LymphedemaV1, Pmc, Corpus, bibRecord, 003D01

Cutaneous Angiosarcoma of the Foot: A Case Report and Review of the Literature

Identifieur interne : 003D01 ( Pmc/Corpus ); précédent : 003D00; suivant : 003D02

Cutaneous Angiosarcoma of the Foot: A Case Report and Review of the Literature

Auteurs : Sharang Tenjarla ; Lucy Ashley Sheils ; Theresa M. Kwiatkowski ; Sheema Chawla

Source :

Case Reports in Oncological Medicine [ 2090-6706 ] ; 2014.

RBID : PMC:4276302

Abstract

Primary Angiosarcoma of the skin of the foot is very rare. Angiosarcoma is typically treated with resection and wide-field postoperative radiation therapy. Chemotherapy and radiation therapy have also been used. Regardless of the treatment, the risk of local and distant relapse remains high for this disease. We present a case of an elderly patient who developed cutaneous angiosarcoma of the foot. It posed as a diagnostic dilemma at presentation. Chronic lymphedema was a possible predisposing factor. Given his age, preexisting renal dysfunction, refusal of surgery, and preference not to receive chemotherapy, the patient was ultimately treated with definitive radiotherapy. We present this case because of its rare site, unique presentation and delay in diagnosis of the condition, and attainment of an excellent response to radiation at the time of follow-up. We also review the current literature on this topic.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276302

DOI: 10.1155/2014/657876
PubMed: 25574410
PubMed Central: 4276302

Links to Exploration step

PMC:4276302

Le document en format XML

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<author><name sortKey="Tenjarla, Sharang" sort="Tenjarla, Sharang" uniqKey="Tenjarla S" first="Sharang" last="Tenjarla">Sharang Tenjarla</name>
<affiliation><nlm:aff id="I1">Department of Radiation Oncology, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA</nlm:aff>
</affiliation>
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<author><name sortKey="Sheils, Lucy Ashley" sort="Sheils, Lucy Ashley" uniqKey="Sheils L" first="Lucy Ashley" last="Sheils">Lucy Ashley Sheils</name>
<affiliation><nlm:aff id="I2">Department of Pathology, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA</nlm:aff>
</affiliation>
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<author><name sortKey="Kwiatkowski, Theresa M" sort="Kwiatkowski, Theresa M" uniqKey="Kwiatkowski T" first="Theresa M." last="Kwiatkowski">Theresa M. Kwiatkowski</name>
<affiliation><nlm:aff id="I1">Department of Radiation Oncology, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chawla, Sheema" sort="Chawla, Sheema" uniqKey="Chawla S" first="Sheema" last="Chawla">Sheema Chawla</name>
<affiliation><nlm:aff id="I1">Department of Radiation Oncology, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA</nlm:aff>
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<author><name sortKey="Kwiatkowski, Theresa M" sort="Kwiatkowski, Theresa M" uniqKey="Kwiatkowski T" first="Theresa M." last="Kwiatkowski">Theresa M. Kwiatkowski</name>
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<front><div type="abstract" xml:lang="en"><p>Primary Angiosarcoma of the skin of the foot is very rare. Angiosarcoma is typically treated with resection and wide-field postoperative radiation therapy. Chemotherapy and radiation therapy have also been used. Regardless of the treatment, the risk of local and distant relapse remains high for this disease. We present a case of an elderly patient who developed cutaneous angiosarcoma of the foot. It posed as a diagnostic dilemma at presentation. Chronic lymphedema was a possible predisposing factor. Given his age, preexisting renal dysfunction, refusal of surgery, and preference not to receive chemotherapy, the patient was ultimately treated with definitive radiotherapy. We present this case because of its rare site, unique presentation and delay in diagnosis of the condition, and attainment of an excellent response to radiation at the time of follow-up. We also review the current literature on this topic.</p>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Case Rep Oncol Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Case Rep Oncol Med</journal-id>
<journal-id journal-id-type="publisher-id">CRIONM</journal-id>
<journal-title-group><journal-title>Case Reports in Oncological Medicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">2090-6706</issn>
<issn pub-type="epub">2090-6714</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25574410</article-id>
<article-id pub-id-type="pmc">4276302</article-id>
<article-id pub-id-type="doi">10.1155/2014/657876</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Cutaneous Angiosarcoma of the Foot: A Case Report and Review of the Literature</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-5180-0003</contrib-id>
<name><surname>Tenjarla</surname>
<given-names>Sharang</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sheils</surname>
<given-names>Lucy Ashley</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kwiatkowski</surname>
<given-names>Theresa M.</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-9279-8552</contrib-id>
<name><surname>Chawla</surname>
<given-names>Sheema</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="cor1"><sup>*</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Department of Radiation Oncology, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA</aff>
<aff id="I2"><sup>2</sup>
Department of Pathology, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA</aff>
<author-notes><corresp id="cor1">*Sheema Chawla: <email>sheemachawla@gmail.com</email>
</corresp>
<fn fn-type="other"><p>Academic Editor: Ossama W. Tawfik</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>9</day>
<month>12</month>
<year>2014</year>
</pub-date>
<volume>2014</volume>
<elocation-id>657876</elocation-id>
<history><date date-type="received"><day>19</day>
<month>8</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>26</day>
<month>11</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 Sharang Tenjarla et al.</copyright-statement>
<copyright-year>2014</copyright-year>
<license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Primary Angiosarcoma of the skin of the foot is very rare. Angiosarcoma is typically treated with resection and wide-field postoperative radiation therapy. Chemotherapy and radiation therapy have also been used. Regardless of the treatment, the risk of local and distant relapse remains high for this disease. We present a case of an elderly patient who developed cutaneous angiosarcoma of the foot. It posed as a diagnostic dilemma at presentation. Chronic lymphedema was a possible predisposing factor. Given his age, preexisting renal dysfunction, refusal of surgery, and preference not to receive chemotherapy, the patient was ultimately treated with definitive radiotherapy. We present this case because of its rare site, unique presentation and delay in diagnosis of the condition, and attainment of an excellent response to radiation at the time of follow-up. We also review the current literature on this topic.</p>
</abstract>
</article-meta>
</front>
<body><sec id="sec1"><title>1. Introduction</title>
<p>Angiosarcoma is a rare, malignant neoplasm comprising 1–3% of adult soft tissue sarcomas [<xref rid="B1" ref-type="bibr">1</xref>
–<xref rid="B4" ref-type="bibr">4</xref>
]. This is typically a tumor of older individuals with a median age of 70–75 years and a male predominance, having a predilection for the scalp and central area of the face. Cutaneous angiosarcoma is clinically aggressive. The reported 5-year survival rate ranges from 12 to 24% [<xref rid="B1" ref-type="bibr">1</xref>
, <xref rid="B5" ref-type="bibr">5</xref>
]. The neoplasm tends to invade tissue more widely than is clinically apparent and is thus prone to incomplete excision. Majority of patients present with locally advanced disease, regional lymph node involvement, or distant metastases at the time of initial diagnosis, all of which are associated with a poor prognosis [<xref rid="B4" ref-type="bibr">4</xref>
]. The present study describes a case of cutaneous angiosarcoma of the foot in the setting of chronic lymphedema which was treated with definitive radiation alone. The patient was informed that data from the case would be submitted for publication and he provided the required consent.</p>
</sec>
<sec id="sec2"><title>2. Case Presentation</title>
<p>A 90-year-old Caucasian gentleman with a past medical history of prostatectomy 20 years ago for prostate cancer, chronic venous insufficiency, and lymphedema since a few years presented to the dermatology office with a nonhealing wound in the left medial foot since a few months. He was initially diagnosed with a fungal infection and was given a 4-week course of antifungal agent and wound dressings, not yielding any response to treatment. Bacterial cultures performed a month later showed mixed infection with aerobic and anaerobic flora. He was then given a course of oral and topical antibiotics for 4 weeks, bearing a minimal response to treatment. In the last 2 months before presentation to the clinic, the lesion progressed. On examination, the epicenter of the lesion was located in the medial aspect of the foot. There were two major areas of ulceration in medial foot measuring approximately 5 × 5 cm that emanated a serosanguinous discharge (<xref ref-type="fig" rid="fig1">Figure 1</xref>
), with blistering satellite lesions in the medial and lateral aspect of the foot. Smaller lesions were also present on the plantar surface of foot. There was nonpitting edema in both extremities. Marked restriction in the movement of the left ankle was noted.</p>
<p>Subsequently, a punch biopsy of the one of the ulcers revealed cutaneous angiosarcoma, moderate to high grade in differentiation. Microscopically, there was extensive spindle cell proliferation involving dermis, subcutis, and deeper fibroadipose tissue (<xref ref-type="fig" rid="fig2">Figure 2</xref>
). There were multiple vascular sinuses lined by tufts of neoplastic endothelial cells (<xref ref-type="fig" rid="fig3">Figure 3</xref>
). Immunohistochemical stains revealed negative staining for cytokeratin while vascular markers CD31 (<xref ref-type="fig" rid="fig4">Figure 4</xref>
), CD34, and D2-40 were strongly positive. No necrosis was identified in the specimen. Mitotic rate was 0 to 9 mitoses per 10 high power fields. Lymphovascular invasion was indeterminate. </p>
<p>The patient was referred to the radiation oncology center with the above clinical and pathological data. MRI of the left foot with contrast revealed diffuse soft tissue T1 hypointense (<xref ref-type="fig" rid="fig5">Figure 5</xref>
) and T2 hyperintense signal within both medial and lateral subcutaneous tissues. This was more prominent in the fat anterior to the Achilles tendon. There was no evidence of invasion in the tendon or the bone. Flourodeoxyglucose (FDG) PET and CT scan revealed heterogeneous uptake in the medial and lateral foot with a more focal uptake in the medial foot, anterior to the Achilles tendon (<xref ref-type="fig" rid="fig6">Figure 6</xref>
). Two subcentimeter lymph nodes, one in the popliteal region and the other in left groin, showed minimum FDG labelling and were thought to be reactive in nature. No abnormal uptake was seen throughout the body to suggest distant metastases.</p>
<p>Given the diffuse dermal involvement of the foot, the patient was not considered a candidate for upfront surgery. He declined surgical evaluation after preoperative radiation. He was not considered a candidate for chemotherapy because of comorbid conditions, poor renal functions, old age, and reluctance to pursue systemic therapy. He was planned for radiation therapy to both medial and lateral aspects of the foot in addition to the plantar surface using a custom immobilization device. This was done with a combination of photons of 6 MV and electrons of 9 Mev energy to achieve a homogenous dose distribution. A custom bolus was used to build up the radiation dose to the surface. The dose prescribed was 50.4 Gy in 1.8 Gy per fraction to the medial and lateral aspect in 5.5 weeks. The plantar surface of the foot was irradiated to a dose of 30.6 Gy at 1.8 Gy per fraction in 3.5 weeks. He was assessed clinically each week.</p>
<p>At the end of the course of radiation, there was anticipated radiation related moist desquamation of the radiated skin which was managed by the wound care center. There was good subjective and objective response to radiation with decline in discharge and excellent diminishment of cutaneous ulceration one month after radiation. At the end of two-month follow-up there was almost complete response and drying of the cutaneous ulceration and satellite nodules in his foot (<xref ref-type="fig" rid="fig7">Figure 7</xref>
).</p>
</sec>
<sec id="sec3"><title>3. Discussion</title>
<p>Angiosarcoma is a rare and aggressive malignant tumor of vascular endothelial origin. Among all cases of angiosarcoma, one-third occur in the skin, one-fourth in soft tissue, and the remainder in other sites [<xref rid="B6" ref-type="bibr">6</xref>
]. Radiation therapy, especially for breast cancer, is a predisposing factor. Vascular insufficiency and chronic lymphedema are other predisposing factors in addition to trauma and sun exposure [<xref rid="B7" ref-type="bibr">7</xref>
]. In many cases, however, the exact cause is unknown [<xref rid="B8" ref-type="bibr">8</xref>
]. In our case, advanced and chronic venous insufficiency leading to vascular stasis and lymphedema was perhaps the predisposing factor.</p>
<p>As regards clinical appearance, the appearance of cutaneous angiosarcoma can be variable [<xref rid="B4" ref-type="bibr">4</xref>
] and it can manifest as bruise-like lesions [<xref rid="B8" ref-type="bibr">8</xref>
], raised purplish-red papules [<xref rid="B9" ref-type="bibr">9</xref>
], and rosacea-like lesions [<xref rid="B10" ref-type="bibr">10</xref>
]. Due to the variability in the appearance of cutaneous angiosarcoma, the correct diagnosis can often be delayed. Differential diagnoses include, but are not limited to, eczema [<xref rid="B4" ref-type="bibr">4</xref>
], Kaposi sarcoma [<xref rid="B11" ref-type="bibr">11</xref>
], scarring alopecia [<xref rid="B12" ref-type="bibr">12</xref>
], sebaceous cysts [<xref rid="B13" ref-type="bibr">13</xref>
], and amelanotic melanoma [<xref rid="B14" ref-type="bibr">14</xref>
]. Our case is unique that it presented with cutaneous ulceration.</p>
<p>Majority of the patients are noted to be elderly males [<xref rid="B15" ref-type="bibr">15</xref>
, <xref rid="B16" ref-type="bibr">16</xref>
] with Caucasians or fairer skinned people being more commonly affected than darker or black race [<xref rid="B17" ref-type="bibr">17</xref>
, <xref rid="B18" ref-type="bibr">18</xref>
]. More than 90% of the cutaneous lesions are located in the head and neck region. Other non-cutaneous regions are breast and liver. It arises infrequently in the lower extremity [<xref rid="B7" ref-type="bibr">7</xref>
]. Our case presented in the skin of foot which is very rare although angiosarcoma arising in bones of the foot or femoral artery have been described in the literature [<xref rid="B19" ref-type="bibr">19</xref>
, <xref rid="B20" ref-type="bibr">20</xref>
].</p>
<p>The most common histological patterns include atypical and pleomorphic (rounded, polygonal, or fusiform) endothelial cells exhibiting a diffuse epithelioid or spindle cell proliferation [<xref rid="B4" ref-type="bibr">4</xref>
, <xref rid="B9" ref-type="bibr">9</xref>
, <xref rid="B13" ref-type="bibr">13</xref>
, <xref rid="B15" ref-type="bibr">15</xref>
]. Immunohistochemical markers include Von Willebrand factor, CD34, CD31, Ulex europaeus agglutinin 1, vascular endothelial growth factor (VEGF), and factor VIII antigen [<xref rid="B4" ref-type="bibr">4</xref>
, <xref rid="B8" ref-type="bibr">8</xref>
]. Our case showed spindle cell proliferation with interspersed vascular sinuses and positivity for CD31 and CD34.</p>
<p>Histological grade [<xref rid="B1" ref-type="bibr">1</xref>
, <xref rid="B21" ref-type="bibr">21</xref>
] and tumor size are important prognostic factors with tumors > 10 cm portending a poor prognosis and tumors < 5 cm correlated with better outcomes [<xref rid="B13" ref-type="bibr">13</xref>
, <xref rid="B22" ref-type="bibr">22</xref>
–<xref rid="B24" ref-type="bibr">24</xref>
]. High mitotic counts are associated with worse outcomes [<xref rid="B25" ref-type="bibr">25</xref>
]. In a case series, lymphocytic infiltrate was associated with a good prognosis [<xref rid="B26" ref-type="bibr">26</xref>
]. Age, sex, and clinical appearance have no prognostic significance [<xref rid="B5" ref-type="bibr">5</xref>
, <xref rid="B7" ref-type="bibr">7</xref>
]. Presence of metastasis, local recurrence, and positive surgical margins correlate with poor outcome [<xref rid="B15" ref-type="bibr">15</xref>
]. Multifocal disease and depth of invasion (>3 mm) are other poor prognostic features [<xref rid="B27" ref-type="bibr">27</xref>
]. Local recurrences have been observed in 35% to 86% of cases [<xref rid="B16" ref-type="bibr">16</xref>
, <xref rid="B28" ref-type="bibr">28</xref>
]. Prognosis of angiosarcoma is poor with a reported 5-year survival rate ranging from 12 to 24% [<xref rid="B5" ref-type="bibr">5</xref>
, <xref rid="B15" ref-type="bibr">15</xref>
, <xref rid="B21" ref-type="bibr">21</xref>
]. In a series of 48 patients with cutaneous angiosarcoma, 45 patients (94%) had disease recurrences [<xref rid="B16" ref-type="bibr">16</xref>
]. In the same series, 37 of those patients had distant metastases to the lungs and a median survival time of 4 months. Lung metastases as a common site of spread have also been reported in other series [<xref rid="B29" ref-type="bibr">29</xref>
, <xref rid="B30" ref-type="bibr">30</xref>
]. Other rare reported sites of spread were cardiac and/or vascular metastases [<xref rid="B2" ref-type="bibr">2</xref>
, <xref rid="B15" ref-type="bibr">15</xref>
]. Mendenhall et al. reported a 5-year locoregional control of 40 to 50%, 5-year distant metastasis-free survival of 20 to 40%, and 5-year overall survival of 10 to 30% [<xref rid="B31" ref-type="bibr">31</xref>
].</p>
<p>Treatment of cutaneous angiosarcoma is based on retrospective data because of the rarity of this disease. Complete resection of the disease is recommended whenever possible, since this disease has a high propensity to recur locally. Surgical excision may not be a feasible option since resectable cutaneous angiosarcoma lesions constitute only a fraction of all cases [<xref rid="B4" ref-type="bibr">4</xref>
]. Recent studies of primary tumors have reported success with a combined-modality approach of surgical resection followed by postoperative radiation therapy [<xref rid="B1" ref-type="bibr">1</xref>
, <xref rid="B4" ref-type="bibr">4</xref>
, <xref rid="B23" ref-type="bibr">23</xref>
, <xref rid="B32" ref-type="bibr">32</xref>
]. A retrospective study reported on survival outcomes of 48 patients who were treated for angiosarcoma of face and scalp with either a single modality or a combination of surgery, radiotherapy, chemotherapy, and immunotherapy [<xref rid="B16" ref-type="bibr">16</xref>
]. The median follow-up for all 48 patients was 13.7 months. Patients who underwent both surgery and radiotherapy (2-year overall survival: 45.8%) had a significantly more favorable overall survival (<italic>P</italic>
 < 0.0001) compared with patients treated with either surgery or radiotherapy (2-year overall survival: 11.1%) alone and patients who received no surgery or radiotherapy (2-year overall survival: 0%).</p>
<p>Although the combined modality therapy is associated with a better outcome, patients are still at risk for the development of distant metastases [<xref rid="B24" ref-type="bibr">24</xref>
]. Radiotherapy is a reasonable approach in unresectable or metastatic cases. Care must be taken to achieve full dose to the lesion and to use wide margins due to the diffuse nature of the tumor [<xref rid="B33" ref-type="bibr">33</xref>
, <xref rid="B34" ref-type="bibr">34</xref>
]. It appears to improve local control and possibly overall survival based on the retrospective series in the literature [<xref rid="B4" ref-type="bibr">4</xref>
, <xref rid="B16" ref-type="bibr">16</xref>
, <xref rid="B28" ref-type="bibr">28</xref>
, <xref rid="B35" ref-type="bibr">35</xref>
], however radiation employed as a single modality of treatment rarely results in complete remission [<xref rid="B36" ref-type="bibr">36</xref>
, <xref rid="B37" ref-type="bibr">37</xref>
]. Radiation doses of > 50 Gy are usually recommended [<xref rid="B4" ref-type="bibr">4</xref>
] but because of the poor tolerance of hands and feet to radiation [<xref rid="B38" ref-type="bibr">38</xref>
, <xref rid="B39" ref-type="bibr">39</xref>
] we kept our radiation dose to about 50 Gy. Data on the role of chemotherapy in the definitive treatment of cutaneous angiosarcoma is limited and varied. Doxorubicin and Taxanes have been used for treatment in unresectable and metastatic setting [<xref rid="B3" ref-type="bibr">3</xref>
, <xref rid="B4" ref-type="bibr">4</xref>
, <xref rid="B40" ref-type="bibr">40</xref>
].</p>
<p>Promising results with bevacizumab [<xref rid="B41" ref-type="bibr">41</xref>
], sunitinib [<xref rid="B42" ref-type="bibr">42</xref>
], and sorafenib [<xref rid="B43" ref-type="bibr">43</xref>
] have also been reported, and their efficacy may be linked to VEGF production in most cases of angiosarcoma. Although single agent therapy with these agents is tolerable, toxicity is significant and patients with advanced age and comorbidities may not qualify for therapy [<xref rid="B4" ref-type="bibr">4</xref>
]. Photodynamic therapy has been tried by Thong et al. for primary cutaneous angiosarcoma and tumor eradication was achieved with spontaneous remission of neighboring and distant untreated lesions [<xref rid="B44" ref-type="bibr">44</xref>
].</p>
<p>Since surgery for diffuse involvement of the foot would have resulted in significant morbidity and poor functional outcome, our patient was not considered a candidate for surgery. He refused surgical evaluation after radiation. Systemic therapy and radiotherapy were the next available options. However, he did not want to consider chemotherapy and in any event it he was not a good candidate for aggressive therapy. Therefore, the patient underwent successful treatment with radiotherapy alone as a single modality.</p>
</sec>
<sec id="sec4"><title>4. Conclusion</title>
<p>A rare case of cutaneous angiosarcoma of the foot has been described in this case report. This case portrayed a clinical picture of a nonhealing ulcer with superadded infection. Physicians should be aware of this diagnosis while managing nonhealing skin lesions in patients with chronic lymphedema and vascular insufficiency. A delay in the diagnosis of angiosarcoma could culminate in significant treatment challenges. Radiotherapy alone may be an effective treatment in a select group of patients with cutaneous angiosarcoma of the foot in cases where surgery is not feasible. An excellent subjective and objective response to radiation was achieved in our case.</p>
</sec>
</body>
<back><sec sec-type="conflict"><title>Conflict of Interests</title>
<p>The authors declare that there is no conflict of interests regarding the publication of this paper.</p>
</sec>
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<given-names>N. E.</given-names>
</name>
<name><surname>Edgar</surname>
<given-names>M. A.</given-names>
</name>
<name><surname>Schwartz</surname>
<given-names>L. H.</given-names>
</name>
<name><surname>Qin</surname>
<given-names>L.-X.</given-names>
</name>
<name><surname>Antonescu</surname>
<given-names>C. R.</given-names>
</name>
<name><surname>Schwartz</surname>
<given-names>G. K.</given-names>
</name>
</person-group>
<article-title>Phase II study of sorafenib in patients with metastatic or recurrent sarcomas</article-title>
<source><italic>Journal of Clinical Oncology</italic>
</source>
<year>2009</year>
<volume>27</volume>
<issue>19</issue>
<fpage>3133</fpage>
<lpage>3140</lpage>
<pub-id pub-id-type="doi">10.1200/JCO.2008.20.4495</pub-id>
<pub-id pub-id-type="other">2-s2.0-67650293850</pub-id>
<pub-id pub-id-type="pmid">19451436</pub-id>
</element-citation>
</ref>
<ref id="B44"><label>44</label>
<element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Thong</surname>
<given-names>P. S.-P.</given-names>
</name>
<name><surname>Ong</surname>
<given-names>K.-W.</given-names>
</name>
<name><surname>Goh</surname>
<given-names>N. S.-G.</given-names>
</name>
<name><surname>Kho</surname>
<given-names>K.-W.</given-names>
</name>
<name><surname>Manivasager</surname>
<given-names>V.</given-names>
</name>
<name><surname>Bhuvaneswari</surname>
<given-names>R.</given-names>
</name>
<name><surname>Olivo</surname>
<given-names>M.</given-names>
</name>
<name><surname>Soo</surname>
<given-names>K.-C.</given-names>
</name>
</person-group>
<article-title>Photodynamic-therapy-activated immune response against distant untreated tumours in recurrent angiosarcoma</article-title>
<source><italic>The Lancet Oncology</italic>
</source>
<year>2007</year>
<volume>8</volume>
<issue>10</issue>
<fpage>950</fpage>
<lpage>952</lpage>
<pub-id pub-id-type="doi">10.1016/S1470-2045(07)70318-2</pub-id>
<pub-id pub-id-type="other">2-s2.0-34748907209</pub-id>
<pub-id pub-id-type="pmid">17913664</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
<floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>Pretreatment: 5 × 5 cm ulcer on the medial left foot emanating a serosanginous discharge and similar ulcer present posteriorly along with blistering satellite lesions on the plantar surface of the foot.</p>
</caption>
<graphic xlink:href="CRIONM2014-657876.001"></graphic>
</fig>
<fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Low power view showing extensive spindle cell proliferation involving dermis, subcutis, and deeper fibroadipose tissue.</p>
</caption>
<graphic xlink:href="CRIONM2014-657876.002"></graphic>
</fig>
<fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>High power view showing multiple vascular sinuses lined by tufts of neoplastic endothelial cells.</p>
</caption>
<graphic xlink:href="CRIONM2014-657876.003"></graphic>
</fig>
<fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>Positivity for vascular marker CD-31.</p>
</caption>
<graphic xlink:href="CRIONM2014-657876.004"></graphic>
</fig>
<fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label>
<caption><p>MRI of the left foot with contrast showing diffuse soft tissue T1 hypointense signal within both medial and lateral subcutaneous tissues, which is more prominent in the fat anterior to the Achilles tendon.</p>
</caption>
<graphic xlink:href="CRIONM2014-657876.005"></graphic>
</fig>
<fig id="fig6" orientation="portrait" position="float"><label>Figure 6</label>
<caption><p>FDG-PET and CT scan showing heterogeneous uptake in the medial and lateral foot with a more focal uptake in the medial foot, anterior to the Achilles tendon.</p>
</caption>
<graphic xlink:href="CRIONM2014-657876.006"></graphic>
</fig>
<fig id="fig7" orientation="portrait" position="float"><label>Figure 7</label>
<caption><p>Two months postradiation: marked diminishment of cutaneous ulceration with decline in discharge and drying of satellite nodules.</p>
</caption>
<graphic xlink:href="CRIONM2014-657876.007"></graphic>
</fig>
</floats-group>
</pmc>
</record>

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Cutaneous Angiosarcoma of the Foot: A Case Report and Review of the Literature

Cutaneous Angiosarcoma of the Foot: A Case Report and Review of the Literature

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