New developments in clinical aspects of lymphatic disease
Identifieur interne : 004847 ( Pmc/Corpus ); précédent : 004846; suivant : 004848New developments in clinical aspects of lymphatic disease
Auteurs : Peter S. Mortimer ; Stanley G. RocksonSource :
- The Journal of Clinical Investigation [ 0021-9738 ] ; 2014.
Abstract
The lymphatic system is fundamentally important to cardiovascular disease, infection and immunity, cancer, and probably obesity — the four major challenges in healthcare in the 21st century. This Review will consider the manner in which new knowledge of lymphatic genes and molecular mechanisms has demonstrated that lymphatic dysfunction should no longer be considered a passive bystander in disease but rather an active player in many pathological processes and, therefore, a genuine target for future therapeutic developments. The specific roles of the lymphatic system in edema, genetic aspects of primary lymphedema, infection (cellulitis/erysipelas), Crohn’s disease, obesity, cancer, and cancer-related lymphedema are highlighted.
Url:
DOI: 10.1172/JCI71608
PubMed: 24590276
PubMed Central: 3938261
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PMC:3938261Le document en format XML
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Invest</journal-id><journal-id journal-id-type="iso-abbrev">J. Clin. Invest</journal-id><journal-id journal-id-type="publisher-id">J CLIN INVEST</journal-id><journal-title-group><journal-title>The Journal of Clinical Investigation</journal-title></journal-title-group><issn pub-type="ppub">0021-9738</issn><issn pub-type="epub">1558-8238</issn><publisher><publisher-name>American Society for Clinical Investigation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24590276</article-id><article-id pub-id-type="pmc">3938261</article-id><article-id pub-id-type="publisher-id">71608</article-id><article-id pub-id-type="doi">10.1172/JCI71608</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Series</subject></subj-group></article-categories><title-group><article-title>New developments in clinical aspects of lymphatic disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mortimer</surname><given-names>Peter S.</given-names></name><xref ref-type="aff" rid="JCI71608">1</xref></contrib><contrib contrib-type="author"><name><surname>Rockson</surname><given-names>Stanley G.</given-names></name><xref ref-type="aff" rid="JCI71608">2</xref></contrib></contrib-group><aff id="JCI71608"><label>1</label>St. George’s Hospital Medical School, University of London, London, United Kingdom.<label>2</label>Stanford University School of Medicine, Stanford, California, USA.</aff><author-notes><corresp>Address correspondence to: Peter S. Mortimer, St. George’s Hospital Medical School, University of London, London, SW17 ORE, United Kingdom. Phone: 44.0.20.8725.1784; Fax: 44.0.20.8725.5955; E-mail:
<email>mortimer@sgul.ac.uk</email>.
</corresp></author-notes><pub-date pub-type="epub"><day>3</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>3</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>1</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 9 months and
29 days and was based on the
<volume>124</volume><issue>3</issue><fpage>915</fpage><lpage>921</lpage><permissions><copyright-statement>Copyright © 2014, American Society for Clinical Investigation</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><p>The lymphatic system is fundamentally important to cardiovascular disease, infection and immunity, cancer, and probably obesity — the four major challenges in healthcare in the 21st century. This Review will consider the manner in which new knowledge of lymphatic genes and molecular mechanisms has demonstrated that lymphatic dysfunction should no longer be considered a passive bystander in disease but rather an active player in many pathological processes and, therefore, a genuine target for future therapeutic developments. The specific roles of the lymphatic system in edema, genetic aspects of primary lymphedema, infection (cellulitis/erysipelas), Crohn’s disease, obesity, cancer, and cancer-related lymphedema are highlighted.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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