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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Molecular Diagnosis: Implications for Ophthalmology</title>
<author><name sortKey="Rosenbaum, James T" sort="Rosenbaum, James T" uniqKey="Rosenbaum J" first="James T." last="Rosenbaum">James T. Rosenbaum</name>
<affiliation><nlm:aff id="A1">Devers Eye Clinic, Legacy Health Systems, 1040 NW 22<sup>nd</sup>
Avenue, Portland, Oregon 97210 USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR. 97239, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR. 97239 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sibley, Cailin H" sort="Sibley, Cailin H" uniqKey="Sibley C" first="Cailin H." last="Sibley">Cailin H. Sibley</name>
<affiliation><nlm:aff id="A3">Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR. 97239 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Choi, Dongseok" sort="Choi, Dongseok" uniqKey="Choi D" first="Dongseok" last="Choi">Dongseok Choi</name>
<affiliation><nlm:aff id="A2">Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR. 97239, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR. 97239 USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">OHSU-PSU School of Public Health, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR. 97239</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harrington, Christina A" sort="Harrington, Christina A" uniqKey="Harrington C" first="Christina A." last="Harrington">Christina A. Harrington</name>
<affiliation><nlm:aff id="A5">Integrated Genomics Laboratory, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Planck, Stephen R" sort="Planck, Stephen R" uniqKey="Planck S" first="Stephen R." last="Planck">Stephen R. Planck</name>
<affiliation><nlm:aff id="A1">Devers Eye Clinic, Legacy Health Systems, 1040 NW 22<sup>nd</sup>
Avenue, Portland, Oregon 97210 USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR. 97239, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR. 97239 USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">26608807</idno>
<idno type="pmc">4912839</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912839</idno>
<idno type="RBID">PMC:4912839</idno>
<idno type="doi">10.1016/j.preteyeres.2015.11.001</idno>
<date when="2015">2015</date>
<idno type="wicri:Area/Pmc/Corpus">003998</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003998</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Molecular Diagnosis: Implications for Ophthalmology</title>
<author><name sortKey="Rosenbaum, James T" sort="Rosenbaum, James T" uniqKey="Rosenbaum J" first="James T." last="Rosenbaum">James T. Rosenbaum</name>
<affiliation><nlm:aff id="A1">Devers Eye Clinic, Legacy Health Systems, 1040 NW 22<sup>nd</sup>
Avenue, Portland, Oregon 97210 USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR. 97239, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR. 97239 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sibley, Cailin H" sort="Sibley, Cailin H" uniqKey="Sibley C" first="Cailin H." last="Sibley">Cailin H. Sibley</name>
<affiliation><nlm:aff id="A3">Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR. 97239 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Choi, Dongseok" sort="Choi, Dongseok" uniqKey="Choi D" first="Dongseok" last="Choi">Dongseok Choi</name>
<affiliation><nlm:aff id="A2">Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR. 97239, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR. 97239 USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A4">OHSU-PSU School of Public Health, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR. 97239</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harrington, Christina A" sort="Harrington, Christina A" uniqKey="Harrington C" first="Christina A." last="Harrington">Christina A. Harrington</name>
<affiliation><nlm:aff id="A5">Integrated Genomics Laboratory, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Planck, Stephen R" sort="Planck, Stephen R" uniqKey="Planck S" first="Stephen R." last="Planck">Stephen R. Planck</name>
<affiliation><nlm:aff id="A1">Devers Eye Clinic, Legacy Health Systems, 1040 NW 22<sup>nd</sup>
Avenue, Portland, Oregon 97210 USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR. 97239, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR. 97239 USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Progress in retinal and eye research</title>
<idno type="ISSN">1350-9462</idno>
<idno type="eISSN">1873-1635</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labelled precision medicine. Jameson and Longo define precision medicine as “treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations” (<xref rid="R22" ref-type="bibr">Jameson and Longo, 2015</xref>
). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9431859</journal-id>
<journal-id journal-id-type="pubmed-jr-id">20937</journal-id>
<journal-id journal-id-type="nlm-ta">Prog Retin Eye Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Prog Retin Eye Res</journal-id>
<journal-title-group><journal-title>Progress in retinal and eye research</journal-title>
</journal-title-group>
<issn pub-type="ppub">1350-9462</issn>
<issn pub-type="epub">1873-1635</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26608807</article-id>
<article-id pub-id-type="pmc">4912839</article-id>
<article-id pub-id-type="doi">10.1016/j.preteyeres.2015.11.001</article-id>
<article-id pub-id-type="manuscript">NIHMS793959</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Molecular Diagnosis: Implications for Ophthalmology</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Rosenbaum</surname>
<given-names>James T.</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<email>rosenbaj@ohsu.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Sibley</surname>
<given-names>Cailin H.</given-names>
</name>
<degrees>M.D.</degrees>
<xref ref-type="aff" rid="A3">3</xref>
<email>sibleyc@ohsu.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Choi</surname>
<given-names>Dongseok</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A4">4</xref>
<email>choid@ohsu.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Harrington</surname>
<given-names>Christina A.</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A5">5</xref>
<email>harringc@ohsu.edu</email>
</contrib>
<contrib contrib-type="author"><name><surname>Planck</surname>
<given-names>Stephen R.</given-names>
</name>
<degrees>Ph.D.</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<email>plancks@ohsu.edu</email>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Devers Eye Clinic, Legacy Health Systems, 1040 NW 22<sup>nd</sup>
Avenue, Portland, Oregon 97210 USA</aff>
<aff id="A2"><label>2</label>
Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR. 97239, USA</aff>
<aff id="A3"><label>3</label>
Department of Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR. 97239 USA</aff>
<aff id="A4"><label>4</label>
OHSU-PSU School of Public Health, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR. 97239</aff>
<aff id="A5"><label>5</label>
Integrated Genomics Laboratory, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239 USA</aff>
<pub-date pub-type="nihms-submitted"><day>11</day>
<month>6</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>01</day>
<month>12</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>1</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>1</month>
<year>2017</year>
</pub-date>
<volume>50</volume>
<fpage>25</fpage>
<lpage>33</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.preteyeres.2015.11.001</pmc-comment>
<abstract><p id="P2">The effort to subdivide diseases and to individualize therapies based on characteristics of the patient has been labelled precision medicine. Jameson and Longo define precision medicine as “treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations” (<xref rid="R22" ref-type="bibr">Jameson and Longo, 2015</xref>
). We illustrate how molecular diagnosis can be applied to orbital inflammatory disease to achieve the goals of precision medicine.</p>
</abstract>
<kwd-group><kwd>molecular diagnosis</kwd>
<kwd>transcriptomics</kwd>
<kwd>thyroid eye disease</kwd>
<kwd>granulomatosis with polyangiitis</kwd>
<kwd>sarcoidosis</kwd>
<kwd>nonspecific orbital inflammatory disease</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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