The optimum marker for the detection of lymphatic vessels
Identifieur interne : 004216 ( Pmc/Corpus ); précédent : 004215; suivant : 004217The optimum marker for the detection of lymphatic vessels
Auteurs : Ling-Ling Kong ; Nian-Zhao Yang ; Liang-Hui Shi ; Guo-Hai Zhao ; Wenbin Zhou ; Qiang Ding ; Ming-Hai Wang ; Yi-Sheng ZhangSource :
- Molecular and Clinical Oncology [ 2049-9450 ] ; 2017.
Abstract
Podoplanin, lymphatic vessel endothelial hyaluronic acid receptor-1, prospero-related homeobox-1 and vascular endothelial growth factor receptor 3 have been demonstrated to have crucial roles in the development of the lymphatic system and lymphangiogenesis process by combining with their corresponding receptors. Thus, the four markers have been widely used in labelling lymphatic vessels for the detection of lymphangiogenesis and lymphatic vessel invasion. Numerous authors have aimed to identify the roles of these four markers in the lymphatic system and the mechanisms have been partly clarified at the molecular level. The aim of the present review was to comprehensively clarify the characteristics and latent action modes of the four markers in order to determine which is the best one for the detection of lymphangiogenesis and lymphatic vessel invasion.
Url:
DOI: 10.3892/mco.2017.1356
PubMed: 28855985
PubMed Central: 5574200
Links to Exploration step
PMC:5574200Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The optimum marker for the detection of lymphatic vessels</title><author><name sortKey="Kong, Ling Ling" sort="Kong, Ling Ling" uniqKey="Kong L" first="Ling-Ling" last="Kong">Ling-Ling Kong</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Yang, Nian Zhao" sort="Yang, Nian Zhao" uniqKey="Yang N" first="Nian-Zhao" last="Yang">Nian-Zhao Yang</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Shi, Liang Hui" sort="Shi, Liang Hui" uniqKey="Shi L" first="Liang-Hui" last="Shi">Liang-Hui Shi</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Zhao, Guo Hai" sort="Zhao, Guo Hai" uniqKey="Zhao G" first="Guo-Hai" last="Zhao">Guo-Hai Zhao</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Zhou, Wenbin" sort="Zhou, Wenbin" uniqKey="Zhou W" first="Wenbin" last="Zhou">Wenbin Zhou</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation><affiliation><nlm:aff id="af2-mco-0-0-1356">Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Ding, Qiang" sort="Ding, Qiang" uniqKey="Ding Q" first="Qiang" last="Ding">Qiang Ding</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation><affiliation><nlm:aff id="af2-mco-0-0-1356">Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Wang, Ming Hai" sort="Wang, Ming Hai" uniqKey="Wang M" first="Ming-Hai" last="Wang">Ming-Hai Wang</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Yi Sheng" sort="Zhang, Yi Sheng" uniqKey="Zhang Y" first="Yi-Sheng" last="Zhang">Yi-Sheng Zhang</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28855985</idno><idno type="pmc">5574200</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574200</idno><idno type="RBID">PMC:5574200</idno><idno type="doi">10.3892/mco.2017.1356</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">004216</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004216</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The optimum marker for the detection of lymphatic vessels</title><author><name sortKey="Kong, Ling Ling" sort="Kong, Ling Ling" uniqKey="Kong L" first="Ling-Ling" last="Kong">Ling-Ling Kong</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Yang, Nian Zhao" sort="Yang, Nian Zhao" uniqKey="Yang N" first="Nian-Zhao" last="Yang">Nian-Zhao Yang</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Shi, Liang Hui" sort="Shi, Liang Hui" uniqKey="Shi L" first="Liang-Hui" last="Shi">Liang-Hui Shi</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Zhao, Guo Hai" sort="Zhao, Guo Hai" uniqKey="Zhao G" first="Guo-Hai" last="Zhao">Guo-Hai Zhao</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Zhou, Wenbin" sort="Zhou, Wenbin" uniqKey="Zhou W" first="Wenbin" last="Zhou">Wenbin Zhou</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation><affiliation><nlm:aff id="af2-mco-0-0-1356">Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Ding, Qiang" sort="Ding, Qiang" uniqKey="Ding Q" first="Qiang" last="Ding">Qiang Ding</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation><affiliation><nlm:aff id="af2-mco-0-0-1356">Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Wang, Ming Hai" sort="Wang, Ming Hai" uniqKey="Wang M" first="Ming-Hai" last="Wang">Ming-Hai Wang</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Yi Sheng" sort="Zhang, Yi Sheng" uniqKey="Zhang Y" first="Yi-Sheng" last="Zhang">Yi-Sheng Zhang</name><affiliation><nlm:aff id="af1-mco-0-0-1356">Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</nlm:aff></affiliation></author></analytic><series><title level="j">Molecular and Clinical Oncology</title><idno type="ISSN">2049-9450</idno><idno type="eISSN">2049-9469</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Podoplanin, lymphatic vessel endothelial hyaluronic acid receptor-1, prospero-related homeobox-1 and vascular endothelial growth factor receptor 3 have been demonstrated to have crucial roles in the development of the lymphatic system and lymphangiogenesis process by combining with their corresponding receptors. Thus, the four markers have been widely used in labelling lymphatic vessels for the detection of lymphangiogenesis and lymphatic vessel invasion. Numerous authors have aimed to identify the roles of these four markers in the lymphatic system and the mechanisms have been partly clarified at the molecular level. The aim of the present review was to comprehensively clarify the characteristics and latent action modes of the four markers in order to determine which is the best one for the detection of lymphangiogenesis and lymphatic vessel invasion.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schulte Merker, S" uniqKey="Schulte Merker S">S Schulte-Merker</name></author><author><name sortKey="Sabine, A" uniqKey="Sabine A">A Sabine</name></author><author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kazenwadel, J" uniqKey="Kazenwadel J">J Kazenwadel</name></author><author><name sortKey="Harvey, Nl" uniqKey="Harvey N">NL Harvey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Witte, Mh" uniqKey="Witte M">MH Witte</name></author><author><name sortKey="Bernas, Mj" uniqKey="Bernas M">MJ Bernas</name></author><author><name sortKey="Martin, Cp" uniqKey="Martin C">CP Martin</name></author><author><name sortKey="Witte, Cl" uniqKey="Witte C">CL Witte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cunnick, Gh" uniqKey="Cunnick G">GH Cunnick</name></author><author><name sortKey="Jiang, Wg" uniqKey="Jiang W">WG Jiang</name></author><author><name sortKey="Douglas Jones, T" uniqKey="Douglas Jones T">T Douglas-Jones</name></author><author><name sortKey="Watkins, G" uniqKey="Watkins G">G Watkins</name></author><author><name sortKey="Gomez, Kf" uniqKey="Gomez K">KF Gomez</name></author><author><name sortKey="Morgan, Mj" uniqKey="Morgan M">MJ Morgan</name></author><author><name sortKey="Subramanian, A" uniqKey="Subramanian A">A Subramanian</name></author><author><name sortKey="Mokbel, K" uniqKey="Mokbel K">K Mokbel</name></author><author><name sortKey="Mansel, Re" uniqKey="Mansel R">RE Mansel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nunomiya, K" uniqKey="Nunomiya K">K Nunomiya</name></author><author><name sortKey="Shibata, Y" uniqKey="Shibata Y">Y Shibata</name></author><author><name sortKey="Abe, S" uniqKey="Abe S">S Abe</name></author><author><name sortKey="Inoue, S" uniqKey="Inoue S">S Inoue</name></author><author><name sortKey="Igarashi, A" uniqKey="Igarashi A">A Igarashi</name></author><author><name sortKey="Yamauchi, K" uniqKey="Yamauchi K">K Yamauchi</name></author><author><name sortKey="Kimura, T" uniqKey="Kimura T">T Kimura</name></author><author><name sortKey="Aida, Y" uniqKey="Aida Y">Y Aida</name></author><author><name sortKey="Nemoto, T" uniqKey="Nemoto T">T Nemoto</name></author><author><name sortKey="Sato, M" uniqKey="Sato M">M Sato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramani, P" uniqKey="Ramani P">P Ramani</name></author><author><name sortKey="Dungwa, Jv" uniqKey="Dungwa J">JV Dungwa</name></author><author><name sortKey="May, Mt" uniqKey="May M">MT May</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wigle, Jt" uniqKey="Wigle J">JT Wigle</name></author><author><name sortKey="Harvey, N" uniqKey="Harvey N">N Harvey</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author><author><name sortKey="Lagutina, I" uniqKey="Lagutina I">I Lagutina</name></author><author><name sortKey="Grosveld, G" uniqKey="Grosveld G">G Grosveld</name></author><author><name sortKey="Gunn, Md" uniqKey="Gunn M">MD Gunn</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author><author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wigle, Jt" uniqKey="Wigle J">JT Wigle</name></author><author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weninger, W" uniqKey="Weninger W">W Weninger</name></author><author><name sortKey="Partanen, Ta" uniqKey="Partanen T">TA Partanen</name></author><author><name sortKey="Breiteneder Geleff, S" uniqKey="Breiteneder Geleff S">S Breiteneder-Geleff</name></author><author><name sortKey="Mayer, C" uniqKey="Mayer C">C Mayer</name></author><author><name sortKey="Kowalski, H" uniqKey="Kowalski H">H Kowalski</name></author><author><name sortKey="Mildner, M" uniqKey="Mildner M">M Mildner</name></author><author><name sortKey="Pammer, J" uniqKey="Pammer J">J Pammer</name></author><author><name sortKey="Sturzl, M" uniqKey="Sturzl M">M Stürzl</name></author><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Tschachler, E" uniqKey="Tschachler E">E Tschachler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breiteneder Geleff, S" uniqKey="Breiteneder Geleff S">S Breiteneder-Geleff</name></author><author><name sortKey="Matsui, K" uniqKey="Matsui K">K Matsui</name></author><author><name sortKey="Soleiman, A" uniqKey="Soleiman A">A Soleiman</name></author><author><name sortKey="Meraner, P" uniqKey="Meraner P">P Meraner</name></author><author><name sortKey="Poczewski, H" uniqKey="Poczewski H">H Poczewski</name></author><author><name sortKey="Kalt, R" uniqKey="Kalt R">R Kalt</name></author><author><name sortKey="Schaffner, G" uniqKey="Schaffner G">G Schaffner</name></author><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kriehuber, E" uniqKey="Kriehuber E">E Kriehuber</name></author><author><name sortKey="Breiteneder Geleff, S" uniqKey="Breiteneder Geleff S">S Breiteneder-Geleff</name></author><author><name sortKey="Groeger, M" uniqKey="Groeger M">M Groeger</name></author><author><name sortKey="Soleiman, A" uniqKey="Soleiman A">A Soleiman</name></author><author><name sortKey="Schoppmann, Sf" uniqKey="Schoppmann S">SF Schoppmann</name></author><author><name sortKey="Stingl, G" uniqKey="Stingl G">G Stingl</name></author><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author><author><name sortKey="Maurer, D" uniqKey="Maurer D">D Maurer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breiteneder Geleff, S" uniqKey="Breiteneder Geleff S">S Breiteneder-Geleff</name></author><author><name sortKey="Soleiman, A" uniqKey="Soleiman A">A Soleiman</name></author><author><name sortKey="Kowalski, H" uniqKey="Kowalski H">H Kowalski</name></author><author><name sortKey="Horvat, R" uniqKey="Horvat R">R Horvat</name></author><author><name sortKey="Amann, G" uniqKey="Amann G">G Amann</name></author><author><name sortKey="Kriehuber, E" uniqKey="Kriehuber E">E Kriehuber</name></author><author><name sortKey="Diem, K" uniqKey="Diem K">K Diem</name></author><author><name sortKey="Weninger, W" uniqKey="Weninger W">W Weninger</name></author><author><name sortKey="Tschachler, E" uniqKey="Tschachler E">E Tschachler</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmid, H" uniqKey="Schmid H">H Schmid</name></author><author><name sortKey="Henger, A" uniqKey="Henger A">A Henger</name></author><author><name sortKey="Cohen, Cd" uniqKey="Cohen C">CD Cohen</name></author><author><name sortKey="Frach, K" uniqKey="Frach K">K Frach</name></author><author><name sortKey="Grone, Hj" uniqKey="Grone H">HJ Gröne</name></author><author><name sortKey="Schlondorff, D" uniqKey="Schlondorff D">D Schlöndorff</name></author><author><name sortKey="Kretzler, M" uniqKey="Kretzler M">M Kretzler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levidiotis, V" uniqKey="Levidiotis V">V Levidiotis</name></author><author><name sortKey="Power, Da" uniqKey="Power D">DA Power</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanner, Wa" uniqKey="Kanner W">WA Kanner</name></author><author><name sortKey="Galgano, Mt" uniqKey="Galgano M">MT Galgano</name></author><author><name sortKey="Atkins, Ka" uniqKey="Atkins K">KA Atkins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin Villar, E" uniqKey="Martin Villar E">E Martín-Villar</name></author><author><name sortKey="Scholl, Fg" uniqKey="Scholl F">FG Scholl</name></author><author><name sortKey="Gamallo, C" uniqKey="Gamallo C">C Gamallo</name></author><author><name sortKey="Yurrita, Mm" uniqKey="Yurrita M">MM Yurrita</name></author><author><name sortKey="Mu Oz Guerra, M" uniqKey="Mu Oz Guerra M">M Muñoz-Guerra</name></author><author><name sortKey="Cruces, J" uniqKey="Cruces J">J Cruces</name></author><author><name sortKey="Quintanilla, M" uniqKey="Quintanilla M">M Quintanilla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kato, Y" uniqKey="Kato Y">Y Kato</name></author><author><name sortKey="Kaneko, M" uniqKey="Kaneko M">M Kaneko</name></author><author><name sortKey="Sata, M" uniqKey="Sata M">M Sata</name></author><author><name sortKey="Fujita, N" uniqKey="Fujita N">N Fujita</name></author><author><name sortKey="Tsuruo, T" uniqKey="Tsuruo T">T Tsuruo</name></author><author><name sortKey="Osawa, M" uniqKey="Osawa M">M Osawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schacht, V" uniqKey="Schacht V">V Schacht</name></author><author><name sortKey="Dadras, Ss" uniqKey="Dadras S">SS Dadras</name></author><author><name sortKey="Johnson, La" uniqKey="Johnson L">LA Johnson</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author><author><name sortKey="Hong, Yk" uniqKey="Hong Y">YK Hong</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zustin, J" uniqKey="Zustin J">J Zustin</name></author><author><name sortKey="Scheuer, Ha" uniqKey="Scheuer H">HA Scheuer</name></author><author><name sortKey="Friedrich, Re" uniqKey="Friedrich R">RE Friedrich</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kikuchi, K" uniqKey="Kikuchi K">K Kikuchi</name></author><author><name sortKey="Ito, S" uniqKey="Ito S">S Ito</name></author><author><name sortKey="Inoue, H" uniqKey="Inoue H">H Inoue</name></author><author><name sortKey="Gonzalez Alva, P" uniqKey="Gonzalez Alva P">P González-Alva</name></author><author><name sortKey="Miyazaki, Y" uniqKey="Miyazaki Y">Y Miyazaki</name></author><author><name sortKey="Sakashita, H" uniqKey="Sakashita H">H Sakashita</name></author><author><name sortKey="Yoshino, A" uniqKey="Yoshino A">A Yoshino</name></author><author><name sortKey="Katayama, Y" uniqKey="Katayama Y">Y Katayama</name></author><author><name sortKey="Terui, T" uniqKey="Terui T">T Terui</name></author><author><name sortKey="Ide, F" uniqKey="Ide F">F Ide</name></author><author><name sortKey="Kusama, K" uniqKey="Kusama K">K Kusama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsuneki, M" uniqKey="Tsuneki M">M Tsuneki</name></author><author><name sortKey="Maruyama, S" uniqKey="Maruyama S">S Maruyama</name></author><author><name sortKey="Yamazaki, M" uniqKey="Yamazaki M">M Yamazaki</name></author><author><name sortKey="Cheng, J" uniqKey="Cheng J">J Cheng</name></author><author><name sortKey="Saku, T" uniqKey="Saku T">T Saku</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moustakas, A" uniqKey="Moustakas A">A Moustakas</name></author><author><name sortKey="Heldin, Ch" uniqKey="Heldin C">CH Heldin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scholl, Fg" uniqKey="Scholl F">FG Scholl</name></author><author><name sortKey="Gamallo, C" uniqKey="Gamallo C">C Gamallo</name></author><author><name sortKey="Vilar, S" uniqKey="Vilar S">S Vilaró</name></author><author><name sortKey="Quintanilla, M" uniqKey="Quintanilla M">M Quintanilla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wicki, A" uniqKey="Wicki A">A Wicki</name></author><author><name sortKey="Lehembre, F" uniqKey="Lehembre F">F Lehembre</name></author><author><name sortKey="Wick, N" uniqKey="Wick N">N Wick</name></author><author><name sortKey="Hantusch, B" uniqKey="Hantusch B">B Hantusch</name></author><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author><author><name sortKey="Christofori, G" uniqKey="Christofori G">G Christofori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin Villar, E" uniqKey="Martin Villar E">E Martín-Villar</name></author><author><name sortKey="Megias, D" uniqKey="Megias D">D Megías</name></author><author><name sortKey="Castel, S" uniqKey="Castel S">S Castel</name></author><author><name sortKey="Yurrita, Mm" uniqKey="Yurrita M">MM Yurrita</name></author><author><name sortKey="Vilar, S" uniqKey="Vilar S">S Vilaró</name></author><author><name sortKey="Quintanilla, M" uniqKey="Quintanilla M">M Quintanilla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marks, A" uniqKey="Marks A">A Marks</name></author><author><name sortKey="Sutherland, Dr" uniqKey="Sutherland D">DR Sutherland</name></author><author><name sortKey="Bailey, D" uniqKey="Bailey D">D Bailey</name></author><author><name sortKey="Iglesias, J" uniqKey="Iglesias J">J Iglesias</name></author><author><name sortKey="Law, J" uniqKey="Law J">J Law</name></author><author><name sortKey="Lei, M" uniqKey="Lei M">M Lei</name></author><author><name sortKey="Yeger, H" uniqKey="Yeger H">H Yeger</name></author><author><name sortKey="Banerjee, D" uniqKey="Banerjee D">D Banerjee</name></author><author><name sortKey="Baumal, R" uniqKey="Baumal R">R Baumal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kahn, Hj" uniqKey="Kahn H">HJ Kahn</name></author><author><name sortKey="Marks, A" uniqKey="Marks A">A Marks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ren, S" uniqKey="Ren S">S Ren</name></author><author><name sortKey="Abuel Haija, M" uniqKey="Abuel Haija M">M Abuel-Haija</name></author><author><name sortKey="Khurana, Js" uniqKey="Khurana J">JS Khurana</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Braun, M" uniqKey="Braun M">M Braun</name></author><author><name sortKey="Flucke, U" uniqKey="Flucke U">U Flucke</name></author><author><name sortKey="Debald, M" uniqKey="Debald M">M Debald</name></author><author><name sortKey="Walgenbach Bruenagel, G" uniqKey="Walgenbach Bruenagel G">G Walgenbach-Bruenagel</name></author><author><name sortKey="Walgenbach, Kj" uniqKey="Walgenbach K">KJ Walgenbach</name></author><author><name sortKey="Holler, T" uniqKey="Holler T">T Höller</name></author><author><name sortKey="Polcher, M" uniqKey="Polcher M">M Pölcher</name></author><author><name sortKey="Wolfgarten, M" uniqKey="Wolfgarten M">M Wolfgarten</name></author><author><name sortKey="Sauerwald, A" uniqKey="Sauerwald A">A Sauerwald</name></author><author><name sortKey="Keyver Paik, M" uniqKey="Keyver Paik M">M Keyver-Paik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Gendi, S" uniqKey="El Gendi S">S El-Gendi</name></author><author><name sortKey="Abdel Hadi, M" uniqKey="Abdel Hadi M">M Abdel-Hadi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Birner, P" uniqKey="Birner P">P Birner</name></author><author><name sortKey="Schindl, M" uniqKey="Schindl M">M Schindl</name></author><author><name sortKey="Obermair, A" uniqKey="Obermair A">A Obermair</name></author><author><name sortKey="Breitenecker, G" uniqKey="Breitenecker G">G Breitenecker</name></author><author><name sortKey="Kowalski, H" uniqKey="Kowalski H">H Kowalski</name></author><author><name sortKey="Oberhuber, G" uniqKey="Oberhuber G">G Oberhuber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niemiec, Ja" uniqKey="Niemiec J">JA Niemiec</name></author><author><name sortKey="Adamczyk, A" uniqKey="Adamczyk A">A Adamczyk</name></author><author><name sortKey="Ambicka, A" uniqKey="Ambicka A">A Ambicka</name></author><author><name sortKey="Mucha Malecka, A" uniqKey="Mucha Malecka A">A Mucha-Malecka</name></author><author><name sortKey="Wysocki, Wm" uniqKey="Wysocki W">WM Wysocki</name></author><author><name sortKey="Ry, J" uniqKey="Ry J">J Ryś</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tezuka, K" uniqKey="Tezuka K">K Tezuka</name></author><author><name sortKey="Onoda, N" uniqKey="Onoda N">N Onoda</name></author><author><name sortKey="Takashima, T" uniqKey="Takashima T">T Takashima</name></author><author><name sortKey="Takagaki, K" uniqKey="Takagaki K">K Takagaki</name></author><author><name sortKey="Ishikawa, T" uniqKey="Ishikawa T">T Ishikawa</name></author><author><name sortKey="Wakasa, T" uniqKey="Wakasa T">T Wakasa</name></author><author><name sortKey="Wakasa, K" uniqKey="Wakasa K">K Wakasa</name></author><author><name sortKey="Hirakawa, K" uniqKey="Hirakawa K">K Hirakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabban, Jt" uniqKey="Rabban J">JT Rabban</name></author><author><name sortKey="Chen, Yy" uniqKey="Chen Y">YY Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laurent, Tc" uniqKey="Laurent T">TC Laurent</name></author><author><name sortKey="Fraser, Jr" uniqKey="Fraser J">JR Fraser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banerji, S" uniqKey="Banerji S">S Banerji</name></author><author><name sortKey="Ni, J" uniqKey="Ni J">J Ni</name></author><author><name sortKey="Wang, Sx" uniqKey="Wang S">SX Wang</name></author><author><name sortKey="Clasper, S" uniqKey="Clasper S">S Clasper</name></author><author><name sortKey="Su, J" uniqKey="Su J">J Su</name></author><author><name sortKey="Tammi, R" uniqKey="Tammi R">R Tammi</name></author><author><name sortKey="Jones, M" uniqKey="Jones M">M Jones</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author><author><name sortKey="Prevo, R" uniqKey="Prevo R">R Prevo</name></author><author><name sortKey="Clasper, S" uniqKey="Clasper S">S Clasper</name></author><author><name sortKey="Banerji, S" uniqKey="Banerji S">S Banerji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, Y" uniqKey="Du Y">Y Du</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Yang, C" uniqKey="Yang C">C Yang</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cunnick, Gh" uniqKey="Cunnick G">GH Cunnick</name></author><author><name sortKey="Jiang, Wg" uniqKey="Jiang W">WG Jiang</name></author><author><name sortKey="Gomez, Kf" uniqKey="Gomez K">KF Gomez</name></author><author><name sortKey="Mansel, Re" uniqKey="Mansel R">RE Mansel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsujii, M" uniqKey="Tsujii M">M Tsujii</name></author><author><name sortKey="Kawano, S" uniqKey="Kawano S">S Kawano</name></author><author><name sortKey="Tsuji, S" uniqKey="Tsuji S">S Tsuji</name></author><author><name sortKey="Sawaoka, H" uniqKey="Sawaoka H">H Sawaoka</name></author><author><name sortKey="Hori, M" uniqKey="Hori M">M Hori</name></author><author><name sortKey="Dubois, Rn" uniqKey="Dubois R">RN DuBois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Timoshenko, Av" uniqKey="Timoshenko A">AV Timoshenko</name></author><author><name sortKey="Chakraborty, C" uniqKey="Chakraborty C">C Chakraborty</name></author><author><name sortKey="Wagner, Gf" uniqKey="Wagner G">GF Wagner</name></author><author><name sortKey="Lala, Pk" uniqKey="Lala P">PK Lala</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Hl" uniqKey="Wong H">HL Wong</name></author><author><name sortKey="Jin, G" uniqKey="Jin G">G Jin</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author><author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gale, Nw" uniqKey="Gale N">NW Gale</name></author><author><name sortKey="Prevo, R" uniqKey="Prevo R">R Prevo</name></author><author><name sortKey="Espinosa, J" uniqKey="Espinosa J">J Espinosa</name></author><author><name sortKey="Ferguson, Dj" uniqKey="Ferguson D">DJ Ferguson</name></author><author><name sortKey="Dominguez, Mg" uniqKey="Dominguez M">MG Dominguez</name></author><author><name sortKey="Yancopoulos, Gd" uniqKey="Yancopoulos G">GD Yancopoulos</name></author><author><name sortKey="Thurston, G" uniqKey="Thurston G">G Thurston</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schledzewski, K" uniqKey="Schledzewski K">K Schledzewski</name></author><author><name sortKey="Falkowski, M" uniqKey="Falkowski M">M Falkowski</name></author><author><name sortKey="Moldenhauer, G" uniqKey="Moldenhauer G">G Moldenhauer</name></author><author><name sortKey="Metharom, P" uniqKey="Metharom P">P Metharom</name></author><author><name sortKey="Kzhyshkowska, J" uniqKey="Kzhyshkowska J">J Kzhyshkowska</name></author><author><name sortKey="Ganss, R" uniqKey="Ganss R">R Ganss</name></author><author><name sortKey="Demory, A" uniqKey="Demory A">A Demory</name></author><author><name sortKey="Falkowska Hansen, B" uniqKey="Falkowska Hansen B">B Falkowska-Hansen</name></author><author><name sortKey="Kurzen, H" uniqKey="Kurzen H">H Kurzen</name></author><author><name sortKey="Ugurel, S" uniqKey="Ugurel S">S Ugurel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name></author><author><name sortKey="Sosa Pineda, B" uniqKey="Sosa Pineda B">B Sosa-Pineda</name></author><author><name sortKey="Geisendorf, S" uniqKey="Geisendorf S">S Geisendorf</name></author><author><name sortKey="Spana, Ep" uniqKey="Spana E">EP Spana</name></author><author><name sortKey="Doe, Cq" uniqKey="Doe C">CQ Doe</name></author><author><name sortKey="Gruss, P" uniqKey="Gruss P">P Gruss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wigle, Jt" uniqKey="Wigle J">JT Wigle</name></author><author><name sortKey="Chowdhury, K" uniqKey="Chowdhury K">K Chowdhury</name></author><author><name sortKey="Gruss, P" uniqKey="Gruss P">P Gruss</name></author><author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Yk" uniqKey="Hong Y">YK Hong</name></author><author><name sortKey="Harvey, N" uniqKey="Harvey N">N Harvey</name></author><author><name sortKey="Noh, Yh" uniqKey="Noh Y">YH Noh</name></author><author><name sortKey="Schacht, V" uniqKey="Schacht V">V Schacht</name></author><author><name sortKey="Hirakawa, S" uniqKey="Hirakawa S">S Hirakawa</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author><author><name sortKey="Oliver, G" uniqKey="Oliver G">G Oliver</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baxter, Sa" uniqKey="Baxter S">SA Baxter</name></author><author><name sortKey="Cheung, Dy" uniqKey="Cheung D">DY Cheung</name></author><author><name sortKey="Bocangel, P" uniqKey="Bocangel P">P Bocangel</name></author><author><name sortKey="Kim, Hk" uniqKey="Kim H">HK Kim</name></author><author><name sortKey="Herbert, K" uniqKey="Herbert K">K Herbert</name></author><author><name sortKey="Douville, Jm" uniqKey="Douville J">JM Douville</name></author><author><name sortKey="Jangamreddy, Jr" uniqKey="Jangamreddy J">JR Jangamreddy</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Eisenstat, Dd" uniqKey="Eisenstat D">DD Eisenstat</name></author><author><name sortKey="Wigle, Jt" uniqKey="Wigle J">JT Wigle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dadras, Ss" uniqKey="Dadras S">SS Dadras</name></author><author><name sortKey="Skrzypek, A" uniqKey="Skrzypek A">A Skrzypek</name></author><author><name sortKey="Nguyen, L" uniqKey="Nguyen L">L Nguyen</name></author><author><name sortKey="Shin, Jw" uniqKey="Shin J">JW Shin</name></author><author><name sortKey="Schulz, Mm" uniqKey="Schulz M">MM Schulz</name></author><author><name sortKey="Arbiser, J" uniqKey="Arbiser J">J Arbiser</name></author><author><name sortKey="Mihm, Mc" uniqKey="Mihm M">MC Mihm</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Andrade, Ba Benevenuto" uniqKey="De Andrade B">BA Benevenuto de Andrade</name></author><author><name sortKey="Ramirez Amador, V" uniqKey="Ramirez Amador V">V Ramírez-Amador</name></author><author><name sortKey="Anaya Saavedra, G" uniqKey="Anaya Saavedra G">G Anaya-Saavedra</name></author><author><name sortKey="Martinez Mata, G" uniqKey="Martinez Mata G">G Martínez-Mata</name></author><author><name sortKey="Fonseca, Fp" uniqKey="Fonseca F">FP Fonseca</name></author><author><name sortKey="Graner, E" uniqKey="Graner E">E Graner</name></author><author><name sortKey="De Almeida, O Paes" uniqKey="De Almeida O">O Paes de Almeida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pajusola, K" uniqKey="Pajusola K">K Pajusola</name></author><author><name sortKey="Aprelikova, O" uniqKey="Aprelikova O">O Aprelikova</name></author><author><name sortKey="Armstrong, E" uniqKey="Armstrong E">E Armstrong</name></author><author><name sortKey="Morris, S" uniqKey="Morris S">S Morris</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valtola, R" uniqKey="Valtola R">R Valtola</name></author><author><name sortKey="Salven, P" uniqKey="Salven P">P Salven</name></author><author><name sortKey="Heikkil, P" uniqKey="Heikkil P">P Heikkilä</name></author><author><name sortKey="Taipale, J" uniqKey="Taipale J">J Taipale</name></author><author><name sortKey="Joensuu, H" uniqKey="Joensuu H">H Joensuu</name></author><author><name sortKey="Rehn, M" uniqKey="Rehn M">M Rehn</name></author><author><name sortKey="Pihlajaniemi, T" uniqKey="Pihlajaniemi T">T Pihlajaniemi</name></author><author><name sortKey="Weich, H" uniqKey="Weich H">H Weich</name></author><author><name sortKey="Dewaal, R" uniqKey="Dewaal R">R deWaal</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Joukov, V" uniqKey="Joukov V">V Joukov</name></author><author><name sortKey="Sorsa, T" uniqKey="Sorsa T">T Sorsa</name></author><author><name sortKey="Kumar, V" uniqKey="Kumar V">V Kumar</name></author><author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name></author><author><name sortKey="Claesson Welsh, L" uniqKey="Claesson Welsh L">L Claesson-Welsh</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author><author><name sortKey="Saksela, O" uniqKey="Saksela O">O Saksela</name></author><author><name sortKey="Kalkkinen, N" uniqKey="Kalkkinen N">N Kalkkinen</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacker, Sa" uniqKey="Stacker S">SA Stacker</name></author><author><name sortKey="Stenvers, K" uniqKey="Stenvers K">K Stenvers</name></author><author><name sortKey="Caesar, C" uniqKey="Caesar C">C Caesar</name></author><author><name sortKey="Vitali, A" uniqKey="Vitali A">A Vitali</name></author><author><name sortKey="Domagala, T" uniqKey="Domagala T">T Domagala</name></author><author><name sortKey="Nice, E" uniqKey="Nice E">E Nice</name></author><author><name sortKey="Roufail, S" uniqKey="Roufail S">S Roufail</name></author><author><name sortKey="Simpson, Rj" uniqKey="Simpson R">RJ Simpson</name></author><author><name sortKey="Moritz, R" uniqKey="Moritz R">R Moritz</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="M Kinen, T" uniqKey="M Kinen T">T Mäkinen</name></author><author><name sortKey="Veikkola, T" uniqKey="Veikkola T">T Veikkola</name></author><author><name sortKey="Mustjoki, S" uniqKey="Mustjoki S">S Mustjoki</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Catimel, B" uniqKey="Catimel B">B Catimel</name></author><author><name sortKey="Nice, Ec" uniqKey="Nice E">EC Nice</name></author><author><name sortKey="Wise, L" uniqKey="Wise L">L Wise</name></author><author><name sortKey="Mercer, A" uniqKey="Mercer A">A Mercer</name></author><author><name sortKey="Kowalski, H" uniqKey="Kowalski H">H Kowalski</name></author><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Strandin, T" uniqKey="Strandin T">T Strandin</name></author><author><name sortKey="Aho, K" uniqKey="Aho K">K Aho</name></author><author><name sortKey="Lankinen, H" uniqKey="Lankinen H">H Lankinen</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lepp Nen, Vm" uniqKey="Lepp Nen V">VM Leppänen</name></author><author><name sortKey="Prota, Ae" uniqKey="Prota A">AE Prota</name></author><author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name></author><author><name sortKey="Anisimov, A" uniqKey="Anisimov A">A Anisimov</name></author><author><name sortKey="Kalkkinen, N" uniqKey="Kalkkinen N">N Kalkkinen</name></author><author><name sortKey="Strandin, T" uniqKey="Strandin T">T Strandin</name></author><author><name sortKey="Lankinen, H" uniqKey="Lankinen H">H Lankinen</name></author><author><name sortKey="Goldman, A" uniqKey="Goldman A">A Goldman</name></author><author><name sortKey="Ballmer Hofer, K" uniqKey="Ballmer Hofer K">K Ballmer-Hofer</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baldwin, Me" uniqKey="Baldwin M">ME Baldwin</name></author><author><name sortKey="Catimel, B" uniqKey="Catimel B">B Catimel</name></author><author><name sortKey="Nice, Ec" uniqKey="Nice E">EC Nice</name></author><author><name sortKey="Roufail, S" uniqKey="Roufail S">S Roufail</name></author><author><name sortKey="Hall, Ne" uniqKey="Hall N">NE Hall</name></author><author><name sortKey="Stenvers, Kl" uniqKey="Stenvers K">KL Stenvers</name></author><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Stacker, Sa" uniqKey="Stacker S">SA Stacker</name></author><author><name sortKey="Achen, Mg" uniqKey="Achen M">MG Achen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lepp Nen, Vm" uniqKey="Lepp Nen V">VM Leppänen</name></author><author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name></author><author><name sortKey="Anisimov, A" uniqKey="Anisimov A">A Anisimov</name></author><author><name sortKey="Tvorogov, D" uniqKey="Tvorogov D">D Tvorogov</name></author><author><name sortKey="Aho, K" uniqKey="Aho K">K Aho</name></author><author><name sortKey="Kalkkinen, N" uniqKey="Kalkkinen N">N Kalkkinen</name></author><author><name sortKey="Toivanen, P" uniqKey="Toivanen P">P Toivanen</name></author><author><name sortKey="Yl Herttuala, S" uniqKey="Yl Herttuala S">S Ylä-Herttuala</name></author><author><name sortKey="Ballmer Hofer, K" uniqKey="Ballmer Hofer K">K Ballmer-Hofer</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaipainen, A" uniqKey="Kaipainen A">A Kaipainen</name></author><author><name sortKey="Korhonen, J" uniqKey="Korhonen J">J Korhonen</name></author><author><name sortKey="Mustonen, T" uniqKey="Mustonen T">T Mustonen</name></author><author><name sortKey="Van Hinsbergh, Vw" uniqKey="Van Hinsbergh V">VW van Hinsbergh</name></author><author><name sortKey="Fang, Gh" uniqKey="Fang G">GH Fang</name></author><author><name sortKey="Dumont, D" uniqKey="Dumont D">D Dumont</name></author><author><name sortKey="Breitman, M" uniqKey="Breitman M">M Breitman</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pajusola, K" uniqKey="Pajusola K">K Pajusola</name></author><author><name sortKey="Aprelikova, O" uniqKey="Aprelikova O">O Aprelikova</name></author><author><name sortKey="Korhonen, J" uniqKey="Korhonen J">J Korhonen</name></author><author><name sortKey="Kaipainen, A" uniqKey="Kaipainen A">A Kaipainen</name></author><author><name sortKey="Pertovaara, L" uniqKey="Pertovaara L">L Pertovaara</name></author><author><name sortKey="Alitalo, R" uniqKey="Alitalo R">R Alitalo</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dumont, Dj" uniqKey="Dumont D">DJ Dumont</name></author><author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name></author><author><name sortKey="Taipale, J" uniqKey="Taipale J">J Taipale</name></author><author><name sortKey="Lymboussaki, A" uniqKey="Lymboussaki A">A Lymboussaki</name></author><author><name sortKey="Mustonen, T" uniqKey="Mustonen T">T Mustonen</name></author><author><name sortKey="Pajusola, K" uniqKey="Pajusola K">K Pajusola</name></author><author><name sortKey="Breitman, M" uniqKey="Breitman M">M Breitman</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stacker, Sa" uniqKey="Stacker S">SA Stacker</name></author><author><name sortKey="Caesar, C" uniqKey="Caesar C">C Caesar</name></author><author><name sortKey="Baldwin, Me" uniqKey="Baldwin M">ME Baldwin</name></author><author><name sortKey="Thornton, Ge" uniqKey="Thornton G">GE Thornton</name></author><author><name sortKey="Williams, Ra" uniqKey="Williams R">RA Williams</name></author><author><name sortKey="Prevo, R" uniqKey="Prevo R">R Prevo</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author><author><name sortKey="Nishikawa, S" uniqKey="Nishikawa S">S Nishikawa</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name></author><author><name sortKey="Achen, Mg" uniqKey="Achen M">MG Achen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jain, Rk" uniqKey="Jain R">RK Jain</name></author><author><name sortKey="Padera, Tp" uniqKey="Padera T">TP Padera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y He</name></author><author><name sortKey="Kozaki, K" uniqKey="Kozaki K">K Kozaki</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Koshikawa, K" uniqKey="Koshikawa K">K Koshikawa</name></author><author><name sortKey="Yla Herttuala, S" uniqKey="Yla Herttuala S">S Yla-Herttuala</name></author><author><name sortKey="Takahashi, T" uniqKey="Takahashi T">T Takahashi</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="M Kinen, T" uniqKey="M Kinen T">T Mäkinen</name></author><author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name></author><author><name sortKey="Veikkola, T" uniqKey="Veikkola T">T Veikkola</name></author><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Kettunen, Mi" uniqKey="Kettunen M">MI Kettunen</name></author><author><name sortKey="Pulkkanen, Kj" uniqKey="Pulkkanen K">KJ Pulkkanen</name></author><author><name sortKey="Kauppinen, R" uniqKey="Kauppinen R">R Kauppinen</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author><author><name sortKey="Kubo, H" uniqKey="Kubo H">H Kubo</name></author><author><name sortKey="Nishikawa, S" uniqKey="Nishikawa S">S Nishikawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mandriota, Sj" uniqKey="Mandriota S">SJ Mandriota</name></author><author><name sortKey="Jussila, L" uniqKey="Jussila L">L Jussila</name></author><author><name sortKey="Jeltsch, M" uniqKey="Jeltsch M">M Jeltsch</name></author><author><name sortKey="Compagni, A" uniqKey="Compagni A">A Compagni</name></author><author><name sortKey="Baetens, D" uniqKey="Baetens D">D Baetens</name></author><author><name sortKey="Prevo, R" uniqKey="Prevo R">R Prevo</name></author><author><name sortKey="Banerji, S" uniqKey="Banerji S">S Banerji</name></author><author><name sortKey="Huarte, J" uniqKey="Huarte J">J Huarte</name></author><author><name sortKey="Montesano, R" uniqKey="Montesano R">R Montesano</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skobe, M" uniqKey="Skobe M">M Skobe</name></author><author><name sortKey="Hawighorst, T" uniqKey="Hawighorst T">T Hawighorst</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author><author><name sortKey="Prevo, R" uniqKey="Prevo R">R Prevo</name></author><author><name sortKey="Janes, L" uniqKey="Janes L">L Janes</name></author><author><name sortKey="Velasco, P" uniqKey="Velasco P">P Velasco</name></author><author><name sortKey="Riccardi, L" uniqKey="Riccardi L">L Riccardi</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Claffey, K" uniqKey="Claffey K">K Claffey</name></author><author><name sortKey="Detmar, M" uniqKey="Detmar M">M Detmar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takahashi, S" uniqKey="Takahashi S">S Takahashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beekman, Kw" uniqKey="Beekman K">KW Beekman</name></author><author><name sortKey="Bradley, D" uniqKey="Bradley D">D Bradley</name></author><author><name sortKey="Hussain, M" uniqKey="Hussain M">M Hussain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sonpavde, G" uniqKey="Sonpavde G">G Sonpavde</name></author><author><name sortKey="Jian, W" uniqKey="Jian W">W Jian</name></author><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Wu, Mf" uniqKey="Wu M">MF Wu</name></author><author><name sortKey="Shen, Ss" uniqKey="Shen S">SS Shen</name></author><author><name sortKey="Lerner, Sp" uniqKey="Lerner S">SP Lerner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rudert, M" uniqKey="Rudert M">M Rudert</name></author><author><name sortKey="Tillmann, B" uniqKey="Tillmann B">B Tillmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kucera, R" uniqKey="Kucera R">R Kucera</name></author><author><name sortKey="Topolcan, O" uniqKey="Topolcan O">O Topolcan</name></author><author><name sortKey="Treskova, I" uniqKey="Treskova I">I Treskova</name></author><author><name sortKey="Kinkorova, J" uniqKey="Kinkorova J">J Kinkorova</name></author><author><name sortKey="Windrichova, J" uniqKey="Windrichova J">J Windrichova</name></author><author><name sortKey="Fuchsova, R" uniqKey="Fuchsova R">R Fuchsova</name></author><author><name sortKey="Svobodova, S" uniqKey="Svobodova S">S Svobodova</name></author><author><name sortKey="Treska, V" uniqKey="Treska V">V Treska</name></author><author><name sortKey="Babuska, V" uniqKey="Babuska V">V Babuska</name></author><author><name sortKey="Novak, J" uniqKey="Novak J">J Novak</name></author><author><name sortKey="Smejkal, J" uniqKey="Smejkal J">J Smejkal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harada, T" uniqKey="Harada T">T Harada</name></author><author><name sortKey="Shinohara, M" uniqKey="Shinohara M">M Shinohara</name></author><author><name sortKey="Nakamura, S" uniqKey="Nakamura S">S Nakamura</name></author><author><name sortKey="Shimada, M" uniqKey="Shimada M">M Shimada</name></author><author><name sortKey="Oka, M" uniqKey="Oka M">M Oka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name></author><author><name sortKey="M Kinen, T" uniqKey="M Kinen T">T Mäkinen</name></author><author><name sortKey="M Kel, Tp" uniqKey="M Kel T">TP Mäkelä</name></author><author><name sortKey="Saarela, J" uniqKey="Saarela J">J Saarela</name></author><author><name sortKey="Virtanen, I" uniqKey="Virtanen I">I Virtanen</name></author><author><name sortKey="Ferrell, Re" uniqKey="Ferrell R">RE Ferrell</name></author><author><name sortKey="Finegold, Dn" uniqKey="Finegold D">DN Finegold</name></author><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author><author><name sortKey="Yl Herttuala, S" uniqKey="Yl Herttuala S">S Ylä-Herttuala</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mol Clin Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Mol Clin Oncol</journal-id><journal-id journal-id-type="publisher-id">MCO</journal-id><journal-title-group><journal-title>Molecular and Clinical Oncology</journal-title></journal-title-group><issn pub-type="ppub">2049-9450</issn><issn pub-type="epub">2049-9469</issn><publisher><publisher-name>D.A. Spandidos</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28855985</article-id><article-id pub-id-type="pmc">5574200</article-id><article-id pub-id-type="doi">10.3892/mco.2017.1356</article-id><article-id pub-id-type="publisher-id">MCO-0-0-1356</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>The optimum marker for the detection of lymphatic vessels</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kong</surname><given-names>Ling-Ling</given-names></name><xref ref-type="aff" rid="af1-mco-0-0-1356">1</xref><xref rid="fn1-mco-0-0-1356" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Nian-Zhao</given-names></name><xref ref-type="aff" rid="af1-mco-0-0-1356">1</xref><xref rid="fn1-mco-0-0-1356" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Shi</surname><given-names>Liang-Hui</given-names></name><xref ref-type="aff" rid="af1-mco-0-0-1356">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Guo-Hai</given-names></name><xref ref-type="aff" rid="af1-mco-0-0-1356">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Wenbin</given-names></name><xref ref-type="aff" rid="af1-mco-0-0-1356">1</xref><xref ref-type="aff" rid="af2-mco-0-0-1356">2</xref></contrib><contrib contrib-type="author"><name><surname>Ding</surname><given-names>Qiang</given-names></name><xref ref-type="aff" rid="af1-mco-0-0-1356">1</xref><xref ref-type="aff" rid="af2-mco-0-0-1356">2</xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Ming-Hai</given-names></name><xref ref-type="aff" rid="af1-mco-0-0-1356">1</xref><xref rid="c1-mco-0-0-1356" ref-type="corresp"></xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Yi-Sheng</given-names></name><xref ref-type="aff" rid="af1-mco-0-0-1356">1</xref><xref rid="c1-mco-0-0-1356" ref-type="corresp"></xref></contrib></contrib-group><aff id="af1-mco-0-0-1356"><label>1</label>Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, Wuhu, Anhui 241000, P.R. China</aff><aff id="af2-mco-0-0-1356"><label>2</label>Department of Breast Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China</aff><author-notes><corresp id="c1-mco-0-0-1356"><italic>Correspondence to</italic>: Dr Ming-Hai Wang or Mr Yi-Sheng Zhang, Department of General Surgery, The First Affiliated Yijishan Hospital of Wannan Medical College, 2 Zheshan Western Road, Wuhu, Anhui 241000, P.R. China, E-mail: <email>wangmh0410@sina.com</email>, E-mail: <email>zhangys0109@hotmail.com</email></corresp><fn id="fn1-mco-0-0-1356"><label>*</label><p>Contributed equally</p></fn></author-notes><pub-date pub-type="ppub"><month>10</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>31</day><month>7</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>31</day><month>7</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>7</volume><issue>4</issue><fpage>515</fpage><lpage>520</lpage><history><date date-type="received"><day>22</day><month>2</month><year>2017</year></date><date date-type="accepted"><day>22</day><month>7</month><year>2017</year></date></history><permissions><copyright-statement>Copyright: © Kong et al.</copyright-statement><copyright-year>2017</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/">Creative Commons Attribution-NonCommercial-NoDerivs License</ext-link>, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.</license-p></license></permissions><abstract><p>Podoplanin, lymphatic vessel endothelial hyaluronic acid receptor-1, prospero-related homeobox-1 and vascular endothelial growth factor receptor 3 have been demonstrated to have crucial roles in the development of the lymphatic system and lymphangiogenesis process by combining with their corresponding receptors. Thus, the four markers have been widely used in labelling lymphatic vessels for the detection of lymphangiogenesis and lymphatic vessel invasion. Numerous authors have aimed to identify the roles of these four markers in the lymphatic system and the mechanisms have been partly clarified at the molecular level. The aim of the present review was to comprehensively clarify the characteristics and latent action modes of the four markers in order to determine which is the best one for the detection of lymphangiogenesis and lymphatic vessel invasion.</p></abstract><kwd-group><kwd>D2-40</kwd><kwd>lymphatic vessel endothelial hyaluronic acid receptor-1</kwd><kwd>prospero-related homeobox 1</kwd><kwd>vascular endothelial growth factor receptor 3</kwd><kwd>lymphangiogenesis</kwd><kwd>lymphatic vessel</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><label>1.</label><title>Introduction</title><p>As part of the circulatory system, lymphatic vessels have particular functions in fluid homeostasis, lipid absorption, immune cell trafficking and causative agent filtration (<xref rid="b1-mco-0-0-1356" ref-type="bibr">1</xref>). Obviously disparate from blood vessels, the lymphatic endothelial cells are ulteriorly sorted in sub-compartments of the lymphatic vasculature (<xref rid="b1-mco-0-0-1356" ref-type="bibr">1</xref>–<xref rid="b3-mco-0-0-1356" ref-type="bibr">3</xref>). The lymphatic vascular system consists of a compact network of blind-ended, slight-walled lymphatic capillaries and collecting lymph vessels that drain exudative protein-rich fluid from the majority of tissues that transport the lymph by way of the thoracic duct to the venous circulation (<xref rid="b4-mco-0-0-1356" ref-type="bibr">4</xref>). In addition, lymphatic channels have a crucial role in the course of tumor development and metastasis; however, the mechanism of tumor metastasis in the lymphatic pathway remains unclear. Nevertheless, several lymphatic endothelial markers, such as vascular endothelial growth factor receptor 3 (VEGFR-3), lymphatic vessel endothelial hyaluronic acid receptor-1 (LYVE-1), prospero-related homeobox-1 (Prox-1) and podoplanin are widely used in the detection of lymphangiogenesis and lymphatic vessel invasion in a variety of cancer types (<xref rid="b5-mco-0-0-1356" ref-type="bibr">5</xref>–<xref rid="b7-mco-0-0-1356" ref-type="bibr">7</xref>). These markers interact with each other in various physiological processes. During murine embryogenesis, the first lymph sacs sprout from the cardinal vein in response to elevating levels of homeobox domain-related transcriptional factor, Prox-1, and the specific receptor of hyaluronan (HA), LYVE-1, around embryonic day 10.5 (E10.5). Meanwhile, the level of lymphatic endothelium specific receptor, VEGFR-3, remains high in lymphatic endothelial cells (LECs), whereas its expression is decreased substantially in vascular endothelial cells (<xref rid="b8-mco-0-0-1356" ref-type="bibr">8</xref>,<xref rid="b9-mco-0-0-1356" ref-type="bibr">9</xref>). Specific markers of LEC, VEGFR-3, LYVE-1, Prox-1 and podoplanin, have provided novel insights into the biology of malignant tumors. Other studies have demonstrated the co-expression of podoplanin, VEGFR-3, Prox-1 and LYVE-1 in LECs of normal adult and tumor tissues (<xref rid="b8-mco-0-0-1356" ref-type="bibr">8</xref>,<xref rid="b10-mco-0-0-1356" ref-type="bibr">10</xref>). The present review aimed to determine which is the most effective marker for the detection of lymphangiogenesis and lymphatic vessel invasion.</p></sec><sec><label>2.</label><title>D2-40</title><p>Podoplanin, first identified in rats, is a 43-kDa membrane glycoprotein of podocytes (<xref rid="b11-mco-0-0-1356" ref-type="bibr">11</xref>). The podoplanin gene is a gene with 34.2 kb and eight exons that is responsible for the synthesis of podoplanin. The plasma membrane is the subcellular location of the encoded protein. Two species of podoplanin mRNA, which most likely stem from alternative splicing, have been verified by northern blotting (<xref rid="b12-mco-0-0-1356" ref-type="bibr">12</xref>).</p><p>Podoplanin is expressed specifically in lymphatic endothelium, and does not exist in the blood vasculature (<xref rid="b13-mco-0-0-1356" ref-type="bibr">13</xref>). It has a crucial role in preventing cellular adhesion and is involved in regulating the formation of podocyte foot processes and the maintenance of glomerular permeability (<xref rid="b11-mco-0-0-1356" ref-type="bibr">11</xref>,<xref rid="b14-mco-0-0-1356" ref-type="bibr">14</xref>,<xref rid="b15-mco-0-0-1356" ref-type="bibr">15</xref>). Additionally, podoplanin is also expressed in a variety of normal and neoplastic tissues (<xref rid="b16-mco-0-0-1356" ref-type="bibr">16</xref>–<xref rid="b19-mco-0-0-1356" ref-type="bibr">19</xref>). Podoplanin has been identified in the development of tooth germ, implicating a role in odontogenesis (<xref rid="b20-mco-0-0-1356" ref-type="bibr">20</xref>). Furthermore, its expression in various odontogenic tumors implies a role in promoting tumor invasiveness (<xref rid="b20-mco-0-0-1356" ref-type="bibr">20</xref>–<xref rid="b22-mco-0-0-1356" ref-type="bibr">22</xref>).</p><p>Podoplanin may increase the invasiveness of tumors through its ability to alter actin in the cytoskeleton of tumor cells, contributing to their intensive motility (<xref rid="b23-mco-0-0-1356" ref-type="bibr">23</xref>). The association between podoplanin and the actin cytoskeleton appears to be mediated by ezrin, whose phosphorylation is notably increased when podoplanin is overexpressed (<xref rid="b24-mco-0-0-1356" ref-type="bibr">24</xref>–<xref rid="b26-mco-0-0-1356" ref-type="bibr">26</xref>). Furthermore, podoplanin increases the activity of Rho GTPases, predominantly RhoA, reflecting a different cytoskeletal organization in different cell types (<xref rid="b19-mco-0-0-1356" ref-type="bibr">19</xref>). Inhibition of RhoA leads to a reduced motility of tumor cells (<xref rid="b26-mco-0-0-1356" ref-type="bibr">26</xref>).</p><p>D2-40 is a selective antibody to podoplanin, based on the recognition of a mixed epitope, whose structure is determined by the polypeptide core together with the O-linked carbohydrate chain (<xref rid="b27-mco-0-0-1356" ref-type="bibr">27</xref>). Compared with anti-podoplanin, D2-40 is monoclonal and may be utilized immediately, whereas anti-podoplanin requires prior affinity purification in nitrocellulose strips containing recombinant protein (<xref rid="b28-mco-0-0-1356" ref-type="bibr">28</xref>). Additionally, D2-40 may be used in staining paraffin sections without the requirement of epitope retrieval, while anti-podoplanin requires heat-dependent epitope retrieval (<xref rid="b28-mco-0-0-1356" ref-type="bibr">28</xref>).</p><p>As D2-40 is strongly expressed in the cytoplasm of LECs, it has been widely used as a specific marker in detecting tumor lymphovascular invasion (<xref rid="b29-mco-0-0-1356" ref-type="bibr">29</xref>). It has been demonstrated that lymphovascular invasion was detected in 13.8–16% of cases of invasive breast cancer on slides marked with hematoxylin and eosin, and this detection rate increased to 28.5% when staining for podoplanin was used (<xref rid="b30-mco-0-0-1356" ref-type="bibr">30</xref>,<xref rid="b31-mco-0-0-1356" ref-type="bibr">31</xref>). The results of multivariate analyses in various tumors have suggested that the expression of D2-40 was the strongest predictor of axillary lymph node metastasis (<xref rid="b30-mco-0-0-1356" ref-type="bibr">30</xref>–<xref rid="b32-mco-0-0-1356" ref-type="bibr">32</xref>). Furthermore, patients with tumors lacking podoplanin-positive vessels have been observed to have a better prognosis (<xref rid="b33-mco-0-0-1356" ref-type="bibr">33</xref>). A previous study has demonstrated that D2-40-positive lymphovascular invasion (LVI) correlates with younger age, premenopausal status and micro-vessel density, but not with tumor size or nuclear grade (<xref rid="b34-mco-0-0-1356" ref-type="bibr">34</xref>).</p><p>D2-40 appears to be an ideal marker for lymphatic vessels on account of the aforementioned evidence. Nevertheless, it should not be ignored that the myoepithelial cells of normal and benign ducts and lobules of the breast are stained when D2-40 is used to mark lymphatic vessels (<xref rid="b29-mco-0-0-1356" ref-type="bibr">29</xref>). A study by Rabban and Chen (<xref rid="b35-mco-0-0-1356" ref-type="bibr">35</xref>) demonstrated that normal breast myoepithelium surrounding solid ductal carcinoma <italic>in situ</italic> express variable degrees of D2-40, which may be misinterpreted as LVI. Therefore, they concluded that p63 should be synchronously used to stain myoepithelial cells when it is difficult to distinguish between lymphangiovascular invasion and stromal myoepithelial cells in close relation to neoplastic cells (<xref rid="b34-mco-0-0-1356" ref-type="bibr">34</xref>).</p></sec><sec><label>3.</label><title>LYVE-1</title><p>HA, an extracellular matrix glycosaminoglycan, is an indispensable element of skin and mesenchymal tissues that regulates cell migration in the course of wound healing, inflammation and embryonic morphogenesis (<xref rid="b36-mco-0-0-1356" ref-type="bibr">36</xref>). LYVE-1 is a specific receptor of HA, first identified by Banerji in 1999 (<xref rid="b37-mco-0-0-1356" ref-type="bibr">37</xref>). It is a member of the Link protein superfamily, with a deduced amino acid sequence of 322 residues, with 41% similarity to the cluster of differentiation 44 HA receptor (<xref rid="b38-mco-0-0-1356" ref-type="bibr">38</xref>). However, LYVE-1 integrates with HA on the luminal face of lymph vessels (<xref rid="f1-mco-0-0-1356" ref-type="fig">Fig. 1</xref>), and is never present in blood vessels (<xref rid="b37-mco-0-0-1356" ref-type="bibr">37</xref>).</p><p>Interactions between LYVE-1 and the extracellular matrix glycosaminoglycan, HA, may regulate leukocyte migration through the lymphatic vasculature (<xref rid="b38-mco-0-0-1356" ref-type="bibr">38</xref>). The serum level of LYVE-1 has been identified to be significantly lower in patients with lung cancer with metastasis in comparison with those without (<xref rid="b6-mco-0-0-1356" ref-type="bibr">6</xref>). It has been suggested that LYVE-1 could be used in predicting cancer progression (<xref rid="b6-mco-0-0-1356" ref-type="bibr">6</xref>). The interaction between LYVE-1 and HA was identified to be involved in the adhesion of tumor cells to lymphatic vessels (<xref rid="b39-mco-0-0-1356" ref-type="bibr">39</xref>). Furthermore, by using a novel approach such as reverse transcription-quantitative polymerase chain reaction, it has been demonstrated that the expression of LYVE-1 in breast tissue implies that lymphangiogenesis is occurring in the area (<xref rid="b40-mco-0-0-1356" ref-type="bibr">40</xref>). Furthermore, the expression of LYVE-1 was higher in breast cancer cases with axillary lymph node metastasis than those without (<xref rid="b40-mco-0-0-1356" ref-type="bibr">40</xref>). A study by Ramani <italic>et al</italic> (<xref rid="b7-mco-0-0-1356" ref-type="bibr">7</xref>) indicated that the upregulation of LYVE-1 may predict a poor prognosis in neuroblastoma. Carcinoma-induced angiogenesis regulated by cyclooxygenase (COX) is controlled via two mechanisms: COX-2 modulates production of angiogenic factors by cancer cells, while COX-1 regulates angiogenesis in endothelial cells (<xref rid="b41-mco-0-0-1356" ref-type="bibr">41</xref>). Expression of LYVE-1 was demonstrated to be positively correlated with COX-2 or vascular endothelial growth factor-C (VEGF-C) expression in breast cancer tissues (<xref rid="b42-mco-0-0-1356" ref-type="bibr">42</xref>). Recent research may explain the feasible mechanism of this phenomenon. The membrane type 1-matrix metalloproteinase, an endogenous suppressor of lymphatic vessel growth, directly sheds LYVE-1 on lymphatic endothelial cells to inhibit LYVE-1-mediated lymphangiogenic reactions and suppresses VEGF-C production from pro-lymphangiogenic macrophages through blocking the nuclear factor-κB signal path to restrain lymphangiogenesis (<xref rid="b43-mco-0-0-1356" ref-type="bibr">43</xref>).</p><p>In order to determine the exact function of LYVE-1 in the development of lymph vasculature, a murine model lacking the LYVE-1 gene has been created. It has been reported that mice lacking the LYVE-1 gene develop properly and establish a functional network of lymphatic vessels and lymph nodes that are thoroughly in accordance with the wild-type mice (<xref rid="b44-mco-0-0-1356" ref-type="bibr">44</xref>). No disruption occurred in the process of HA metabolism, in the development or differentiation of leukocyte subsets, or in dendritic cell trafficking or tumor growth (<xref rid="b44-mco-0-0-1356" ref-type="bibr">44</xref>). This lack of an obvious phenotype suggests that LYVE-1 does not have a major structural, developmental or regulatory role and implies that the lack of LYVE-1 is compensated by an unidentified module or that the role of LYVE-1 is much more specialized than previously imagined (<xref rid="b44-mco-0-0-1356" ref-type="bibr">44</xref>). Furthermore, true endothelial trans-differentiation vs. non-continuous endothelial-like macrophages (LYVE-1<sup>+</sup> and stabilin-1<sup>+</sup>) cannot be clarified completely, unless double markers are used in staining LYVE-1 for distinguishing clearly between LYVE-1<sup>+</sup> lymphatics and LYVE-1<sup>+</sup> tumor-infiltrating macrophages (<xref rid="b45-mco-0-0-1356" ref-type="bibr">45</xref>).</p></sec><sec><label>4.</label><title>Prox-1</title><p>The homeobox gene, Prox-1, was originally cloned by homology to the <italic>Drosophila melanogaster</italic> gene, prospero (<xref rid="b46-mco-0-0-1356" ref-type="bibr">46</xref>). Analysis of the expression pattern of Prox-1 suggested that it performs different functions in a variety of tissues, including the lens, heart, liver, pancreas and central nervous system (<xref rid="b46-mco-0-0-1356" ref-type="bibr">46</xref>).</p><p>It has been demonstrated that inactivation of the Prox-1 gene in mice results in embryonic lethality and phenotypic alterations of the lens and liver (<xref rid="b47-mco-0-0-1356" ref-type="bibr">47</xref>). A study by Wigle and Oliver (<xref rid="b9-mco-0-0-1356" ref-type="bibr">9</xref>) indicated that Prox-1 has an important function during the early formation of the lymph sacs by endothelial venous budding, and likely later during lymphatic growth by endothelial sprouting from these primary lymph sacs. Prox-1 appears to function in a time-dependent manner, following the formation of the lymphatic vasculature in each individual embryonic structure (<xref rid="b9-mco-0-0-1356" ref-type="bibr">9</xref>). It was also demonstrated that Prox-1 merely had a role in the development of the lymphatic but not the blood vascular system (<xref rid="b9-mco-0-0-1356" ref-type="bibr">9</xref>). At a similar time, a study by Hong <italic>et al</italic> (<xref rid="b48-mco-0-0-1356" ref-type="bibr">48</xref>) indicated that Prox-1 regulated the procedure of vascular phenotype conversion into a lymphatic phenotype. Its activity is sufficient to override the blood vasculature phenotype in primary human dermal microvascular endothelial cells by promoting a lymphatic endothelial phenotype instead (<xref rid="b47-mco-0-0-1356" ref-type="bibr">47</xref>).</p><p>Other research has demonstrated that the viability of Prox-1 in a conservative subpopulation of embryonic vein endothelial cells is crucial not only to promote lymphangiogenesis but also to determine a lymphatic fate (<xref rid="b8-mco-0-0-1356" ref-type="bibr">8</xref>). Prox-1 activates transcription of a key cell cycle regulatory gene by blocking it from binding to DNA, and regulates lymphatic endothelial cell proliferation (<xref rid="b49-mco-0-0-1356" ref-type="bibr">49</xref>). In 2008, Dadras <italic>et al</italic> (<xref rid="b50-mco-0-0-1356" ref-type="bibr">50</xref>) discovered that Prox1 may be related to a more aggressive vascular tumor phenotype with partial lymphatic differentiation, with characteristics of Kaposi's sarcoma. Following this, Prox-1 was indicated to be correlated with the pathogenesis of oral Kaposi's sarcoma, as there is a gradual increase in the number of positive spindle cells from patch/plaque to nodular stages (<xref rid="b51-mco-0-0-1356" ref-type="bibr">51</xref>). Therefore, Prox-1 may be used as a novel diagnostic biomarker to discriminate between oral Kaposi's sarcoma and benign oral vascular lesions (<xref rid="b51-mco-0-0-1356" ref-type="bibr">51</xref>).</p></sec><sec><label>5.</label><title>VEGFR-3</title><p>VEGFR-3 (also denoted Flt4) is a protein compound of 195 kDa. The compound is primarily cleaved in the fifth immunoglobulin (Ig)-like domain, producing an N-terminal peptide, which remains attached to the original protein via a disulfide bond (<xref rid="b52-mco-0-0-1356" ref-type="bibr">52</xref>). VEGFR-3 is sensitized through binding with VEGF-C and VEGF-D (<xref rid="b53-mco-0-0-1356" ref-type="bibr">53</xref>). Proteolytic processing of VEGF-C and VEGF-D results in increased affinity for binding to both VEGFR-2 and VEGFR-3 (<xref rid="b54-mco-0-0-1356" ref-type="bibr">54</xref>,<xref rid="b55-mco-0-0-1356" ref-type="bibr">55</xref>). It is easier for VEGF-C to combine with VEGFR-3 than to VEGFR-2 (<xref rid="b56-mco-0-0-1356" ref-type="bibr">56</xref>). VEGF-C binding requires Ig-loops 1 and 2 in VEGFR-3 (<xref rid="b57-mco-0-0-1356" ref-type="bibr">57</xref>), while binding to VEGFR-2 requires loops 2 and 3 (<xref rid="b58-mco-0-0-1356" ref-type="bibr">58</xref>). Human VEGF-D demonstrates analogical affinity for both VEGFR-2 and VEGFR-3, conversely, murine VEGF-D integrates only with VEGFR-3 (<xref rid="b59-mco-0-0-1356" ref-type="bibr">59</xref>). Furthermore, N-terminal residues in VEGF-D are a prerequisite for the activation of VEGFR-3, but not VEGFR-2 (<xref rid="b60-mco-0-0-1356" ref-type="bibr">60</xref>).</p><p>A study by Kaipainen <italic>et al</italic> (<xref rid="b61-mco-0-0-1356" ref-type="bibr">61</xref>) demonstrated that the expression of VEGFR-3 is restricted to lymphatic vessels during murine development. Also, VEGFR-3 is specifically expressed in lymphatic vessels by cloning the human fms-like tyrosine kinase (FLT)4 gene, in human adult tissues (<xref rid="b62-mco-0-0-1356" ref-type="bibr">62</xref>). Knockout of the VEGFR-3 gene leads to defectiveness of blood vessel development only in the early embryonic period of mice, which implies that VEGFR-3 has a vital role in the formation of the embryonic cardiovascular system before the emergence of lymphatic vessels (<xref rid="b63-mco-0-0-1356" ref-type="bibr">63</xref>). VEGFR-3 is also expressed weakly in capillary endothelium of normal breast tissue, but expressed strongly in intraductal carcinomas (<xref rid="b53-mco-0-0-1356" ref-type="bibr">53</xref>).</p><p>In an experimental model with VEGF-D-expressing tumors, administration of VEGF-D monoclonal antibody reduced the growth of primary tumors and the rate of lymph node metastases (<xref rid="b64-mco-0-0-1356" ref-type="bibr">64</xref>,<xref rid="b65-mco-0-0-1356" ref-type="bibr">65</xref>). A similar result was obtained with anti-VEGFR-3; however, no effect was observed on the development of lung metastasis (<xref rid="b66-mco-0-0-1356" ref-type="bibr">66</xref>). Other studies have indicated that both VEGF-C and VEGF-D, which are ligands for VEGFR-3, may promote tumor lymphangiogenesis and lymphatic metastasis (<xref rid="b64-mco-0-0-1356" ref-type="bibr">64</xref>,<xref rid="b67-mco-0-0-1356" ref-type="bibr">67</xref>–<xref rid="b69-mco-0-0-1356" ref-type="bibr">69</xref>). Furthermore, VEGFR-3 has been reported to stimulate the proliferation of angiogenic blood vessel endothelium in breast cancer (<xref rid="b53-mco-0-0-1356" ref-type="bibr">53</xref>).</p><p>Therapeutic agents that block VEGF signaling have been developed with the aim of retarding angiogenesis in diseases involved in tissue growth and inflammation, such as cancer. Sunitinib, an oral multiple-receptor tyrosine kinase inhibitor, has been authorized to be used in different types of solid tumors and targets VEGF receptors, stem cell factor receptor, platelet-derived growth factor receptor and FLT3 (<xref rid="b70-mco-0-0-1356" ref-type="bibr">70</xref>). It has been demonstrated to be biochemically active against urothelial carcinoma cells <italic>in vitro</italic> and <italic>in vivo</italic> (<xref rid="b71-mco-0-0-1356" ref-type="bibr">71</xref>,<xref rid="b72-mco-0-0-1356" ref-type="bibr">72</xref>).</p><p>Furthermore, there are many other kinds of biomarkers, such as 5′-nucleotidase, the second lymphatic chemokines, desmoplakin and β-chemotactic factor D6, that may be used in the detection of lymphatic vasculature (<xref rid="b73-mco-0-0-1356" ref-type="bibr">73</xref>–<xref rid="b75-mco-0-0-1356" ref-type="bibr">75</xref>). However, these markers have not been widely used in tumor lymph vessel examination due to the lack of reliability.</p></sec><sec sec-type="conclusions"><label>6.</label><title>Conclusion</title><p>The aforementioned markers bind to their own specific binding site in different modes. They all function in diverse ways at different stages of growth and development. At E9.5-E10.0, LYVE-1 is expressed uniformly in the endothelial cells of the cardinal vein, whereas Prox-1 is only able to be detected in a rigorous subpopulation of endothelial cells around this stage (<xref rid="b8-mco-0-0-1356" ref-type="bibr">8</xref>). These markers may also regulate each other in unclarified ways. The aberrant expression of Prox-1 in differentiated blood vessel endothelial cells leads to lymphatic endothelial regrouping, which is associated with increasing blood vascular-specific gene expression and the decreased expression of a large number of lymphatic-specific genes, such as VEGFR-3 and D2-40 (<xref rid="b48-mco-0-0-1356" ref-type="bibr">48</xref>,<xref rid="b76-mco-0-0-1356" ref-type="bibr">76</xref>). However, the intrinsic mechanism remains unclear. Not all of these markers are detected in all cancer types. For instance, LYVE-1 cannot be detected in MDA-MB-231 breast cancer cells (<xref rid="b40-mco-0-0-1356" ref-type="bibr">40</xref>). Therefore, it is essential that the combined application of lymphatic endothelium markers is used to detect lymphatic vessels for improving the sensitivity and veracity of detection.</p></sec></body><back><ack><title>Acknowledgements</title><p>The present study was supported by grants from the National Science Foundation of China (grant no. 81372828) and The First Affiliated Yijishan Hospital with Wannan Medical College Introduce Talents of Scientific Research Fund Project (grant no. YR201305).</p></ack><ref-list><title>References</title><ref id="b1-mco-0-0-1356"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schulte-Merker</surname><given-names>S</given-names></name><name><surname>Sabine</surname><given-names>A</given-names></name><name><surname>Petrova</surname><given-names>TV</given-names></name></person-group><article-title>Lymphatic vascular morphogenesis in development, physiology and disease</article-title><source>J Cell Biol</source><volume>193</volume><fpage>607</fpage><lpage>618</lpage><year>2011</year><pub-id pub-id-type="doi">10.1083/jcb.201012094</pub-id><pub-id pub-id-type="pmid">21576390</pub-id></element-citation></ref><ref id="b2-mco-0-0-1356"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tammela</surname><given-names>T</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Lymphangiogenesis: Molecular mechanisms and future promise</article-title><source>Cell</source><volume>140</volume><fpage>460</fpage><lpage>476</lpage><year>2010</year><pub-id pub-id-type="doi">10.1016/j.cell.2010.01.045</pub-id><pub-id pub-id-type="pmid">20178740</pub-id></element-citation></ref><ref id="b3-mco-0-0-1356"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kazenwadel</surname><given-names>J</given-names></name><name><surname>Harvey</surname><given-names>NL</given-names></name></person-group><article-title>Morphogenesis of the lymphatic vasculature: A focus on new progenitors and cellular mechanisms important for constructing lymphatic vessels</article-title><source>Dev Dyn</source><volume>245</volume><fpage>209</fpage><lpage>219</lpage><year>2016</year><pub-id pub-id-type="doi">10.1002/dvdy.24313</pub-id><pub-id pub-id-type="pmid">26228815</pub-id></element-citation></ref><ref id="b4-mco-0-0-1356"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Witte</surname><given-names>MH</given-names></name><name><surname>Bernas</surname><given-names>MJ</given-names></name><name><surname>Martin</surname><given-names>CP</given-names></name><name><surname>Witte</surname><given-names>CL</given-names></name></person-group><article-title>Lymphangiogenesis and lymphangiodysplasia: From molecular to clinical lymphology</article-title><source>Microsc Res Tech</source><volume>55</volume><fpage>122</fpage><lpage>145</lpage><year>2001</year><pub-id pub-id-type="doi">10.1002/jemt.1163</pub-id><pub-id pub-id-type="pmid">11596157</pub-id></element-citation></ref><ref id="b5-mco-0-0-1356"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cunnick</surname><given-names>GH</given-names></name><name><surname>Jiang</surname><given-names>WG</given-names></name><name><surname>Douglas-Jones</surname><given-names>T</given-names></name><name><surname>Watkins</surname><given-names>G</given-names></name><name><surname>Gomez</surname><given-names>KF</given-names></name><name><surname>Morgan</surname><given-names>MJ</given-names></name><name><surname>Subramanian</surname><given-names>A</given-names></name><name><surname>Mokbel</surname><given-names>K</given-names></name><name><surname>Mansel</surname><given-names>RE</given-names></name></person-group><article-title>Lymphangiogenesis and lymph node metastasis in breast cancer</article-title><source>Mol Cancer</source><volume>7</volume><fpage>23</fpage><year>2008</year><pub-id pub-id-type="doi">10.1186/1476-4598-7-23</pub-id><pub-id pub-id-type="pmid">18325094</pub-id></element-citation></ref><ref id="b6-mco-0-0-1356"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nunomiya</surname><given-names>K</given-names></name><name><surname>Shibata</surname><given-names>Y</given-names></name><name><surname>Abe</surname><given-names>S</given-names></name><name><surname>Inoue</surname><given-names>S</given-names></name><name><surname>Igarashi</surname><given-names>A</given-names></name><name><surname>Yamauchi</surname><given-names>K</given-names></name><name><surname>Kimura</surname><given-names>T</given-names></name><name><surname>Aida</surname><given-names>Y</given-names></name><name><surname>Nemoto</surname><given-names>T</given-names></name><name><surname>Sato</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Relationship between serum level of lymphatic vessel endothelial hyaluronan receptor-1 and prognosis in patients with lung cancer</article-title><source>J Cancer</source><volume>5</volume><fpage>242</fpage><lpage>247</lpage><year>2014</year><pub-id pub-id-type="doi">10.7150/jca.8486</pub-id><pub-id pub-id-type="pmid">24665348</pub-id></element-citation></ref><ref id="b7-mco-0-0-1356"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ramani</surname><given-names>P</given-names></name><name><surname>Dungwa</surname><given-names>JV</given-names></name><name><surname>May</surname><given-names>MT</given-names></name></person-group><article-title>LYVE-1 upregulation and lymphatic invasion correlate with adverse prognostic factors and lymph node metastasis in neuroblastoma</article-title><source>Virchows Arch</source><volume>460</volume><fpage>183</fpage><lpage>191</lpage><year>2012</year><pub-id pub-id-type="doi">10.1007/s00428-011-1190-y</pub-id><pub-id pub-id-type="pmid">22241180</pub-id></element-citation></ref><ref id="b8-mco-0-0-1356"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wigle</surname><given-names>JT</given-names></name><name><surname>Harvey</surname><given-names>N</given-names></name><name><surname>Detmar</surname><given-names>M</given-names></name><name><surname>Lagutina</surname><given-names>I</given-names></name><name><surname>Grosveld</surname><given-names>G</given-names></name><name><surname>Gunn</surname><given-names>MD</given-names></name><name><surname>Jackson</surname><given-names>DG</given-names></name><name><surname>Oliver</surname><given-names>G</given-names></name></person-group><article-title>An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype</article-title><source>EMBO J</source><volume>21</volume><fpage>1505</fpage><lpage>1513</lpage><year>2002</year><pub-id pub-id-type="doi">10.1093/emboj/21.7.1505</pub-id><pub-id pub-id-type="pmid">11927535</pub-id></element-citation></ref><ref id="b9-mco-0-0-1356"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wigle</surname><given-names>JT</given-names></name><name><surname>Oliver</surname><given-names>G</given-names></name></person-group><article-title>Prox1 function is required for the development of the murine lymphatic system</article-title><source>Cell</source><volume>98</volume><fpage>769</fpage><lpage>778</lpage><year>1999</year><pub-id pub-id-type="doi">10.1016/S0092-8674(00)81511-1</pub-id><pub-id pub-id-type="pmid">10499794</pub-id></element-citation></ref><ref id="b10-mco-0-0-1356"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Weninger</surname><given-names>W</given-names></name><name><surname>Partanen</surname><given-names>TA</given-names></name><name><surname>Breiteneder-Geleff</surname><given-names>S</given-names></name><name><surname>Mayer</surname><given-names>C</given-names></name><name><surname>Kowalski</surname><given-names>H</given-names></name><name><surname>Mildner</surname><given-names>M</given-names></name><name><surname>Pammer</surname><given-names>J</given-names></name><name><surname>Stürzl</surname><given-names>M</given-names></name><name><surname>Kerjaschki</surname><given-names>D</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name><name><surname>Tschachler</surname><given-names>E</given-names></name></person-group><article-title>Expression of vascular endothelial growth factor receptor-3 and podoplanin suggests a lymphatic endothelial cell origin of Kaposi's sarcoma tumor cells</article-title><source>Lab Invest</source><volume>79</volume><fpage>243</fpage><lpage>251</lpage><year>1999</year><pub-id pub-id-type="pmid">10068212</pub-id></element-citation></ref><ref id="b11-mco-0-0-1356"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Breiteneder-Geleff</surname><given-names>S</given-names></name><name><surname>Matsui</surname><given-names>K</given-names></name><name><surname>Soleiman</surname><given-names>A</given-names></name><name><surname>Meraner</surname><given-names>P</given-names></name><name><surname>Poczewski</surname><given-names>H</given-names></name><name><surname>Kalt</surname><given-names>R</given-names></name><name><surname>Schaffner</surname><given-names>G</given-names></name><name><surname>Kerjaschki</surname><given-names>D</given-names></name></person-group><article-title>Podoplanin, novel 43-kd membrane protein of glomerular epithelial cells, is down-regulated in puromycin nephrosis</article-title><source>Am J Pathol</source><volume>151</volume><fpage>1141</fpage><lpage>1152</lpage><year>1997</year><pub-id pub-id-type="pmid">9327748</pub-id></element-citation></ref><ref id="b12-mco-0-0-1356"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kriehuber</surname><given-names>E</given-names></name><name><surname>Breiteneder-Geleff</surname><given-names>S</given-names></name><name><surname>Groeger</surname><given-names>M</given-names></name><name><surname>Soleiman</surname><given-names>A</given-names></name><name><surname>Schoppmann</surname><given-names>SF</given-names></name><name><surname>Stingl</surname><given-names>G</given-names></name><name><surname>Kerjaschki</surname><given-names>D</given-names></name><name><surname>Maurer</surname><given-names>D</given-names></name></person-group><article-title>Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages</article-title><source>J Exp Med</source><volume>194</volume><fpage>797</fpage><lpage>808</lpage><year>2001</year><pub-id pub-id-type="doi">10.1084/jem.194.6.797</pub-id><pub-id pub-id-type="pmid">11560995</pub-id></element-citation></ref><ref id="b13-mco-0-0-1356"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Breiteneder-Geleff</surname><given-names>S</given-names></name><name><surname>Soleiman</surname><given-names>A</given-names></name><name><surname>Kowalski</surname><given-names>H</given-names></name><name><surname>Horvat</surname><given-names>R</given-names></name><name><surname>Amann</surname><given-names>G</given-names></name><name><surname>Kriehuber</surname><given-names>E</given-names></name><name><surname>Diem</surname><given-names>K</given-names></name><name><surname>Weninger</surname><given-names>W</given-names></name><name><surname>Tschachler</surname><given-names>E</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name><name><surname>Kerjaschki</surname><given-names>D</given-names></name></person-group><article-title>Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium</article-title><source>Am J Pathol</source><volume>154</volume><fpage>385</fpage><lpage>394</lpage><year>1999</year><pub-id pub-id-type="doi">10.1016/S0002-9440(10)65285-6</pub-id><pub-id pub-id-type="pmid">10027397</pub-id></element-citation></ref><ref id="b14-mco-0-0-1356"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schmid</surname><given-names>H</given-names></name><name><surname>Henger</surname><given-names>A</given-names></name><name><surname>Cohen</surname><given-names>CD</given-names></name><name><surname>Frach</surname><given-names>K</given-names></name><name><surname>Gröne</surname><given-names>HJ</given-names></name><name><surname>Schlöndorff</surname><given-names>D</given-names></name><name><surname>Kretzler</surname><given-names>M</given-names></name></person-group><article-title>Gene expression profiles of podocyte-associated molecules as diagnostic markers in acquired proteinuric diseases</article-title><source>J Am Soc Nephrol</source><volume>14</volume><fpage>2958</fpage><lpage>2966</lpage><year>2003</year><pub-id pub-id-type="doi">10.1097/01.ASN.0000090745.85482.06</pub-id><pub-id pub-id-type="pmid">14569107</pub-id></element-citation></ref><ref id="b15-mco-0-0-1356"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Levidiotis</surname><given-names>V</given-names></name><name><surname>Power</surname><given-names>DA</given-names></name></person-group><article-title>New insights into the molecular biology of the glomerular filtration barrier and associated disease</article-title><source>Nephrology (Carlton)</source><volume>10</volume><fpage>157</fpage><lpage>166</lpage><year>2005</year><pub-id pub-id-type="doi">10.1111/j.1440-1797.2005.00385.x</pub-id><pub-id pub-id-type="pmid">15877676</pub-id></element-citation></ref><ref id="b16-mco-0-0-1356"><label>16</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kanner</surname><given-names>WA</given-names></name><name><surname>Galgano</surname><given-names>MT</given-names></name><name><surname>Atkins</surname><given-names>KA</given-names></name></person-group><article-title>Podoplanin expression in basal and myoepithelial cells: Utility and potential pitfalls</article-title><source>Appl Immunohistochem Mol Morphol</source><volume>18</volume><fpage>226</fpage><lpage>230</lpage><year>2010</year><pub-id pub-id-type="doi">10.1097/PAI.0b013e3181c65141</pub-id><pub-id pub-id-type="pmid">20042851</pub-id></element-citation></ref><ref id="b17-mco-0-0-1356"><label>17</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Martín-Villar</surname><given-names>E</given-names></name><name><surname>Scholl</surname><given-names>FG</given-names></name><name><surname>Gamallo</surname><given-names>C</given-names></name><name><surname>Yurrita</surname><given-names>MM</given-names></name><name><surname>Muñoz-Guerra</surname><given-names>M</given-names></name><name><surname>Cruces</surname><given-names>J</given-names></name><name><surname>Quintanilla</surname><given-names>M</given-names></name></person-group><article-title>Characterization of human PA2.26 antigen (T1alpha-2, podoplanin), a small membrane mucin induced in oral squamous cell carcinomas</article-title><source>Int J Cancer</source><volume>113</volume><fpage>899</fpage><lpage>910</lpage><year>2005</year><pub-id pub-id-type="doi">10.1002/ijc.20656</pub-id><pub-id pub-id-type="pmid">15515019</pub-id></element-citation></ref><ref id="b18-mco-0-0-1356"><label>18</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kato</surname><given-names>Y</given-names></name><name><surname>Kaneko</surname><given-names>M</given-names></name><name><surname>Sata</surname><given-names>M</given-names></name><name><surname>Fujita</surname><given-names>N</given-names></name><name><surname>Tsuruo</surname><given-names>T</given-names></name><name><surname>Osawa</surname><given-names>M</given-names></name></person-group><article-title>Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma</article-title><source>Tumour Biol</source><volume>26</volume><fpage>195</fpage><lpage>200</lpage><year>2005</year><pub-id pub-id-type="doi">10.1159/000086952</pub-id><pub-id pub-id-type="pmid">16006773</pub-id></element-citation></ref><ref id="b19-mco-0-0-1356"><label>19</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schacht</surname><given-names>V</given-names></name><name><surname>Dadras</surname><given-names>SS</given-names></name><name><surname>Johnson</surname><given-names>LA</given-names></name><name><surname>Jackson</surname><given-names>DG</given-names></name><name><surname>Hong</surname><given-names>YK</given-names></name><name><surname>Detmar</surname><given-names>M</given-names></name></person-group><article-title>Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors</article-title><source>Am J Pathol</source><volume>166</volume><fpage>913</fpage><lpage>921</lpage><year>2005</year><pub-id pub-id-type="doi">10.1016/S0002-9440(10)62311-5</pub-id><pub-id pub-id-type="pmid">15743802</pub-id></element-citation></ref><ref id="b20-mco-0-0-1356"><label>20</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zustin</surname><given-names>J</given-names></name><name><surname>Scheuer</surname><given-names>HA</given-names></name><name><surname>Friedrich</surname><given-names>RE</given-names></name></person-group><article-title>Podoplanin expression in human tooth germ tissues and cystic odontogenic lesions: An immunohistochemical study</article-title><source>J Oral Pathol Med</source><volume>39</volume><fpage>115</fpage><lpage>120</lpage><year>2010</year><pub-id pub-id-type="doi">10.1111/j.1600-0714.2009.00853.x</pub-id><pub-id pub-id-type="pmid">20359309</pub-id></element-citation></ref><ref id="b21-mco-0-0-1356"><label>21</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kikuchi</surname><given-names>K</given-names></name><name><surname>Ito</surname><given-names>S</given-names></name><name><surname>Inoue</surname><given-names>H</given-names></name><name><surname>González-Alva</surname><given-names>P</given-names></name><name><surname>Miyazaki</surname><given-names>Y</given-names></name><name><surname>Sakashita</surname><given-names>H</given-names></name><name><surname>Yoshino</surname><given-names>A</given-names></name><name><surname>Katayama</surname><given-names>Y</given-names></name><name><surname>Terui</surname><given-names>T</given-names></name><name><surname>Ide</surname><given-names>F</given-names></name><name><surname>Kusama</surname><given-names>K</given-names></name></person-group><article-title>Immunohistochemical expression of podoplanin in so-called hard α-keratin-expressing tumors, including calcifying cystic odontogenic tumor, craniopharyngioma and pilomatrixoma</article-title><source>J Oral Sci</source><volume>54</volume><fpage>165</fpage><lpage>175</lpage><year>2012</year><pub-id pub-id-type="doi">10.2334/josnusd.54.165</pub-id><pub-id pub-id-type="pmid">22790409</pub-id></element-citation></ref><ref id="b22-mco-0-0-1356"><label>22</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tsuneki</surname><given-names>M</given-names></name><name><surname>Maruyama</surname><given-names>S</given-names></name><name><surname>Yamazaki</surname><given-names>M</given-names></name><name><surname>Cheng</surname><given-names>J</given-names></name><name><surname>Saku</surname><given-names>T</given-names></name></person-group><article-title>Podoplanin expression profiles characteristic of odontogenic tumor-specific tissue architectures</article-title><source>Pathol Res Pract</source><volume>208</volume><fpage>140</fpage><lpage>146</lpage><year>2012</year><pub-id pub-id-type="doi">10.1016/j.prp.2011.12.016</pub-id><pub-id pub-id-type="pmid">22326634</pub-id></element-citation></ref><ref id="b23-mco-0-0-1356"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Moustakas</surname><given-names>A</given-names></name><name><surname>Heldin</surname><given-names>CH</given-names></name></person-group><article-title>Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression</article-title><source>Cancer Sci</source><volume>98</volume><fpage>1512</fpage><lpage>1520</lpage><year>2007</year><pub-id pub-id-type="doi">10.1111/j.1349-7006.2007.00550.x</pub-id><pub-id pub-id-type="pmid">17645776</pub-id></element-citation></ref><ref id="b24-mco-0-0-1356"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Scholl</surname><given-names>FG</given-names></name><name><surname>Gamallo</surname><given-names>C</given-names></name><name><surname>Vilaró</surname><given-names>S</given-names></name><name><surname>Quintanilla</surname><given-names>M</given-names></name></person-group><article-title>Identification of PA2.26 antigen as a novel cell-surface mucin-type glycoprotein that induces plasma membrane extensions and increased motility in keratinocytes</article-title><source>J Cell Sci</source><volume>112</volume><fpage>4601</fpage><lpage>4613</lpage><year>1999</year><pub-id pub-id-type="pmid">10574709</pub-id></element-citation></ref><ref id="b25-mco-0-0-1356"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wicki</surname><given-names>A</given-names></name><name><surname>Lehembre</surname><given-names>F</given-names></name><name><surname>Wick</surname><given-names>N</given-names></name><name><surname>Hantusch</surname><given-names>B</given-names></name><name><surname>Kerjaschki</surname><given-names>D</given-names></name><name><surname>Christofori</surname><given-names>G</given-names></name></person-group><article-title>Tumor invasion in the absence of epithelial-mesenchymal transition: Podoplanin-mediated remodeling of the actin cytoskeleton</article-title><source>Cancer cell</source><volume>9</volume><fpage>261</fpage><lpage>272</lpage><year>2006</year><pub-id pub-id-type="doi">10.1016/j.ccr.2006.03.010</pub-id><pub-id pub-id-type="pmid">16616332</pub-id></element-citation></ref><ref id="b26-mco-0-0-1356"><label>26</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Martín-Villar</surname><given-names>E</given-names></name><name><surname>Megías</surname><given-names>D</given-names></name><name><surname>Castel</surname><given-names>S</given-names></name><name><surname>Yurrita</surname><given-names>MM</given-names></name><name><surname>Vilaró</surname><given-names>S</given-names></name><name><surname>Quintanilla</surname><given-names>M</given-names></name></person-group><article-title>Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition</article-title><source>J Cell Sci</source><volume>119</volume><fpage>4541</fpage><lpage>4553</lpage><year>2006</year><pub-id pub-id-type="doi">10.1242/jcs.03218</pub-id><pub-id pub-id-type="pmid">17046996</pub-id></element-citation></ref><ref id="b27-mco-0-0-1356"><label>27</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Marks</surname><given-names>A</given-names></name><name><surname>Sutherland</surname><given-names>DR</given-names></name><name><surname>Bailey</surname><given-names>D</given-names></name><name><surname>Iglesias</surname><given-names>J</given-names></name><name><surname>Law</surname><given-names>J</given-names></name><name><surname>Lei</surname><given-names>M</given-names></name><name><surname>Yeger</surname><given-names>H</given-names></name><name><surname>Banerjee</surname><given-names>D</given-names></name><name><surname>Baumal</surname><given-names>R</given-names></name></person-group><article-title>Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours</article-title><source>Br J Cancer</source><volume>80</volume><fpage>569</fpage><lpage>578</lpage><year>1999</year><pub-id pub-id-type="doi">10.1038/sj.bjc.6690393</pub-id><pub-id pub-id-type="pmid">10408868</pub-id></element-citation></ref><ref id="b28-mco-0-0-1356"><label>28</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kahn</surname><given-names>HJ</given-names></name><name><surname>Marks</surname><given-names>A</given-names></name></person-group><article-title>A new monoclonal antibody, D2-40, for detection of lymphatic invasion in primary tumors</article-title><source>Lab Invest</source><volume>82</volume><fpage>1255</fpage><lpage>1257</lpage><year>2002</year><pub-id pub-id-type="doi">10.1097/01.LAB.0000028824.03032.AB</pub-id><pub-id pub-id-type="pmid">12218087</pub-id></element-citation></ref><ref id="b29-mco-0-0-1356"><label>29</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ren</surname><given-names>S</given-names></name><name><surname>Abuel-Haija</surname><given-names>M</given-names></name><name><surname>Khurana</surname><given-names>JS</given-names></name><name><surname>Zhang</surname><given-names>X</given-names></name></person-group><article-title>D2-40: An additional marker for myoepithelial cells of breast and the precaution in interpreting tumor lymphovascular invasion</article-title><source>Int J Clin Exp Pathol</source><volume>4</volume><fpage>175</fpage><lpage>182</lpage><year>2011</year><pub-id pub-id-type="pmid">21326813</pub-id></element-citation></ref><ref id="b30-mco-0-0-1356"><label>30</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Braun</surname><given-names>M</given-names></name><name><surname>Flucke</surname><given-names>U</given-names></name><name><surname>Debald</surname><given-names>M</given-names></name><name><surname>Walgenbach-Bruenagel</surname><given-names>G</given-names></name><name><surname>Walgenbach</surname><given-names>KJ</given-names></name><name><surname>Höller</surname><given-names>T</given-names></name><name><surname>Pölcher</surname><given-names>M</given-names></name><name><surname>Wolfgarten</surname><given-names>M</given-names></name><name><surname>Sauerwald</surname><given-names>A</given-names></name><name><surname>Keyver-Paik</surname><given-names>M</given-names></name><etal></etal></person-group><article-title>Detection of lymphovascular invasion in early breast cancer by D2-40 (podoplanin): A clinically useful predictor for axillary lymph node metastases</article-title><source>Breast Cancer Res Treat</source><volume>112</volume><fpage>503</fpage><lpage>511</lpage><year>2008</year><pub-id pub-id-type="doi">10.1007/s10549-007-9875-2</pub-id><pub-id pub-id-type="pmid">18165897</pub-id></element-citation></ref><ref id="b31-mco-0-0-1356"><label>31</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>El-Gendi</surname><given-names>S</given-names></name><name><surname>Abdel-Hadi</surname><given-names>M</given-names></name></person-group><article-title>Lymphatic vessel density as prognostic factor in breast carcinoma: Relation to clinicopathologic parameters</article-title><source>J Egypt Natl Canc Inst</source><volume>21</volume><fpage>139</fpage><lpage>149</lpage><year>2009</year><pub-id pub-id-type="pmid">21057565</pub-id></element-citation></ref><ref id="b32-mco-0-0-1356"><label>32</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Birner</surname><given-names>P</given-names></name><name><surname>Schindl</surname><given-names>M</given-names></name><name><surname>Obermair</surname><given-names>A</given-names></name><name><surname>Breitenecker</surname><given-names>G</given-names></name><name><surname>Kowalski</surname><given-names>H</given-names></name><name><surname>Oberhuber</surname><given-names>G</given-names></name></person-group><article-title>Lymphatic microvessel density as a novel prognostic factor in early-stage invasive cervical cancer</article-title><source>Int J Cancer</source><volume>95</volume><fpage>29</fpage><lpage>33</lpage><year>2001</year><pub-id pub-id-type="doi">10.1002/1097-0215(20010120)95:1<29::AID-IJC1005>3.0.CO;2-W</pub-id><pub-id pub-id-type="pmid">11241307</pub-id></element-citation></ref><ref id="b33-mco-0-0-1356"><label>33</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Niemiec</surname><given-names>JA</given-names></name><name><surname>Adamczyk</surname><given-names>A</given-names></name><name><surname>Ambicka</surname><given-names>A</given-names></name><name><surname>Mucha-Malecka</surname><given-names>A</given-names></name><name><surname>Wysocki</surname><given-names>WM</given-names></name><name><surname>Ryś</surname><given-names>J</given-names></name></person-group><article-title>Distribution of podoplanin-positive tumor vessels predicts disease-specific survival of node-positive breast cancer patients treated with anthracyclines and/or taxanes</article-title><source>Cancer Invest</source><volume>32</volume><fpage>168</fpage><lpage>177</lpage><year>2014</year><pub-id pub-id-type="doi">10.3109/07357907.2014.889704</pub-id><pub-id pub-id-type="pmid">24605901</pub-id></element-citation></ref><ref id="b34-mco-0-0-1356"><label>34</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tezuka</surname><given-names>K</given-names></name><name><surname>Onoda</surname><given-names>N</given-names></name><name><surname>Takashima</surname><given-names>T</given-names></name><name><surname>Takagaki</surname><given-names>K</given-names></name><name><surname>Ishikawa</surname><given-names>T</given-names></name><name><surname>Wakasa</surname><given-names>T</given-names></name><name><surname>Wakasa</surname><given-names>K</given-names></name><name><surname>Hirakawa</surname><given-names>K</given-names></name></person-group><article-title>Prognostic significance of lymphovascular invasion diagnosed by lymphatic endothelium immunostaining in breast cancer patients</article-title><source>Oncol Rep</source><volume>17</volume><fpage>997</fpage><lpage>1003</lpage><year>2007</year><pub-id pub-id-type="pmid">17390035</pub-id></element-citation></ref><ref id="b35-mco-0-0-1356"><label>35</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rabban</surname><given-names>JT</given-names></name><name><surname>Chen</surname><given-names>YY</given-names></name></person-group><article-title>D2-40 expression by breast myoepithelium: Potential pitfalls in distinguishing intralymphatic carcinoma from in situ carcinoma</article-title><source>Hum Pathol</source><volume>39</volume><fpage>175</fpage><lpage>183</lpage><year>2008</year><pub-id pub-id-type="doi">10.1016/j.humpath.2007.06.018</pub-id><pub-id pub-id-type="pmid">18206495</pub-id></element-citation></ref><ref id="b36-mco-0-0-1356"><label>36</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Laurent</surname><given-names>TC</given-names></name><name><surname>Fraser</surname><given-names>JR</given-names></name></person-group><article-title>Hyaluronan</article-title><source>FASEB J</source><volume>6</volume><fpage>2397</fpage><lpage>2404</lpage><year>1992</year><pub-id pub-id-type="pmid">1563592</pub-id></element-citation></ref><ref id="b37-mco-0-0-1356"><label>37</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Banerji</surname><given-names>S</given-names></name><name><surname>Ni</surname><given-names>J</given-names></name><name><surname>Wang</surname><given-names>SX</given-names></name><name><surname>Clasper</surname><given-names>S</given-names></name><name><surname>Su</surname><given-names>J</given-names></name><name><surname>Tammi</surname><given-names>R</given-names></name><name><surname>Jones</surname><given-names>M</given-names></name><name><surname>Jackson</surname><given-names>DG</given-names></name></person-group><article-title>LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan</article-title><source>J Cell Biol</source><volume>144</volume><fpage>789</fpage><lpage>801</lpage><year>1999</year><pub-id pub-id-type="doi">10.1083/jcb.144.4.789</pub-id><pub-id pub-id-type="pmid">10037799</pub-id></element-citation></ref><ref id="b38-mco-0-0-1356"><label>38</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jackson</surname><given-names>DG</given-names></name><name><surname>Prevo</surname><given-names>R</given-names></name><name><surname>Clasper</surname><given-names>S</given-names></name><name><surname>Banerji</surname><given-names>S</given-names></name></person-group><article-title>LYVE-1, the lymphatic system and tumor lymphangiogenesis</article-title><source>Trends Immunol</source><volume>22</volume><fpage>317</fpage><lpage>321</lpage><year>2001</year><pub-id pub-id-type="doi">10.1016/S1471-4906(01)01936-6</pub-id><pub-id pub-id-type="pmid">11377291</pub-id></element-citation></ref><ref id="b39-mco-0-0-1356"><label>39</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Du</surname><given-names>Y</given-names></name><name><surname>Liu</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><name><surname>He</surname><given-names>Y</given-names></name><name><surname>Yang</surname><given-names>C</given-names></name><name><surname>Gao</surname><given-names>F</given-names></name></person-group><article-title>LYVE-1 enhances the adhesion of HS-578T cells to COS-7 cells via hyaluronan</article-title><source>Clin Invest Med</source><volume>34</volume><fpage>E45</fpage><lpage>E54</lpage><year>2011</year><pub-id pub-id-type="doi">10.25011/cim.v34i1.14912</pub-id><pub-id pub-id-type="pmid">21291635</pub-id></element-citation></ref><ref id="b40-mco-0-0-1356"><label>40</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cunnick</surname><given-names>GH</given-names></name><name><surname>Jiang</surname><given-names>WG</given-names></name><name><surname>Gomez</surname><given-names>KF</given-names></name><name><surname>Mansel</surname><given-names>RE</given-names></name></person-group><article-title>Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model</article-title><source>Biochem Biophys Res Commun</source><volume>288</volume><fpage>1043</fpage><lpage>1046</lpage><year>2001</year><pub-id pub-id-type="doi">10.1006/bbrc.2001.5869</pub-id><pub-id pub-id-type="pmid">11689016</pub-id></element-citation></ref><ref id="b41-mco-0-0-1356"><label>41</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tsujii</surname><given-names>M</given-names></name><name><surname>Kawano</surname><given-names>S</given-names></name><name><surname>Tsuji</surname><given-names>S</given-names></name><name><surname>Sawaoka</surname><given-names>H</given-names></name><name><surname>Hori</surname><given-names>M</given-names></name><name><surname>DuBois</surname><given-names>RN</given-names></name></person-group><article-title>Cyclooxygenase regulates angiogenesis induced by colon cancer cells</article-title><source>Cell</source><volume>93</volume><fpage>705</fpage><lpage>716</lpage><year>1998</year><pub-id pub-id-type="doi">10.1016/S0092-8674(00)81433-6</pub-id><pub-id pub-id-type="pmid">9630216</pub-id></element-citation></ref><ref id="b42-mco-0-0-1356"><label>42</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Timoshenko</surname><given-names>AV</given-names></name><name><surname>Chakraborty</surname><given-names>C</given-names></name><name><surname>Wagner</surname><given-names>GF</given-names></name><name><surname>Lala</surname><given-names>PK</given-names></name></person-group><article-title>COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer</article-title><source>Br J Cancer</source><volume>94</volume><fpage>1154</fpage><lpage>1163</lpage><year>2006</year><pub-id pub-id-type="doi">10.1038/sj.bjc.6603067</pub-id><pub-id pub-id-type="pmid">16570043</pub-id></element-citation></ref><ref id="b43-mco-0-0-1356"><label>43</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wong</surname><given-names>HL</given-names></name><name><surname>Jin</surname><given-names>G</given-names></name><name><surname>Cao</surname><given-names>R</given-names></name><name><surname>Zhang</surname><given-names>S</given-names></name><name><surname>Cao</surname><given-names>Y</given-names></name><name><surname>Zhou</surname><given-names>Z</given-names></name></person-group><article-title>MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis</article-title><source>Nat Commun</source><volume>7</volume><fpage>10824</fpage><year>2016</year><pub-id pub-id-type="doi">10.1038/ncomms10824</pub-id><pub-id pub-id-type="pmid">26926389</pub-id></element-citation></ref><ref id="b44-mco-0-0-1356"><label>44</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Gale</surname><given-names>NW</given-names></name><name><surname>Prevo</surname><given-names>R</given-names></name><name><surname>Espinosa</surname><given-names>J</given-names></name><name><surname>Ferguson</surname><given-names>DJ</given-names></name><name><surname>Dominguez</surname><given-names>MG</given-names></name><name><surname>Yancopoulos</surname><given-names>GD</given-names></name><name><surname>Thurston</surname><given-names>G</given-names></name><name><surname>Jackson</surname><given-names>DG</given-names></name></person-group><article-title>Normal lymphatic development and function in mice deficient for the lymphatic hyaluronan receptor LYVE-1</article-title><source>Mol Cell Biol</source><volume>27</volume><fpage>595</fpage><lpage>604</lpage><year>2007</year><pub-id pub-id-type="doi">10.1128/MCB.01503-06</pub-id><pub-id pub-id-type="pmid">17101772</pub-id></element-citation></ref><ref id="b45-mco-0-0-1356"><label>45</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Schledzewski</surname><given-names>K</given-names></name><name><surname>Falkowski</surname><given-names>M</given-names></name><name><surname>Moldenhauer</surname><given-names>G</given-names></name><name><surname>Metharom</surname><given-names>P</given-names></name><name><surname>Kzhyshkowska</surname><given-names>J</given-names></name><name><surname>Ganss</surname><given-names>R</given-names></name><name><surname>Demory</surname><given-names>A</given-names></name><name><surname>Falkowska-Hansen</surname><given-names>B</given-names></name><name><surname>Kurzen</surname><given-names>H</given-names></name><name><surname>Ugurel</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Lymphatic endothelium-specific hyaluronan receptor LYVE-1 is expressed by stabilin-1+, F4/80+, CD11b+ macrophages in malignant tumours and wound healing tissue in vivo and in bone marrow cultures in vitro: Implications for the assessment of lymphangiogenesis</article-title><source>J Pathol</source><volume>209</volume><fpage>67</fpage><lpage>77</lpage><year>2006</year><pub-id pub-id-type="doi">10.1002/path.1942</pub-id><pub-id pub-id-type="pmid">16482496</pub-id></element-citation></ref><ref id="b46-mco-0-0-1356"><label>46</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Oliver</surname><given-names>G</given-names></name><name><surname>Sosa-Pineda</surname><given-names>B</given-names></name><name><surname>Geisendorf</surname><given-names>S</given-names></name><name><surname>Spana</surname><given-names>EP</given-names></name><name><surname>Doe</surname><given-names>CQ</given-names></name><name><surname>Gruss</surname><given-names>P</given-names></name></person-group><article-title>Prox 1, a prospero-related homeobox gene expressed during mouse development</article-title><source>Mech Dev</source><volume>44</volume><fpage>3</fpage><lpage>16</lpage><year>1993</year><pub-id pub-id-type="doi">10.1016/0925-4773(93)90012-M</pub-id><pub-id pub-id-type="pmid">7908825</pub-id></element-citation></ref><ref id="b47-mco-0-0-1356"><label>47</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Wigle</surname><given-names>JT</given-names></name><name><surname>Chowdhury</surname><given-names>K</given-names></name><name><surname>Gruss</surname><given-names>P</given-names></name><name><surname>Oliver</surname><given-names>G</given-names></name></person-group><article-title>Prox1 function is crucial for mouse lens-fibre elongation</article-title><source>Nat Genet</source><volume>21</volume><fpage>318</fpage><lpage>322</lpage><year>1999</year><pub-id pub-id-type="doi">10.1038/6844</pub-id><pub-id pub-id-type="pmid">10080188</pub-id></element-citation></ref><ref id="b48-mco-0-0-1356"><label>48</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hong</surname><given-names>YK</given-names></name><name><surname>Harvey</surname><given-names>N</given-names></name><name><surname>Noh</surname><given-names>YH</given-names></name><name><surname>Schacht</surname><given-names>V</given-names></name><name><surname>Hirakawa</surname><given-names>S</given-names></name><name><surname>Detmar</surname><given-names>M</given-names></name><name><surname>Oliver</surname><given-names>G</given-names></name></person-group><article-title>Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate</article-title><source>Dev Dyn</source><volume>225</volume><fpage>351</fpage><lpage>357</lpage><year>2002</year><pub-id pub-id-type="doi">10.1002/dvdy.10163</pub-id><pub-id pub-id-type="pmid">12412020</pub-id></element-citation></ref><ref id="b49-mco-0-0-1356"><label>49</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baxter</surname><given-names>SA</given-names></name><name><surname>Cheung</surname><given-names>DY</given-names></name><name><surname>Bocangel</surname><given-names>P</given-names></name><name><surname>Kim</surname><given-names>HK</given-names></name><name><surname>Herbert</surname><given-names>K</given-names></name><name><surname>Douville</surname><given-names>JM</given-names></name><name><surname>Jangamreddy</surname><given-names>JR</given-names></name><name><surname>Zhang</surname><given-names>S</given-names></name><name><surname>Eisenstat</surname><given-names>DD</given-names></name><name><surname>Wigle</surname><given-names>JT</given-names></name></person-group><article-title>Regulation of the lymphatic endothelial cell cycle by the PROX1 homeodomain protein</article-title><source>Biochim Biophys Acta</source><volume>1813</volume><fpage>201</fpage><lpage>212</lpage><year>2011</year><pub-id pub-id-type="doi">10.1016/j.bbamcr.2010.10.015</pub-id><pub-id pub-id-type="pmid">21040746</pub-id></element-citation></ref><ref id="b50-mco-0-0-1356"><label>50</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dadras</surname><given-names>SS</given-names></name><name><surname>Skrzypek</surname><given-names>A</given-names></name><name><surname>Nguyen</surname><given-names>L</given-names></name><name><surname>Shin</surname><given-names>JW</given-names></name><name><surname>Schulz</surname><given-names>MM</given-names></name><name><surname>Arbiser</surname><given-names>J</given-names></name><name><surname>Mihm</surname><given-names>MC</given-names></name><name><surname>Detmar</surname><given-names>M</given-names></name></person-group><article-title>Prox-1 promotes invasion of kaposiform hemangioendotheliomas</article-title><source>J Invest Dermatol</source><volume>128</volume><fpage>2798</fpage><lpage>2806</lpage><year>2008</year><pub-id pub-id-type="doi">10.1038/jid.2008.176</pub-id><pub-id pub-id-type="pmid">18580962</pub-id></element-citation></ref><ref id="b51-mco-0-0-1356"><label>51</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de Andrade</surname><given-names>BA Benevenuto</given-names></name><name><surname>Ramírez-Amador</surname><given-names>V</given-names></name><name><surname>Anaya-Saavedra</surname><given-names>G</given-names></name><name><surname>Martínez-Mata</surname><given-names>G</given-names></name><name><surname>Fonseca</surname><given-names>FP</given-names></name><name><surname>Graner</surname><given-names>E</given-names></name><name><surname>de Almeida</surname><given-names>O Paes</given-names></name></person-group><article-title>Expression of PROX-1 in oral Kaposi's sarcoma spindle cells</article-title><source>J Oral Pathol Med</source><volume>43</volume><fpage>132</fpage><lpage>136</lpage><year>2014</year><pub-id pub-id-type="doi">10.1111/jop.12097</pub-id><pub-id pub-id-type="pmid">23763431</pub-id></element-citation></ref><ref id="b52-mco-0-0-1356"><label>52</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pajusola</surname><given-names>K</given-names></name><name><surname>Aprelikova</surname><given-names>O</given-names></name><name><surname>Armstrong</surname><given-names>E</given-names></name><name><surname>Morris</surname><given-names>S</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts</article-title><source>Oncogene</source><volume>8</volume><fpage>2931</fpage><lpage>2937</lpage><year>1993</year><pub-id pub-id-type="pmid">7692369</pub-id></element-citation></ref><ref id="b53-mco-0-0-1356"><label>53</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Valtola</surname><given-names>R</given-names></name><name><surname>Salven</surname><given-names>P</given-names></name><name><surname>Heikkilä</surname><given-names>P</given-names></name><name><surname>Taipale</surname><given-names>J</given-names></name><name><surname>Joensuu</surname><given-names>H</given-names></name><name><surname>Rehn</surname><given-names>M</given-names></name><name><surname>Pihlajaniemi</surname><given-names>T</given-names></name><name><surname>Weich</surname><given-names>H</given-names></name><name><surname>deWaal</surname><given-names>R</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>VEGFR-3 and its ligand VEGF-C are associated with angiogenesis in breast cancer</article-title><source>Am J Pathol</source><volume>154</volume><fpage>1381</fpage><lpage>1390</lpage><year>1999</year><pub-id pub-id-type="doi">10.1016/S0002-9440(10)65392-8</pub-id><pub-id pub-id-type="pmid">10329591</pub-id></element-citation></ref><ref id="b54-mco-0-0-1356"><label>54</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Joukov</surname><given-names>V</given-names></name><name><surname>Sorsa</surname><given-names>T</given-names></name><name><surname>Kumar</surname><given-names>V</given-names></name><name><surname>Jeltsch</surname><given-names>M</given-names></name><name><surname>Claesson-Welsh</surname><given-names>L</given-names></name><name><surname>Cao</surname><given-names>Y</given-names></name><name><surname>Saksela</surname><given-names>O</given-names></name><name><surname>Kalkkinen</surname><given-names>N</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Proteolytic processing regulates receptor specificity and activity of VEGF-C</article-title><source>EMBO J</source><volume>16</volume><fpage>3898</fpage><lpage>3911</lpage><year>1997</year><pub-id pub-id-type="doi">10.1093/emboj/16.13.3898</pub-id><pub-id pub-id-type="pmid">9233800</pub-id></element-citation></ref><ref id="b55-mco-0-0-1356"><label>55</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stacker</surname><given-names>SA</given-names></name><name><surname>Stenvers</surname><given-names>K</given-names></name><name><surname>Caesar</surname><given-names>C</given-names></name><name><surname>Vitali</surname><given-names>A</given-names></name><name><surname>Domagala</surname><given-names>T</given-names></name><name><surname>Nice</surname><given-names>E</given-names></name><name><surname>Roufail</surname><given-names>S</given-names></name><name><surname>Simpson</surname><given-names>RJ</given-names></name><name><surname>Moritz</surname><given-names>R</given-names></name><name><surname>Karpanen</surname><given-names>T</given-names></name><etal></etal></person-group><article-title>Biosynthesis of vascular endothelial growth factor-D involves proteolytic processing which generates non-covalent homodimers</article-title><source>J Biol Chem</source><volume>274</volume><fpage>32127</fpage><lpage>32136</lpage><year>1999</year><pub-id pub-id-type="doi">10.1074/jbc.274.45.32127</pub-id><pub-id pub-id-type="pmid">10542248</pub-id></element-citation></ref><ref id="b56-mco-0-0-1356"><label>56</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mäkinen</surname><given-names>T</given-names></name><name><surname>Veikkola</surname><given-names>T</given-names></name><name><surname>Mustjoki</surname><given-names>S</given-names></name><name><surname>Karpanen</surname><given-names>T</given-names></name><name><surname>Catimel</surname><given-names>B</given-names></name><name><surname>Nice</surname><given-names>EC</given-names></name><name><surname>Wise</surname><given-names>L</given-names></name><name><surname>Mercer</surname><given-names>A</given-names></name><name><surname>Kowalski</surname><given-names>H</given-names></name><name><surname>Kerjaschki</surname><given-names>D</given-names></name><etal></etal></person-group><article-title>Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3</article-title><source>EMBO J</source><volume>20</volume><fpage>4762</fpage><lpage>4773</lpage><year>2001</year><pub-id pub-id-type="doi">10.1093/emboj/20.17.4762</pub-id><pub-id pub-id-type="pmid">11532940</pub-id></element-citation></ref><ref id="b57-mco-0-0-1356"><label>57</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jeltsch</surname><given-names>M</given-names></name><name><surname>Karpanen</surname><given-names>T</given-names></name><name><surname>Strandin</surname><given-names>T</given-names></name><name><surname>Aho</surname><given-names>K</given-names></name><name><surname>Lankinen</surname><given-names>H</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Vascular endothelial growth factor (VEGF)/VEGF-C mosaic molecules reveal specificity determinants and feature novel receptor binding patterns</article-title><source>J Biol Chem</source><volume>281</volume><fpage>12187</fpage><lpage>12195</lpage><year>2006</year><pub-id pub-id-type="doi">10.1074/jbc.M511593200</pub-id><pub-id pub-id-type="pmid">16505489</pub-id></element-citation></ref><ref id="b58-mco-0-0-1356"><label>58</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leppänen</surname><given-names>VM</given-names></name><name><surname>Prota</surname><given-names>AE</given-names></name><name><surname>Jeltsch</surname><given-names>M</given-names></name><name><surname>Anisimov</surname><given-names>A</given-names></name><name><surname>Kalkkinen</surname><given-names>N</given-names></name><name><surname>Strandin</surname><given-names>T</given-names></name><name><surname>Lankinen</surname><given-names>H</given-names></name><name><surname>Goldman</surname><given-names>A</given-names></name><name><surname>Ballmer-Hofer</surname><given-names>K</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Structural determinants of growth factor binding and specificity by VEGF receptor 2</article-title><source>Proc Natl Acad Sci USA</source><volume>107</volume><fpage>2425</fpage><lpage>2430</lpage><year>2010</year><pub-id pub-id-type="doi">10.1073/pnas.0914318107</pub-id><pub-id pub-id-type="pmid">20145116</pub-id></element-citation></ref><ref id="b59-mco-0-0-1356"><label>59</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baldwin</surname><given-names>ME</given-names></name><name><surname>Catimel</surname><given-names>B</given-names></name><name><surname>Nice</surname><given-names>EC</given-names></name><name><surname>Roufail</surname><given-names>S</given-names></name><name><surname>Hall</surname><given-names>NE</given-names></name><name><surname>Stenvers</surname><given-names>KL</given-names></name><name><surname>Karkkainen</surname><given-names>MJ</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name><name><surname>Stacker</surname><given-names>SA</given-names></name><name><surname>Achen</surname><given-names>MG</given-names></name></person-group><article-title>The specificity of receptor binding by vascular endothelial growth factor-d is different in mouse and man</article-title><source>J Biol Chem</source><volume>276</volume><fpage>19166</fpage><lpage>19171</lpage><year>2001</year><pub-id pub-id-type="doi">10.1074/jbc.M100097200</pub-id><pub-id pub-id-type="pmid">11279005</pub-id></element-citation></ref><ref id="b60-mco-0-0-1356"><label>60</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leppänen</surname><given-names>VM</given-names></name><name><surname>Jeltsch</surname><given-names>M</given-names></name><name><surname>Anisimov</surname><given-names>A</given-names></name><name><surname>Tvorogov</surname><given-names>D</given-names></name><name><surname>Aho</surname><given-names>K</given-names></name><name><surname>Kalkkinen</surname><given-names>N</given-names></name><name><surname>Toivanen</surname><given-names>P</given-names></name><name><surname>Ylä-Herttuala</surname><given-names>S</given-names></name><name><surname>Ballmer-Hofer</surname><given-names>K</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Structural determinants of vascular endothelial growth factor-D receptor binding and specificity</article-title><source>Blood</source><volume>117</volume><fpage>1507</fpage><lpage>1515</lpage><year>2011</year><pub-id pub-id-type="doi">10.1182/blood-2010-08-301549</pub-id><pub-id pub-id-type="pmid">21148085</pub-id></element-citation></ref><ref id="b61-mco-0-0-1356"><label>61</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kaipainen</surname><given-names>A</given-names></name><name><surname>Korhonen</surname><given-names>J</given-names></name><name><surname>Mustonen</surname><given-names>T</given-names></name><name><surname>van Hinsbergh</surname><given-names>VW</given-names></name><name><surname>Fang</surname><given-names>GH</given-names></name><name><surname>Dumont</surname><given-names>D</given-names></name><name><surname>Breitman</surname><given-names>M</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development</article-title><source>Proc Natl Acad Sci USA</source><volume>92</volume><fpage>3566</fpage><lpage>3570</lpage><year>1995</year><pub-id pub-id-type="doi">10.1073/pnas.92.8.3566</pub-id><pub-id pub-id-type="pmid">7724599</pub-id></element-citation></ref><ref id="b62-mco-0-0-1356"><label>62</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pajusola</surname><given-names>K</given-names></name><name><surname>Aprelikova</surname><given-names>O</given-names></name><name><surname>Korhonen</surname><given-names>J</given-names></name><name><surname>Kaipainen</surname><given-names>A</given-names></name><name><surname>Pertovaara</surname><given-names>L</given-names></name><name><surname>Alitalo</surname><given-names>R</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines</article-title><source>Cancer Res</source><volume>52</volume><fpage>5738</fpage><lpage>5743</lpage><year>1992</year><pub-id pub-id-type="pmid">1327515</pub-id></element-citation></ref><ref id="b63-mco-0-0-1356"><label>63</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dumont</surname><given-names>DJ</given-names></name><name><surname>Jussila</surname><given-names>L</given-names></name><name><surname>Taipale</surname><given-names>J</given-names></name><name><surname>Lymboussaki</surname><given-names>A</given-names></name><name><surname>Mustonen</surname><given-names>T</given-names></name><name><surname>Pajusola</surname><given-names>K</given-names></name><name><surname>Breitman</surname><given-names>M</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Cardiovascular failure in mouse embryos deficient in VEGF receptor-3</article-title><source>Science</source><volume>282</volume><fpage>946</fpage><lpage>949</lpage><year>1998</year><pub-id pub-id-type="doi">10.1126/science.282.5390.946</pub-id><pub-id pub-id-type="pmid">9794766</pub-id></element-citation></ref><ref id="b64-mco-0-0-1356"><label>64</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Stacker</surname><given-names>SA</given-names></name><name><surname>Caesar</surname><given-names>C</given-names></name><name><surname>Baldwin</surname><given-names>ME</given-names></name><name><surname>Thornton</surname><given-names>GE</given-names></name><name><surname>Williams</surname><given-names>RA</given-names></name><name><surname>Prevo</surname><given-names>R</given-names></name><name><surname>Jackson</surname><given-names>DG</given-names></name><name><surname>Nishikawa</surname><given-names>S</given-names></name><name><surname>Kubo</surname><given-names>H</given-names></name><name><surname>Achen</surname><given-names>MG</given-names></name></person-group><article-title>VEGF-D promotes the metastatic spread of tumor cells via the lymphatics</article-title><source>Nat Med</source><volume>7</volume><fpage>186</fpage><lpage>191</lpage><year>2001</year><pub-id pub-id-type="doi">10.1038/84635</pub-id><pub-id pub-id-type="pmid">11175849</pub-id></element-citation></ref><ref id="b65-mco-0-0-1356"><label>65</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jain</surname><given-names>RK</given-names></name><name><surname>Padera</surname><given-names>TP</given-names></name></person-group><article-title>Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy</article-title><source>J Natl Cancer Inst</source><volume>94</volume><fpage>785</fpage><lpage>787</lpage><year>2002</year><pub-id pub-id-type="doi">10.1093/jnci/94.11.785</pub-id><pub-id pub-id-type="pmid">12048260</pub-id></element-citation></ref><ref id="b66-mco-0-0-1356"><label>66</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>He</surname><given-names>Y</given-names></name><name><surname>Kozaki</surname><given-names>K</given-names></name><name><surname>Karpanen</surname><given-names>T</given-names></name><name><surname>Koshikawa</surname><given-names>K</given-names></name><name><surname>Yla-Herttuala</surname><given-names>S</given-names></name><name><surname>Takahashi</surname><given-names>T</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling</article-title><source>J Natl Cancer Inst</source><volume>94</volume><fpage>819</fpage><lpage>825</lpage><year>2002</year><pub-id pub-id-type="doi">10.1093/jnci/94.11.819</pub-id><pub-id pub-id-type="pmid">12048269</pub-id></element-citation></ref><ref id="b67-mco-0-0-1356"><label>67</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mäkinen</surname><given-names>T</given-names></name><name><surname>Jussila</surname><given-names>L</given-names></name><name><surname>Veikkola</surname><given-names>T</given-names></name><name><surname>Karpanen</surname><given-names>T</given-names></name><name><surname>Kettunen</surname><given-names>MI</given-names></name><name><surname>Pulkkanen</surname><given-names>KJ</given-names></name><name><surname>Kauppinen</surname><given-names>R</given-names></name><name><surname>Jackson</surname><given-names>DG</given-names></name><name><surname>Kubo</surname><given-names>H</given-names></name><name><surname>Nishikawa</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3</article-title><source>Nat Med</source><volume>7</volume><fpage>199</fpage><lpage>205</lpage><year>2001</year><pub-id pub-id-type="doi">10.1038/84651</pub-id><pub-id pub-id-type="pmid">11175851</pub-id></element-citation></ref><ref id="b68-mco-0-0-1356"><label>68</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mandriota</surname><given-names>SJ</given-names></name><name><surname>Jussila</surname><given-names>L</given-names></name><name><surname>Jeltsch</surname><given-names>M</given-names></name><name><surname>Compagni</surname><given-names>A</given-names></name><name><surname>Baetens</surname><given-names>D</given-names></name><name><surname>Prevo</surname><given-names>R</given-names></name><name><surname>Banerji</surname><given-names>S</given-names></name><name><surname>Huarte</surname><given-names>J</given-names></name><name><surname>Montesano</surname><given-names>R</given-names></name><name><surname>Jackson</surname><given-names>DG</given-names></name><etal></etal></person-group><article-title>Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis</article-title><source>EMBO J</source><volume>20</volume><fpage>672</fpage><lpage>682</lpage><year>2001</year><pub-id pub-id-type="doi">10.1093/emboj/20.4.672</pub-id><pub-id pub-id-type="pmid">11179212</pub-id></element-citation></ref><ref id="b69-mco-0-0-1356"><label>69</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Skobe</surname><given-names>M</given-names></name><name><surname>Hawighorst</surname><given-names>T</given-names></name><name><surname>Jackson</surname><given-names>DG</given-names></name><name><surname>Prevo</surname><given-names>R</given-names></name><name><surname>Janes</surname><given-names>L</given-names></name><name><surname>Velasco</surname><given-names>P</given-names></name><name><surname>Riccardi</surname><given-names>L</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name><name><surname>Claffey</surname><given-names>K</given-names></name><name><surname>Detmar</surname><given-names>M</given-names></name></person-group><article-title>Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis</article-title><source>Nat Med</source><volume>7</volume><fpage>192</fpage><lpage>198</lpage><year>2001</year><pub-id pub-id-type="doi">10.1038/84643</pub-id><pub-id pub-id-type="pmid">11175850</pub-id></element-citation></ref><ref id="b70-mco-0-0-1356"><label>70</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Takahashi</surname><given-names>S</given-names></name></person-group><article-title>Vascular endothelial growth factor (VEGF), VEGF receptors and their inhibitors for antiangiogenic tumor therapy</article-title><source>Biol Pharm Bull</source><volume>34</volume><fpage>1785</fpage><lpage>1788</lpage><year>2011</year><pub-id pub-id-type="doi">10.1248/bpb.34.1785</pub-id><pub-id pub-id-type="pmid">22130231</pub-id></element-citation></ref><ref id="b71-mco-0-0-1356"><label>71</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Beekman</surname><given-names>KW</given-names></name><name><surname>Bradley</surname><given-names>D</given-names></name><name><surname>Hussain</surname><given-names>M</given-names></name></person-group><article-title>New molecular targets and novel agents in the treatment of advanced urothelial cancer</article-title><source>Semin Oncol</source><volume>34</volume><fpage>154</fpage><lpage>164</lpage><year>2007</year><pub-id pub-id-type="doi">10.1053/j.seminoncol.2006.12.007</pub-id><pub-id pub-id-type="pmid">17382799</pub-id></element-citation></ref><ref id="b72-mco-0-0-1356"><label>72</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sonpavde</surname><given-names>G</given-names></name><name><surname>Jian</surname><given-names>W</given-names></name><name><surname>Liu</surname><given-names>H</given-names></name><name><surname>Wu</surname><given-names>MF</given-names></name><name><surname>Shen</surname><given-names>SS</given-names></name><name><surname>Lerner</surname><given-names>SP</given-names></name></person-group><article-title>Sunitinib malate is active against human urothelial carcinoma and enhances the activity of cisplatin in a preclinical model</article-title><source>Urol Oncol</source><volume>27</volume><fpage>391</fpage><lpage>399</lpage><year>2009</year><pub-id pub-id-type="doi">10.1016/j.urolonc.2008.03.017</pub-id><pub-id pub-id-type="pmid">18534874</pub-id></element-citation></ref><ref id="b73-mco-0-0-1356"><label>73</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Rudert</surname><given-names>M</given-names></name><name><surname>Tillmann</surname><given-names>B</given-names></name></person-group><article-title>Detection of lymph and blood vessels in the human intervertebral disc by histochemical and immunohistochemical methods</article-title><source>Ann Anat</source><volume>175</volume><fpage>237</fpage><lpage>242</lpage><year>1993</year><pub-id pub-id-type="doi">10.1016/S0940-9602(11)80009-9</pub-id><pub-id pub-id-type="pmid">8338222</pub-id></element-citation></ref><ref id="b74-mco-0-0-1356"><label>74</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kucera</surname><given-names>R</given-names></name><name><surname>Topolcan</surname><given-names>O</given-names></name><name><surname>Treskova</surname><given-names>I</given-names></name><name><surname>Kinkorova</surname><given-names>J</given-names></name><name><surname>Windrichova</surname><given-names>J</given-names></name><name><surname>Fuchsova</surname><given-names>R</given-names></name><name><surname>Svobodova</surname><given-names>S</given-names></name><name><surname>Treska</surname><given-names>V</given-names></name><name><surname>Babuska</surname><given-names>V</given-names></name><name><surname>Novak</surname><given-names>J</given-names></name><name><surname>Smejkal</surname><given-names>J</given-names></name></person-group><article-title>Evaluation of IL-2, IL-6, IL-8 and IL-10 in Malignant Melanoma Diagnostics</article-title><source>Anticancer Res</source><volume>35</volume><fpage>3537</fpage><lpage>3541</lpage><year>2015</year><pub-id pub-id-type="pmid">26026122</pub-id></element-citation></ref><ref id="b75-mco-0-0-1356"><label>75</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Harada</surname><given-names>T</given-names></name><name><surname>Shinohara</surname><given-names>M</given-names></name><name><surname>Nakamura</surname><given-names>S</given-names></name><name><surname>Shimada</surname><given-names>M</given-names></name><name><surname>Oka</surname><given-names>M</given-names></name></person-group><article-title>Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: Correlation with differentiation, mode of invasion, and metastatic potential</article-title><source>Int J Oral Maxillofac Surg</source><volume>21</volume><fpage>346</fpage><lpage>349</lpage><year>1992</year><pub-id pub-id-type="doi">10.1016/S0901-5027(05)80759-3</pub-id><pub-id pub-id-type="pmid">1282923</pub-id></element-citation></ref><ref id="b76-mco-0-0-1356"><label>76</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Petrova</surname><given-names>TV</given-names></name><name><surname>Mäkinen</surname><given-names>T</given-names></name><name><surname>Mäkelä</surname><given-names>TP</given-names></name><name><surname>Saarela</surname><given-names>J</given-names></name><name><surname>Virtanen</surname><given-names>I</given-names></name><name><surname>Ferrell</surname><given-names>RE</given-names></name><name><surname>Finegold</surname><given-names>DN</given-names></name><name><surname>Kerjaschki</surname><given-names>D</given-names></name><name><surname>Ylä-Herttuala</surname><given-names>S</given-names></name><name><surname>Alitalo</surname><given-names>K</given-names></name></person-group><article-title>Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor</article-title><source>EMBO J</source><volume>21</volume><fpage>4593</fpage><lpage>4599</lpage><year>2002</year><pub-id pub-id-type="doi">10.1093/emboj/cdf470</pub-id><pub-id pub-id-type="pmid">12198161</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="f1-mco-0-0-1356" orientation="portrait" position="float"><label>Figure 1.</label><caption><p>Possible relationship between markers of lymphatic vessels. The aberrant expression of Prox-1 decreases the expression of VEGFR-3 and D2-40. LYVE-1 integrates with HA on the luminal face of the lymph vessel. Prox-1, prospero-related homeobox-1; VEGFR-3, vascular endothelial growth factor receptor 3; LYVE-1, lymphatic vessel endothelial hyaluronic acid receptor-1; ?, currently unclear.</p></caption><graphic xlink:href="mco-07-04-0515-g00"></graphic></fig></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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