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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?</title><author><name sortKey="Tsirlis, Theodore D" sort="Tsirlis, Theodore D" uniqKey="Tsirlis T" first="Theodore D" last="Tsirlis">Theodore D. Tsirlis</name></author><author><name sortKey="Papastratis, George" sort="Papastratis, George" uniqKey="Papastratis G" first="George" last="Papastratis">George Papastratis</name></author><author><name sortKey="Masselou, Kyriaki" sort="Masselou, Kyriaki" uniqKey="Masselou K" first="Kyriaki" last="Masselou">Kyriaki Masselou</name></author><author><name sortKey="Tsigris, Christos" sort="Tsigris, Christos" uniqKey="Tsigris C" first="Christos" last="Tsigris">Christos Tsigris</name></author><author><name sortKey="Papachristodoulou, Antonis" sort="Papachristodoulou, Antonis" uniqKey="Papachristodoulou A" first="Antonis" last="Papachristodoulou">Antonis Papachristodoulou</name></author><author><name sortKey="Kostakis, Alkiviadis" sort="Kostakis, Alkiviadis" uniqKey="Kostakis A" first="Alkiviadis" last="Kostakis">Alkiviadis Kostakis</name></author><author><name sortKey="Nikiteas, Nikolaos I" sort="Nikiteas, Nikolaos I" uniqKey="Nikiteas N" first="Nikolaos I" last="Nikiteas">Nikolaos I. Nikiteas</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18461654</idno><idno type="pmc">2709051</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709051</idno><idno type="RBID">PMC:2709051</idno><idno type="doi">10.3748/wjg.14.2691</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">004897</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004897</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?</title><author><name sortKey="Tsirlis, Theodore D" sort="Tsirlis, Theodore D" uniqKey="Tsirlis T" first="Theodore D" last="Tsirlis">Theodore D. Tsirlis</name></author><author><name sortKey="Papastratis, George" sort="Papastratis, George" uniqKey="Papastratis G" first="George" last="Papastratis">George Papastratis</name></author><author><name sortKey="Masselou, Kyriaki" sort="Masselou, Kyriaki" uniqKey="Masselou K" first="Kyriaki" last="Masselou">Kyriaki Masselou</name></author><author><name sortKey="Tsigris, Christos" sort="Tsigris, Christos" uniqKey="Tsigris C" first="Christos" last="Tsigris">Christos Tsigris</name></author><author><name sortKey="Papachristodoulou, Antonis" sort="Papachristodoulou, Antonis" uniqKey="Papachristodoulou A" first="Antonis" last="Papachristodoulou">Antonis Papachristodoulou</name></author><author><name sortKey="Kostakis, Alkiviadis" sort="Kostakis, Alkiviadis" uniqKey="Kostakis A" first="Alkiviadis" last="Kostakis">Alkiviadis Kostakis</name></author><author><name sortKey="Nikiteas, Nikolaos I" sort="Nikiteas, Nikolaos I" uniqKey="Nikiteas N" first="Nikolaos I" last="Nikiteas">Nikolaos I. Nikiteas</name></author></analytic><series><title level="j">World Journal of Gastroenterology : WJG</title><idno type="ISSN">1007-9327</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denote that quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Gastroenterol</journal-id><journal-id journal-id-type="publisher-id">WJG</journal-id><journal-title-group><journal-title>World Journal of Gastroenterology : WJG</journal-title></journal-title-group><issn pub-type="ppub">1007-9327</issn><publisher><publisher-name>The WJG Press and Baishideng</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18461654</article-id><article-id pub-id-type="pmc">2709051</article-id><article-id pub-id-type="other">jWJG.v14.i17.pg2691</article-id><article-id pub-id-type="doi">10.3748/wjg.14.2691</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tsirlis</surname><given-names>Theodore D</given-names></name></contrib><contrib contrib-type="author"><name><surname>Papastratis</surname><given-names>George</given-names></name></contrib><contrib contrib-type="author"><name><surname>Masselou</surname><given-names>Kyriaki</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tsigris</surname><given-names>Christos</given-names></name></contrib><contrib contrib-type="author"><name><surname>Papachristodoulou</surname><given-names>Antonis</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kostakis</surname><given-names>Alkiviadis</given-names></name></contrib><contrib contrib-type="author"><name><surname>Nikiteas</surname><given-names>Nikolaos I</given-names></name></contrib><aff>Theodore D Tsirlis, George Papastratis, Third Department of Surgery, General Hospital of Athens “G.Gennimatas”, Athens 115 26, Greece</aff><aff>Kyriaki Masselou, Department of Immunology, National Tissue Typing Center, General Hospital of Athens “G.Gennimatas”, Athens 115 26, Greece</aff><aff>Christos Tsigris, Antonis Papachristodoulou, Alkiviadis Kostakis, Nikolaos I Nikiteas, Second Department of Surgery, University of Athens Medical School, Laikon General Hospital, Athens 115 27, Greece</aff></contrib-group><author-notes><fn><p>Author contributions: Tsirlis TD, Nikiteas NI contributed equally to conception and design of the review; Tsirlis TD wrote and revised the review; Papastratis G, Masselou K, Tsigris C, Papachristodoulou A and Kostakis A contributed equally to supportive work and supervision.</p><p>Correspondence to: Theodore D Tsirlis, Third Department of Surgery, General Hospital of Athens “G.Gennimatas”, Psaron 20 str. Agia Paraskevi, Athens 153 43, Greece. <email>theotsir@med.uoa.gr</email></p><p>Telephone: +30-210-6016351</p><p>Fax: +30-210-6867191</p></fn></author-notes><pub-date pub-type="ppub"><day>7</day><month>5</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>7</day><month>5</month><year>2008</year></pub-date><volume>14</volume><issue>17</issue><fpage>2691</fpage><lpage>2701</lpage><history><date date-type="received"><day>8</day><month>1</month><year>2008</year></date><date date-type="rev-recd"><day>22</day><month>3</month><year>2008</year></date></history><permissions><copyright-statement>©2008 The WJG Press and Baishideng. All rights reserved.</copyright-statement><copyright-year>2008</copyright-year></permissions><abstract><p>Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denote that quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies.</p></abstract><kwd-group><kwd>Circulating VEGF-C and VEGF-D</kwd><kwd>Gastric</kwd><kwd>Oesophageal</kwd><kwd>Colorectal cancer</kwd><kwd>Preoperative staging</kwd><kwd>Lymph node metastasis predictive markers</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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