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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bridging the divide between pathogenesis and detection in lymphedema</title><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><affiliation><nlm:aff id="A1">George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology</nlm:aff></affiliation></author><author><name sortKey="Weiler, Michael J" sort="Weiler, Michael J" uniqKey="Weiler M" first="Michael J." last="Weiler">Michael J. Weiler</name><affiliation><nlm:aff id="A3">Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25545813</idno><idno type="pmc">4418628</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418628</idno><idno type="RBID">PMC:4418628</idno><idno type="doi">10.1016/j.semcdb.2014.12.003</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">003A42</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003A42</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bridging the divide between pathogenesis and detection in lymphedema</title><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><affiliation><nlm:aff id="A1">George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology</nlm:aff></affiliation></author><author><name sortKey="Weiler, Michael J" sort="Weiler, Michael J" uniqKey="Weiler M" first="Michael J." last="Weiler">Michael J. Weiler</name><affiliation><nlm:aff id="A3">Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology</nlm:aff></affiliation></author></analytic><series><title level="j">Seminars in cell & developmental biology</title><idno type="ISSN">1084-9521</idno><idno type="eISSN">1096-3634</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">While our understanding of the lymphatic system has improved substantially in the past few decades, the translation of this knowledge into improved healthcare solutions for patients suffering from secondary lymphedema has been severely limited. The challenge facing clinicians is two-fold. First, there is no reliable, affordable, diagnostic capable of detecting the disease before symptoms of the lymphedema develop and the efficacy of treatment options becomes limited. Second, our understanding of the disease pathogenesis, its risk factors, and the underlying physiologic mechanisms is still in its infancy. These two challenges go hand in hand as limited diagnostic options have hindered our ability to understand lymphedema progression, and the lack of known underlying mechanisms involved in the disease prohibits the development of new diagnostic targets. This review serves to discuss the recent developments in clinical and lab research settings of both lymphedema diagnostic technologies and our understanding of the mechanisms driving disease risk and progression. We will show how these two lines of research are synergistically working with the ultimate goal of improving patient outcomes for those suffering from this horrible disease, identifying key areas of further research that are warranted to move the field forward and provide clinical relief for this neglected patient population.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9607332</journal-id><journal-id journal-id-type="pubmed-jr-id">20707</journal-id><journal-id journal-id-type="nlm-ta">Semin Cell Dev Biol</journal-id><journal-id journal-id-type="iso-abbrev">Semin. Cell Dev. Biol.</journal-id><journal-title-group><journal-title>Seminars in cell & developmental biology</journal-title></journal-title-group><issn pub-type="ppub">1084-9521</issn><issn pub-type="epub">1096-3634</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25545813</article-id><article-id pub-id-type="pmc">4418628</article-id><article-id pub-id-type="doi">10.1016/j.semcdb.2014.12.003</article-id><article-id pub-id-type="manuscript">NIHMS683062</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Bridging the divide between pathogenesis and detection in lymphedema</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Dixon</surname><given-names>J. Brandon</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Weiler</surname><given-names>Michael J.</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib></contrib-group><aff id="A1"><label>1</label>George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology</aff><aff id="A2"><label>2</label>Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology</aff><aff id="A3"><label>3</label>Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology</aff><pub-date pub-type="nihms-submitted"><day>23</day><month>4</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>26</day><month>12</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>2</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>2</month><year>2016</year></pub-date><volume>38</volume><fpage>75</fpage><lpage>82</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.semcdb.2014.12.003</pmc-comment>
<abstract><p id="P1">While our understanding of the lymphatic system has improved substantially in the past few decades, the translation of this knowledge into improved healthcare solutions for patients suffering from secondary lymphedema has been severely limited. The challenge facing clinicians is two-fold. First, there is no reliable, affordable, diagnostic capable of detecting the disease before symptoms of the lymphedema develop and the efficacy of treatment options becomes limited. Second, our understanding of the disease pathogenesis, its risk factors, and the underlying physiologic mechanisms is still in its infancy. These two challenges go hand in hand as limited diagnostic options have hindered our ability to understand lymphedema progression, and the lack of known underlying mechanisms involved in the disease prohibits the development of new diagnostic targets. This review serves to discuss the recent developments in clinical and lab research settings of both lymphedema diagnostic technologies and our understanding of the mechanisms driving disease risk and progression. We will show how these two lines of research are synergistically working with the ultimate goal of improving patient outcomes for those suffering from this horrible disease, identifying key areas of further research that are warranted to move the field forward and provide clinical relief for this neglected patient population.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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