Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Radiation-induced sarcomas of the head and neck</title><author><name sortKey="Thiagarajan, Anuradha" sort="Thiagarajan, Anuradha" uniqKey="Thiagarajan A" first="Anuradha" last="Thiagarajan">Anuradha Thiagarajan</name></author><author><name sortKey="Iyer, N Gopalakrishna" sort="Iyer, N Gopalakrishna" uniqKey="Iyer N" first="N Gopalakrishna" last="Iyer">N Gopalakrishna Iyer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25493233</idno><idno type="pmc">4259957</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259957</idno><idno type="RBID">PMC:4259957</idno><idno type="doi">10.5306/wjco.v5.i5.973</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">004891</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004891</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Radiation-induced sarcomas of the head and neck</title><author><name sortKey="Thiagarajan, Anuradha" sort="Thiagarajan, Anuradha" uniqKey="Thiagarajan A" first="Anuradha" last="Thiagarajan">Anuradha Thiagarajan</name></author><author><name sortKey="Iyer, N Gopalakrishna" sort="Iyer, N Gopalakrishna" uniqKey="Iyer N" first="N Gopalakrishna" last="Iyer">N Gopalakrishna Iyer</name></author></analytic><series><title level="j">World Journal of Clinical Oncology</title><idno type="ISSN">2218-4333</idno><idno type="eISSN">2218-4333</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>With improved outcomes associated with radiotherapy, radiation-induced sarcomas (RIS) are increasingly seen in long-term survivors of head and neck cancers, with an estimated risk of up to 0.3%. They exhibit no subsite predilection within the head and neck and can arise in any irradiated tissue of mesenchymal origin. Common histologic subtypes of RIS parallel their de novo counterparts and include osteosarcoma, chondrosarcoma, malignant fibrous histiocytoma/sarcoma nitricoxide synthase, and fibrosarcoma. While imaging features of RIS are not pathognomonic, large size, extensive local invasion with bony destruction, marked enhancement within a prior radiotherapy field, and an appropriate latency period are suggestive of a diagnosis of RIS. RIS development may be influenced by factors such as radiation dose, age at initial exposure, exposure to chemotherapeutic agents and genetic tendency. Precise pathogenetic mechanisms of RIS are poorly understood and both directly mutagenizing effects of radiotherapy as well as changes in microenvironments are thought to play a role. Management of RIS is challenging, entailing surgery in irradiated tissue and a limited scope for further radiotherapy and chemotherapy. RIS is associated with significantly poorer outcomes than stage-matched sarcomas that arise independent of irradiation and surgical resection with clear margins seems to offer the best chance for cure.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">World J Clin Oncol</journal-id><journal-id journal-id-type="publisher-id">WJCO</journal-id><journal-title-group><journal-title>World Journal of Clinical Oncology</journal-title></journal-title-group><issn pub-type="ppub">2218-4333</issn><issn pub-type="epub">2218-4333</issn><publisher><publisher-name>Baishideng Publishing Group Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25493233</article-id><article-id pub-id-type="pmc">4259957</article-id><article-id pub-id-type="other">jWJCO.v5.i5.pg973</article-id><article-id pub-id-type="doi">10.5306/wjco.v5.i5.973</article-id><article-categories><subj-group subj-group-type="heading"><subject>Topic Highlight</subject></subj-group></article-categories><title-group><article-title>Radiation-induced sarcomas of the head and neck</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Thiagarajan</surname><given-names>Anuradha</given-names></name></contrib><contrib contrib-type="author"><name><surname>Iyer</surname><given-names>N Gopalakrishna</given-names></name></contrib><aff>Anuradha Thiagarajan, Department of Radiation Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore</aff><aff>N Gopalakrishna Iyer, Department of Surgical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore</aff></contrib-group><author-notes><fn><p>Author contributions: Thiagarajan A and Iyer NG conceived, wrote and edited this manuscript.</p><p>Correspondence to: Dr. N Gopalakrishna Iyer, MD, PhD, Department of Surgical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore. <email>gopaliyer@yahoo.com</email></p><p>Telephone: +65-64368294 Fax: +65-62257559</p></fn></author-notes><pub-date pub-type="ppub"><day>10</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>10</day><month>12</month><year>2014</year></pub-date><volume>5</volume><issue>5</issue><fpage>973</fpage><lpage>981</lpage><history><date date-type="received"><day>2</day><month>6</month><year>2014</year></date><date date-type="rev-recd"><day>28</day><month>8</month><year>2014</year></date><date date-type="accepted"><day>14</day><month>10</month><year>2014</year></date></history><permissions><copyright-statement>©2014 Baishideng Publishing Group Inc. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p>With improved outcomes associated with radiotherapy, radiation-induced sarcomas (RIS) are increasingly seen in long-term survivors of head and neck cancers, with an estimated risk of up to 0.3%. They exhibit no subsite predilection within the head and neck and can arise in any irradiated tissue of mesenchymal origin. Common histologic subtypes of RIS parallel their de novo counterparts and include osteosarcoma, chondrosarcoma, malignant fibrous histiocytoma/sarcoma nitricoxide synthase, and fibrosarcoma. While imaging features of RIS are not pathognomonic, large size, extensive local invasion with bony destruction, marked enhancement within a prior radiotherapy field, and an appropriate latency period are suggestive of a diagnosis of RIS. RIS development may be influenced by factors such as radiation dose, age at initial exposure, exposure to chemotherapeutic agents and genetic tendency. Precise pathogenetic mechanisms of RIS are poorly understood and both directly mutagenizing effects of radiotherapy as well as changes in microenvironments are thought to play a role. Management of RIS is challenging, entailing surgery in irradiated tissue and a limited scope for further radiotherapy and chemotherapy. RIS is associated with significantly poorer outcomes than stage-matched sarcomas that arise independent of irradiation and surgical resection with clear margins seems to offer the best chance for cure.</p></abstract><kwd-group><kwd>Post-irradiation</kwd><kwd>Nasopharyngeal carcinoma</kwd><kwd>In-field</kwd><kwd>Radiotherapy</kwd><kwd>Head and neck cancer</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004891 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 004891 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.31. |  |