Advancing Our Understanding of Osteocyte Cell Biology
Identifieur interne : 004880 ( Pmc/Corpus ); précédent : 004879; suivant : 004881Advancing Our Understanding of Osteocyte Cell Biology
Auteurs : Dayong Guo ; Lynda F. BonewaldSource :
- Therapeutic Advances in Musculoskeletal Disease [ 1759-720X ] ; 2009.
Abstract
Osteocytes were the forgotten bone cell until the bone community could become convinced that these cells do serve an important role in bone function and maintenance. In this review we trace the history of osteocyte characterization and present some of the major observations that are leading to the conclusion that these cells are not passive placeholders residing in the bone matrix, but are indeed, major orchestrators of bone remodeling.
Url:
DOI: 10.1177/1759720X09341484
PubMed: 22870430
PubMed Central: 3383482
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PMC:3383482Le document en format XML
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<author><name sortKey="Guo, Dayong" sort="Guo, Dayong" uniqKey="Guo D" first="Dayong" last="Guo">Dayong Guo</name>
<affiliation><nlm:aff id="aff1-1759720X09341484"> University of Missouri, Kansas City, MO, USA</nlm:aff>
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<author><name sortKey="Bonewald, Lynda F" sort="Bonewald, Lynda F" uniqKey="Bonewald L" first="Lynda F." last="Bonewald">Lynda F. Bonewald</name>
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<series><title level="j">Therapeutic Advances in Musculoskeletal Disease</title>
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<front><div type="abstract" xml:lang="en"><p>Osteocytes were the forgotten bone cell until the bone community could become convinced that these cells do serve an important role in bone function and maintenance. In this review we trace the history of osteocyte characterization and present some of the major observations that are leading to the conclusion that these cells are not passive placeholders residing in the bone matrix, but are indeed, major orchestrators of bone remodeling.</p>
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<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ther Adv Musculoskelet Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Ther Adv Musculoskelet Dis</journal-id>
<journal-id journal-id-type="publisher-id">TAB</journal-id>
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<journal-title-group><journal-title>Therapeutic Advances in Musculoskeletal Disease</journal-title>
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<issn pub-type="ppub">1759-720X</issn>
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<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
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<title-group><article-title>Advancing Our Understanding of Osteocyte Cell Biology</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Guo</surname>
<given-names>Dayong</given-names>
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<contrib contrib-type="author"><name><surname>Bonewald</surname>
<given-names>Lynda F.</given-names>
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<degrees>PhD</degrees>
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<aff id="aff1-1759720X09341484"><label>1</label>
University of Missouri, Kansas City, MO, USA</aff>
<author-notes><corresp id="corresp1-1759720X09341484"><label>2</label>
650 E 25th Street, School of Dentistry, Department of Oral Biology, University of Missouri at Kansas City, Kansas City, MO 64108, USA <email xlink:href="bonewaldl@umkc.edu">bonewaldl@umkc.edu</email>
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<pub-date pub-type="epub-ppub"><month>4</month>
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<pub-date pub-type="ppub"><month>4</month>
<year>2009</year>
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<volume>1</volume>
<issue>2</issue>
<fpage>87</fpage>
<lpage>96</lpage>
<permissions><copyright-statement>© The Author(s), 2009</copyright-statement>
<copyright-year>2009</copyright-year>
<copyright-holder content-type="sage">SAGE Publications</copyright-holder>
</permissions>
<abstract><p>Osteocytes were the forgotten bone cell until the bone community could become convinced that these cells do serve an important role in bone function and maintenance. In this review we trace the history of osteocyte characterization and present some of the major observations that are leading to the conclusion that these cells are not passive placeholders residing in the bone matrix, but are indeed, major orchestrators of bone remodeling.</p>
</abstract>
<kwd-group><kwd>osteocytes</kwd>
<kwd>bone remodelling</kwd>
<kwd>parathyroid hormone</kwd>
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