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<title xml:lang="en">Medical ultrasound: imaging of soft tissue strain and elasticity</title>
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<name sortKey="Wells, Peter N T" sort="Wells, Peter N T" uniqKey="Wells P" first="Peter N. T." last="Wells">Peter N. T. Wells</name>
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<addr-line>School of Engineering</addr-line>
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<institution>Cardiff University</institution>
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<addr-line>Queen's Buildings, The Parade, Cardiff CF24 3AA</addr-line>
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<country>UK</country>
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<name sortKey="Liang, Hai Dong" sort="Liang, Hai Dong" uniqKey="Liang H" first="Hai-Dong" last="Liang">Hai-Dong Liang</name>
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<addr-line>School of Engineering</addr-line>
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<country>UK</country>
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<addr-line>Department of Medical Physics and Bioengineering</addr-line>
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<institution>University Hospitals Bristol NHS Foundation Trust, Bristol General Hospital</institution>
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<addr-line>Bristol BS1 6SY</addr-line>
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<country>UK</country>
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<title xml:lang="en" level="a" type="main">Medical ultrasound: imaging of soft tissue strain and elasticity</title>
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<name sortKey="Wells, Peter N T" sort="Wells, Peter N T" uniqKey="Wells P" first="Peter N. T." last="Wells">Peter N. T. Wells</name>
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<addr-line>School of Engineering</addr-line>
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<institution>Cardiff University</institution>
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<addr-line>Queen's Buildings, The Parade, Cardiff CF24 3AA</addr-line>
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<country>UK</country>
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<name sortKey="Liang, Hai Dong" sort="Liang, Hai Dong" uniqKey="Liang H" first="Hai-Dong" last="Liang">Hai-Dong Liang</name>
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<nlm:aff id="af1">
<addr-line>School of Engineering</addr-line>
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<institution>Cardiff University</institution>
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<addr-line>Queen's Buildings, The Parade, Cardiff CF24 3AA</addr-line>
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<country>UK</country>
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</affiliation>
<affiliation>
<nlm:aff id="af2">
<addr-line>Department of Medical Physics and Bioengineering</addr-line>
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<institution>University Hospitals Bristol NHS Foundation Trust, Bristol General Hospital</institution>
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<addr-line>Bristol BS1 6SY</addr-line>
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<country>UK</country>
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<title level="j">Journal of the Royal Society Interface</title>
<idno type="ISSN">1742-5689</idno>
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<date when="2011">2011</date>
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<p>After X-radiography, ultrasound is now the most common of all the medical imaging technologies. For millennia, manual palpation has been used to assist in diagnosis, but it is subjective and restricted to larger and more superficial structures. Following an introduction to the subject of elasticity, the elasticity of biological soft tissues is discussed and published data are presented. The basic physical principles of pulse-echo and Doppler ultrasonic techniques are explained. The history of ultrasonic imaging of soft tissue strain and elasticity is summarized, together with a brief critique of previously published reviews. The relevant techniques—low-frequency vibration, step, freehand and physiological displacement, and radiation force (displacement, impulse, shear wave and acoustic emission)—are described. Tissue-mimicking materials are indispensible for the assessment of these techniques and their characteristics are reported. Emerging clinical applications in breast disease, cardiology, dermatology, gastroenterology, gynaecology, minimally invasive surgery, musculoskeletal studies, radiotherapy, tissue engineering, urology and vascular disease are critically discussed. It is concluded that ultrasonic imaging of soft tissue strain and elasticity is now sufficiently well developed to have clinical utility. The potential for further research is examined and it is anticipated that the technology will become a powerful mainstream investigative tool.</p>
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<publisher-name>The Royal Society</publisher-name>
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<article-title>Medical ultrasound: imaging of soft tissue strain and elasticity</article-title>
<alt-title alt-title-type="short">Review. Medical ultrasonic elastography</alt-title>
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<contrib contrib-type="author">
<name>
<surname>Wells</surname>
<given-names>Peter N. T.</given-names>
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<contrib contrib-type="author">
<name>
<surname>Liang</surname>
<given-names>Hai-Dong</given-names>
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<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
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<addr-line>School of Engineering</addr-line>
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<institution>Cardiff University</institution>
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<addr-line>Queen's Buildings, The Parade, Cardiff CF24 3AA</addr-line>
,
<country>UK</country>
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<aff id="af2">
<label>2</label>
<addr-line>Department of Medical Physics and Bioengineering</addr-line>
,
<institution>University Hospitals Bristol NHS Foundation Trust, Bristol General Hospital</institution>
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<addr-line>Bristol BS1 6SY</addr-line>
,
<country>UK</country>
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<author-notes>
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<label>*</label>
Author for correspondence (
<email>wellspn@cardiff.ac.uk</email>
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<pub-date pub-type="ppub">
<day>7</day>
<month>11</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub">
<day>16</day>
<month>6</month>
<year>2011</year>
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<volume>8</volume>
<issue>64</issue>
<fpage>1521</fpage>
<lpage>1549</lpage>
<history>
<date date-type="received">
<day>29</day>
<month>1</month>
<year>2011</year>
</date>
<date date-type="accepted">
<day>23</day>
<month>5</month>
<year>2011</year>
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<permissions>
<copyright-statement>This journal is © 2011 The Royal Society</copyright-statement>
<copyright-year>2011</copyright-year>
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<self-uri content-type="pdf" xlink:type="simple" xlink:href="rsif20110054.pdf"></self-uri>
<abstract>
<p>After X-radiography, ultrasound is now the most common of all the medical imaging technologies. For millennia, manual palpation has been used to assist in diagnosis, but it is subjective and restricted to larger and more superficial structures. Following an introduction to the subject of elasticity, the elasticity of biological soft tissues is discussed and published data are presented. The basic physical principles of pulse-echo and Doppler ultrasonic techniques are explained. The history of ultrasonic imaging of soft tissue strain and elasticity is summarized, together with a brief critique of previously published reviews. The relevant techniques—low-frequency vibration, step, freehand and physiological displacement, and radiation force (displacement, impulse, shear wave and acoustic emission)—are described. Tissue-mimicking materials are indispensible for the assessment of these techniques and their characteristics are reported. Emerging clinical applications in breast disease, cardiology, dermatology, gastroenterology, gynaecology, minimally invasive surgery, musculoskeletal studies, radiotherapy, tissue engineering, urology and vascular disease are critically discussed. It is concluded that ultrasonic imaging of soft tissue strain and elasticity is now sufficiently well developed to have clinical utility. The potential for further research is examined and it is anticipated that the technology will become a powerful mainstream investigative tool.</p>
</abstract>
<kwd-group>
<kwd>medical ultrasound</kwd>
<kwd>ultrasonic imaging</kwd>
<kwd>tissue palpation</kwd>
<kwd>soft tissue</kwd>
<kwd>ultrasonic elastography</kwd>
<kwd>strain in tissue</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
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