Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Lymphatics at the crossroads of angiogenesis and lymphangiogenesis</title><author><name sortKey="Scavelli, Claudio" sort="Scavelli, Claudio" uniqKey="Scavelli C" first="Claudio" last="Scavelli">Claudio Scavelli</name><affiliation><nlm:aff id="au1"><institution>Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weber, Elisabetta" sort="Weber, Elisabetta" uniqKey="Weber E" first="Elisabetta" last="Weber">Elisabetta Weber</name><affiliation><nlm:aff id="au2"><institution>Department of Neurosciences, Section of Molecular Medicine, University of Siena Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Aglian, Margherita" sort="Aglian, Margherita" uniqKey="Aglian M" first="Margherita" last="Aglian">Margherita Aglian</name><affiliation><nlm:aff id="au2"><institution>Department of Neurosciences, Section of Molecular Medicine, University of Siena Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cirulli, Teresa" sort="Cirulli, Teresa" uniqKey="Cirulli T" first="Teresa" last="Cirulli">Teresa Cirulli</name><affiliation><nlm:aff id="au1"><institution>Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nico, Beatrice" sort="Nico, Beatrice" uniqKey="Nico B" first="Beatrice" last="Nico">Beatrice Nico</name><affiliation><nlm:aff id="au3"><institution>Department of Human Anatomy and Histology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vacca, Angelo" sort="Vacca, Angelo" uniqKey="Vacca A" first="Angelo" last="Vacca">Angelo Vacca</name><affiliation><nlm:aff id="au1"><institution>Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ribatti, Domenico" sort="Ribatti, Domenico" uniqKey="Ribatti D" first="Domenico" last="Ribatti">Domenico Ribatti</name><affiliation><nlm:aff id="au3"><institution>Department of Human Anatomy and Histology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">15198686</idno><idno type="pmc">1571315</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571315</idno><idno type="RBID">PMC:1571315</idno><idno type="doi">10.1111/j.0021-8782.2004.00293.x</idno><date when="2004">2004</date><idno type="wicri:Area/Pmc/Corpus">004837</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004837</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Lymphatics at the crossroads of angiogenesis and lymphangiogenesis</title><author><name sortKey="Scavelli, Claudio" sort="Scavelli, Claudio" uniqKey="Scavelli C" first="Claudio" last="Scavelli">Claudio Scavelli</name><affiliation><nlm:aff id="au1"><institution>Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Weber, Elisabetta" sort="Weber, Elisabetta" uniqKey="Weber E" first="Elisabetta" last="Weber">Elisabetta Weber</name><affiliation><nlm:aff id="au2"><institution>Department of Neurosciences, Section of Molecular Medicine, University of Siena Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Aglian, Margherita" sort="Aglian, Margherita" uniqKey="Aglian M" first="Margherita" last="Aglian">Margherita Aglian</name><affiliation><nlm:aff id="au2"><institution>Department of Neurosciences, Section of Molecular Medicine, University of Siena Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Cirulli, Teresa" sort="Cirulli, Teresa" uniqKey="Cirulli T" first="Teresa" last="Cirulli">Teresa Cirulli</name><affiliation><nlm:aff id="au1"><institution>Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Nico, Beatrice" sort="Nico, Beatrice" uniqKey="Nico B" first="Beatrice" last="Nico">Beatrice Nico</name><affiliation><nlm:aff id="au3"><institution>Department of Human Anatomy and Histology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Vacca, Angelo" sort="Vacca, Angelo" uniqKey="Vacca A" first="Angelo" last="Vacca">Angelo Vacca</name><affiliation><nlm:aff id="au1"><institution>Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author><author><name sortKey="Ribatti, Domenico" sort="Ribatti, Domenico" uniqKey="Ribatti D" first="Domenico" last="Ribatti">Domenico Ribatti</name><affiliation><nlm:aff id="au3"><institution>Department of Human Anatomy and Histology, University of Bari Medical School</institution><addr-line>Italy</addr-line></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Anatomy</title><idno type="ISSN">0021-8782</idno><idno type="eISSN">1469-7580</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The lymphatic system is implicated in interstitial fluid balance regulation, immune cell trafficking, oedema and cancer metastasis. However, the sequence of events that initiate and coordinate lymphatic vessel development (lymphangiogenesis) remains obscure. In effect, the understanding of physiological regulation of lymphatic vasculature has been overshadowed by the greater emphasis focused on angiogenesis, and delayed by a lack of specific markers, thereby limiting this field to no more than a descriptive characterization. Recently, new insights into lymphangiogenesis research have been due to the discovery of lymphatic-specific markers and growth factors of vascular endothelial growth factor (VEGF) family, such as VEGF-C and VEGF-D. Studies using transgenic mice overexpressing VEGF-C and VEGF-D have demonstrated a crucial role for these factors in tumour lymphangiogenesis. Knowledge of lymphatic development has now been redefined at the molecular level, providing an interesting target for innovative therapies. This review highlights the recent insights and advances into the field of lymphatic vascular research, outlining the most important aspects of the embryo development, structure, specific markers and methods applied for studying lymphangiogenesis. Finally, molecular mechanisms involved in the regulation of lymphangiogenesis are described.</p></div></front></TEI><pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Anat</journal-id><journal-id journal-id-type="publisher-id">joa</journal-id><journal-title>Journal of Anatomy</journal-title><issn pub-type="ppub">0021-8782</issn><issn pub-type="epub">1469-7580</issn><publisher><publisher-name>Blackwell Science Inc</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">15198686</article-id><article-id pub-id-type="pmc">1571315</article-id><article-id pub-id-type="doi">10.1111/j.0021-8782.2004.00293.x</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Lymphatics at the crossroads of angiogenesis and lymphangiogenesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Scavelli</surname><given-names>Claudio</given-names></name><xref rid="au1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Weber</surname><given-names>Elisabetta</given-names></name><xref rid="au2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Aglianò</surname><given-names>Margherita</given-names></name><xref rid="au2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Cirulli</surname><given-names>Teresa</given-names></name><xref rid="au1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Nico</surname><given-names>Beatrice</given-names></name><xref rid="au3" ref-type="aff">3</xref></contrib><contrib contrib-type="author"><name><surname>Vacca</surname><given-names>Angelo</given-names></name><xref rid="au1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Ribatti</surname><given-names>Domenico</given-names></name><xref rid="au3" ref-type="aff">3</xref></contrib><aff id="au1"><label>1</label><institution>Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School</institution><addr-line>Italy</addr-line></aff><aff id="au2"><label>2</label><institution>Department of Neurosciences, Section of Molecular Medicine, University of Siena Medical School</institution><addr-line>Italy</addr-line></aff><aff id="au3"><label>3</label><institution>Department of Human Anatomy and Histology, University of Bari Medical School</institution><addr-line>Italy</addr-line></aff></contrib-group><author-notes><corresp id="cor1"><italic>Correspondence</italic> Professor Domenico Ribatti, MD, Department of Human Anatomy and Histology, Piazza Giulio Cesare, 11, Policlinico, I-70124 Bari, Italy. T: +39 080 547.82.40; F: +39 080 547.83.10, E: <email>ribatti@anatomia.uniba.it</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2004</year></pub-date><volume>204</volume><issue>6</issue><fpage>433</fpage><lpage>449</lpage><history><date date-type="accepted"><day>26</day><month>3</month><year>2004</year></date></history><copyright-statement>© Anatomical Society of Great Britain and Ireland 2004</copyright-statement><copyright-year>2004</copyright-year><abstract><p>The lymphatic system is implicated in interstitial fluid balance regulation, immune cell trafficking, oedema and cancer metastasis. However, the sequence of events that initiate and coordinate lymphatic vessel development (lymphangiogenesis) remains obscure. In effect, the understanding of physiological regulation of lymphatic vasculature has been overshadowed by the greater emphasis focused on angiogenesis, and delayed by a lack of specific markers, thereby limiting this field to no more than a descriptive characterization. Recently, new insights into lymphangiogenesis research have been due to the discovery of lymphatic-specific markers and growth factors of vascular endothelial growth factor (VEGF) family, such as VEGF-C and VEGF-D. Studies using transgenic mice overexpressing VEGF-C and VEGF-D have demonstrated a crucial role for these factors in tumour lymphangiogenesis. Knowledge of lymphatic development has now been redefined at the molecular level, providing an interesting target for innovative therapies. This review highlights the recent insights and advances into the field of lymphatic vascular research, outlining the most important aspects of the embryo development, structure, specific markers and methods applied for studying lymphangiogenesis. Finally, molecular mechanisms involved in the regulation of lymphangiogenesis are described.</p></abstract><kwd-group><kwd>endothelial cells</kwd><kwd>growth factors</kwd><kwd>lymphangiogenesis</kwd><kwd>tumour progression</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 0048370 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 0048370 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.31. |  |