of skin and give the appearance of increased penile length. The main limb of the Z-plasty is placed on the median raphe, and all limbs should be of equal length and at the same acute angles (<xref rid="r20" ref-type="bibr">20</xref>). However, a common criticism of the Z-plasty is that the apices carry too much tension and might have poor blood supply thus making the wound more prone to breakdown. The V-Y advancement scrotoplasty is another recently described contemporary maneuver to potentially avoid some of the limitations of the Z-plasty by maintaining the underlying blood supply. In this approach, a V-shaped incision with its apex at the penoscrotal junction is created, mobilized, and then closed such that a Y-configuration is formed by the suture line (<xref rid="r21" ref-type="bibr">21</xref>). Each time an advancement is formed, the length gained is approximately 0.4 times that of the vertical limb (<xref rid="r21" ref-type="bibr">21</xref>). At our institution, we perform a variation of the previous technique called a V-Y flap scrotoplasty (VYFS) in which the apex of an inverted V-shaped incision is oriented toward the urethral meatus and mobilized. As the inverted V is mobilized caudally, it can then be tailored, amputated, and closed in a longitudinal axis based on the severity of PSW (<xref ref-type="fig" rid="f1"><italic>Figure 1</italic></xref>). We stress a three-layer wound closure with great attention paid towards reducing any tension on the skin closure layer. In summary, we utilize two running layers of Dartos with a running 3-0 Monocryl (Ethicon, Inc., Piscataway, NJ, USA) suture, and skin with interrupted 3-0 Chromic catgut (Ethicon, Inc., Piscataway, NJ, USA) suture. We have found that performance of an interrupted skin closure rather than a running closure leads to less overall wound breakdowns as any tension on the wound is distributed over a number of individual sutures instead of on a continuous running suture line.</p><fig id="f1" fig-type="figure" orientation="portrait" position="float"><label>Figure 1</label><caption><p>PSW. (A) Preoperative PSW with distal attachment of scrotal skin to ventral penile shaft; (B) VYFS. An inverted V-shaped incision is mobilized caudally and excess tissue is excised. The incision is closed in a longitudinal axis; (C) complete correction of PSW using VYFS at time of penile prosthesis implantation. PSW, penoscrotal web; VYFS, V-Y flap scrotoplasty.</p></caption><graphic xlink:href="tau-06-04-710-f1"></graphic></fig><p>Overall, performance of scrotoplasty is an important tool in the armamentarium of general and reconstructive urologists that gives patients a high level of satisfaction. For concomitant scrotoplasty and penile implant cases, we most certainly caution surgeons to avoid an over-exuberant scrotoplasty incision as this might lead to a closure on tension and subsequent wound breakdown. Such wound breakdowns risk device exposure and a subsequent need for device removal.</p></sec><sec><title>Incidence and etiology of scrotal skin loss</title><p>Scrotal skin loss is an uncommonly encountered condition, and its etiology is wide-ranging: scrotal/perineal infections [Fournier’s gangrene (FG)], trauma (blunt, penetrating, burn), lymphedema (congenital, acquired, infectious), hidradenitis suppurativa (HS), and genital cancers, amongst others. After initial management of all such conditions, a thorough understanding of complex reconstructive maneuvers is mandatory prior to undertaking a cosmetic repair.</p><p>FG is an often-insipid, gangrenous infection of genital/perineal soft tissue. Its estimated incidence is reported to be 1.6 per 100,000 males (<xref rid="r22" ref-type="bibr">22</xref>), with an almost 10:1 predilection over females (<xref rid="r23" ref-type="bibr">23</xref>). The local infection causes microbial toxin release which directly breaks-down soft tissues, as well as forcing small arterial and venous thrombi which lead to further tissue hypoxia and breakdown (<xref rid="r24" ref-type="bibr">24</xref>,<xref rid="r25" ref-type="bibr">25</xref>). A number of host factors are known to be associated with FG, and likely contribute to an immunocompromised state, making infection more severe, including: diabetes mellitus, HIV, blood dyscrasias, alcoholism, chronic steroid use, iatrogenic immunosuppression (e.g., transplant patients), or malignancy requiring chemotherapy (<xref rid="r24" ref-type="bibr">24</xref>-<xref rid="r26" ref-type="bibr">26</xref>). Diagnosis of FG is often multimodal and includes history, physical exam, routine labs, and/or scrotal ultrasound, and computed tomography (CT). The pathognomonic or classical physical exam finding is crepitus, which indicates the presence of subcutaneous gas, and is present in up 64% of patients (<xref rid="r27" ref-type="bibr">27</xref>).</p><p>Although genitourinary trauma comprises up to 10% of all patients presenting with other traumatic issues, scrotal/testicular trauma comprises 27.8% to 68.1% of those cases (<xref rid="r28" ref-type="bibr">28</xref>,<xref rid="r29" ref-type="bibr">29</xref>). Scrotal trauma encompasses both blunt and penetrating injuries, animal/human bites, and burns. The majority of scrotal trauma is blunt in nature (85%) (<xref rid="r30" ref-type="bibr">30</xref>), while gun-shot wounds (GSWs) (55%), stab wounds (42%), and bites (3%) account for the remaining 15% of injuries (<xref rid="r30" ref-type="bibr">30</xref>). Genital burn injuries are relatively rare, as the penis and scrotum are mobile, and protected on either side by the lower extremities. In patients presenting to burn centers, the reported incidence was 2.8% to 13%, and the most frequent causes include: flames (24–77%), hot liquids (15–64%), and chemicals (8–16%) (<xref rid="r31" ref-type="bibr">31</xref>,<xref rid="r32" ref-type="bibr">32</xref>).</p><p>Genital lymphedema encompasses a wide-variety of pathologies, and can present as mild edema or overt elephantiasis (<xref ref-type="fig" rid="f2"><italic>Figure 2</italic></xref>). Typically, it is categorized based on its time of onset, underlying pathology, or by its location (penile, scrotal, penoscrotal). As it is an amalgamation of multiple underlying disease processes, its true incidence is difficult to discern. Underlying causes include: neoplasm, infection, radiation therapy, iatrogenic, and congenital, amongst others (<xref rid="r33" ref-type="bibr">33</xref>,<xref rid="r34" ref-type="bibr">34</xref>). Neoplasm, such as prostate, bladder, penile, colorectal, gynecologic, or hematologic can cause malignant infiltration of inguinal lymphatic channels with resultant dilation of distal vessels. Prostatectomy with pelvic lymph node dissection may carry an up to 15–30% risk of lower extremity lymphedema, and 50% of these patients may have involvement of penis/scrotum (<xref rid="r35" ref-type="bibr">35</xref>). Patients with scrotal lymphedema may be present with slowly- or rapidly-progressing edema of the scrotum, depending on pathology. Diagnosis is usually made with history and physical examination, although occasionally imaging using ultrasound, CT, or magnetic resonance imaging (MRI), or lymphoscintigraphy may be needed to diagnose underlying cause.</p><fig id="f2" fig-type="figure" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Genital lymphedema. (A) Idiopathic genital lymphedema refractory to conservative management; (B) several months post-operative from excision of edematous tissue and STSG with donor site from left anterior thigh. STSG, split-thickness skin grafts.</p></caption><graphic xlink:href="tau-06-04-710-f2"></graphic></fig><p>HS is a debilitating, chronic inflammatory disease of apocrine glands, commonly in the axilla, groin/perineum, and gluteal clefts. Although not frequently discussed, its incidence is anywhere between 1–4% of the population (<xref rid="r36" ref-type="bibr">36</xref>), more frequently affecting those in their third decade. Perineal and genital involvement occurs in 24% of all patients with HS, and may recur in up to 75% (<xref rid="r37" ref-type="bibr">37</xref>). Important risk factors implicated in the development of HS include tobacco smoking, obesity and a positive family history (<xref rid="r38" ref-type="bibr">38</xref>). HS typically presents with an insidious nature, with small areas of pain, erythema, or tender nodularity and can progress to large, sometimes coalescent abscesses, which lead to sinus-tract formation, progressive fibrosis, and local lymphedema.</p></sec><sec><title>Management of conditions requiring scrotal skin resection</title><p>The initial management of scrotal skin loss is largely dependent on the inciting disease process. In order to appropriately manage FG, genital lymphedema, and hidradenitis, surgical principles mandate the resection of affected genital skin with either immediate or eventual reconstruction of the wound defects. FG, in particular, carries with it substantial morbidity, and a reported mortality between 20–40% in historical series, although this is likely an overestimation in contemporary practice (<xref rid="r22" ref-type="bibr">22</xref>). As such, the necrotizing soft tissue infection must be treated early and aggressively. Immediate management includes hemodynamic monitoring, fluid resuscitation, and administration of broad-spectrum antibiotics with adequate coverage of gram-positive, gram-negative, aerobic, and anaerobic bacteria. We prefer a common antibiotic regimen consisting of gentamicin, metronidazole or clindamycin, and a third-generation cephalosporin (ceftriaxone, ceftazidime, etc.); unusual causes may require the use of alternative antibiotics or antifungals. FG requires emergent and radical surgical debridement with irrigation of all non-viable tissue until healthy, bleeding edges are encountered. However, it is almost always necessary to perform multiple debridements and we often recommend at least one “second look” visit to the operating room to thoroughly examine the patient and assess the viability of the tissues with the patient asleep (<xref rid="r39" ref-type="bibr">39</xref>). At our institution, our second-look procedures serve to validate our previous debridements; if we encounter additional non-viable tissue, we proceed to additional take-backs until no additional debridement is necessary. In highly aggressive cases, a multidisciplinary approach with general surgery colleagues may be required in the event of abdominal involvement as loop colostomy performance might be necessary. However, at our institution, we manage all genital wounds primarily; for extensive wounds that start in the genitalia and proceed into the abdomen, we have involved plastic surgery for management of the abdominal component. Another acceptable management strategy might call for urologists to debride the patient’s genitalia as much as is indicated prior transitioning all wound management to plastic surgery colleagues.</p><p>Due to the robust blood supply to the testicles, orchiectomy during FG presentation is only rarely indicated (<xref rid="r40" ref-type="bibr">40</xref>,<xref rid="r41" ref-type="bibr">41</xref>). In cases of extensive scrotal involvement, the use of anteromedial thigh pouches was historically described in order to house the testicles and preserve viability and future fertility. This is accomplished first by complete mobilization of the testes and spermatic cord to the external inguinal ring for adequate length. The thigh pouches are then created on the anteromedial thigh using blunt dissection to expose the fascia lata. As described historically, the testicles are to be placed within the pouch anteriorly, and at differing levels such that rubbing and local trauma is avoided when the patient is moving their lower extremities. Importantly, though, we feel thigh pouches to be an unnecessary step in FG management as this historic technique is often not necessary in contemporary practice. Further, in our experience, patients with thigh pouches tend to have significant groin pain and discomfort while walking regardless of anterior location of the pouches. Instead, we prefer to keep the testicles wrapped with saline gauze or included in the vacuum-assisted closure (VAC) dressing of the entire FG wound.</p><p>Following surgical debridement, local wound care is paramount and consists of several options: wet-to-dry (WTD) dressings with frequent changes (BID or TID) and/or the use of negative-pressure vacuum therapy or VAC. We usually prefer to initially manage all patients with WTD dressings prior to the “second look” operation. Once tissue viability is confirmed at the second operation and no additional debridement is required, we often perform VAC therapy with a plan of changing the VAC every 48–72 hours. Depending on severity of the infection and patient comfort, we have often brought patients to the operating room simply for wound inspection and VAC change under anesthesia—as successful VAC placement is predicated on having a good seal for the VAC sponges. The use of the wound-VAC confers multiple advantages to the patient and surgeon alike: a theoretically faster rate of granulation tissue formation, reduced microbial load, fewer dressing changes, and faster wound healing (<xref rid="r42" ref-type="bibr">42</xref>-<xref rid="r45" ref-type="bibr">45</xref>). Usual settings for VAC therapy are continuous suction at 125 mmHg, as higher pressures may decrease local blood flow. Importantly, urologists may struggle in maintaining suction to 125 mmHg due to the various creases in and around the genitalia. In these cases, we have had success with placing the wound VAC to wall suction in our inpatient population. Once the serial debridements have been performed and the patient has been stabilized, the urologist is often confronted with a large defect that requires closure (<xref ref-type="fig" rid="f3"><italic>Figure 3</italic></xref>). Our preference is to wait at least a period of 7–10 days prior to undertaking skin graft closure of genital wound defects in FG patients.</p><fig id="f3" fig-type="figure" orientation="portrait" position="float"><label>Figure 3</label><caption><p>Fournier’s gangrene. (A) A large penoscrotal and suprapubic defect after multiple surgical debridements for Fournier’s gangrene. The majority of the wound base is covered in healthy, “beefy-red” granulation tissue; (B) approximately 2 weeks post-operative from STSG of penoscrotal defects. STSG, split-thickness skin grafts.</p></caption><graphic xlink:href="tau-06-04-710-f3"></graphic></fig><p>In contrast to FG, scrotal injuries caused by trauma, burns, and occasionally bites are initially managed as per ATLS algorithms, and are usually found on secondary or tertiary survey. Typically, once the patient is stable hemodynamically and concerns over other visceral injuries have ruled out, attention can be turned to the scrotum. Scrotal wounds should be copiously irrigated with normal saline and all visible debris should be removed. If indicated, the patient should receive antimicrobial and tetanus prophylaxis. Scrotal injuries caused by burns, penetrating trauma, or infection should undergo local exploration and debridement per the AUA urotrauma guidelines (<xref rid="r46" ref-type="bibr">46</xref>). If there is any indication of Dartos violation, we have an extremely low-threshold to proceed for scrotal exploration since missed testicular injuries could result in orchalgia, hematoma, or testicular atrophy. However, in cases where the degree of injury is unknown or where we might have an exceedingly low threshold to intervene surgically, we prefer to utilize scrotal ultrasound to rule-out testicular violation. The ultrasound finding of testicular heterogeneity with loss of contour has been shown previously to be highly sensitive and specific for testicular injury (<xref rid="r47" ref-type="bibr">47</xref>).</p><p>Burns to the genitalia and perineum should be managed similarly to burns elsewhere: removal of substance or clothing that may be contaminated/burning, rapid cooling of tissue to prevent further burns, and local wound care. Non-viable tissue should be debrided until healthy tissue is apparent, however, it appears that conservative management of genital burns may salvage tissue between 61–90% of the time (<xref rid="r32" ref-type="bibr">32</xref>). The use of fecal and urinary diversion to promote wound healing, or prevent wound infection in burns or other forms of scrotal skin loss remains controversial and might not be necessary (<xref rid="r48" ref-type="bibr">48</xref>). In a review of 1987 patients presenting to the University of Washington Burn Center, Peck and colleagues were able to show that none of their patients required use of indwelling urinary catheter for management of burns, other than acute resuscitation (<xref rid="r49" ref-type="bibr">49</xref>). The only instances where we have found urinary and/or fecal diversion to be useful has been in highly refractory and aggressive cases of FG that require extensive and numerous attempts at debridement.</p><p>Genital lymphedema is managed conservatively at first, focused on treating the underlying disease process. Initial management includes scrotal elevation and/or compression, and local wound-care once lymphorrhea occurs. In a series of 90 patients presenting with genital lymphedema, Garaffa and colleagues showed that 64% (56/90) were successfully managed with conservative therapy (<xref rid="r34" ref-type="bibr">34</xref>). Once local therapy fails, however, the patient may opt for surgical therapy and this consists of complete resection of scrotal epidermis and dermis, which carry the lymphatic channels. Likewise, HS is managed conservatively at first with antibiotic therapy, immunosuppressive agents, and incision and drainage of small abscesses. In a 10-year study of 56 patients undergoing surgical management for their HS, Kagan and colleagues reported roughly two-thirds of patients underwent more than one incision and drainage, and more than 90% were treated with long-term antibiotics (<xref rid="r50" ref-type="bibr">50</xref>). Although there are promising trials for targeted immunotherapy as a sole management strategy for HS, surgery remains the mainstay for refractory cases in contemporary practice (<xref rid="r51" ref-type="bibr">51</xref>). These findings indicate that conservative measures are likely not curative in nature.</p><p>In many non-aggressive and isolated cases of trauma, hidradenitis, and lymphedema, once resection and/or debridement of all involved tissue has been performed, the possibility of primary skin closure needs to be assessed. It is our experience for scrotal pathology in particular that only 40% of the native, uninvolved scrotum needs to be present in order for the urologist to undertake primary closure. In these cases, our recommendation would be to utilize at least 2 to 3 layers of Dartos closure with absorbable suture prior to undertaking skin closure in an interrupted fashion. In most cases of primary scrotal wound closure, it is also our recommendation to leave a closed suction drain for a period of at least 3 days.</p></sec><sec><title>Technical considerations of skin grafting for scrotal reconstruction</title><p>Once total or near-total (>60%) scrotal skin loss has occurred, there are several reconstructive management options: split-thickness skin grafts (STSG), full-thickness skin grafts (FTSG), or a variety of myocutaneous or fasciocutaneous flaps (<xref rid="r52" ref-type="bibr">52</xref>-<xref rid="r55" ref-type="bibr">55</xref>). Although there are potential benefits and risks to these approaches, the reality is that outcomes are relatively similar when comparing these approaches (<xref rid="r56" ref-type="bibr">56</xref>). There are several important issues to consider prior to scrotal reconstruction, in particular: optimal timing, choice of technique and their effects on sexual function, and after-care. At a minimum, reconstructive efforts should be delayed until all infected or non-viable tissue has been debrided—this effort may take several separate debridements—but in many cases of hidradenitis and lymphedema involving the scrotum/penis, concomitant STSG can be performed after all tissue has been resected and healthy bleeding edges are achieved, many times during the index operation itself.</p><p>The choice of technique is often dependent on surgeon comfort, wound-type, the patient’s fertility goals, and the health of surrounding tissues. At our institution, we tend to utilize STSGs for scrotal reconstruction, as it carries high-success rates in a variety of conditions (<xref rid="r38" ref-type="bibr">38</xref>,<xref rid="r57" ref-type="bibr">57</xref>,<xref rid="r58" ref-type="bibr">58</xref>), and is technically easy to perform. Specifically, when comparing STSG to flaps, skin grafting offers a more natural appearance of the scrotum, provides sub-abdominal temperatures for spermatogenesis, results in minimal post-operative morbidity, and can often be performed in a single stage (<xref rid="r59" ref-type="bibr">59</xref>).</p><p>Our preference is to utilize the thigh as the donor site for all STSG cases involving only the scrotum and penis. For extensive reconstructions that involve abdominal tissue resection (due to buried penis or lymphedema), we have also had success with utilizing the abdominal skin as a donor site at the area of resection if the skin is not diseased with the primary pathology. We utilize a pneumatic dermatome at a thickness of 0.018 inches and proceed to mesh the graft for all scrotal and abdominal coverage at a ratio of 1.5:1 which allows for relatively small grafts to cover a larger defect (<xref ref-type="fig" rid="f4"><italic>Figure 4</italic></xref>). In order to promote the best cosmetic appearance, we tend to avoid meshed grafts for penile wound coverage only. Importantly, we also feel that meshing results in a more natural cosmetic appearance for the scrotum weeks to months following reconstruction (<xref ref-type="fig" rid="f2"><italic>Figures 2-4</italic></xref><xref ref-type="fig" rid="f3"></xref><xref ref-type="fig" rid="f4"></xref>). Importantly, lubricants such as mineral oil should be spread liberally over the donor site in order to reduce friction prior to dermatome passage. We also stress application of the dermatome at a 45-degree angle to ensure proper and even depth. Before the graft is applied to the scrotal defect, the testes should be sutured together in the midline using 3-0 absorbable suture, and we prefer Vicryl (Ethicon, Inc., Piscataway, NJ, USA); this prevents testicular torsion and allows for the appearance of a bifid, natural-appearing scrotum (<xref ref-type="fig" rid="f3"><italic>Figure 3</italic></xref>). If the testes do not come together in the midline, further mobilization of the spermatic cord up to the level of the external ring may be required. Before the testes are covered with the skin graft, we cover the surgical bed with Artiss fibrin sealant which is a longer acting version of Tisseel (Baxter Healthcare, Inc., Deerfield, Il, USA). Artiss allows the surgeon several additional minutes to place the graft and tailor it appropriately prior to the graft being set.</p><fig id="f4" fig-type="figure" orientation="portrait" position="float"><label>Figure 4</label><caption><p>Hidradenitis suppurativa. (A) Refractory HS of the lower abdomen, penis, scrotum, and superomedial thighs; (B) wide excision of involved tissue; (C) immediate post-STSG with donor sites from anterior thigh and abdominal pannus. A mesh ratio of 1.5:1 allows the relatively small donor sites to cover the expansive wound base. STSG, split-thickness skin grafts; HS, hidradenitis suppurativa.</p></caption><graphic xlink:href="tau-06-04-710-f4"></graphic></fig><p>We strongly believe in previously reported data that wound sealants help overall success with graft adherence (<xref rid="r60" ref-type="bibr">60</xref>-<xref rid="r62" ref-type="bibr">62</xref>). Once the graft has been laid, its edges should be fixated with either skin staples or absorbable sutures, although we exclusively use 3-0 or 4-0 Chromic sutures (Ethicon, Inc., Piscataway, NJ, USA) in an interrupted fashion around the graft edges and have found that quilting stitches can be kept to a minimum following fibrin glue fixation. Traditionally, grafts were held in-place post-operatively with bolstered dressings, commonly using petroleum-based gauze directly over the graft site; however, our preference is to immobilize grafts with VAC devices which stay for a period of 3–5 days based on the severity of the reconstructive repair. The use of negative-pressure dressings has been well-studied and shown to be efficacious at improving graft-take compared to traditional dressings (<xref rid="r63" ref-type="bibr">63</xref>,<xref rid="r64" ref-type="bibr">64</xref>). During this time period, patients should be on strict bed-rest to prevent disruption of the graft during its most vulnerable period. The donor sites can be coated with mineral oil or antibiotic ointment and covered with Tegaderm dressings (3M, Maplewood, MN, USA) for as long as possible (hopefully days to even weeks). For large donor defects, our preference is to place a closed suction drain underneath the Tegaderm dressing in order to prevent wound seepage. Once the dressings have been removed, patients are instructed to apply antibiotic ointment or Xeroform (Medtronic, Minneapolis, MN, USA) bandaging as needed, bathe as usual, and to keep the area dry if good wound healing has occurred.</p><p>In our experience, the most common complication after scrotal skin grafting is wound breakdown, which commonly occurs around the graft edges. In most instances, local wound care with topical agents will provide sufficient treatment. Our patients with non-healing wounds are encouraged to visit our office frequently for wound checks. Additionally, patients can send pictures—securely—for more frequent monitoring of their wounds. Rarely in our experience have patients needed reoperation for wound breakdown after STSG.</p></sec><sec><title>Testicular prosthetics</title><p>Testicular absence can represent a psychologically traumatic experience in both male children and adults (<xref rid="r65" ref-type="bibr">65</xref>). As such, testicular prostheses can be used for a variety of reasons in both children and adults, including testicular torsion, trauma, cancer, atrophy, or transgender reassignment. Though the prosthesis does not provide function, the preservation of male sexual body image is achieved. Testicular prostheses have transformed over the years to today’s current model, which is silicone-coated and saline filled.</p><p>Though a variety of testicular prostheses exist, only one is FDA-approved in the United States, the Coloplast Torosa (Coloplast, Minneapolis, MN, USA). Although there are other testicular prostheses available in the European and Asian markets, these are not FDA-approved due to the silicone composition of these devices (<xref rid="r66" ref-type="bibr">66</xref>). A 5-year multi-center prospective trial across 18 centers in 1998–1999 assessing the efficacy and safety of the saline-filled testicular prosthesis solidified the FDA’s approval as the current gold-standard testicular prosthesis (<xref rid="r67" ref-type="bibr">67</xref>). The Torosa comes in four sizes: extra small, small, medium, and large. Each size corresponds to a fill-volume, and the injectable saline is introduced into the injection port opposite the suture tab. The injection port can only be pierced a total of five times.</p><p>Strict aseptic technique is critical during placement of testicular prostheses to prevent infection. A retrospective cohort study out of UCLA in 2002 reported an incidence of 7.3% of patients having a superficial or local wound infection (<xref rid="r68" ref-type="bibr">68</xref>). Although there is not one single way to achieve complete sterility, the common routine involves a pre-scrub, perioperative antibiotics, and irrigation within the wound with an antimicrobial solution once the prosthesis is inserted. Most surgeons will change gloves prior to handling the prosthesis. Similar to penile implants, perioperative antibiotics should be geared towards gram-positive, gram-negative, and anaerobic organisms. Bodiwala and colleagues describe conditions used to prevent testicular prosthesis-associated infections, including: sterile urine, pre-operative chlorhexidine shower, perioperative pubic hair shave, systemic and local antibiotics, 10 minute betadine scrub, double gloving, water-proof drapes, and avoiding hematomas (<xref rid="r65" ref-type="bibr">65</xref>).</p><p>Testicular implants can be placed through a variety of approaches. Surgically implanting a testicular prosthesis can be achieved via a trans-scrotal, high-scrotal, or an inguinal incision. In our adult population, it is our preference to utilize a high scrotal incision for device placement, while some pediatric colleagues tend to perform inguinal approaches due to a higher risk of scrotal erosion (<xref rid="r66" ref-type="bibr">66</xref>). Utilization of a high scrotal incision in adults allows for more directed placement and anchoring of the testicular device while also preventing the device from eroding through the scrotum due to the higher location of the incision.</p><p>Alternatively, Bush and colleagues describe a technique of placing a testicular prostheses intravaginally at the time of orchiectomy in patients with unsalvageable testes secondary to testicular torsion (<xref rid="r69" ref-type="bibr">69</xref>). Although reported with a relatively small cohort (n=12), there were no infectious complications or extrusions at a 5-month median follow up. Furthermore, reported advantages included orthotopic position, extra tunica vaginalis barrier layer, and avoidance of a second anesthetic procedure for placement.</p><p>The supra-scrotal or low-inguinal incision is an additional approach commonly used and preferred by pediatric urology colleagues in our region. In this technique, a semilunar incision is made at the junction of the scrotum and the abdominal pubic skin, the intrascrotal space is developed, and the prosthesis is placed. Advocates of this technique report a lower rate of infection as the prosthesis is not in contact with the incision, the pubic hairline can easily hide the incision, and the distance from incision to the scrotum is shorter compared to the inguinal approach (<xref rid="r70" ref-type="bibr">70</xref>). Zaontz and colleagues also describe a technique involving the use of a vaginal speculum in placing a prosthesis through an inguinal incision in pediatric patients (<xref rid="r71" ref-type="bibr">71</xref>). Placement of testicular prosthesis through an inguinal incision is an easy, ancillary maneuver at the time of orchiectomy, especially for those undergoing orchiectomy for testis cancer. Once orchiectomy has been performed, the scrotum is invaginated, and the prosthesis is sutured into place using permanent suture, taking care to not button-hole the scrotal skin.</p><p>Although testicular prostheses have high patient satisfaction, they are not without issues. The most common somatic complications associated with testicular prosthetic surgery are infection (0.6–4%), chronic pain (1–3%), extrusion (3–8%), and hematoma (0.3–3%) (<xref rid="r72" ref-type="bibr">72</xref>,<xref rid="r73" ref-type="bibr">73</xref>). In terms of dissatisfaction, common complaints include abnormal perceived size of the prosthesis, firmness different than the normal testis, or implant migration to a higher location (<xref rid="r73" ref-type="bibr">73</xref>). Regardless, implantation of prostheses is associated with significant improvements in self-esteem using various validated questionnaires (<xref rid="r73" ref-type="bibr">73</xref>,<xref rid="r74" ref-type="bibr">74</xref>), and can be easily accomplished using a variety of techniques.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>We describe several surgical conditions of the scrotum commonly encountered by urologists, ranging from hydrocelectomy to split-thickness skin grafting of the scrotum. Our hope is that the techniques described along with their associated pearls, pitfalls, and complications, will allow more urologists to feel confident in performing these procedures. Below are several key take-home points that summarize our review:</p><list list-type="roman-upper" id="L1"><list-item><p>Early surgical take-back for evacuation of scrotal hematomas is a difficult, but often-necessary decision following scrotal surgery;</p></list-item><list-item><p>The use of closed-suctions drains for complex scrotal wounds may obviate the need for repeat surgical intervention and we believe this may further help prevent scrotal hematoma formation;</p></list-item><list-item><p>The management of FG should include, at a minimum, one second-look procedure under anesthesia to ensure adequate debridement of non-viable tissue;</p></list-item><list-item><p>Wound/graft breakdown of the genitalia can frequently be managed successfully with conservative, local wound-care, and home/office nursing visits;</p></list-item><list-item><p>In cases with large wound VAC coverage, adherence can be improved with wall-suction, and/or using smaller strips of clear, occlusive dressing;</p></list-item><list-item><p>STSG adherence can be optimized with the use of a fibrin glue, and often makes placement of the graft technically easier obviating the need for excessive quilting sutures.</p></list-item></list></sec></body><back><ack><title>Acknowledgements</title><p>None.</p></ack><fn-group><fn fn-type="COI-statement"><p><italic>Conflicts of Interest</italic>: Jay Simhan is a consultant/advisor for the Coloplast Group and Boston Scientific.</p></fn></fn-group><ref-list><title>References</title><ref id="r1"><label>1</label><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mihmanli</surname><given-names>I</given-names></name><name><surname>Kantarci</surname><given-names>F</given-names></name><name><surname>Kulaksizoglu</surname><given-names>H</given-names></name><etal></etal></person-group><article-title>Testicular size and vascular resistance before and after hydrocelectomy.</article-title><source>AJR Am J 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