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Advancing Our Understanding of Osteocyte Cell Biology

Identifieur interne : 004880 ( Pmc/Corpus ); précédent : 004879; suivant : 004881

Advancing Our Understanding of Osteocyte Cell Biology

Auteurs : Dayong Guo ; Lynda F. Bonewald

Source :

RBID : PMC:3383482

Abstract

Osteocytes were the forgotten bone cell until the bone community could become convinced that these cells do serve an important role in bone function and maintenance. In this review we trace the history of osteocyte characterization and present some of the major observations that are leading to the conclusion that these cells are not passive placeholders residing in the bone matrix, but are indeed, major orchestrators of bone remodeling.


Url:
DOI: 10.1177/1759720X09341484
PubMed: 22870430
PubMed Central: 3383482

Links to Exploration step

PMC:3383482

Le document en format XML

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<title xml:lang="en">Advancing Our Understanding of Osteocyte Cell Biology</title>
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<name sortKey="Guo, Dayong" sort="Guo, Dayong" uniqKey="Guo D" first="Dayong" last="Guo">Dayong Guo</name>
<affiliation>
<nlm:aff id="aff1-1759720X09341484"> University of Missouri, Kansas City, MO, USA</nlm:aff>
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<author>
<name sortKey="Bonewald, Lynda F" sort="Bonewald, Lynda F" uniqKey="Bonewald L" first="Lynda F." last="Bonewald">Lynda F. Bonewald</name>
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<nlm:aff id="aff1-1759720X09341484"> University of Missouri, Kansas City, MO, USA</nlm:aff>
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<author>
<name sortKey="Bonewald, Lynda F" sort="Bonewald, Lynda F" uniqKey="Bonewald L" first="Lynda F." last="Bonewald">Lynda F. Bonewald</name>
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<title level="j">Therapeutic Advances in Musculoskeletal Disease</title>
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<date when="2009">2009</date>
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<p>Osteocytes were the forgotten bone cell until the bone community could become convinced that these cells do serve an important role in bone function and maintenance. In this review we trace the history of osteocyte characterization and present some of the major observations that are leading to the conclusion that these cells are not passive placeholders residing in the bone matrix, but are indeed, major orchestrators of bone remodeling.</p>
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<journal-id journal-id-type="nlm-ta">Ther Adv Musculoskelet Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Ther Adv Musculoskelet Dis</journal-id>
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<surname>Guo</surname>
<given-names>Dayong</given-names>
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<contrib contrib-type="author">
<name>
<surname>Bonewald</surname>
<given-names>Lynda F.</given-names>
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<degrees>PhD</degrees>
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<label>1</label>
University of Missouri, Kansas City, MO, USA</aff>
<author-notes>
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<label>2</label>
650 E 25th Street, School of Dentistry, Department of Oral Biology, University of Missouri at Kansas City, Kansas City, MO 64108, USA
<email xlink:href="bonewaldl@umkc.edu">bonewaldl@umkc.edu</email>
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<year>2009</year>
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<month>4</month>
<year>2009</year>
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<volume>1</volume>
<issue>2</issue>
<fpage>87</fpage>
<lpage>96</lpage>
<permissions>
<copyright-statement>© The Author(s), 2009</copyright-statement>
<copyright-year>2009</copyright-year>
<copyright-holder content-type="sage">SAGE Publications</copyright-holder>
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<abstract>
<p>Osteocytes were the forgotten bone cell until the bone community could become convinced that these cells do serve an important role in bone function and maintenance. In this review we trace the history of osteocyte characterization and present some of the major observations that are leading to the conclusion that these cells are not passive placeholders residing in the bone matrix, but are indeed, major orchestrators of bone remodeling.</p>
</abstract>
<kwd-group>
<kwd>osteocytes</kwd>
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<kwd>parathyroid hormone</kwd>
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