Assessment of multifactor gene-environment interactions and ovarian cancer risk: Candidate genes, obesity, and hormone-related risk factors
Identifieur interne : 003916 ( Pmc/Corpus ); précédent : 003915; suivant : 003917Assessment of multifactor gene-environment interactions and ovarian cancer risk: Candidate genes, obesity, and hormone-related risk factors
Auteurs : Joseph L. Usset ; Rama Raghavan ; Jonathan P. Tyrer ; Valerie Mcguire ; Weiva Sieh ; Penelope Webb ; Jenny Chang-Claude ; Anja Rudolph ; Hoda Anton-Culver ; Andrew Berchuck ; Louise Brinton ; Julie M. Cunningham ; Anna Defazio ; Jennifer A. Doherty ; Robert P. Edwards ; Simon A. Gayther ; Aleksandra Gentry-Maharaj ; Marc T. Goodman ; Estrid H Gdall ; Allan Jensen ; Sharon E. Johnatty ; Lambertus A. Kiemeney ; Susanne K. Kjaer ; Melissa C. Larson ; Galina Lurie ; Leon Massuger ; Usha Menon ; Francesmary Modugno ; Kirsten B. Moysich ; Roberta B. Ness ; Malcolm C. Pike ; Susan J. Ramus ; Mary Anne Rossing ; Joseph Rothstein ; Honglin Song ; Pamela J. Thompson ; David J. Van Den Berg ; Robert A. Vierkant ; Shan Wang-Gohrke ; Nicolas Wentzensen ; Alice S. Whittemore ; Lynne R. Wilkens ; Anna H. Wu ; Hannah Yang ; Celeste L. Pearce ; Joellen M. Schildkraut ; Paul Pharoah ; Ellen L. Goode ; Brooke L. FridleySource :
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [ 1055-9965 ] ; 2016.
Abstract
Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure, and elevated estrogen levels are associated with obesity in post-menopausal women. Therefore, we hypothesized that gene-environment interactions related to hormone-related risk factors could differ between obese and non-obese women.
We considered interactions between 11,441 single nucleotide polymorphisms (SNPs) within 80 candidate genes related to hormone biosynthesis & metabolism and insulin-like growth factors with six hormone-related factors: oral contraceptive use; parity; endometriosis; tubal ligation; hormone replacement therapy; and estrogen use; and assessed whether these interactions differed between obese and non-obese women. Interactions were assessed using logistic regression models and data from 14 case-control studies (6,247 cases; 10,379 controls). Histotype specific analyses were also completed.
SNPs in the following candidate genes showed notable interaction:
We have demonstrated the feasibility of assessing multi-factor interactions in large genetic epidemiology studies. Follow-up studies are necessary to assess the robustness of our findings for
Assessment of multifactor interaction is feasible, and, here, suggest that the relationship between genetic variants within candidate genes and hormone-related risk factors may vary EOC susceptibility.
Url:
DOI: 10.1158/1055-9965.EPI-15-1039
PubMed: 26976855
PubMed Central: 4873330
Links to Exploration step
PMC:4873330Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assessment of multifactor gene-environment interactions and ovarian cancer risk: Candidate genes, obesity, and hormone-related risk factors</title><author><name sortKey="Usset, Joseph L" sort="Usset, Joseph L" uniqKey="Usset J" first="Joseph L" last="Usset">Joseph L. Usset</name><affiliation><nlm:aff id="A1">Department of Biostatistics, University of Kansas Medical Center</nlm:aff></affiliation></author><author><name sortKey="Raghavan, Rama" sort="Raghavan, Rama" uniqKey="Raghavan R" first="Rama" last="Raghavan">Rama Raghavan</name><affiliation><nlm:aff id="A1">Department of Biostatistics, University of Kansas Medical Center</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P" last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:aff id="A2">Department of Oncology, University of Cambridge, Strangeways Research Laboratory</nlm:aff></affiliation></author><author><name sortKey="Mcguire, Valerie" sort="Mcguire, Valerie" uniqKey="Mcguire V" first="Valerie" last="Mcguire">Valerie Mcguire</name><affiliation><nlm:aff id="A3">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Sieh, Weiva" sort="Sieh, Weiva" uniqKey="Sieh W" first="Weiva" last="Sieh">Weiva Sieh</name><affiliation><nlm:aff id="A3">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Webb, Penelope" sort="Webb, Penelope" uniqKey="Webb P" first="Penelope" last="Webb">Penelope Webb</name><affiliation><nlm:aff id="A4">Population Health Department, QIMR Berghofer Medical Research Institute</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology, German Cancer Research Center</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology, German Cancer Research Center</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A6">Department of Epidemiology, University of California Irvine</nlm:aff></affiliation></author><author><name sortKey="Berchuck, Andrew" sort="Berchuck, Andrew" uniqKey="Berchuck A" first="Andrew" last="Berchuck">Andrew Berchuck</name><affiliation><nlm:aff id="A7">Department of Obstetrics and Gynecology, Duke University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute</nlm:aff></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M" last="Cunningham">Julie M. Cunningham</name><affiliation><nlm:aff id="A9">Department of Laboratory Medicine and Pathology, Mayo Clinic</nlm:aff></affiliation></author><author><name sortKey="Defazio, Anna" sort="Defazio, Anna" uniqKey="Defazio A" first="Anna" last="Defazio">Anna Defazio</name><affiliation><nlm:aff id="A10">Discipline of Obstetrics, Gynecology and Neonatology, University of Sydney, Westmead Institute for Cancer Research, Westmead Millennium Institute</nlm:aff></affiliation></author><author><name sortKey="Doherty, Jennifer A" sort="Doherty, Jennifer A" uniqKey="Doherty J" first="Jennifer A" last="Doherty">Jennifer A. Doherty</name><affiliation><nlm:aff id="A11">Department of Epidemiology, Geisel School of Medicine, Dartmouth</nlm:aff></affiliation></author><author><name sortKey="Edwards, Robert P" sort="Edwards, Robert P" uniqKey="Edwards R" first="Robert P" last="Edwards">Robert P. Edwards</name><affiliation><nlm:aff id="A12">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A13">Department of Biomedical Sciences, Cedars-Sinai Medical Center</nlm:aff></affiliation></author><author><name sortKey="Gentry Maharaj, Aleksandra" sort="Gentry Maharaj, Aleksandra" uniqKey="Gentry Maharaj A" first="Aleksandra" last="Gentry-Maharaj">Aleksandra Gentry-Maharaj</name><affiliation><nlm:aff id="A14">Women's Cancer, Institute for Women's Health, University College London</nlm:aff></affiliation></author><author><name sortKey="Goodman, Marc T" sort="Goodman, Marc T" uniqKey="Goodman M" first="Marc T" last="Goodman">Marc T. Goodman</name><affiliation><nlm:aff id="A13">Department of Biomedical Sciences, Cedars-Sinai Medical Center</nlm:aff></affiliation></author><author><name sortKey="H Gdall, Estrid" sort="H Gdall, Estrid" uniqKey="H Gdall E" first="Estrid" last="H Gdall">Estrid H Gdall</name><affiliation><nlm:aff id="A15">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Pathology, Herlev Hospital, University of Copenhagen</nlm:aff></affiliation></author><author><name sortKey="Jensen, Allan" sort="Jensen, Allan" uniqKey="Jensen A" first="Allan" last="Jensen">Allan Jensen</name><affiliation><nlm:aff id="A15">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center</nlm:aff></affiliation></author><author><name sortKey="Johnatty, Sharon E" sort="Johnatty, Sharon E" uniqKey="Johnatty S" first="Sharon E" last="Johnatty">Sharon E. Johnatty</name><affiliation><nlm:aff id="A17">Division of Genetics and Public Health, QIMR Berghofer Medical Research Institute</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A" last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A18">Department of Health Evidence, Radboud University Medical Centre</nlm:aff></affiliation></author><author><name sortKey="Kjaer, Susanne K" sort="Kjaer, Susanne K" uniqKey="Kjaer S" first="Susanne K" last="Kjaer">Susanne K. Kjaer</name><affiliation><nlm:aff id="A19">Department of Gynecology, Rigshospitalet, University of Copenhagen</nlm:aff></affiliation></author><author><name sortKey="Larson, Melissa C" sort="Larson, Melissa C" uniqKey="Larson M" first="Melissa C" last="Larson">Melissa C. Larson</name><affiliation><nlm:aff id="A20">Department of Health Science Research, Mayo Clinic</nlm:aff></affiliation></author><author><name sortKey="Lurie, Galina" sort="Lurie, Galina" uniqKey="Lurie G" first="Galina" last="Lurie">Galina Lurie</name><affiliation><nlm:aff id="A21">Cancer Epidemiology Program, University of Hawaii Cancer Center</nlm:aff></affiliation></author><author><name sortKey="Massuger, Leon" sort="Massuger, Leon" uniqKey="Massuger L" first="Leon" last="Massuger">Leon Massuger</name><affiliation><nlm:aff id="A22">Department of Obstetrics & Gynecology, Radboud University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Menon, Usha" sort="Menon, Usha" uniqKey="Menon U" first="Usha" last="Menon">Usha Menon</name><affiliation><nlm:aff id="A14">Women's Cancer, Institute for Women's Health, University College London</nlm:aff></affiliation></author><author><name sortKey="Modugno, Francesmary" sort="Modugno, Francesmary" uniqKey="Modugno F" first="Francesmary" last="Modugno">Francesmary Modugno</name><affiliation><nlm:aff id="A12">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology, University of Pittsburgh</nlm:aff></affiliation></author><author><name sortKey="Moysich, Kirsten B" sort="Moysich, Kirsten B" uniqKey="Moysich K" first="Kirsten B" last="Moysich">Kirsten B. Moysich</name><affiliation><nlm:aff id="A24">Department of Cancer Prevention and Control, Roswell Park Cancer Institute</nlm:aff></affiliation></author><author><name sortKey="Ness, Roberta B" sort="Ness, Roberta B" uniqKey="Ness R" first="Roberta B" last="Ness">Roberta B. Ness</name><affiliation><nlm:aff id="A25">School of Public Health, The University of Texas School</nlm:aff></affiliation></author><author><name sortKey="Pike, Malcolm C" sort="Pike, Malcolm C" uniqKey="Pike M" first="Malcolm C" last="Pike">Malcolm C. Pike</name><affiliation><nlm:aff id="A26">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A27">Department of Preventive Medicine, University of Southern California</nlm:aff></affiliation></author><author><name sortKey="Rossing, Mary Anne" sort="Rossing, Mary Anne" uniqKey="Rossing M" first="Mary Anne" last="Rossing">Mary Anne Rossing</name><affiliation><nlm:aff id="A28">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Department of Epidemiology, University of Washington</nlm:aff></affiliation></author><author><name sortKey="Rothstein, Joseph" sort="Rothstein, Joseph" uniqKey="Rothstein J" first="Joseph" last="Rothstein">Joseph Rothstein</name><affiliation><nlm:aff id="A3">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Song, Honglin" sort="Song, Honglin" uniqKey="Song H" first="Honglin" last="Song">Honglin Song</name><affiliation><nlm:aff id="A2">Department of Oncology, University of Cambridge, Strangeways Research Laboratory</nlm:aff></affiliation></author><author><name sortKey="Thompson, Pamela J" sort="Thompson, Pamela J" uniqKey="Thompson P" first="Pamela J" last="Thompson">Pamela J. Thompson</name><affiliation><nlm:aff id="A13">Department of Biomedical Sciences, Cedars-Sinai Medical Center</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David J" sort="Van Den Berg, David J" uniqKey="Van Den Berg D" first="David J." last="Van Den Berg">David J. Van Den Berg</name><affiliation><nlm:aff id="A27">Department of Preventive Medicine, University of Southern California</nlm:aff></affiliation></author><author><name sortKey="Vierkant, Robert A" sort="Vierkant, Robert A" uniqKey="Vierkant R" first="Robert A" last="Vierkant">Robert A. Vierkant</name><affiliation><nlm:aff id="A20">Department of Health Science Research, Mayo Clinic</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A30">Department of Obstetrics and Gynecology, University of Ulm</nlm:aff></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S" last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A3">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R" last="Wilkens">Lynne R. Wilkens</name><affiliation><nlm:aff id="A21">Cancer Epidemiology Program, University of Hawaii Cancer Center</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A27">Department of Preventive Medicine, University of Southern California</nlm:aff></affiliation></author><author><name sortKey="Yang, Hannah" sort="Yang, Hannah" uniqKey="Yang H" first="Hannah" last="Yang">Hannah Yang</name><affiliation><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute</nlm:aff></affiliation></author><author><name sortKey="Pearce, Celeste L" sort="Pearce, Celeste L" uniqKey="Pearce C" first="Celeste L" last="Pearce">Celeste L. Pearce</name><affiliation><nlm:aff id="A27">Department of Preventive Medicine, University of Southern California</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Department of Epidemiology, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Schildkraut, Joellen M" sort="Schildkraut, Joellen M" uniqKey="Schildkraut J" first="Joellen M" last="Schildkraut">Joellen M. Schildkraut</name><affiliation><nlm:aff id="A32">Department of Public Health Sciences, University of Virginia</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation><nlm:aff id="A2">Department of Oncology, University of Cambridge, Strangeways Research Laboratory</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Dept of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory</nlm:aff></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L" last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A20">Department of Health Science Research, Mayo Clinic</nlm:aff></affiliation></author><author><name sortKey="Fridley, Brooke L" sort="Fridley, Brooke L" uniqKey="Fridley B" first="Brooke L" last="Fridley">Brooke L. Fridley</name><affiliation><nlm:aff id="A1">Department of Biostatistics, University of Kansas Medical Center</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26976855</idno><idno type="pmc">4873330</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4873330</idno><idno type="RBID">PMC:4873330</idno><idno type="doi">10.1158/1055-9965.EPI-15-1039</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">003916</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003916</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Assessment of multifactor gene-environment interactions and ovarian cancer risk: Candidate genes, obesity, and hormone-related risk factors</title><author><name sortKey="Usset, Joseph L" sort="Usset, Joseph L" uniqKey="Usset J" first="Joseph L" last="Usset">Joseph L. Usset</name><affiliation><nlm:aff id="A1">Department of Biostatistics, University of Kansas Medical Center</nlm:aff></affiliation></author><author><name sortKey="Raghavan, Rama" sort="Raghavan, Rama" uniqKey="Raghavan R" first="Rama" last="Raghavan">Rama Raghavan</name><affiliation><nlm:aff id="A1">Department of Biostatistics, University of Kansas Medical Center</nlm:aff></affiliation></author><author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P" last="Tyrer">Jonathan P. Tyrer</name><affiliation><nlm:aff id="A2">Department of Oncology, University of Cambridge, Strangeways Research Laboratory</nlm:aff></affiliation></author><author><name sortKey="Mcguire, Valerie" sort="Mcguire, Valerie" uniqKey="Mcguire V" first="Valerie" last="Mcguire">Valerie Mcguire</name><affiliation><nlm:aff id="A3">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Sieh, Weiva" sort="Sieh, Weiva" uniqKey="Sieh W" first="Weiva" last="Sieh">Weiva Sieh</name><affiliation><nlm:aff id="A3">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Webb, Penelope" sort="Webb, Penelope" uniqKey="Webb P" first="Penelope" last="Webb">Penelope Webb</name><affiliation><nlm:aff id="A4">Population Health Department, QIMR Berghofer Medical Research Institute</nlm:aff></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology, German Cancer Research Center</nlm:aff></affiliation></author><author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name><affiliation><nlm:aff id="A5">Division of Cancer Epidemiology, German Cancer Research Center</nlm:aff></affiliation></author><author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name><affiliation><nlm:aff id="A6">Department of Epidemiology, University of California Irvine</nlm:aff></affiliation></author><author><name sortKey="Berchuck, Andrew" sort="Berchuck, Andrew" uniqKey="Berchuck A" first="Andrew" last="Berchuck">Andrew Berchuck</name><affiliation><nlm:aff id="A7">Department of Obstetrics and Gynecology, Duke University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Brinton, Louise" sort="Brinton, Louise" uniqKey="Brinton L" first="Louise" last="Brinton">Louise Brinton</name><affiliation><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute</nlm:aff></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M" last="Cunningham">Julie M. Cunningham</name><affiliation><nlm:aff id="A9">Department of Laboratory Medicine and Pathology, Mayo Clinic</nlm:aff></affiliation></author><author><name sortKey="Defazio, Anna" sort="Defazio, Anna" uniqKey="Defazio A" first="Anna" last="Defazio">Anna Defazio</name><affiliation><nlm:aff id="A10">Discipline of Obstetrics, Gynecology and Neonatology, University of Sydney, Westmead Institute for Cancer Research, Westmead Millennium Institute</nlm:aff></affiliation></author><author><name sortKey="Doherty, Jennifer A" sort="Doherty, Jennifer A" uniqKey="Doherty J" first="Jennifer A" last="Doherty">Jennifer A. Doherty</name><affiliation><nlm:aff id="A11">Department of Epidemiology, Geisel School of Medicine, Dartmouth</nlm:aff></affiliation></author><author><name sortKey="Edwards, Robert P" sort="Edwards, Robert P" uniqKey="Edwards R" first="Robert P" last="Edwards">Robert P. Edwards</name><affiliation><nlm:aff id="A12">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Gayther, Simon A" sort="Gayther, Simon A" uniqKey="Gayther S" first="Simon A" last="Gayther">Simon A. Gayther</name><affiliation><nlm:aff id="A13">Department of Biomedical Sciences, Cedars-Sinai Medical Center</nlm:aff></affiliation></author><author><name sortKey="Gentry Maharaj, Aleksandra" sort="Gentry Maharaj, Aleksandra" uniqKey="Gentry Maharaj A" first="Aleksandra" last="Gentry-Maharaj">Aleksandra Gentry-Maharaj</name><affiliation><nlm:aff id="A14">Women's Cancer, Institute for Women's Health, University College London</nlm:aff></affiliation></author><author><name sortKey="Goodman, Marc T" sort="Goodman, Marc T" uniqKey="Goodman M" first="Marc T" last="Goodman">Marc T. Goodman</name><affiliation><nlm:aff id="A13">Department of Biomedical Sciences, Cedars-Sinai Medical Center</nlm:aff></affiliation></author><author><name sortKey="H Gdall, Estrid" sort="H Gdall, Estrid" uniqKey="H Gdall E" first="Estrid" last="H Gdall">Estrid H Gdall</name><affiliation><nlm:aff id="A15">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center</nlm:aff></affiliation><affiliation><nlm:aff id="A16">Department of Pathology, Herlev Hospital, University of Copenhagen</nlm:aff></affiliation></author><author><name sortKey="Jensen, Allan" sort="Jensen, Allan" uniqKey="Jensen A" first="Allan" last="Jensen">Allan Jensen</name><affiliation><nlm:aff id="A15">Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center</nlm:aff></affiliation></author><author><name sortKey="Johnatty, Sharon E" sort="Johnatty, Sharon E" uniqKey="Johnatty S" first="Sharon E" last="Johnatty">Sharon E. Johnatty</name><affiliation><nlm:aff id="A17">Division of Genetics and Public Health, QIMR Berghofer Medical Research Institute</nlm:aff></affiliation></author><author><name sortKey="Kiemeney, Lambertus A" sort="Kiemeney, Lambertus A" uniqKey="Kiemeney L" first="Lambertus A" last="Kiemeney">Lambertus A. Kiemeney</name><affiliation><nlm:aff id="A18">Department of Health Evidence, Radboud University Medical Centre</nlm:aff></affiliation></author><author><name sortKey="Kjaer, Susanne K" sort="Kjaer, Susanne K" uniqKey="Kjaer S" first="Susanne K" last="Kjaer">Susanne K. Kjaer</name><affiliation><nlm:aff id="A19">Department of Gynecology, Rigshospitalet, University of Copenhagen</nlm:aff></affiliation></author><author><name sortKey="Larson, Melissa C" sort="Larson, Melissa C" uniqKey="Larson M" first="Melissa C" last="Larson">Melissa C. Larson</name><affiliation><nlm:aff id="A20">Department of Health Science Research, Mayo Clinic</nlm:aff></affiliation></author><author><name sortKey="Lurie, Galina" sort="Lurie, Galina" uniqKey="Lurie G" first="Galina" last="Lurie">Galina Lurie</name><affiliation><nlm:aff id="A21">Cancer Epidemiology Program, University of Hawaii Cancer Center</nlm:aff></affiliation></author><author><name sortKey="Massuger, Leon" sort="Massuger, Leon" uniqKey="Massuger L" first="Leon" last="Massuger">Leon Massuger</name><affiliation><nlm:aff id="A22">Department of Obstetrics & Gynecology, Radboud University Medical Center</nlm:aff></affiliation></author><author><name sortKey="Menon, Usha" sort="Menon, Usha" uniqKey="Menon U" first="Usha" last="Menon">Usha Menon</name><affiliation><nlm:aff id="A14">Women's Cancer, Institute for Women's Health, University College London</nlm:aff></affiliation></author><author><name sortKey="Modugno, Francesmary" sort="Modugno, Francesmary" uniqKey="Modugno F" first="Francesmary" last="Modugno">Francesmary Modugno</name><affiliation><nlm:aff id="A12">Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine</nlm:aff></affiliation><affiliation><nlm:aff id="A23">Department of Epidemiology, University of Pittsburgh</nlm:aff></affiliation></author><author><name sortKey="Moysich, Kirsten B" sort="Moysich, Kirsten B" uniqKey="Moysich K" first="Kirsten B" last="Moysich">Kirsten B. Moysich</name><affiliation><nlm:aff id="A24">Department of Cancer Prevention and Control, Roswell Park Cancer Institute</nlm:aff></affiliation></author><author><name sortKey="Ness, Roberta B" sort="Ness, Roberta B" uniqKey="Ness R" first="Roberta B" last="Ness">Roberta B. Ness</name><affiliation><nlm:aff id="A25">School of Public Health, The University of Texas School</nlm:aff></affiliation></author><author><name sortKey="Pike, Malcolm C" sort="Pike, Malcolm C" uniqKey="Pike M" first="Malcolm C" last="Pike">Malcolm C. Pike</name><affiliation><nlm:aff id="A26">Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center</nlm:aff></affiliation></author><author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name><affiliation><nlm:aff id="A27">Department of Preventive Medicine, University of Southern California</nlm:aff></affiliation></author><author><name sortKey="Rossing, Mary Anne" sort="Rossing, Mary Anne" uniqKey="Rossing M" first="Mary Anne" last="Rossing">Mary Anne Rossing</name><affiliation><nlm:aff id="A28">Division of Public Health Sciences, Fred Hutchinson Cancer Research Center</nlm:aff></affiliation><affiliation><nlm:aff id="A29">Department of Epidemiology, University of Washington</nlm:aff></affiliation></author><author><name sortKey="Rothstein, Joseph" sort="Rothstein, Joseph" uniqKey="Rothstein J" first="Joseph" last="Rothstein">Joseph Rothstein</name><affiliation><nlm:aff id="A3">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Song, Honglin" sort="Song, Honglin" uniqKey="Song H" first="Honglin" last="Song">Honglin Song</name><affiliation><nlm:aff id="A2">Department of Oncology, University of Cambridge, Strangeways Research Laboratory</nlm:aff></affiliation></author><author><name sortKey="Thompson, Pamela J" sort="Thompson, Pamela J" uniqKey="Thompson P" first="Pamela J" last="Thompson">Pamela J. Thompson</name><affiliation><nlm:aff id="A13">Department of Biomedical Sciences, Cedars-Sinai Medical Center</nlm:aff></affiliation></author><author><name sortKey="Van Den Berg, David J" sort="Van Den Berg, David J" uniqKey="Van Den Berg D" first="David J." last="Van Den Berg">David J. Van Den Berg</name><affiliation><nlm:aff id="A27">Department of Preventive Medicine, University of Southern California</nlm:aff></affiliation></author><author><name sortKey="Vierkant, Robert A" sort="Vierkant, Robert A" uniqKey="Vierkant R" first="Robert A" last="Vierkant">Robert A. Vierkant</name><affiliation><nlm:aff id="A20">Department of Health Science Research, Mayo Clinic</nlm:aff></affiliation></author><author><name sortKey="Wang Gohrke, Shan" sort="Wang Gohrke, Shan" uniqKey="Wang Gohrke S" first="Shan" last="Wang-Gohrke">Shan Wang-Gohrke</name><affiliation><nlm:aff id="A30">Department of Obstetrics and Gynecology, University of Ulm</nlm:aff></affiliation></author><author><name sortKey="Wentzensen, Nicolas" sort="Wentzensen, Nicolas" uniqKey="Wentzensen N" first="Nicolas" last="Wentzensen">Nicolas Wentzensen</name><affiliation><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute</nlm:aff></affiliation></author><author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S" last="Whittemore">Alice S. Whittemore</name><affiliation><nlm:aff id="A3">Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine</nlm:aff></affiliation></author><author><name sortKey="Wilkens, Lynne R" sort="Wilkens, Lynne R" uniqKey="Wilkens L" first="Lynne R" last="Wilkens">Lynne R. Wilkens</name><affiliation><nlm:aff id="A21">Cancer Epidemiology Program, University of Hawaii Cancer Center</nlm:aff></affiliation></author><author><name sortKey="Wu, Anna H" sort="Wu, Anna H" uniqKey="Wu A" first="Anna H" last="Wu">Anna H. Wu</name><affiliation><nlm:aff id="A27">Department of Preventive Medicine, University of Southern California</nlm:aff></affiliation></author><author><name sortKey="Yang, Hannah" sort="Yang, Hannah" uniqKey="Yang H" first="Hannah" last="Yang">Hannah Yang</name><affiliation><nlm:aff id="A8">Division of Cancer Epidemiology and Genetics, National Cancer Institute</nlm:aff></affiliation></author><author><name sortKey="Pearce, Celeste L" sort="Pearce, Celeste L" uniqKey="Pearce C" first="Celeste L" last="Pearce">Celeste L. Pearce</name><affiliation><nlm:aff id="A27">Department of Preventive Medicine, University of Southern California</nlm:aff></affiliation><affiliation><nlm:aff id="A31">Department of Epidemiology, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Schildkraut, Joellen M" sort="Schildkraut, Joellen M" uniqKey="Schildkraut J" first="Joellen M" last="Schildkraut">Joellen M. Schildkraut</name><affiliation><nlm:aff id="A32">Department of Public Health Sciences, University of Virginia</nlm:aff></affiliation></author><author><name sortKey="Pharoah, Paul" sort="Pharoah, Paul" uniqKey="Pharoah P" first="Paul" last="Pharoah">Paul Pharoah</name><affiliation><nlm:aff id="A2">Department of Oncology, University of Cambridge, Strangeways Research Laboratory</nlm:aff></affiliation><affiliation><nlm:aff id="A33">Dept of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory</nlm:aff></affiliation></author><author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L" last="Goode">Ellen L. Goode</name><affiliation><nlm:aff id="A20">Department of Health Science Research, Mayo Clinic</nlm:aff></affiliation></author><author><name sortKey="Fridley, Brooke L" sort="Fridley, Brooke L" uniqKey="Fridley B" first="Brooke L" last="Fridley">Brooke L. Fridley</name><affiliation><nlm:aff id="A1">Department of Biostatistics, University of Kansas Medical Center</nlm:aff></affiliation></author></analytic><series><title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title><idno type="ISSN">1055-9965</idno><idno type="eISSN">1538-7755</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure, and elevated estrogen levels are associated with obesity in post-menopausal women. Therefore, we hypothesized that gene-environment interactions related to hormone-related risk factors could differ between obese and non-obese women.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We considered interactions between 11,441 single nucleotide polymorphisms (SNPs) within 80 candidate genes related to hormone biosynthesis & metabolism and insulin-like growth factors with six hormone-related factors: oral contraceptive use; parity; endometriosis; tubal ligation; hormone replacement therapy; and estrogen use; and assessed whether these interactions differed between obese and non-obese women. Interactions were assessed using logistic regression models and data from 14 case-control studies (6,247 cases; 10,379 controls). Histotype specific analyses were also completed.</p></sec><sec id="S3"><title>Results</title><p id="P3">SNPs in the following candidate genes showed notable interaction: <italic>IGF1R</italic> (rs41497346, estrogen plus progesterone hormone therapy, histology = all, p = 4.9×10<sup>−6</sup>) and <italic>ESR1</italic> (rs12661437, endometriosis, histology = all, p = 1.5×10<sup>−5</sup>). The most notable obesity - gene - hormone risk factor interaction was within <italic>INSR</italic> (rs113759408, parity, histology = endometrioid, p = 8.8×10<sup>−6</sup>).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">We have demonstrated the feasibility of assessing multi-factor interactions in large genetic epidemiology studies. Follow-up studies are necessary to assess the robustness of our findings for <italic>ESR1, CYP11A1, IGF1R, CYP11B1, INSR</italic>, and <italic>IGFBP2</italic>. Future work is needed to develop powerful statistical methods able to detect these complex interactions.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Assessment of multifactor interaction is feasible, and, here, suggest that the relationship between genetic variants within candidate genes and hormone-related risk factors may vary EOC susceptibility.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9200608</journal-id><journal-id journal-id-type="pubmed-jr-id">2299</journal-id><journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id><journal-title-group><journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title></journal-title-group><issn pub-type="ppub">1055-9965</issn><issn pub-type="epub">1538-7755</issn></journal-meta><article-meta><article-id pub-id-type="pmid">26976855</article-id><article-id pub-id-type="pmc">4873330</article-id><article-id pub-id-type="doi">10.1158/1055-9965.EPI-15-1039</article-id><article-id pub-id-type="manuscript">NIHMS778316</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Assessment of multifactor gene-environment interactions and ovarian cancer risk: Candidate genes, obesity, and hormone-related risk factors</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Usset</surname><given-names>Joseph L</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Raghavan</surname><given-names>Rama</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tyrer</surname><given-names>Jonathan P</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>McGuire</surname><given-names>Valerie</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Sieh</surname><given-names>Weiva</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Webb</surname><given-names>Penelope</given-names></name><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Chang-Claude</surname><given-names>Jenny</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Rudolph</surname><given-names>Anja</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Anton-Culver</surname><given-names>Hoda</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Berchuck</surname><given-names>Andrew</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Brinton</surname><given-names>Louise</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Cunningham</surname><given-names>Julie M</given-names></name><xref ref-type="aff" rid="A9">9</xref></contrib><contrib contrib-type="author"><name><surname>DeFazio</surname><given-names>Anna</given-names></name><xref ref-type="aff" rid="A10">10</xref></contrib><contrib contrib-type="author"><name><surname>Doherty</surname><given-names>Jennifer A</given-names></name><xref ref-type="aff" rid="A11">11</xref></contrib><contrib contrib-type="author"><name><surname>Edwards</surname><given-names>Robert P</given-names></name><xref ref-type="aff" rid="A12">12</xref></contrib><contrib contrib-type="author"><name><surname>Gayther</surname><given-names>Simon A</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Gentry-Maharaj</surname><given-names>Aleksandra</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Goodman</surname><given-names>Marc T</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>Høgdall</surname><given-names>Estrid</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref></contrib><contrib contrib-type="author"><name><surname>Jensen</surname><given-names>Allan</given-names></name><xref ref-type="aff" rid="A15">15</xref></contrib><contrib contrib-type="author"><name><surname>Johnatty</surname><given-names>Sharon E</given-names></name><xref ref-type="aff" rid="A17">17</xref></contrib><contrib contrib-type="author"><name><surname>Kiemeney</surname><given-names>Lambertus A</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Kjaer</surname><given-names>Susanne K</given-names></name><xref ref-type="aff" rid="A19">19</xref></contrib><contrib contrib-type="author"><name><surname>Larson</surname><given-names>Melissa C</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Lurie</surname><given-names>Galina</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Massuger</surname><given-names>Leon</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>Menon</surname><given-names>Usha</given-names></name><xref ref-type="aff" rid="A14">14</xref></contrib><contrib contrib-type="author"><name><surname>Modugno</surname><given-names>Francesmary</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A23">23</xref></contrib><contrib contrib-type="author"><name><surname>Moysich</surname><given-names>Kirsten B</given-names></name><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Ness</surname><given-names>Roberta B</given-names></name><xref ref-type="aff" rid="A25">25</xref></contrib><contrib contrib-type="author"><name><surname>Pike</surname><given-names>Malcolm C</given-names></name><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Ramus</surname><given-names>Susan J</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Rossing</surname><given-names>Mary Anne</given-names></name><xref ref-type="aff" rid="A28">28</xref><xref ref-type="aff" rid="A29">29</xref></contrib><contrib contrib-type="author"><name><surname>Rothstein</surname><given-names>Joseph</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Song</surname><given-names>Honglin</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Pamela J</given-names></name><xref ref-type="aff" rid="A13">13</xref></contrib><contrib contrib-type="author"><name><surname>van den Berg</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Vierkant</surname><given-names>Robert A</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Wang-Gohrke</surname><given-names>Shan</given-names></name><xref ref-type="aff" rid="A30">30</xref></contrib><contrib contrib-type="author"><name><surname>Wentzensen</surname><given-names>Nicolas</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Whittemore</surname><given-names>Alice S</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Wilkens</surname><given-names>Lynne R</given-names></name><xref ref-type="aff" rid="A21">21</xref></contrib><contrib contrib-type="author"><name><surname>Wu</surname><given-names>Anna H</given-names></name><xref ref-type="aff" rid="A27">27</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Hannah</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Pearce</surname><given-names>Celeste L</given-names></name><xref ref-type="aff" rid="A27">27</xref><xref ref-type="aff" rid="A31">31</xref></contrib><contrib contrib-type="author"><name><surname>Schildkraut</surname><given-names>Joellen M</given-names></name><xref ref-type="aff" rid="A32">32</xref></contrib><contrib contrib-type="author"><name><surname>Pharoah</surname><given-names>Paul</given-names></name><xref ref-type="aff" rid="A2">2</xref><xref ref-type="aff" rid="A33">33</xref></contrib><contrib contrib-type="author"><name><surname>Goode</surname><given-names>Ellen L</given-names></name><xref ref-type="aff" rid="A20">20</xref></contrib><contrib contrib-type="author"><name><surname>Fridley</surname><given-names>Brooke L</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="corresp" rid="cor1">*</xref><on-behalf-of>on behalf of Ovarian Cancer Association Consortium the Australian Cancer Study</on-behalf-of></contrib></contrib-group><aff id="A1"><label>1</label>Department of Biostatistics, University of Kansas Medical Center</aff><aff id="A2"><label>2</label>Department of Oncology, University of Cambridge, Strangeways Research Laboratory</aff><aff id="A3"><label>3</label>Department of Health Research and Policy - Epidemiology, Stanford University School of Medicine</aff><aff id="A4"><label>4</label>Population Health Department, QIMR Berghofer Medical Research Institute</aff><aff id="A5"><label>5</label>Division of Cancer Epidemiology, German Cancer Research Center</aff><aff id="A6"><label>6</label>Department of Epidemiology, University of California Irvine</aff><aff id="A7"><label>7</label>Department of Obstetrics and Gynecology, Duke University Medical Center</aff><aff id="A8"><label>8</label>Division of Cancer Epidemiology and Genetics, National Cancer Institute</aff><aff id="A9"><label>9</label>Department of Laboratory Medicine and Pathology, Mayo Clinic</aff><aff id="A10"><label>10</label>Discipline of Obstetrics, Gynecology and Neonatology, University of Sydney, Westmead Institute for Cancer Research, Westmead Millennium Institute</aff><aff id="A11"><label>11</label>Department of Epidemiology, Geisel School of Medicine, Dartmouth</aff><aff id="A12"><label>12</label>Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine</aff><aff id="A13"><label>13</label>Department of Biomedical Sciences, Cedars-Sinai Medical Center</aff><aff id="A14"><label>14</label>Women's Cancer, Institute for Women's Health, University College London</aff><aff id="A15"><label>15</label>Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center</aff><aff id="A16"><label>16</label>Department of Pathology, Herlev Hospital, University of Copenhagen</aff><aff id="A17"><label>17</label>Division of Genetics and Public Health, QIMR Berghofer Medical Research Institute</aff><aff id="A18"><label>18</label>Department of Health Evidence, Radboud University Medical Centre</aff><aff id="A19"><label>19</label>Department of Gynecology, Rigshospitalet, University of Copenhagen</aff><aff id="A20"><label>20</label>Department of Health Science Research, Mayo Clinic</aff><aff id="A21"><label>21</label>Cancer Epidemiology Program, University of Hawaii Cancer Center</aff><aff id="A22"><label>22</label>Department of Obstetrics & Gynecology, Radboud University Medical Center</aff><aff id="A23"><label>23</label>Department of Epidemiology, University of Pittsburgh</aff><aff id="A24"><label>24</label>Department of Cancer Prevention and Control, Roswell Park Cancer Institute</aff><aff id="A25"><label>25</label>School of Public Health, The University of Texas School</aff><aff id="A26"><label>26</label>Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center</aff><aff id="A27"><label>27</label>Department of Preventive Medicine, University of Southern California</aff><aff id="A28"><label>28</label>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center</aff><aff id="A29"><label>29</label>Department of Epidemiology, University of Washington</aff><aff id="A30"><label>30</label>Department of Obstetrics and Gynecology, University of Ulm</aff><aff id="A31"><label>31</label>Department of Epidemiology, University of Michigan</aff><aff id="A32"><label>32</label>Department of Public Health Sciences, University of Virginia</aff><aff id="A33"><label>33</label>Dept of Public Health and Primary Care, University of Cambridge, Strangeways Research laboratory</aff><author-notes><corresp id="cor1"><label>*</label>CORRESPONDING AUTHOR: Brooke L. Fridley, Ph.D., 3901 Rainbow Blvd, University of Kansas Medical Center, Kansas City, KS 66160, <email>bfridley@kumc.edu</email>, phone: 913-945-5039, fax:913-588-0252</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>20</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>14</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2017</year></pub-date><volume>25</volume><issue>5</issue><fpage>780</fpage><lpage>790</lpage><pmc-comment>elocation-id from pubmed: 10.1158/1055-9965.EPI-15-1039</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">Many epithelial ovarian cancer (EOC) risk factors relate to hormone exposure, and elevated estrogen levels are associated with obesity in post-menopausal women. Therefore, we hypothesized that gene-environment interactions related to hormone-related risk factors could differ between obese and non-obese women.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We considered interactions between 11,441 single nucleotide polymorphisms (SNPs) within 80 candidate genes related to hormone biosynthesis & metabolism and insulin-like growth factors with six hormone-related factors: oral contraceptive use; parity; endometriosis; tubal ligation; hormone replacement therapy; and estrogen use; and assessed whether these interactions differed between obese and non-obese women. Interactions were assessed using logistic regression models and data from 14 case-control studies (6,247 cases; 10,379 controls). Histotype specific analyses were also completed.</p></sec><sec id="S3"><title>Results</title><p id="P3">SNPs in the following candidate genes showed notable interaction: <italic>IGF1R</italic> (rs41497346, estrogen plus progesterone hormone therapy, histology = all, p = 4.9×10<sup>−6</sup>) and <italic>ESR1</italic> (rs12661437, endometriosis, histology = all, p = 1.5×10<sup>−5</sup>). The most notable obesity - gene - hormone risk factor interaction was within <italic>INSR</italic> (rs113759408, parity, histology = endometrioid, p = 8.8×10<sup>−6</sup>).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">We have demonstrated the feasibility of assessing multi-factor interactions in large genetic epidemiology studies. Follow-up studies are necessary to assess the robustness of our findings for <italic>ESR1, CYP11A1, IGF1R, CYP11B1, INSR</italic>, and <italic>IGFBP2</italic>. Future work is needed to develop powerful statistical methods able to detect these complex interactions.</p></sec><sec id="S5"><title>Impact</title><p id="P5">Assessment of multifactor interaction is feasible, and, here, suggest that the relationship between genetic variants within candidate genes and hormone-related risk factors may vary EOC susceptibility.</p></sec></abstract><kwd-group><kwd>body mass index</kwd><kwd>obesity</kwd><kwd>hormone related factors</kwd><kwd>SNP</kwd><kwd>gene-environment interaction</kwd><kwd>ovarian cancer</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003916 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 003916 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:4873330
|texte= Assessment of multifactor gene-environment interactions and ovarian cancer risk: Candidate genes, obesity, and hormone-related risk factors
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:26976855" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |