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<title xml:lang="en">Novel aspects of corneal angiogenic and lymphangiogenic privilege</title>
<author>
<name sortKey="Ellenberg, David" sort="Ellenberg, David" uniqKey="Ellenberg D" first="David" last="Ellenberg">David Ellenberg</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hallak, Joelle A" sort="Hallak, Joelle A" uniqKey="Hallak J" first="Joelle A." last="Hallak">Joelle A. Hallak</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tobaigy, Faisal" sort="Tobaigy, Faisal" uniqKey="Tobaigy F" first="Faisal" last="Tobaigy">Faisal Tobaigy</name>
<affiliation>
<nlm:aff id="A2">Department of Ophthalmology, Harvard Medical School, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Han, Kyu Yeon" sort="Han, Kyu Yeon" uniqKey="Han K" first="Kyu Yeon" last="Han">Kyu Yeon Han</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jain, Sandeep" sort="Jain, Sandeep" uniqKey="Jain S" first="Sandeep" last="Jain">Sandeep Jain</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name>
<affiliation>
<nlm:aff id="A3">Department of Biochemistry, The University of Hong Kong, Hong Kong</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
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<idno type="pmid">20100589</idno>
<idno type="pmc">3685179</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685179</idno>
<idno type="RBID">PMC:3685179</idno>
<idno type="doi">10.1016/j.preteyeres.2010.01.002</idno>
<date when="2010">2010</date>
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<title xml:lang="en" level="a" type="main">Novel aspects of corneal angiogenic and lymphangiogenic privilege</title>
<author>
<name sortKey="Ellenberg, David" sort="Ellenberg, David" uniqKey="Ellenberg D" first="David" last="Ellenberg">David Ellenberg</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Azar, Dimitri T" sort="Azar, Dimitri T" uniqKey="Azar D" first="Dimitri T." last="Azar">Dimitri T. Azar</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Hallak, Joelle A" sort="Hallak, Joelle A" uniqKey="Hallak J" first="Joelle A." last="Hallak">Joelle A. Hallak</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Tobaigy, Faisal" sort="Tobaigy, Faisal" uniqKey="Tobaigy F" first="Faisal" last="Tobaigy">Faisal Tobaigy</name>
<affiliation>
<nlm:aff id="A2">Department of Ophthalmology, Harvard Medical School, Boston, MA, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Han, Kyu Yeon" sort="Han, Kyu Yeon" uniqKey="Han K" first="Kyu Yeon" last="Han">Kyu Yeon Han</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Jain, Sandeep" sort="Jain, Sandeep" uniqKey="Jain S" first="Sandeep" last="Jain">Sandeep Jain</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name>
<affiliation>
<nlm:aff id="A3">Department of Biochemistry, The University of Hong Kong, Hong Kong</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Chang, Jin Hong" sort="Chang, Jin Hong" uniqKey="Chang J" first="Jin-Hong" last="Chang">Jin-Hong Chang</name>
<affiliation>
<nlm:aff id="A1">Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Progress in retinal and eye research</title>
<idno type="ISSN">1350-9462</idno>
<idno type="eISSN">1873-1635</idno>
<imprint>
<date when="2010">2010</date>
</imprint>
</series>
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<front>
<div type="abstract" xml:lang="en">
<p id="P1">In this article, we provide the results of experimental studies demonstrating that corneal avascularity is an active process involving the production of anti-angiogenic factors, which counterbalance the proangiogenic/lymphangiogenic factors that are upregulated during wound healing. We also summarize pertinent published reports regarding corneal neovascularization (NV), corneal lymphangiogenesis and corneal angiogenic/lymphangiogenic privilege. We outline the clinical causes of corneal NV, and discuss the angiogenic proteins (VEGF and bFGF) and angiogenesis regulatory proteins. We also describe the role of matrix metalloproteinases MMP-2, -7, and MT1-MMP, anti-angiogenic factors, and lymphangiogenic regulatory proteins during corneal wound healing. Established and potential new therapies for the treatment of corneal neovascularization are also discussed.</p>
</div>
</front>
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<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">9431859</journal-id>
<journal-id journal-id-type="pubmed-jr-id">20937</journal-id>
<journal-id journal-id-type="nlm-ta">Prog Retin Eye Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Prog Retin Eye Res</journal-id>
<journal-title-group>
<journal-title>Progress in retinal and eye research</journal-title>
</journal-title-group>
<issn pub-type="ppub">1350-9462</issn>
<issn pub-type="epub">1873-1635</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">20100589</article-id>
<article-id pub-id-type="pmc">3685179</article-id>
<article-id pub-id-type="doi">10.1016/j.preteyeres.2010.01.002</article-id>
<article-id pub-id-type="manuscript">NIHMS482877</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Novel aspects of corneal angiogenic and lymphangiogenic privilege</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Ellenberg</surname>
<given-names>David</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Azar</surname>
<given-names>Dimitri T.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Hallak</surname>
<given-names>Joelle A.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Tobaigy</surname>
<given-names>Faisal</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Han</surname>
<given-names>Kyu Yeon</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Jain</surname>
<given-names>Sandeep</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Zhou</surname>
<given-names>Zhongjun</given-names>
</name>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Chang</surname>
<given-names>Jin-Hong</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
</contrib-group>
<aff id="A1">
<label>a</label>
Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, University of Illinois at Chicago, 1855W. Taylor Street, Chicago, IL, USA</aff>
<aff id="A2">
<label>b</label>
Department of Ophthalmology, Harvard Medical School, Boston, MA, USA</aff>
<aff id="A3">
<label>c</label>
Department of Biochemistry, The University of Hong Kong, Hong Kong</aff>
<author-notes>
<corresp id="CR1">
<label>*</label>
Corresponding authors. Tel.: +1 312 996 6590; fax: +1 312 996 7770.
<email>dazar@uic.edu</email>
(D.T. Azar),
<email>changr@uic.edu</email>
(J.-H. Chang).</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>10</day>
<month>6</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub">
<day>25</day>
<month>1</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub">
<month>5</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>18</day>
<month>6</month>
<year>2013</year>
</pub-date>
<volume>29</volume>
<issue>3</issue>
<fpage>208</fpage>
<lpage>248</lpage>
<abstract>
<p id="P1">In this article, we provide the results of experimental studies demonstrating that corneal avascularity is an active process involving the production of anti-angiogenic factors, which counterbalance the proangiogenic/lymphangiogenic factors that are upregulated during wound healing. We also summarize pertinent published reports regarding corneal neovascularization (NV), corneal lymphangiogenesis and corneal angiogenic/lymphangiogenic privilege. We outline the clinical causes of corneal NV, and discuss the angiogenic proteins (VEGF and bFGF) and angiogenesis regulatory proteins. We also describe the role of matrix metalloproteinases MMP-2, -7, and MT1-MMP, anti-angiogenic factors, and lymphangiogenic regulatory proteins during corneal wound healing. Established and potential new therapies for the treatment of corneal neovascularization are also discussed.</p>
</abstract>
<funding-group>
<award-group>
<funding-source country="United States">National Eye Institute : NEI</funding-source>
<award-id>R01 EY014048 || EY</award-id>
</award-group>
<award-group>
<funding-source country="United States">National Eye Institute : NEI</funding-source>
<award-id>R01 EY010101-16 || EY</award-id>
</award-group>
<award-group>
<funding-source country="United States">National Eye Institute : NEI</funding-source>
<award-id>R01 EY010101-15 || EY</award-id>
</award-group>
<award-group>
<funding-source country="United States">National Eye Institute : NEI</funding-source>
<award-id>R01 EY010101 || EY</award-id>
</award-group>
<award-group>
<funding-source country="United States">National Eye Institute : NEI</funding-source>
<award-id>P30 EY001792 || EY</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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