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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer</title><author><name sortKey="Torres, Keila E" sort="Torres, Keila E" uniqKey="Torres K" first="Keila E." last="Torres">Keila E. Torres</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Ravi, Vinod" sort="Ravi, Vinod" uniqKey="Ravi V" first="Vinod" last="Ravi">Vinod Ravi</name><affiliation><nlm:aff id="A3">Dept. of Sarcoma Medical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Kin, Katherine" sort="Kin, Katherine" uniqKey="Kin K" first="Katherine" last="Kin">Katherine Kin</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Yi, Min" sort="Yi, Min" uniqKey="Yi M" first="Min" last="Yi">Min Yi</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Guadagnolo, B Ashleigh" sort="Guadagnolo, B Ashleigh" uniqKey="Guadagnolo B" first="B. Ashleigh" last="Guadagnolo">B. Ashleigh Guadagnolo</name><affiliation><nlm:aff id="A4">Dept. of Radiation Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="May, Caitlin D" sort="May, Caitlin D" uniqKey="May C" first="Caitlin D." last="May">Caitlin D. May</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K." last="Arun">Banu K. Arun</name><affiliation><nlm:aff id="A5">Dept. of Breast Medical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Hunt, Kelly K" sort="Hunt, Kelly K" uniqKey="Hunt K" first="Kelly K." last="Hunt">Kelly K. Hunt</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Lam, Ryan" sort="Lam, Ryan" uniqKey="Lam R" first="Ryan" last="Lam">Ryan Lam</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Lahat, Guy" sort="Lahat, Guy" uniqKey="Lahat G" first="Guy" last="Lahat">Guy Lahat</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Hoffman, Aviad" sort="Hoffman, Aviad" uniqKey="Hoffman A" first="Aviad" last="Hoffman">Aviad Hoffman</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Cormier, Janice N" sort="Cormier, Janice N" uniqKey="Cormier J" first="Janice N." last="Cormier">Janice N. Cormier</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Feig, Barry W" sort="Feig, Barry W" uniqKey="Feig B" first="Barry W." last="Feig">Barry W. Feig</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Lazar, Alexander J" sort="Lazar, Alexander J" uniqKey="Lazar A" first="Alexander J." last="Lazar">Alexander J. Lazar</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Dept. of Pathology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Lev, Dina" sort="Lev, Dina" uniqKey="Lev D" first="Dina" last="Lev">Dina Lev</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Dept. of Cancer Biology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Pollock, Raphael E" sort="Pollock, Raphael E" uniqKey="Pollock R" first="Raphael E." last="Pollock">Raphael E. Pollock</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23224828</idno><idno type="pmc">5036516</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036516</idno><idno type="RBID">PMC:5036516</idno><idno type="doi">10.1245/s10434-012-2755-y</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">003975</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003975</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer</title><author><name sortKey="Torres, Keila E" sort="Torres, Keila E" uniqKey="Torres K" first="Keila E." last="Torres">Keila E. Torres</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Ravi, Vinod" sort="Ravi, Vinod" uniqKey="Ravi V" first="Vinod" last="Ravi">Vinod Ravi</name><affiliation><nlm:aff id="A3">Dept. of Sarcoma Medical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Kin, Katherine" sort="Kin, Katherine" uniqKey="Kin K" first="Katherine" last="Kin">Katherine Kin</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Yi, Min" sort="Yi, Min" uniqKey="Yi M" first="Min" last="Yi">Min Yi</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Guadagnolo, B Ashleigh" sort="Guadagnolo, B Ashleigh" uniqKey="Guadagnolo B" first="B. Ashleigh" last="Guadagnolo">B. Ashleigh Guadagnolo</name><affiliation><nlm:aff id="A4">Dept. of Radiation Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="May, Caitlin D" sort="May, Caitlin D" uniqKey="May C" first="Caitlin D." last="May">Caitlin D. May</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K." last="Arun">Banu K. Arun</name><affiliation><nlm:aff id="A5">Dept. of Breast Medical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Hunt, Kelly K" sort="Hunt, Kelly K" uniqKey="Hunt K" first="Kelly K." last="Hunt">Kelly K. Hunt</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Lam, Ryan" sort="Lam, Ryan" uniqKey="Lam R" first="Ryan" last="Lam">Ryan Lam</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Lahat, Guy" sort="Lahat, Guy" uniqKey="Lahat G" first="Guy" last="Lahat">Guy Lahat</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Hoffman, Aviad" sort="Hoffman, Aviad" uniqKey="Hoffman A" first="Aviad" last="Hoffman">Aviad Hoffman</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Cormier, Janice N" sort="Cormier, Janice N" uniqKey="Cormier J" first="Janice N." last="Cormier">Janice N. Cormier</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Feig, Barry W" sort="Feig, Barry W" uniqKey="Feig B" first="Barry W." last="Feig">Barry W. Feig</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Lazar, Alexander J" sort="Lazar, Alexander J" uniqKey="Lazar A" first="Alexander J." last="Lazar">Alexander J. Lazar</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation><affiliation><nlm:aff id="A6">Dept. of Pathology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Lev, Dina" sort="Lev, Dina" uniqKey="Lev D" first="Dina" last="Lev">Dina Lev</name><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation><affiliation><nlm:aff id="A7">Dept. of Cancer Biology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Pollock, Raphael E" sort="Pollock, Raphael E" uniqKey="Pollock R" first="Raphael E." last="Pollock">Raphael E. Pollock</name><affiliation><nlm:aff id="A1">Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</nlm:aff></affiliation></author></analytic><series><title level="j">Annals of surgical oncology</title><idno type="ISSN">1068-9265</idno><idno type="eISSN">1534-4681</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Radiation-associated angiosarcoma (RAAS) is a devastating disease occasionally observed in breast cancer patients treated with radiation. Due to its rarity, our knowledge—of disease risk factors, epidemiology, treatment, and outcome—is extremely limited. Therefore, we sought to identify clinicopathologic factors associated with local and distant recurrence, and disease-specific survival (DSS).</p></sec><sec id="S2"><title>Methods</title><p id="P2">Radiation-associated angiosarcoma was defined as pathologically confirmed breast or chest wall angiosarcoma arising within a previously irradiated field. A comprehensive search of our institutional tumor registry (1/1/93 through 2/28/11) was used to identify patients (n=95 females); patient, original tumor, RAAS treatment, and outcome variables were retrospectively retrieved and assembled into a database.</p></sec><sec id="S3"><title>Results</title><p id="P3">The median follow-up for all RAAS patients was 10.3 years (range, 2.4 – 31.8 years). The latency period following radiation exposure ranged from 1.4 to 26 years (median = 7 years). One- and five-year DSS rates were 93.5% and 62.6%, respectively. Reduced risk of local recurrence was observed in patients who received chemotherapy (<italic>P</italic> = 0.0003). In multivariable analysis, size was found to be an independent predictor of adverse outcome (<italic>P</italic> = 0.015).</p></sec><sec id="S4"><title>Discussion</title><p id="P4">Our study demonstrates that RAAS exhibits high recurrence rates. It also highlights the need for well-designed multicenter clinical trials to inform the true utility of chemotherapy in this disease.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9420840</journal-id><journal-id journal-id-type="pubmed-jr-id">8578</journal-id><journal-id journal-id-type="nlm-ta">Ann Surg Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Ann. Surg. Oncol.</journal-id><journal-title-group><journal-title>Annals of surgical oncology</journal-title></journal-title-group><issn pub-type="ppub">1068-9265</issn><issn pub-type="epub">1534-4681</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23224828</article-id><article-id pub-id-type="pmc">5036516</article-id><article-id pub-id-type="doi">10.1245/s10434-012-2755-y</article-id><article-id pub-id-type="manuscript">NIHMS812737</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Long-term outcomes in patients with radiation-associated angiosarcomas of the breast following surgery and radiotherapy for breast cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Torres</surname><given-names>Keila E.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Ravi</surname><given-names>Vinod</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kin</surname><given-names>Katherine</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Yi</surname><given-names>Min</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Guadagnolo</surname><given-names>B. Ashleigh</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>May</surname><given-names>Caitlin D.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Arun</surname><given-names>Banu K.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Hunt</surname><given-names>Kelly K.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lam</surname><given-names>Ryan</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lahat</surname><given-names>Guy</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Hoffman</surname><given-names>Aviad</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cormier</surname><given-names>Janice N.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Feig</surname><given-names>Barry W.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Lazar</surname><given-names>Alexander J.</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Lev</surname><given-names>Dina</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Pollock</surname><given-names>Raphael E.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Dept. of Surgical Oncology, UT MD Anderson Cancer Center, Houston, Texas</aff><aff id="A2"><label>2</label>Sarcoma Research Center, UT MD Anderson Cancer Center, Houston, Texas</aff><aff id="A3"><label>3</label>Dept. of Sarcoma Medical Oncology, UT MD Anderson Cancer Center, Houston, Texas</aff><aff id="A4"><label>4</label>Dept. of Radiation Oncology, UT MD Anderson Cancer Center, Houston, Texas</aff><aff id="A5"><label>5</label>Dept. of Breast Medical Oncology, UT MD Anderson Cancer Center, Houston, Texas</aff><aff id="A6"><label>6</label>Dept. of Pathology, UT MD Anderson Cancer Center, Houston, Texas</aff><aff id="A7"><label>7</label>Dept. of Cancer Biology, UT MD Anderson Cancer Center, Houston, Texas</aff><author-notes><corresp id="CR1">Corresponding author: Keila E. Torres, M.D., Ph.D., Department of Surgical Oncology, 1400 Pressler Street, Unit 1484, Houston, TX 77030, <email>ketorres@mdanderson.org</email>, T 713.792.4301, F 713.745.4926</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>28</day><month>8</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>06</day><month>12</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>26</day><month>9</month><year>2016</year></pub-date><volume>20</volume><issue>4</issue><fpage>1267</fpage><lpage>1274</lpage><pmc-comment>elocation-id from pubmed: 10.1245/s10434-012-2755-y</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Radiation-associated angiosarcoma (RAAS) is a devastating disease occasionally observed in breast cancer patients treated with radiation. Due to its rarity, our knowledge—of disease risk factors, epidemiology, treatment, and outcome—is extremely limited. Therefore, we sought to identify clinicopathologic factors associated with local and distant recurrence, and disease-specific survival (DSS).</p></sec><sec id="S2"><title>Methods</title><p id="P2">Radiation-associated angiosarcoma was defined as pathologically confirmed breast or chest wall angiosarcoma arising within a previously irradiated field. A comprehensive search of our institutional tumor registry (1/1/93 through 2/28/11) was used to identify patients (n=95 females); patient, original tumor, RAAS treatment, and outcome variables were retrospectively retrieved and assembled into a database.</p></sec><sec id="S3"><title>Results</title><p id="P3">The median follow-up for all RAAS patients was 10.3 years (range, 2.4 – 31.8 years). The latency period following radiation exposure ranged from 1.4 to 26 years (median = 7 years). One- and five-year DSS rates were 93.5% and 62.6%, respectively. Reduced risk of local recurrence was observed in patients who received chemotherapy (<italic>P</italic> = 0.0003). In multivariable analysis, size was found to be an independent predictor of adverse outcome (<italic>P</italic> = 0.015).</p></sec><sec id="S4"><title>Discussion</title><p id="P4">Our study demonstrates that RAAS exhibits high recurrence rates. It also highlights the need for well-designed multicenter clinical trials to inform the true utility of chemotherapy in this disease.</p></sec></abstract><kwd-group><kwd>Radiation-associated sarcoma</kwd><kwd>angiosarcoma</kwd><kwd>breast</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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