Comparison of quality of life, satisfaction with surgery and shoulder-arm morbidity in breast cancer survivors submitted to breast-conserving therapy or mastectomy followed by immediate breast reconstruction
Identifieur interne : 003D60 ( Pmc/Corpus ); précédent : 003D59; suivant : 003D61Comparison of quality of life, satisfaction with surgery and shoulder-arm morbidity in breast cancer survivors submitted to breast-conserving therapy or mastectomy followed by immediate breast reconstruction
Auteurs : Renata Freitas-Silva ; Délio Marques Conde ; Ruffo De Freitas-Júnior ; Edson Zangiacomi MartinezSource :
- Clinics [ 1807-5932 ] ; 2010.
Abstract
This study was designed to compare the prevalence of shoulder-arm morbidity, patient satisfaction with surgery and the quality of life of women submitted to breast-conserving therapy or modified radical mastectomy and immediate breast reconstruction.
This study was a cross-sectional study of women who underwent breast-conserving therapy (n = 44) or modified radical mastectomy and immediate breast reconstruction (n = 26). Quality of life was evaluated with the SF-36 Health Survey Questionnaire.
No differences were found in the prevalence of lymphedema. The movements that were most commonly affected by these procedures were abduction, flexion and external rotation. When the two groups were compared, however, we only found a statistically significant difference for the prevalence of restricted internal rotation, which occurred in 32% of women in the breast-conserving therapy group and 12% of those in the modified radical mastectomy and immediate breast reconstruction group (OR: 7.23; p = 0.03 following adjustment for potential confounding factors). No difference in quality of life or satisfaction with surgery was found between the two groups.
These data suggest that the type of surgery did not affect the occurrence of lymphedema. Breast-conserving therapy, however, increased the risk of shoulder movement limitation. No differences were found between the two surgical techniques with respect to quality of life or satisfaction with surgery.
Url:
DOI: 10.1590/S1807-59322010000800009
PubMed: 20835555
PubMed Central: 2933125
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PMC:2933125Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of quality of life, satisfaction with surgery and shoulder-arm morbidity in breast cancer survivors submitted to breast-conserving therapy or mastectomy followed by immediate breast reconstruction</title><author><name sortKey="Freitas Silva, Renata" sort="Freitas Silva, Renata" uniqKey="Freitas Silva R" first="Renata" last="Freitas-Silva">Renata Freitas-Silva</name><affiliation><nlm:aff id="af1-cln_65p781">Department of Gynecology and Obstetrics, Universidade Federal de Goiás (UFG), Goiânia/GO, Brasil</nlm:aff></affiliation></author><author><name sortKey="Conde, Delio Marques" sort="Conde, Delio Marques" uniqKey="Conde D" first="Délio Marques" last="Conde">Délio Marques Conde</name><affiliation><nlm:aff id="af2-cln_65p781">Breast Service, Hospital Materno Infantil (HMI), Goiânia/GO, Brasil</nlm:aff></affiliation></author><author><name sortKey="De Freitas Junior, Ruffo" sort="De Freitas Junior, Ruffo" uniqKey="De Freitas Junior R" first="Ruffo" last="De Freitas-Júnior">Ruffo De Freitas-Júnior</name><affiliation><nlm:aff id="af1-cln_65p781">Department of Gynecology and Obstetrics, Universidade Federal de Goiás (UFG), Goiânia/GO, Brasil</nlm:aff></affiliation></author><author><name sortKey="Martinez, Edson Zangiacomi" sort="Martinez, Edson Zangiacomi" uniqKey="Martinez E" first="Edson Zangiacomi" last="Martinez">Edson Zangiacomi Martinez</name><affiliation><nlm:aff id="af3-cln_65p781">Department of Social Medicine, Universidade de São Paulo (USP), Ribeirão Preto/SP, Brasil</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20835555</idno><idno type="pmc">2933125</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2933125</idno><idno type="RBID">PMC:2933125</idno><idno type="doi">10.1590/S1807-59322010000800009</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">003D60</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003D60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparison of quality of life, satisfaction with surgery and shoulder-arm morbidity in breast cancer survivors submitted to breast-conserving therapy or mastectomy followed by immediate breast reconstruction</title><author><name sortKey="Freitas Silva, Renata" sort="Freitas Silva, Renata" uniqKey="Freitas Silva R" first="Renata" last="Freitas-Silva">Renata Freitas-Silva</name><affiliation><nlm:aff id="af1-cln_65p781">Department of Gynecology and Obstetrics, Universidade Federal de Goiás (UFG), Goiânia/GO, Brasil</nlm:aff></affiliation></author><author><name sortKey="Conde, Delio Marques" sort="Conde, Delio Marques" uniqKey="Conde D" first="Délio Marques" last="Conde">Délio Marques Conde</name><affiliation><nlm:aff id="af2-cln_65p781">Breast Service, Hospital Materno Infantil (HMI), Goiânia/GO, Brasil</nlm:aff></affiliation></author><author><name sortKey="De Freitas Junior, Ruffo" sort="De Freitas Junior, Ruffo" uniqKey="De Freitas Junior R" first="Ruffo" last="De Freitas-Júnior">Ruffo De Freitas-Júnior</name><affiliation><nlm:aff id="af1-cln_65p781">Department of Gynecology and Obstetrics, Universidade Federal de Goiás (UFG), Goiânia/GO, Brasil</nlm:aff></affiliation></author><author><name sortKey="Martinez, Edson Zangiacomi" sort="Martinez, Edson Zangiacomi" uniqKey="Martinez E" first="Edson Zangiacomi" last="Martinez">Edson Zangiacomi Martinez</name><affiliation><nlm:aff id="af3-cln_65p781">Department of Social Medicine, Universidade de São Paulo (USP), Ribeirão Preto/SP, Brasil</nlm:aff></affiliation></author></analytic><series><title level="j">Clinics</title><idno type="ISSN">1807-5932</idno><idno type="eISSN">1980-5322</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>OBJECTIVES:</title><p>This study was designed to compare the prevalence of shoulder-arm morbidity, patient satisfaction with surgery and the quality of life of women submitted to breast-conserving therapy or modified radical mastectomy and immediate breast reconstruction.</p></sec><sec><title>METHODS:</title><p>This study was a cross-sectional study of women who underwent breast-conserving therapy (n = 44) or modified radical mastectomy and immediate breast reconstruction (n = 26). Quality of life was evaluated with the SF-36 Health Survey Questionnaire.</p></sec><sec><title>RESULTS:</title><p>No differences were found in the prevalence of lymphedema. The movements that were most commonly affected by these procedures were abduction, flexion and external rotation. When the two groups were compared, however, we only found a statistically significant difference for the prevalence of restricted internal rotation, which occurred in 32% of women in the breast-conserving therapy group and 12% of those in the modified radical mastectomy and immediate breast reconstruction group (OR: 7.23; p = 0.03 following adjustment for potential confounding factors). No difference in quality of life or satisfaction with surgery was found between the two groups.</p></sec><sec><title>CONCLUSIONS:</title><p>These data suggest that the type of surgery did not affect the occurrence of lymphedema. Breast-conserving therapy, however, increased the risk of shoulder movement limitation. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Clinics (Sao Paulo)</journal-id><journal-title-group><journal-title>Clinics</journal-title></journal-title-group><issn pub-type="ppub">1807-5932</issn><issn pub-type="epub">1980-5322</issn><publisher><publisher-name>Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">20835555</article-id><article-id pub-id-type="pmc">2933125</article-id><article-id pub-id-type="doi">10.1590/S1807-59322010000800009</article-id><article-id pub-id-type="publisher-id">cln_65p781</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Science</subject></subj-group></article-categories><title-group><article-title>Comparison of quality of life, satisfaction with surgery and shoulder-arm morbidity in breast cancer survivors submitted to breast-conserving therapy or mastectomy followed by immediate breast reconstruction</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Freitas-Silva</surname><given-names>Renata</given-names></name><xref ref-type="aff" rid="af1-cln_65p781">1</xref></contrib><contrib contrib-type="author"><name><surname>Conde</surname><given-names>Délio Marques</given-names></name><xref ref-type="aff" rid="af2-cln_65p781">2</xref><xref ref-type="corresp" rid="c1-cln_65p781"></xref></contrib><contrib contrib-type="author"><name><surname>de Freitas-Júnior</surname><given-names>Ruffo</given-names></name><xref ref-type="aff" rid="af1-cln_65p781">1</xref></contrib><contrib contrib-type="author"><name><surname>Martinez</surname><given-names>Edson Zangiacomi</given-names></name><xref ref-type="aff" rid="af3-cln_65p781">3</xref></contrib><aff id="af1-cln_65p781"><label>1</label>Department of Gynecology and Obstetrics, Universidade Federal de Goiás (UFG), Goiânia/GO, Brasil</aff><aff id="af2-cln_65p781"><label>2</label>Breast Service, Hospital Materno Infantil (HMI), Goiânia/GO, Brasil</aff><aff id="af3-cln_65p781"><label>3</label>Department of Social Medicine, Universidade de São Paulo (USP), Ribeirão Preto/SP, Brasil</aff></contrib-group><author-notes><corresp id="c1-cln_65p781">E-mail: <email>condedelio@uol.com.br</email> Tel.: <phone>55 62 3209-6151</phone></corresp></author-notes><pub-date pub-type="ppub"><month>8</month><year>2010</year></pub-date><volume>65</volume><issue>8</issue><fpage seq="b">781</fpage><lpage>787</lpage><history><date date-type="received"><day>8</day><month>3</month><year>2010</year></date><date date-type="rev-recd"><day>14</day><month>4</month><year>2010</year></date><date date-type="accepted"><day>11</day><month>5</month><year>2010</year></date></history><permissions><copyright-statement>Copyright © 2010 Hospital das Clínicas da FMUSP</copyright-statement><copyright-year>2010</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>OBJECTIVES:</title><p>This study was designed to compare the prevalence of shoulder-arm morbidity, patient satisfaction with surgery and the quality of life of women submitted to breast-conserving therapy or modified radical mastectomy and immediate breast reconstruction.</p></sec><sec><title>METHODS:</title><p>This study was a cross-sectional study of women who underwent breast-conserving therapy (n = 44) or modified radical mastectomy and immediate breast reconstruction (n = 26). Quality of life was evaluated with the SF-36 Health Survey Questionnaire.</p></sec><sec><title>RESULTS:</title><p>No differences were found in the prevalence of lymphedema. The movements that were most commonly affected by these procedures were abduction, flexion and external rotation. When the two groups were compared, however, we only found a statistically significant difference for the prevalence of restricted internal rotation, which occurred in 32% of women in the breast-conserving therapy group and 12% of those in the modified radical mastectomy and immediate breast reconstruction group (OR: 7.23; p = 0.03 following adjustment for potential confounding factors). No difference in quality of life or satisfaction with surgery was found between the two groups.</p></sec><sec><title>CONCLUSIONS:</title><p>These data suggest that the type of surgery did not affect the occurrence of lymphedema. Breast-conserving therapy, however, increased the risk of shoulder movement limitation. No differences were found between the two surgical techniques with respect to quality of life or satisfaction with surgery.</p></sec></abstract><kwd-group><kwd>Breast cancer</kwd><kwd>Quality of life</kwd><kwd>Lymphedema</kwd><kwd>Shoulder-arm morbidity, Aesthetic outcome</kwd></kwd-group><counts><page-count count="7"></page-count></counts></article-meta></front><body><sec sec-type="intro"><title>INTRODUCTION</title><p>Breast-conserving therapy (BCT) has become a safe option for the primary surgical treatment of early breast cancer.<xref ref-type="bibr" rid="b1-cln_65p781">1</xref> Nevertheless, there are cases where conservative treatment is impossible. In these cases, mastectomy followed by immediate reconstruction is one type of alternative treatment, and this procedure has yielded better aesthetic results.<xref ref-type="bibr" rid="b2-cln_65p781">2</xref> Another step in breast cancer surgery is the management of the axilla, which is done either by performing sentinel lymph node biopsy or complete axillary lymph node dissection. Breast-conserving therapy and mastectomy may be associated with complications such as lymphedema<xref ref-type="bibr" rid="b3-cln_65p781">3</xref>-<xref ref-type="bibr" rid="b7-cln_65p781">7</xref> and impaired shoulder function.<xref ref-type="bibr" rid="b3-cln_65p781">3</xref>,<xref ref-type="bibr" rid="b4-cln_65p781">4</xref>,<xref ref-type="bibr" rid="b6-cln_65p781">6</xref>,<xref ref-type="bibr" rid="b8-cln_65p781">8</xref> </p><p>Previous studies associated shoulder-arm impairment, including lymphedema, with different techniques for breast cancer surgery.<xref ref-type="bibr" rid="b3-cln_65p781">3</xref>,<xref ref-type="bibr" rid="b6-cln_65p781">6</xref>,<xref ref-type="bibr" rid="b7-cln_65p781">7</xref> Risk factors reported for arm lymphedema include the number of affected lymph nodes, being overweight, the type of surgery<xref ref-type="bibr" rid="b7-cln_65p781">7</xref> and radiotherapy.<xref ref-type="bibr" rid="b9-cln_65p781">9</xref> Interestingly, some investigators have described a greater occurrence of lymphedema in women who underwent mastectomy.<xref ref-type="bibr" rid="b6-cln_65p781">6</xref>-<xref ref-type="bibr" rid="b8-cln_65p781">8</xref>,<xref ref-type="bibr" rid="b9-cln_65p781">9</xref>,<xref ref-type="bibr" rid="b10-cln_65p781">10</xref> However, other studies have failed to identify the type of surgery as a risk factor for arm swelling.<xref ref-type="bibr" rid="b3-cln_65p781">3</xref>,<xref ref-type="bibr" rid="b11-cln_65p781">11</xref> </p><p>In addition to lymphedema, previous studies have investigated shoulder-arm function and evaluated different movements such as flexion, abduction, extension and rotation.<xref ref-type="bibr" rid="b3-cln_65p781">3</xref>,<xref ref-type="bibr" rid="b8-cln_65p781">8</xref>,<xref ref-type="bibr" rid="b11-cln_65p781">11</xref> Studies have reported that women submitted to mastectomy were more likely to experience restricted range of motion (ROM) compared to women submitted to BCT.<xref ref-type="bibr" rid="b6-cln_65p781">6</xref>,<xref ref-type="bibr" rid="b8-cln_65p781">8</xref> Nonetheless, other investigators failed to find any differences in arm mobility between different types of surgery.<xref ref-type="bibr" rid="b3-cln_65p781">3</xref>,<xref ref-type="bibr" rid="b11-cln_65p781">11</xref> In addition to physical complications, breast cancer surgery may be associated with emotional repercussions,<xref ref-type="bibr" rid="b12-cln_65p781">12</xref> depression,<xref ref-type="bibr" rid="b13-cln_65p781">13</xref> difficulties at work and anxiety.<xref ref-type="bibr" rid="b14-cln_65p781">14</xref> </p><p>Satisfaction with breast cancer surgery has also been investigated. Previous studies have shown that women submitted to BCT were more satisfied with the results of surgery than those submitted to mastectomy without reconstruction, BCT having been reported to be associated with a better body image<xref ref-type="bibr" rid="b15-cln_65p781">15</xref>-<xref ref-type="bibr" rid="b17-cln_65p781">17</xref> and greater satisfaction with cosmetic results.<xref ref-type="bibr" rid="b12-cln_65p781">12</xref>,<xref ref-type="bibr" rid="b17-cln_65p781">17</xref> Other authors, however, have described higher levels of satisfaction in women submitted to mastectomy with reconstruction compared to women submitted to BCT.<xref ref-type="bibr" rid="b2-cln_65p781">2</xref>,<xref ref-type="bibr" rid="b18-cln_65p781">18</xref> </p><p>Physical complications, emotional repercussions and satisfaction with the aesthetic results may affect the patient's perception of quality of life (QOL). Investigators have studied the association between the type of breast surgery and the patient's QOL; however, the results have been contradictory.<xref ref-type="bibr" rid="b2-cln_65p781">2</xref>,<xref ref-type="bibr" rid="b3-cln_65p781">3</xref>,<xref ref-type="bibr" rid="b16-cln_65p781">16</xref>,<xref ref-type="bibr" rid="b19-cln_65p781">19</xref> Few studies have compared shoulder-arm morbidity, satisfaction with surgery and the QOL of breast cancer survivors submitted to different forms of surgical therapy. The majority of the studies that have been published were conducted in developed countries, and conflicting data have been reported. Taking these factors into consideration and also considering the sociocultural factors that may affect a women's perception of QOL, the present study was designed to compare the prevalence of shoulder-arm morbidity, patient satisfaction with the primary surgical treatment and the QOL of breast cancer survivors submitted to BCT or modified radical mastectomy immediately followed by breast reconstruction (MRM+IBR).</p></sec><sec sec-type="methods"><title>PATIENTS AND METHODS</title><sec><title>Subjects</title><p>A cross-sectional study was conducted at the Breast Cancer Outpatient Department of the Universidade Federal de Goiás, Goiânia Brazil between October 2007 and November 2008. This was a public healthcare service for women with breast cancer.</p><p>Patients in this study were recruited from a population of patients undergoing routine follow-up at the clinic. Breast cancer survivors were invited to participate in the study if they fulfilled all of the following criteria: patients who had been submitted to BCT or MRM+IBR with a transverse rectus abdominis myocutaneous (TRAM) flap, patients who had undergone complete axillary lymph node dissection and patients diagnosed at stages I, II or III who had completed oncological treatment at least six months prior to this study and were considered to be free of the disease. Women with bilateral breast cancer, women with a history of lymphedema of the arm, women who had been submitted to radiotherapy prior to breast cancer surgery and women with a history of other types of malignant neoplasia were excluded from the study. All patients underwent clinical staging according to the TMN classification system (T describes the size of the tumor and whether it has invaded nearby tissue; N describes regional lymph nodes that are involved; M describes distant metastasis) and the staging system established by the American Joint Committee on Cancer in 1988.</p><p>Following outpatient consultation, 75 consecutive breast cancer patients were invited to participate in the study. Five patients refused to participate: two did not want to talk about the subject, and three claimed that they did not have time. Therefore, 70 breast cancer patients were included in the present study: 44 patients were in the BCT group, and 26 patients were in the MRM+IBR group.</p><p>Patients were interviewed for the purpose of collecting data on their sociodemographic and clinical characteristics, such as age, ethnicity, menopausal status, education level, marital status, smoking habits, employment status, monthly family income, body mass index (BMI) and current use of tamoxifen. Disease and treatment-related data were obtained from the patients' medical records, including age at the time of surgery, time since surgery, histological findings, number of lymph nodes removed, number of lymph nodes affected by the neoplasia, cancer stage, use of chemotherapy and radiotherapy. This study was approved by the Internal Review Board of the institution, and all women signed an informed consent form prior to enrollment.</p></sec><sec><title>Quality of life assessment</title><p>Quality of life was assessed with the Medical Outcomes Study 36-item Short-Form Health Survey (SF-36) questionnaire, <xref ref-type="bibr" rid="b20-cln_65p781">20</xref> a generic tool for evaluating QOL. The SF-36 had already been translated into Brazilian Portuguese and validated.<xref ref-type="bibr" rid="b21-cln_65p781">21</xref> This instrument was previously used in other studies carried out in breast cancer survivors.<xref ref-type="bibr" rid="b19-cln_65p781">19</xref>,<xref ref-type="bibr" rid="b22-cln_65p781">22</xref>,<xref ref-type="bibr" rid="b23-cln_65p781">23</xref> It is a multidimensional questionnaire with eight components: physical functioning, physical role functioning, bodily pain, general health perceptions, vitality, social role functioning, emotional role functioning and mental health. These components may be grouped into two sets: the physical component summary (PCS) and the mental component summary (MCS). Each component is measured with a value ranging from 0 to 100, with 0 and 100 corresponding to the poorest and optimal health statuses, respectively.<xref ref-type="bibr" rid="b24-cln_65p781">24</xref> The questionnaire was applied by one of the investigators in the form of an interview.</p></sec><sec><title>Patient satisfaction with breast cancer surgery</title><p>Patient satisfaction with the primary surgical treatment was investigated by posing seven additional questions that had already been used in a previous study<xref ref-type="bibr" rid="b12-cln_65p781">12</xref>. The patients were asked the following questions, and they were told to respond to questions 2 through 6 using a 4-point scale (1 – not at all; 2 – slightly; 3 – moderately; or 4 – very much so): 1) rate the aesthetic results of the operation using scores ranging from 1 (dreadful) to 7 (excellent); 2) was there a substantial change in physical appearance caused by the surgery; 3) did the patient's physical appearance cause her any emotional stress; 4) was everyday life still impaired as a result of the primary treatment; 5) did the patient regret her choice of surgical treatment; 6) to what extent did the patient fear a recurrence of the disease; and 7) whether a different choice of surgical treatment would have been made in hindsight (yes/no) (<xref ref-type="table" rid="t1-cln_65p781">Table 1</xref>).<xref ref-type="bibr" rid="b12-cln_65p781">12</xref> </p></sec><sec><title>Evaluation of shoulder-arm morbidity</title><p>Shoulder-arm morbidity was evaluated following breast surgery by investigating the prevalence of lymphedema and restrictions in the ROM of the arm. Lymphedema was evaluated by measuring the circumference of both arms. Using a tape measure, the circumference of the upper arms was measured at a point 15 cm above the olecranon, and the circumference of the forearms was measured at a point 10 cm below the olecranon. Lymphedema was diagnosed when a difference ≥2 cm was found between the circumference of the ipsilateral arm and the contralateral arm at one of the measuring points.<xref ref-type="bibr" rid="b4-cln_65p781">4</xref>,<xref ref-type="bibr" rid="b8-cln_65p781">8</xref> This criterion is commonly used in the current literature. <xref ref-type="bibr" rid="b25-cln_65p781">25</xref> Following identification, the lymphedema was then classified as mild (<3 cm), moderate (3–5 cm) or severe (>5 cm).<xref ref-type="bibr" rid="b26-cln_65p781">26</xref> </p><p>To evaluate arm mobility, ROM was measured on both sides using a goniometer. Comparing goniometric measurements of the affected and unaffected arms, a difference ≥10° was considered to constitute restricted mobility or impaired shoulder function.<xref ref-type="bibr" rid="b3-cln_65p781">3</xref> The following shoulder movements were evaluated: abduction, flexion, extension, internal rotation and external rotation.</p></sec><sec><title>Statistical analysis</title><p>The distribution of the sociodemographic and clinical characteristics of the breast cancer survivors, expressed as qualitative variables, was compared between the groups submitted to MRM+IBR and BCT using Fisher's exact test. The means of the population characteristics, expressed as continuous variables, were compared using Student's t-tests for independent samples. The associations with lymphedema and restricted ROM were measured using odds ratios (OR) with the respective 95% confidence intervals (95% CI), which were obtained by unconditional logistic regression analysis<xref ref-type="bibr" rid="b27-cln_65p781">27</xref> with adjustments for potential confounding variables. The median scores for satisfaction with the surgery and QOL were compared between groups using least absolute value regression<xref ref-type="bibr" rid="b28-cln_65p781">28</xref> with adjustments for potential confounding variables. A significance level of 0.05 was adopted for all of the tests.</p></sec></sec><sec sec-type="results"><title>RESULTS</title><p>The mean ages of the patients in this study were 47.6±7.4 years old for the women submitted to MRM+IBR and 50.2±7.3 years old for the women submitted to BCT (p = 0.16). Eighty-five percent of the women submitted to MRM+IBR and 93% of those submitted to BCT were postmenopausal (p = 0.41). The mean monthly family income in U.S. dollars was $430.45±241.75 and $490.31±432.22 for women submitted to MRM+IBR and BCT, respectively (p = 0.49) (<xref ref-type="table" rid="t2-cln_65p781">Table 2</xref>).</p><p>The mean ages at surgery were 45.0±7.4 years old for the women submitted to MRM+IBR and 46.9±7.0 years old for women submitted to BCT (p = 0.29). In the group of women submitted to MRM+IBR, 15% of the cases were classified as stage III, whereas 5% of the cases in the BCT group were classified as stage III (p = 0.02). All of the women in the BCT group and 38% of the women in the MRM+IBR group were submitted to radiotherapy (p<0.01). There was no difference between the two groups with respect to other disease characteristics or treatment-related features (<xref ref-type="table" rid="t3-cln_65p781">Table 3</xref>).</p><p>The prevalence of lymphedema in the total population of the study was 15.7%, whereas it was 12% in the MRM+IBR group and 18% in the BCT group (OR: 0.51; p = 0.66). All of the cases of lymphedema in our patients were mild. The most commonly affected movements were abduction, flexion and external rotation; however, we only observed a statistically significant difference between the two groups for restricted internal rotation (32% in the BCT group vs. 12% in the MRM+IBR group; OR: 7.23, p = 0.03 following adjustment for potential confounding factors) (<xref ref-type="table" rid="t4-cln_65p781">Table 4</xref>).</p><p>When the patients were asked whether they would have opted for a different surgical technique, 25% in the MRM+IBR group and 12% in the BCT group stated that they would have made a different choice (adjusted analysis, OR: 7.4; 95%CI: 0.7–73.3; p = 0.09). No differences in the other items regarding satisfaction with surgery were found between the two groups in the adjusted or non-adjusted analyses (<xref ref-type="table" rid="t5-cln_65p781">Table 5</xref>).</p><p>The highest QOL scores were found in the emotional role functioning domain for women in both the BCT and MRM+IBR groups (the median was 100 for both groups). The lowest scores were in the physical role functioning domain with medians of 0 and 25 for the MRM+IBR and BCT groups, respectively. No differences were found in the median QOL scores in the non-adjusted analyses or in the analyses adjusted for potential confounding factors (<xref ref-type="table" rid="t6-cln_65p781">Table 6</xref>).</p></sec><sec sec-type="discussion"><title>DISCUSSION</title><p>This cross-sectional study compared shoulder-arm morbidity, patient satisfaction with the primary surgical treatment and the QOL of breast cancer survivors submitted to MRM+IBR or BCT. Previous studies that investigated these parameters reported conflicting results, and the majority of these studies were conducted in developed countries. <xref ref-type="bibr" rid="b3-cln_65p781">3</xref>,<xref ref-type="bibr" rid="b5-cln_65p781">5</xref>,<xref ref-type="bibr" rid="b12-cln_65p781">12</xref>,<xref ref-type="bibr" rid="b17-cln_65p781">17</xref>,<xref ref-type="bibr" rid="b19-cln_65p781">19</xref>,<xref ref-type="bibr" rid="b29-cln_65p781">29</xref> The present study reports findings in a cohort of Brazilian breast cancer survivors.</p><p>One study suggested that the frequency of lymphedema in breast cancer survivors varied between 0 and 56%.<xref ref-type="bibr" rid="b30-cln_65p781">30</xref> In the present study, the prevalence of arm edema in the overall study population was 15.7%, and there was no difference in frequency between the group of women submitted to MRM+IBR and the group submitted to BCT. Some investigators failed to identify any association between the type of surgery and lymphedema;<xref ref-type="bibr" rid="b3-cln_65p781">3</xref>,<xref ref-type="bibr" rid="b11-cln_65p781">11</xref> however, other authors reported a correlation.<xref ref-type="bibr" rid="b6-cln_65p781">6</xref>-<xref ref-type="bibr" rid="b10-cln_65p781">10</xref> Kuehn et al.<xref ref-type="bibr" rid="b3-cln_65p781">3</xref> used a difference in volume of ≥10% between arms as a diagnostic criterion and reported lymphedema in 22.7% of women submitted to mastectomy or BCT. In agreement with the present results, these authors did not find an association between the type of surgery and arm edema. A prospective observational study<xref ref-type="bibr" rid="b10-cln_65p781">10</xref>, however, showed that mastectomy was more likely to be associated with lymphedema than wide local excision and lumpectomy. In a case-control study, the investigators performed a univariate analysis and identified mastectomy as a risk factor for lymphedema; however, the association between mastectomy and lymphedema disappeared after multivariate analysis.<xref ref-type="bibr" rid="b7-cln_65p781">7</xref> The same study found that reconstructive surgery was not associated with the occurrence of lymphedema. Nesvold et al.<xref ref-type="bibr" rid="b6-cln_65p781">6</xref> investigated breast cancer survivors at a median of 47 months following surgery and described an association between mastectomy and arm edema. In addition, a recent meta-analysis found an association between mastectomy and lymphedema.<xref ref-type="bibr" rid="b9-cln_65p781">9</xref> The differences between the results of these studies may be related to the different criteria for lymphedema and the time between breast cancer surgery and analysis.</p><p>Another possible complication of breast cancer surgery is reduced ROM. Only a few studies have compared the prevalence of this complication across different types of surgery, and they have reported conflicting results. Some investigators failed to find any difference in the prevalence of restricted ROM between women submitted to mastectomy and those submitted to BCT.<xref ref-type="bibr" rid="b3-cln_65p781">3</xref>,<xref ref-type="bibr" rid="b11-cln_65p781">11</xref> Other authors, however, have described a greater occurrence of impaired shoulder-arm function in mastectomized women.<xref ref-type="bibr" rid="b5-cln_65p781">5</xref>,<xref ref-type="bibr" rid="b6-cln_65p781">6</xref>,<xref ref-type="bibr" rid="b8-cln_65p781">8</xref> In this case study, restriction of internal rotation was more common in the BCT group. Interestingly, a recent cross-sectional study<xref ref-type="bibr" rid="b6-cln_65p781">6</xref> found that MRM was associated with a greater risk of limitation of shoulder abduction and flexion, which confirmed the findings of other investigators.<xref ref-type="bibr" rid="b5-cln_65p781">5</xref>,<xref ref-type="bibr" rid="b8-cln_65p781">8</xref> In another study<xref ref-type="bibr" rid="b5-cln_65p781">5</xref> involving breast cancer survivors with a mean age of 59 years, limitation of shoulder abduction was found to be more common in mastectomized women than women in receiving BCT. When comparing the findings from the different studies, certain aspects must be taken into consideration. These studies differ with respect to design, the definition of reduced movement and surgical techniques. Kuehn et al.<xref ref-type="bibr" rid="b3-cln_65p781">3</xref> used a difference of ≥10° as a cut-off value to define reduced ROM, whereas Nesvold et al.<xref ref-type="bibr" rid="b6-cln_65p781">6</xref> used a difference of ≥25°, and Ernst et al.<xref ref-type="bibr" rid="b11-cln_65p781">11</xref> and Voogd et al.<xref ref-type="bibr" rid="b5-cln_65p781">5</xref> used a difference of ≥20°. These studies included women submitted to either BCT or MRM. It is important to note that the present study included women submitted to BCT or MRM+IBR. Therefore, we suggest that future prospective studies with larger sample sizes should be carried out to investigate impaired shoulder-arm function in women submitted to mastectomy with reconstruction.</p><p>According to the literature, the association between the type of surgery, body image and satisfaction is controversial. The two surgical techniques investigated in the present study were used with the objective of achieving oncological safety and good aesthetic results. Although tumor-related aspects must be taken into consideration, the participation of the woman is fundamental in selecting the type of surgery because sociocultural factors may affect the choice. Some studies have shown better aesthetic results with conservative surgery<xref ref-type="bibr" rid="b2-cln_65p781">2</xref>,<xref ref-type="bibr" rid="b31-cln_65p781">31</xref>, whereas other studies found that breast reconstruction resulted in a better outcome.<xref ref-type="bibr" rid="b32-cln_65p781">32</xref> Nicholson et al.<xref ref-type="bibr" rid="b32-cln_65p781">32</xref> compared women submitted to reconstructive surgery, conservative surgery or simple mastectomy and reported a better aesthetic outcome with reconstructive surgery (compared with conservative surgery) and better results with conservative surgery compared to simple mastectomy. The patients of the present study declared themselves satisfied with the aesthetic results of their surgery, and no difference was found between the groups in this respect.<xref ref-type="bibr" rid="b18-cln_65p781">18</xref> </p><p>Using the same questionnaire that was applied in the present study, Janni et al.<xref ref-type="bibr" rid="b12-cln_65p781">12</xref> showed that German women submitted to mastectomy were less satisfied with the aesthetic results of their surgery than women submitted to BCT. These authors also reported that mastectomized women had a greater dislike of their physical appearance and more emotional stress resulting from the surgery.<xref ref-type="bibr" rid="b12-cln_65p781">12</xref> In addition, a greater proportion of these women reported that they would have opted for a different type of surgery if they could choose again. These differences were not found in the women of the present cohort. Although conservative treatment was associated with a greater risk of disease recurrence,<xref ref-type="bibr" rid="b1-cln_65p781">1</xref> no difference was found between the groups with respect to the fear of a recurrence. Interestingly, some studies<xref ref-type="bibr" rid="b17-cln_65p781">17</xref>,<xref ref-type="bibr" rid="b33-cln_65p781">33</xref> have described a greater fear of recurrence in women submitted to BCT, but other studies could not confirm this difference<xref ref-type="bibr" rid="b34-cln_65p781">34</xref>,<xref ref-type="bibr" rid="b35-cln_65p781">35</xref>, even when the women were aware of the higher risk of recurrence with conservative surgery.<xref ref-type="bibr" rid="b1-cln_65p781">1</xref> Fear of recurrence and satisfaction with aesthetic results are factors that may affect psychological adjustment and the woman's perception of her QOL.<xref ref-type="bibr" rid="b32-cln_65p781">32</xref> </p><p>In the current study, no difference was found between the two surgical groups with respect to QOL. Findings from some previous studies are in agreement with the present results.<xref ref-type="bibr" rid="b2-cln_65p781">2</xref>,<xref ref-type="bibr" rid="b12-cln_65p781">12</xref>,<xref ref-type="bibr" rid="b15-cln_65p781">15</xref>,<xref ref-type="bibr" rid="b36-cln_65p781">36</xref> Other studies, however, have identified differences in QOL in breast cancer survivors as a function of the type of surgical procedure.<xref ref-type="bibr" rid="b16-cln_65p781">16</xref>,<xref ref-type="bibr" rid="b19-cln_65p781">19</xref>,<xref ref-type="bibr" rid="b22-cln_65p781">22</xref>,<xref ref-type="bibr" rid="b23-cln_65p781">23</xref>,<xref ref-type="bibr" rid="b37-cln_65p781">37</xref> Dian et al.<xref ref-type="bibr" rid="b19-cln_65p781">19</xref> investigated QOL using the SF-36 questionnaire and reported better scores in physical functioning in women submitted to breast reconstruction compared with those submitted to conservative surgery. Other investigators have reported poor physical functioning in women undergoing BCT compared with those submitted to mastectomy.<xref ref-type="bibr" rid="b22-cln_65p781">22</xref>,<xref ref-type="bibr" rid="b37-cln_65p781">37</xref> </p><p>Recently, Parker et al.<xref ref-type="bibr" rid="b23-cln_65p781">23</xref> conducted a prospective study comparing the QOL of women submitted to mastectomy with reconstruction to that of women submitted to mastectomy without reconstruction or women submitted to breast conservation. One month after surgery, these authors showed a reduction in PCS and MCS scores in all three groups. There were no differences between the groups with respect to QOL during long-term follow-up. These results are in agreement with the findings of the present study, which did not find any differences in the PCS or MCS scores of women submitted to MRM+IBR or breast conservation. In the present study, better scores were found in the emotional role-functioning and social role-functioning domains, which suggests that conditions were favorable for these women in these domains. Despite the possible negative repercussions of diagnosis and treatment, these components of QOL were not severely affected. The lowest scores were found for the physical role functioning domain; however, there were no differences between the two surgical groups. This finding indicates that breast cancer survivors experienced physical limitations in performing their daily activities regardless of the type of surgery.</p><p>The differences between the various studies that have investigated associations between the type of surgery and the QOL of breast cancer survivors may be related to several aspects, particularly the type of questionnaire used (specific versus generic), sociocultural characteristics and the time between surgery and evaluation because QOL tends to return to pre-surgical levels over time.<xref ref-type="bibr" rid="b23-cln_65p781">23</xref> </p><p>There are some limitations in the interpretation of the findings of the present study. Because this was a cross-sectional study, it was not possible to establish causal inferences. Another possible limitation is posed by the absence of a group of women submitted to mastectomy without reconstruction, which may have introduced new findings. In addition, the relatively small sample size was a limitation.</p><p>The fact that the QOL questionnaire used in this study has been validated internationally and used in various studies involving breast cancer survivors constitutes one of the strengths of the present study. Moreover, in addition to QOL, this study also investigated specific aspects related to breast cancer surgery, such as lymphedema, reduced ROM and satisfaction with aesthetic outcome.</p><p>In conclusion, these findings offer interesting data for professionals involved in the care of breast cancer survivors. The results show that BCT and MRM+IBR score similarly with respect to QOL and satisfaction with surgery. Moreover, they show that shoulder-arm morbidity and the frequency of lymphedema were similar in both surgical groups, and the risk of a restriction in ROM was greater in Brazilian breast cancer survivors submitted to BCT.</p><p>Future prospective studies should be carried out in women submitted to mastectomy with or without reconstruction to permit comparison of different techniques of breast reconstruction, including TRAM flap and breast implant reconstruction. 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used to investigate patient satisfaction with breast cancer surgery.</p></caption><table frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Questions</td><td colspan="7" align="center" valign="bottom" rowspan="1">Answers</td></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">1. How would you evaluate the aesthetic results of your breast cancer surgery?</td><td align="center" valign="top" rowspan="1" colspan="1">1 dreadful</td><td align="center" valign="top" rowspan="1" colspan="1">2</td><td align="center" valign="top" rowspan="1" colspan="1">3</td><td align="center" valign="top" rowspan="1" colspan="1">4</td><td align="center" valign="top" rowspan="1" colspan="1">5</td><td align="center" valign="top" rowspan="1" colspan="1">6</td><td align="center" valign="top" rowspan="1" colspan="1">7 excellent</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="center" valign="top" rowspan="1" colspan="1">not at all</td><td colspan="2" align="center" valign="top" rowspan="1">slightly</td><td colspan="2" align="center" valign="top" rowspan="1">moderately</td><td colspan="2" align="center" valign="top" rowspan="1">very much so</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">2. In your opinion, did breast cancer surgery result in a substantial change to your physical appearance?</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td colspan="2" align="center" valign="top" rowspan="1">2</td><td colspan="2" align="center" valign="top" rowspan="1">3</td><td colspan="2" align="center" valign="top" rowspan="1">4</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">3. Has your physical appearance caused you any emotional stress in your relationship with your partner, family or close friends?</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td colspan="2" align="center" valign="top" rowspan="1">2</td><td colspan="2" align="center" valign="top" rowspan="1">3</td><td colspan="2" align="center" valign="top" rowspan="1">4</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">4. Is your everyday life still impaired as a result of the breast cancer surgery?</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td colspan="2" align="center" valign="top" rowspan="1">2</td><td colspan="2" align="center" valign="top" rowspan="1">3</td><td colspan="2" align="center" valign="top" rowspan="1">4</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">5. Do you regret your choice of breast cancer surgery (BCT or MRM+IBR)?</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td colspan="2" align="center" valign="top" rowspan="1">2</td><td colspan="2" align="center" valign="top" rowspan="1">3</td><td colspan="2" align="center" valign="top" rowspan="1">4</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">6. Do you fear a recurrence of breast cancer?</td><td align="center" valign="top" rowspan="1" colspan="1">1</td><td colspan="2" align="center" valign="top" rowspan="1">2</td><td colspan="2" align="center" valign="top" rowspan="1">3</td><td colspan="2" align="center" valign="top" rowspan="1">4</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">7. In hindsight, would you opt for a different surgical treatment of breast cancer?</td><td align="center" valign="top" rowspan="1" colspan="1">Yes</td><td colspan="2" align="center" valign="top" rowspan="1">-</td><td colspan="2" align="center" valign="top" rowspan="1">-</td><td colspan="2" align="center" valign="top" rowspan="1">No</td></tr></tbody></table></table-wrap><table-wrap id="t2-cln_65p781" position="float"><label>Table 2</label><caption><p>Sociodemographic and clinical features of women with breast cancer submitted to MRM+IBR(n = 26) or BCT (n = 44).</p></caption><table frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Characteristic</td><td align="center" valign="bottom" rowspan="1" colspan="1">MRM+IBR</td><td align="center" valign="bottom" rowspan="1" colspan="1">BCT</td><td align="center" valign="bottom" rowspan="1" colspan="1">p-value</td></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Age (years)<xref ref-type="table-fn" rid="tfn2-cln_65p781">*</xref></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">47.6 (7.4)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">50.2 (7.3)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.16<xref ref-type="table-fn" rid="tfn4-cln_65p781">1</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Education level (years of schooling)<xref ref-type="table-fn" rid="tfn2-cln_65p781">*</xref></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">7.6 (3.3)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">6.3 (3.5)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.14<xref ref-type="table-fn" rid="tfn4-cln_65p781">1</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Race/ethnicity<xref ref-type="table-fn" rid="tfn3-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.28<xref ref-type="table-fn" rid="tfn5-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> White</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">7 (27)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">15 (34)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Other</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">19 (73)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">29 (66)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Marital status<xref ref-type="table-fn" rid="tfn3-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.83<xref ref-type="table-fn" rid="tfn5-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Single</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">5 (19)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">8 (18)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Married</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">10 (38)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">21 (48)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Cohabiting</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">4 (15)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">7 (16)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Separated/divorced</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">3 (12)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">2 (5)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Smoker<xref ref-type="table-fn" rid="tfn3-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.53<xref ref-type="table-fn" rid="tfn5-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> yes</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0 (0)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">2 (5)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> no</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">26 (100)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">42 (95)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Monthly family income ($US)<xref ref-type="table-fn" rid="tfn2-cln_65p781">*</xref></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">430.45 (241.75)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">490.31 (432.22)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.49<xref ref-type="table-fn" rid="tfn4-cln_65p781">1</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Employment status<xref ref-type="table-fn" rid="tfn3-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">1.00<xref ref-type="table-fn" rid="tfn5-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> In paid employment</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">7 (27)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">11 (25)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Housewife</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">16 (62)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">28 (64)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Retired</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">3 (12)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">5 (11)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Body index mass (kg/m<xref ref-type="table-fn" rid="tfn5-cln_65p781">2</xref>)<xref ref-type="table-fn" rid="tfn3-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.17<xref ref-type="table-fn" rid="tfn5-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> <25</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">12 (48)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">13 (30)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> 25–30</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">10 (40)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">18 (41)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> ≥30</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">3 (12)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">13 (30)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Menopausal status<xref ref-type="table-fn" rid="tfn3-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.41<xref ref-type="table-fn" rid="tfn5-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Premenopausal</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">4 (15)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">3 (7)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Postmenopausal</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">22 (85)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">41 (93)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="tfn2-cln_65p781"><label>*</label><p>Values expressed as means (± SD)</p></fn><fn id="tfn3-cln_65p781"><label>#</label><p>Values expressed as N (%)</p></fn><fn id="tfn4-cln_65p781"><label>1</label><p>Student's <italic>t</italic> test</p></fn><fn id="tfn5-cln_65p781"><label>2</label><p>Fisher's exact test</p></fn></table-wrap-foot></table-wrap><table-wrap id="t3-cln_65p781" position="float"><label>Table 3</label><caption><p>Disease and treatment-related features of women with breast cancer submitted to MRM+IBR (n = 26) or BCT (n = 44).</p></caption><table frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Characteristics</td><td align="center" valign="bottom" rowspan="1" colspan="1">MRM+IBR</td><td align="center" valign="bottom" rowspan="1" colspan="1">BCT</td><td align="center" valign="bottom" rowspan="1" colspan="1">p-value</td></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Age at surgery (years)<xref ref-type="table-fn" rid="tfn7-cln_65p781">*</xref></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">45.0 (7.4)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">46.9 (7.0)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.29<xref ref-type="table-fn" rid="tfn9-cln_65p781">1</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Time since surgery (months)<xref ref-type="table-fn" rid="tfn7-cln_65p781">*</xref></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">31.5 (26.7)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">44.3 (29.5)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.07<xref ref-type="table-fn" rid="tfn9-cln_65p781">1</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Histology<xref ref-type="table-fn" rid="tfn8-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.34<xref ref-type="table-fn" rid="tfn10-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Invasive ductal carcinoma</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">22 (85)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">39 (89)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Invasive lobular carcinoma</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">4 (15)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">3 (7)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Others</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0 (0)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">2 (5)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Number of lymph nodes removed <xref ref-type="table-fn" rid="tfn7-cln_65p781">*</xref></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">17.2 (4.4)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">15.4 (6.5)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.16<xref ref-type="table-fn" rid="tfn9-cln_65p781">1</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Number of affected lymph nodes<xref ref-type="table-fn" rid="tfn7-cln_65p781">*</xref></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">1.8 (3.6)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">2.4 (6.1)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.62<xref ref-type="table-fn" rid="tfn9-cln_65p781">1</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Stage<xref ref-type="table-fn" rid="tfn8-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.02<xref ref-type="table-fn" rid="tfn10-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> I</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">3 (12)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">17 (39)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> II</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">19 (73)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">25 (57)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> III</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">4 (15)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">2 (5)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Radiotherapy<xref ref-type="table-fn" rid="tfn8-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1"><0.01<xref ref-type="table-fn" rid="tfn10-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Yes</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">10 (38)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">44 (100)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> No</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">16 (62)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0 (0)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Adjuvant chemotherapy<xref ref-type="table-fn" rid="tfn8-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.13<xref ref-type="table-fn" rid="tfn10-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Yes</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">14 (54)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">32 (73)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> No</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">12 (46)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">12 (27)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Tamoxifen<xref ref-type="table-fn" rid="tfn8-cln_65p781">#</xref></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="char" char="(" valign="top" rowspan="1" colspan="1">0.53<xref ref-type="table-fn" rid="tfn10-cln_65p781">2</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> Yes</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">20 (77)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">37 (84)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"> No</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">6 (23)</td><td align="char" char="(" valign="top" rowspan="1" colspan="1">7 (16)</td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="tfn7-cln_65p781"><label>*</label><p>Values expressed as means (±SD)</p></fn><fn id="tfn8-cln_65p781"><label>#</label><p>Values expressed as N (%)</p></fn><fn id="tfn9-cln_65p781"><label>1</label><p>Student's <italic>t</italic> test</p></fn><fn id="tfn10-cln_65p781"><label>2</label><p>Fisher's exact test</p></fn></table-wrap-foot></table-wrap><table-wrap id="t4-cln_65p781" position="float"><label>Table 4</label><caption><p>Prevalence of lymphedema and restriction of shoulder movement in breast cancer survivors submitted to MRM+IBR (n = 26) or BCT (n = 44).</p></caption><table frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Variables</td><td align="center" valign="bottom" rowspan="1" colspan="1">Group</td><td align="center" valign="bottom" rowspan="1" colspan="1">n (%)</td><td align="center" valign="bottom" rowspan="1" colspan="1">Adjusted OR<xref ref-type="table-fn" rid="tfn12-cln_65p781">a</xref> (95% CI)</td><td align="center" valign="bottom" rowspan="1" colspan="1">Adjusted p-value<xref ref-type="table-fn" rid="tfn12-cln_65p781">a</xref></td></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Lymphedema</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBRBCT</td><td align="center" valign="top" rowspan="1" colspan="1">3 (12)8 (18)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.51 (0.02–10.1)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.66</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Abduction</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBRBCT</td><td align="center" valign="top" rowspan="1" colspan="1">18 (69)24 (55)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.17 (0.08–3.37)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.25</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Flexion</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBRBCT</td><td align="center" valign="top" rowspan="1" colspan="1">17 (65)33 (35)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.50 (0.02–9.91)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.65</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Extension</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBRBCT</td><td align="center" valign="top" rowspan="1" colspan="1">1 (4)9 (30)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">3.88 (0.05–291)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.12</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Internal rotation</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBRBCT</td><td align="center" valign="top" rowspan="1" colspan="1">3 (12)14 (32)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">7.23 (1.28–17.1)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.03</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">External rotation</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBRBCT</td><td align="center" valign="top" rowspan="1" colspan="1">15 (58)16 (36)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.20 (0.03–1.70)</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.14</td></tr></tbody></table><table-wrap-foot><fn id="tfn12-cln_65p781"><label>a</label><p>Adjusted for age, BMI, time since surgery, clinical stage, chemotherapy, radiotherapy, number of lymph nodes removed, presence of affected lymph nodes and current use of tamoxifen, using unconditional logistic regression models.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t5-cln_65p781" position="float"><label>Table 5</label><caption><p>Comparison between the median scores of patient satisfaction with surgery in women with breast cancer submitted to MRM+IBR (n = 26) or BCT (n = 44).</p></caption><table frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" rowspan="1" colspan="1">Variables</td><td align="center" valign="bottom" rowspan="1" colspan="1">Group</td><td align="center" valign="bottom" rowspan="1" colspan="1">Median</td><td align="center" valign="bottom" rowspan="1" colspan="1">Percentiles</td><td align="center" valign="bottom" rowspan="1" colspan="1">Crude</td><td align="center" valign="bottom" rowspan="1" colspan="1">Adjusted</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1">25–75%</td><td align="center" valign="bottom" rowspan="1" colspan="1">p-value</td><td align="center" valign="bottom" rowspan="1" colspan="1">p-value<xref ref-type="table-fn" rid="tfn14-cln_65p781">*</xref></td></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Aesthetic outcome</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">66.7</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">66.7–83.3</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.88</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">75.0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">50.0–83.3</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Change in physical appearance</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">33.3</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–66.7</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.95</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">33.3</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–66.7</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Disturbed by appearance</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–33.3</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Impairment to daily life</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">33.3</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–66.7</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.50</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">33.3</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–66.7</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Regret</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–0</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Fear of recurrence</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">66.7</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">33.3–100</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.70</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">66.7</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">33.3–100</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="tfn14-cln_65p781"><label>*</label><p>Comparison between medians using least absolute value regression with adjustment for age, BMI, time since surgery, clinical stage, chemotherapy, radiotherapy, lymphedema, number of removed lymph nodes, presence of affected lymph nodes and current use of tamoxifen.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t6-cln_65p781" position="float"><label>Table 6</label><caption><p>Comparison between the median SF-36 scores for women with breast cancer submitted to MRM+IBR (n = 26) or BCT (n = 44).</p></caption><table frame="hsides" rules="groups"><thead><tr><td align="left" valign="bottom" rowspan="1" colspan="1">SF-36 domains</td><td align="center" valign="bottom" rowspan="1" colspan="1">Group</td><td align="center" valign="bottom" rowspan="1" colspan="1">Median</td><td align="center" valign="bottom" rowspan="1" colspan="1">Percentiles</td><td align="center" valign="bottom" rowspan="1" colspan="1">Crude</td><td align="center" valign="bottom" rowspan="1" colspan="1">Adjusted</td></tr><tr><td align="left" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1"></td><td align="center" valign="bottom" rowspan="1" colspan="1">25–75%</td><td align="center" valign="bottom" rowspan="1" colspan="1">p-value</td><td align="center" valign="bottom" rowspan="1" colspan="1">p-value<xref ref-type="table-fn" rid="tfn16-cln_65p781">*</xref></td></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Physical functioning</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">72.5</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">65.0–85.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.23</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.16</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">62.5</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">40.0–80.0</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Physical role functioning</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–50.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.28</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.55</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">25.0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–75.0</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Emotional role functioning</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">100</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">33.3–100</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.44</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">100</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">0–100</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Bodily pain</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">51.0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">30.0–64.5</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.87</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.48</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">51.5</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">34.2–72.0</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Vitality</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">72.5</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">50.0–90.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.38</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.56</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">67.5</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">51.2–78.8</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Mental health</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">72.0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">52.0–81.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">1.0</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.95</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">74.0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">57.0–84.0</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Social role functioning</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">100</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">59.3–100</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.47</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.94</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">87.5</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">37.5–100</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">General health perceptions</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">63.5</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">60.0–72.7</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.37</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.95</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">60.0</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">45.5–77.0</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Physical component summary</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">40.7</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">34.1–49.4</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.88</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.76</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">41.4</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">34.0–48.1</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Mental component summary</td><td align="left" valign="top" rowspan="1" colspan="1">MRM+IBR</td><td align="char" char="." valign="top" rowspan="1" colspan="1">51.2</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">45.2–58.1</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.99</td><td align="char" char="." valign="top" rowspan="1" colspan="1">0.58</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1">BCT</td><td align="char" char="." valign="top" rowspan="1" colspan="1">51.1</td><td align="char" char="--" valign="top" rowspan="1" colspan="1">38.3–59.2</td><td align="left" valign="top" rowspan="1" colspan="1"></td><td align="left" valign="top" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="tfn16-cln_65p781"><label>*</label><p>Comparison between medians using least absolute value regression with adjustment for age, BMI, duration of surgery, clinical stage, chemotherapy, radiotherapy, lymphedema, number of removed lymph nodes, presence of affected lymph nodes and current use of tamoxifen.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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