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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Role of Pelvic Lymphadenectomy in the Treatment of Bladder Cancer: A Mini Review</title><author><name sortKey="Ku, Ja Hyeon" sort="Ku, Ja Hyeon" uniqKey="Ku J" first="Ja Hyeon" last="Ku">Ja Hyeon Ku</name><affiliation><nlm:aff id="A1">Department of Urology, Seoul National University Hospital, Seoul, Korea.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20577602</idno><idno type="pmc">2890052</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890052</idno><idno type="RBID">PMC:2890052</idno><idno type="doi">10.4111/kju.2010.51.6.371</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">004B31</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004B31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Role of Pelvic Lymphadenectomy in the Treatment of Bladder Cancer: A Mini Review</title><author><name sortKey="Ku, Ja Hyeon" sort="Ku, Ja Hyeon" uniqKey="Ku J" first="Ja Hyeon" last="Ku">Ja Hyeon Ku</name><affiliation><nlm:aff id="A1">Department of Urology, Seoul National University Hospital, Seoul, Korea.</nlm:aff></affiliation></author></analytic><series><title level="j">Korean Journal of Urology</title><idno type="ISSN">2005-6737</idno><idno type="eISSN">2005-6745</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Although radical cystectomy with pelvic lymph node dissection (PLND) is the standard treatment for muscle-invasive bladder cancer, the optimal extent of PLND and the minimum number of nodes that should be examined for pathology remain unclear. However, evidence is growing that extended PLND has additional diagnostic and therapeutic benefits relative to standard PLND. In particular, a more meticulous and extended PLND may improve the disease-free survival of node-negative patients because it removes undetected micrometastases. Indeed, some patients with positive nodes can be cured by surgery alone, even those with gross adenopathy. Increasing lines of evidence also suggest that the extent of the primary bladder tumor, the number of lymph nodes that are removed, and the lymph node tumor burden are important prognostic variables in patients undergoing cystectomy. Therefore, extended PLND may not only provide improved prognostic information, it may also have a clinically significant therapeutic benefit for both lymph node-positive and node-negative patients undergoing radical cystectomy. Although the absolute limits of PLND remain to be determined, evidence supports the notion that a more extended PLND should include the common iliac vessels and presacral lymph nodes at cystectomy. Such PLND should only be performed in patients who are appropriate surgical candidates. Prospective, randomized trials are needed to properly establish the extent of PLND that is required to generate these benefits.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Prout, Gr" uniqKey="Prout G">GR Prout</name></author><author><name sortKey="Marshall, Vf" uniqKey="Marshall V">VF Marshall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skinner, Dg" uniqKey="Skinner D">DG Skinner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vazina, A" uniqKey="Vazina A">A Vazina</name></author><author><name sortKey="Dugi, D" uniqKey="Dugi D">D Dugi</name></author><author><name sortKey="Shariat, Sf" uniqKey="Shariat S">SF Shariat</name></author><author><name sortKey="Evans, J" uniqKey="Evans J">J Evans</name></author><author><name sortKey="Link, R" uniqKey="Link R">R Link</name></author><author><name sortKey="Lerner, Sp" uniqKey="Lerner S">SP 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article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Korean J Urol</journal-id><journal-id journal-id-type="publisher-id">KJU</journal-id><journal-title-group><journal-title>Korean Journal of Urology</journal-title></journal-title-group><issn pub-type="ppub">2005-6737</issn><issn pub-type="epub">2005-6745</issn><publisher><publisher-name>The Korean Urological Association</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20577602</article-id><article-id pub-id-type="pmc">2890052</article-id><article-id pub-id-type="doi">10.4111/kju.2010.51.6.371</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Role of Pelvic Lymphadenectomy in the Treatment of Bladder Cancer: A Mini Review</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Ku</surname><given-names>Ja Hyeon</given-names></name><xref ref-type="aff" rid="A1"></xref></contrib></contrib-group><aff id="A1">Department of Urology, Seoul National University Hospital, Seoul, Korea.</aff><author-notes><corresp>Corresponding Author: Ja Hyeon Ku. Department of Urology, Seoul National University Hospital, 28, Yeongeon-dong, Jongno-gu, Seoul 110-744, Korea. TEL: +82-2-2072-0361, FAX: +82-2-742-4665, <email>kuuro70@snu.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>21</day><month>6</month><year>2010</year></pub-date><volume>51</volume><issue>6</issue><fpage>371</fpage><lpage>378</lpage><history><date date-type="received"><day>14</day><month>5</month><year>2010</year></date><date date-type="accepted"><day>28</day><month>5</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © The Korean Urological Association, 2010</copyright-statement><copyright-year>2010</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0">http://creativecommons.org/licenses/by-nc/3.0</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Although radical cystectomy with pelvic lymph node dissection (PLND) is the standard treatment for muscle-invasive bladder cancer, the optimal extent of PLND and the minimum number of nodes that should be examined for pathology remain unclear. However, evidence is growing that extended PLND has additional diagnostic and therapeutic benefits relative to standard PLND. In particular, a more meticulous and extended PLND may improve the disease-free survival of node-negative patients because it removes undetected micrometastases. Indeed, some patients with positive nodes can be cured by surgery alone, even those with gross adenopathy. Increasing lines of evidence also suggest that the extent of the primary bladder tumor, the number of lymph nodes that are removed, and the lymph node tumor burden are important prognostic variables in patients undergoing cystectomy. Therefore, extended PLND may not only provide improved prognostic information, it may also have a clinically significant therapeutic benefit for both lymph node-positive and node-negative patients undergoing radical cystectomy. Although the absolute limits of PLND remain to be determined, evidence supports the notion that a more extended PLND should include the common iliac vessels and presacral lymph nodes at cystectomy. Such PLND should only be performed in patients who are appropriate surgical candidates. Prospective, randomized trials are needed to properly establish the extent of PLND that is required to generate these benefits.</p></abstract><kwd-group><kwd>Cystectomy</kwd><kwd>Lymph node excision</kwd><kwd>Urinary bladder neoplasms</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>INTRODUCTION</title><p>High-grade muscle-invasive bladder cancer is regarded as a potentially lethal disease that has a high propensity for spreading. If left untreated, 85% of these patients will die from the disease within 2 years of diagnosis [<xref ref-type="bibr" rid="B1">1</xref>]. Radical cystectomy with bilateral pelvic lymph node dissection (PLND) is the standard treatment for high-grade invasive bladder cancer. In 1982, Skinner recognized for the first time that PLND could be curative for those bladder cancer patients who have only a few small positive lymph nodes [<xref ref-type="bibr" rid="B2">2</xref>]. He concluded that a meticulous PLND that extends to the common iliac vessels and the distal aorta and vena cava does not increase the morbidity or mortality associated with cystectomy and can make a difference in terms of survival. However, despite the accumulating evidence suggesting that a more extensive PLND is an important component in the surgical management of bladder cancer, how extensive PLND should be and what role it plays in reducing bladder cancer mortality remain unclear.</p></sec><sec><title>LYMPHATIC DRAINAGE OF THE BLADDER</title><p>The primary drainage of the bladder starts from the external and internal iliac and obturator sites, secondary drainage is from the common iliac sites, and tertiary drainage to the presacral nodes is from the trigone and posterior bladder wall [<xref ref-type="bibr" rid="B3">3</xref>].</p><p>Standard PLND is currently defined by the following boundaries: the common iliac bifurcation (cephalad extent), the genito-femoral nerve (lateral), the circumflex caudal iliac vein and lymph node of Cloquet (distal), and the hypogastric vessels (posterior), including the obturator fossa. The whole primary lymphatic drainage system of the bladder is contained within these boundaries. Extended PLND should include the nodes contained within the following boundaries: the aortic bifurcation and common iliac vessels (proximal/cephalad); the genito-femoral nerve (lateral); the circumflex (distal) and caudal iliac vein and lymph node of Cloquet; the hypogastric vessels (posterior), including the obturator fossa; and the presacral lymph nodes anterior to the sacral promontory. These boundaries potentially guarantee the complete removal of the primary, secondary, and tertiary lymph node drainage systems of the bladder, which will aid the accuracy of staging.</p><p>The group from Mansoura suggested that the endopelvic (obturator and internal iliac) lymph nodes could serve as lymphatic drainage sentinels; they also speculated that if histology of frozen sections of endopelvic nodes revealed that the nodes were negative, there was no justification for extending the PLND superiorly [<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B5">5</xref>]. This possibility should be confirmed by larger studies.</p></sec><sec><title>INCIDENCE OF NODE INVOLVEMENT FOLLOWING RADICAL CYSTECTOMY</title><p>The reported incidence of regional lymph node involvement following radical cystectomy for bladder cancer is between 13% and 30% (<xref ref-type="table" rid="T1">Table 1</xref>) [<xref ref-type="bibr" rid="B3">3</xref>,<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B6">6</xref>-<xref ref-type="bibr" rid="B34">34</xref>]. This incidence correlates positively with the stage of the primary tumor: the higher the stage, the greater the incidence of node involvement [<xref ref-type="bibr" rid="B10">10</xref>,<xref ref-type="bibr" rid="B12">12</xref>]. The rate of lymph node metastasis increases from 5% in non-muscle-invasive bladder cancer to 18% in superficial muscle-invasive cancer, 27% in deep-muscle-invasive cancer, and 45% in extravesical cancer (pT3-4) [<xref ref-type="bibr" rid="B13">13</xref>]. In addition, Herr reported that the number of patients with positive nodes increases with the number of lymph nodes that are removed [<xref ref-type="bibr" rid="B35">35</xref>]. <xref ref-type="table" rid="T1">Table 1</xref> summarizes the incidence of node metastases in patients treated by radical cystectomy.</p></sec><sec><title>ASSOCIATION BETWEEN LYMPH NODE DISSECTION AND THE NUMBER OF RETRIEVED NODES</title><p>The absolute boundaries of the PLND may be the most important factor determining the number of lymph nodes that can be removed during cystectomy. The extent of PLND and the number of retrieved nodes are summarized in <xref ref-type="table" rid="T2">Table 2</xref> [<xref ref-type="bibr" rid="B3">3</xref>-<xref ref-type="bibr" rid="B5">5</xref>,<xref ref-type="bibr" rid="B7">7</xref>,<xref ref-type="bibr" rid="B10">10</xref>,<xref ref-type="bibr" rid="B12">12</xref>,<xref ref-type="bibr" rid="B17">17</xref>,<xref ref-type="bibr" rid="B22">22</xref>-<xref ref-type="bibr" rid="B26">26</xref>,<xref ref-type="bibr" rid="B28">28</xref>-<xref ref-type="bibr" rid="B30">30</xref>,<xref ref-type="bibr" rid="B34">34</xref>-<xref ref-type="bibr" rid="B43">43</xref>]. In two large cystectomy series that involved extended PLND, the median number of lymph nodes removed was 30 to 43 [<xref ref-type="bibr" rid="B4">4</xref>,<xref ref-type="bibr" rid="B37">37</xref>]. Poulsen et al reported that extending the boundaries of the PLND increased the mean number of retrieved lymph nodes from 14 in a standard PLND to 25 when the dissection was extended to the bifurcation of the aorta [<xref ref-type="bibr" rid="B7">7</xref>].</p><p>The number of lymph nodes that are assessed for pathology also depends on several other factors, including the pathologist's diligence in searching for and preparing the lymph nodes for histopathological evaluation and how the specimen is actually submitted for pathological evaluation. Simply converting from an <italic>en bloc</italic> technique to the submission of six separate lymph node packets increases the mean number of retrieved lymph nodes by more than three-fold [<xref ref-type="bibr" rid="B44">44</xref>]. In addition, individual variation between patients in terms of lymph node numbers may also affect the number of nodes that are retrieved.</p></sec><sec><title>LYMPH NODE STATUS AND PROGNOSIS</title><p>Lymph node status is known to be an important prognostic variable in bladder cancer. Patients with nodal metastases are at high risk of cancer recurrence and death from the disease. Therefore, adjuvant treatment with chemotherapy could benefit this patient population. However, although accurate determination of lymph node status is vital in determining patient prognosis, it is unclear to what extent it should influence decision-making regarding adjuvant therapy.</p><sec><title>1. Number of removed lymph nodes</title><p>A Danish group was the first to assess how the extent of PLND influenced survival [<xref ref-type="bibr" rid="B7">7</xref>]. For this purpose, 194 consecutive patients treated by radical cystectomy were analyzed retrospectively. The authors reported that the 5-year recurrence-free survival rate was 62% for the extended PLND group and 56% for the limited PLND group; this difference did not achieve statistical significance. However, a subgroup analysis of 117 patients with ≤pT3a primary tumors showed that extended and limited PLND were associated with survival rates of 85% and 64%, respectively; this difference was significant.</p><p>Leissner et al reviewed their experience with 447 radical cystectomy cases [<xref ref-type="bibr" rid="B10">10</xref>]. The planned field of dissection was up to the aortic bifurcation and the mean number of removed nodes was 14.7. They found that the number of retrieved nodes correlated with cancer-specific survival and that a significant survival advantage was noted when ≥16 nodes were removed: if more than 16 lymph nodes were removed, the 5-year recurrence-free survival increased from 63% to 85% in organ-confined tumors, from 40% to 55% in pT3 tumors, and from 25% to 53% in patients with up to five lymph node metastases.</p><p>Further support for a thorough PLND at cystectomy is demonstrated by the fact that even N0 patients demonstrate improved survival if more nodes are removed, presumably because this eliminates micrometastatic disease [<xref ref-type="bibr" rid="B35">35</xref>]. Moreover, when Herr et al analyzed 667 patients undergoing radical cystectomy, they found that the survival of both node-negative and node-positive patients was improved and the local recurrence rate was reduced when more lymph nodes were removed [<xref ref-type="bibr" rid="B45">45</xref>].</p><p>These data underscore the importance of a more extended PLND regardless of the presence of node metastases. However, the reasons for the observations described above are less clear. Some clinicians suggest that extended PLND has a potential therapeutic effect that is due to the surgical clearance of micrometastases. Equally if not more plausible explanations are that the retrieval of more lymph nodes improves the accuracy of staging, the guidance of downstream adjuvant therapies, and the differential selection based on health status; however, these possibilities have been relatively discounted.</p><p>These findings indicate that the higher lymph node counts obtained by an extended PLND are associated with improved survival. This observation, together with the fact that up to 25% of the patients who undergo radical cystectomy have nodal metastases and 30% of patients with node-positive disease can be cured by surgery, suggests that thorough PLND is needed to completely remove the disease burden [<xref ref-type="bibr" rid="B13">13</xref>]. However, at present, there is still no widely held consensus regarding the limits or absolute boundaries of PLND or the minimum number of lymph nodes that should be removed.</p></sec><sec><title>2. Tumor burden</title><p>Several studies have demonstrated that greater numbers of cancer-containing nodes are associated with worse survival outcomes, which suggests that a higher number of positive nodes is indicative of a greater tumor burden.</p><p>When Smith and Whitmore analyzed 134 patients who were found after radical cystectomy to have lymph node metastases, they discovered that survival correlated directly with the number of metastatic lymph nodes [<xref ref-type="bibr" rid="B46">46</xref>]. This study was followed by several studies examining the prognostic impact of the tumor burden as defined by the number of positive nodes. This included the study by Herr and colleagues [<xref ref-type="bibr" rid="B45">45</xref>], who showed that the survival of patients with positive nodes who underwent radical cystectomy was significantly better if ≤4 positive nodes were present than if there were >4 positive nodes (37% vs. 13%). In addition, they went on to show that when >11 nodes were resected, patients showed better survival and less recurrence [<xref ref-type="bibr" rid="B45">45</xref>]. Similar observations were made by other groups. For example, Steven and Poulsen [<xref ref-type="bibr" rid="B25">25</xref>] found that overall survival was improved if 5 or fewer positive nodes were detected (50% vs. 13%). Mills et al also showed this [<xref ref-type="bibr" rid="B12">12</xref>], whereas Stein et al found that patients with ≤8 metastatic nodes had significantly better 10-year recurrence-free survival rates than did those with >8 metastatic nodes (40% vs. 10%) [<xref ref-type="bibr" rid="B37">37</xref>]. Moreover, when the Mansoura group stratified positive nodes (1 vs. 2-5 vs. >5), this variable was statistically significant in both the univariate and the multivariate analyses [<xref ref-type="bibr" rid="B17">17</xref>]. This was also the case for a population-based study that used the SEER database (1 vs. 2 vs. 3 vs. >3 positive nodes) [<xref ref-type="bibr" rid="B43">43</xref>].</p><p>However, in the study by Kassouf et al, although the number of involved nodes was significantly associated with recurrence-free survival in the univariate analysis, this variable lost statistical significance in the multivariate analysis [<xref ref-type="bibr" rid="B41">41</xref>].</p></sec><sec><title>3. The concept of lymph node density</title><p>In 2003, Herr introduced the concept of ratio-based lymph node staging for bladder cancer, in which the ratio is the number of positive nodes divided by the total number of retrieved nodes [<xref ref-type="bibr" rid="B35">35</xref>]. This lymph node density concept was an attempt to standardize lymph node staging, which had been complicated by variability in the extent of PLND, the meticulousness with which the pathologist identified and reported nodal counts, and the innate anatomy of individual patients. By standardizing lymph node staging in this manner, patients could be stratified according to node-positivity and adjuvant therapies, and clinical trials could be applied more uniformly. Although various lymph node density cutoff values have been reported in the literature, the most commonly used lymph node cutoff is 20%. Almost all studies performed on this issue have confirmed the independent prognostic significance of lymph node density upon multivariate analysis [<xref ref-type="bibr" rid="B17">17</xref>,<xref ref-type="bibr" rid="B22">22</xref>,<xref ref-type="bibr" rid="B25">25</xref>,<xref ref-type="bibr" rid="B28">28</xref>,<xref ref-type="bibr" rid="B29">29</xref>,<xref ref-type="bibr" rid="B31">31</xref>,<xref ref-type="bibr" rid="B35">35</xref>-<xref ref-type="bibr" rid="B37">37</xref>,<xref ref-type="bibr" rid="B40">40</xref>-<xref ref-type="bibr" rid="B43">43</xref>,<xref ref-type="bibr" rid="B47">47</xref>]. These data are summarized in <xref ref-type="table" rid="T3">Table 3</xref>.</p><p>Because the tumor-node-metastasis (TNM) classification does not account for the surgeon's ability to remove the affected nodal tissue, it may underestimate the extent of regional nodal involvement. Herr et al reported that in a multivariate analysis, lymph node density stratified patients according to disease-specific survival better than did either the conventional staging system or the absolute number of positive lymph nodes [<xref ref-type="bibr" rid="B45">45</xref>]. Similarly, Kassouf et al found that, of the variables tested, only a lymph node density greater than 20% was significantly predictive of a decreased disease-specific survival [<xref ref-type="bibr" rid="B42">42</xref>]. In contrast, Fleischmann et al reported that when multivariate analysis was performed by use of primary tumor stage, the number of positive lymph nodes, lymph node density, and extracapsular nodal extension, only extracapsular nodal extension retained statistical significance [<xref ref-type="bibr" rid="B40">40</xref>].</p><p>Several studies have compared the absolute number of positive nodes with lymph node density in terms of their ability to predict disease-specific survival. Stein et al reported that on multivariate analysis, the number of lymph nodes involved (>8 vs. ≤8) performed better than did lymph node density (>20 vs. ≤20%) in predicting recurrence-free survival, though both factors remained statistically significant [<xref ref-type="bibr" rid="B37">37</xref>]. Similarly, Abdel-Latif et al demonstrated that whereas both the number of positive nodes (1 vs. 2-5 vs. >5) and the lymph node density (<10 vs. 10-20 vs. >20%) were statistically significant in univariate analyses, only the number of positive nodes remained significant in multivariate modeling [<xref ref-type="bibr" rid="B17">17</xref>]. In contrast, Kassouf et al reported that whereas lymph node density (>25 vs. <25%) remained significantly associated with overall and recurrence-free survival in a multivariate model, the number of positive nodes lost statistical significance [<xref ref-type="bibr" rid="B41">41</xref>]. With regard to population-based studies, Konety et al reported that whereas the number of positive nodes did not correlate significantly with survival, the lymph node density showed some predictive ability, especially at a cutoff of 50% [<xref ref-type="bibr" rid="B47">47</xref>]. However, Wright et al found that the number of positive nodes (1 vs. 2 vs. 3 vs. >3) and lymph node density (divided into quartiles) both correlated significantly with diseasespecific and overall survival [<xref ref-type="bibr" rid="B43">43</xref>].</p><p>Thus, lymph node density may be an attractive alternative to lymph node staging. However, because all lymph node density studies performed to date are retrospective, it remains unclear whether lymph node density improves prognostication relative to the standard nodal staging system or the absolute number of positive nodes.</p></sec><sec><title>4. New parameters</title><p>The current TNM system is based on the number of positive lymph nodes and the size of the largest positive lymph node. Recently, a new concept in bladder oncology, namely, the aggregate size of all lymph node metastases, was investigated. Stephenson et al reported that, after adjusting for pathologic T stage, lymphovascular invasion, lymph node density, comorbidity, and extranodal extension, the aggregate lymph node metastasis diameter was a significant predictor of recurrence-free survival and overall survival [<xref ref-type="bibr" rid="B32">32</xref>]. However, important limitations of this study were that few patients underwent an extended PLND and the analysis was retrospective.</p></sec></sec><sec><title>MORBIDITY ASSOCIATED WITH PELVIC LYMPH NODE DISSECTION</title><p>A retrospective analysis did not detect a difference between limited and extended PLND groups in terms of mortality; moreover, the lymphocele formation rate was similar for these two groups (1.5% and 1.6%, respectively) [<xref ref-type="bibr" rid="B7">7</xref>]. Similarly, another study showed that lymphoceles and lymphoedema occurred in 2% and 1% of patients who had <16 and ≥16 lymph nodes removed, respectively [<xref ref-type="bibr" rid="B10">10</xref>]. Moreover, perioperative deaths or early complications that related directly to the PLND were not observed in 1,054 patients who all underwent an extended PLND [<xref ref-type="bibr" rid="B13">13</xref>]. These findings were confirmed recently by a study that questioned whether an extended PLND would increase morbidity in patients who underwent radical cystectomy [<xref ref-type="bibr" rid="B48">48</xref>]. Although the extended PLND increased the operative duration by 63 min, the limited and extended PLND groups did not differ significantly in terms of perioperative mortality, early complications, or the need for blood transfusions. Similarly, when a multicentre study prospectively evaluated the role of an extended PLND in 290 patients undergoing cystectomy for bladder cancer, none of the participating centers reported any significant adverse effects that were related to the extended PLND [<xref ref-type="bibr" rid="B4">4</xref>]. These findings suggest that despite prolonging the operation, an extended PLND does not increase the complication rate either during or after surgery. Indeed, it appears that the morbidity associated with an extended PLND is low and comparable to that associated with a more limited PLND.</p><p>It should be noted that although the administration of neoadjuvant radiation or chemotherapy before cystectomy does not increase the morbidity and mortality associated with cystectomy, patients who have received these treatments should be judged carefully with regard to also undergoing extended PLND [<xref ref-type="bibr" rid="B49">49</xref>]. This is because patients who have had higher doses of radiation therapy (>60 Gy) are at greater risk of vascular and associated injuries when undergoing a cystectomy [<xref ref-type="bibr" rid="B50">50</xref>].</p></sec><sec sec-type="conclusions"><title>CONCLUSIONS</title><p>A recent SEER analysis of 3,603 cystectomies that were performed between 1992 and 2003 revealed that PLND did not seem to be performed routinely during this period; moreover, when it was performed, the number of nodes retrieved was suboptimal [<xref ref-type="bibr" rid="B51">51</xref>]. However, a more recent SEER analysis showed that there has been an improvement over time in terms of the performance of PLND and the node counts obtained during radical cystectomy [<xref ref-type="bibr" rid="B52">52</xref>].</p><p>Lymph node assessment is an important component of bladder cancer staging because nodal status correlates strongly with prognosis. PLND also contributes to the cure of some patients with nodal metastases. Lymph node density may become a more useful prognostic variable in patients with high-risk node-positive disease.</p><p>Although the optimal extent of PLND remains to be defined and cannot be determined on the basis of the retrospective studies that have been published to date, current observations suggest that an extended PLND not only provides prognostic information, it also has a clinically significant therapeutic benefit for patients with invasive bladder cancer. However, whether extended PLND improves overall survival or whether that benefit applies only to particular subgroups should be addressed by randomized clinical trials. 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