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<title xml:lang="en">The Role of Obesity in Cancer Survival and Recurrence</title>
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<name sortKey="Demark Wahnefried, Wendy" sort="Demark Wahnefried, Wendy" uniqKey="Demark Wahnefried W" first="Wendy" last="Demark-Wahnefried">Wendy Demark-Wahnefried</name>
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<name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A." last="Platz">Elizabeth A. Platz</name>
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<nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</nlm:aff>
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<name sortKey="Ligibel, Jennifer A" sort="Ligibel, Jennifer A" uniqKey="Ligibel J" first="Jennifer A." last="Ligibel">Jennifer A. Ligibel</name>
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<nlm:aff id="A3">Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</nlm:aff>
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<name sortKey="Blair, Cindy K" sort="Blair, Cindy K" uniqKey="Blair C" first="Cindy K." last="Blair">Cindy K. Blair</name>
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<nlm:aff id="A1">Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL</nlm:aff>
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<name sortKey="Courneya, Kerry S" sort="Courneya, Kerry S" uniqKey="Courneya K" first="Kerry S." last="Courneya">Kerry S. Courneya</name>
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<name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name>
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<nlm:aff id="A5">Schools of Medicine and Public Health, University of California–Los Angeles, Los Angeles, CA</nlm:aff>
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<name sortKey="Rock, Cheryl L" sort="Rock, Cheryl L" uniqKey="Rock C" first="Cheryl L." last="Rock">Cheryl L. Rock</name>
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<nlm:aff id="A6">Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA</nlm:aff>
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<name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name>
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<nlm:aff id="A7">Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA</nlm:aff>
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<name sortKey="Wadden, Thomas" sort="Wadden, Thomas" uniqKey="Wadden T" first="Thomas" last="Wadden">Thomas Wadden</name>
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<nlm:aff id="A8">Center for Weight and Eating Disorders, University of Pennsylvania, Philadelphia, PA</nlm:aff>
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<name sortKey="Philip, Errol J" sort="Philip, Errol J" uniqKey="Philip E" first="Errol J." last="Philip">Errol J. Philip</name>
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<nlm:aff id="A9">Dept of Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Ctr, New York, NY</nlm:aff>
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<name sortKey="Wolfe, Bruce" sort="Wolfe, Bruce" uniqKey="Wolfe B" first="Bruce" last="Wolfe">Bruce Wolfe</name>
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<name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
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</affiliation>
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<name sortKey="Ballard Barbash, Rachel" sort="Ballard Barbash, Rachel" uniqKey="Ballard Barbash R" first="Rachel" last="Ballard-Barbash">Rachel Ballard-Barbash</name>
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<nlm:aff id="A12">Applied Research Program, National Cancer Institute (NCI), Bethesda, MD</nlm:aff>
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<name sortKey="Mctiernan, Anne" sort="Mctiernan, Anne" uniqKey="Mctiernan A" first="Anne" last="Mctiernan">Anne Mctiernan</name>
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<nlm:aff id="A13">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
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<name sortKey="Minasian, Lori" sort="Minasian, Lori" uniqKey="Minasian L" first="Lori" last="Minasian">Lori Minasian</name>
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<nlm:aff id="A14">Community Oncology and Prevention Trials Research Group, NCI, Bethesda, MD</nlm:aff>
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<name sortKey="Nebeling, Linda" sort="Nebeling, Linda" uniqKey="Nebeling L" first="Linda" last="Nebeling">Linda Nebeling</name>
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<nlm:aff id="A15">Behavioral Research Program, NCI, Bethesda, MD</nlm:aff>
</affiliation>
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<name sortKey="Goodwin, Pamela J" sort="Goodwin, Pamela J" uniqKey="Goodwin P" first="Pamela J." last="Goodwin">Pamela J. Goodwin</name>
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<title xml:lang="en" level="a" type="main">The Role of Obesity in Cancer Survival and Recurrence</title>
<author>
<name sortKey="Demark Wahnefried, Wendy" sort="Demark Wahnefried, Wendy" uniqKey="Demark Wahnefried W" first="Wendy" last="Demark-Wahnefried">Wendy Demark-Wahnefried</name>
<affiliation>
<nlm:aff id="A1">Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A." last="Platz">Elizabeth A. Platz</name>
<affiliation>
<nlm:aff id="A2">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ligibel, Jennifer A" sort="Ligibel, Jennifer A" uniqKey="Ligibel J" first="Jennifer A." last="Ligibel">Jennifer A. Ligibel</name>
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<nlm:aff id="A3">Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Blair, Cindy K" sort="Blair, Cindy K" uniqKey="Blair C" first="Cindy K." last="Blair">Cindy K. Blair</name>
<affiliation>
<nlm:aff id="A1">Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Courneya, Kerry S" sort="Courneya, Kerry S" uniqKey="Courneya K" first="Kerry S." last="Courneya">Kerry S. Courneya</name>
<affiliation>
<nlm:aff id="A4">Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Meyerhardt, Jeffrey A" sort="Meyerhardt, Jeffrey A" uniqKey="Meyerhardt J" first="Jeffrey A." last="Meyerhardt">Jeffrey A. Meyerhardt</name>
<affiliation>
<nlm:aff id="A3">Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A." last="Ganz">Patricia A. Ganz</name>
<affiliation>
<nlm:aff id="A5">Schools of Medicine and Public Health, University of California–Los Angeles, Los Angeles, CA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Rock, Cheryl L" sort="Rock, Cheryl L" uniqKey="Rock C" first="Cheryl L." last="Rock">Cheryl L. Rock</name>
<affiliation>
<nlm:aff id="A6">Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name>
<affiliation>
<nlm:aff id="A7">Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wadden, Thomas" sort="Wadden, Thomas" uniqKey="Wadden T" first="Thomas" last="Wadden">Thomas Wadden</name>
<affiliation>
<nlm:aff id="A8">Center for Weight and Eating Disorders, University of Pennsylvania, Philadelphia, PA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Philip, Errol J" sort="Philip, Errol J" uniqKey="Philip E" first="Errol J." last="Philip">Errol J. Philip</name>
<affiliation>
<nlm:aff id="A9">Dept of Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Ctr, New York, NY</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Wolfe, Bruce" sort="Wolfe, Bruce" uniqKey="Wolfe B" first="Bruce" last="Wolfe">Bruce Wolfe</name>
<affiliation>
<nlm:aff id="A10">Department of Surgery, Oregon Health and Science University, Portland, OR</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Gapstur, Susan M" sort="Gapstur, Susan M" uniqKey="Gapstur S" first="Susan M." last="Gapstur">Susan M. Gapstur</name>
<affiliation>
<nlm:aff id="A11">Epidemiology Research Program, American Cancer Society, Atlanta, GA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Ballard Barbash, Rachel" sort="Ballard Barbash, Rachel" uniqKey="Ballard Barbash R" first="Rachel" last="Ballard-Barbash">Rachel Ballard-Barbash</name>
<affiliation>
<nlm:aff id="A12">Applied Research Program, National Cancer Institute (NCI), Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Mctiernan, Anne" sort="Mctiernan, Anne" uniqKey="Mctiernan A" first="Anne" last="Mctiernan">Anne Mctiernan</name>
<affiliation>
<nlm:aff id="A13">Fred Hutchinson Cancer Research Center, Seattle, WA</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Minasian, Lori" sort="Minasian, Lori" uniqKey="Minasian L" first="Lori" last="Minasian">Lori Minasian</name>
<affiliation>
<nlm:aff id="A14">Community Oncology and Prevention Trials Research Group, NCI, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Nebeling, Linda" sort="Nebeling, Linda" uniqKey="Nebeling L" first="Linda" last="Nebeling">Linda Nebeling</name>
<affiliation>
<nlm:aff id="A15">Behavioral Research Program, NCI, Bethesda, MD</nlm:aff>
</affiliation>
</author>
<author>
<name sortKey="Goodwin, Pamela J" sort="Goodwin, Pamela J" uniqKey="Goodwin P" first="Pamela J." last="Goodwin">Pamela J. Goodwin</name>
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<series>
<title level="j">Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</title>
<idno type="ISSN">1055-9965</idno>
<idno type="eISSN">1538-7755</idno>
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<date when="2012">2012</date>
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<front>
<div type="abstract" xml:lang="en">
<p id="P1">Obesity and components of energy imbalance, i.e., excessive energy intake and suboptimal levels of physical activity, are established risk factors for cancer incidence. Accumulating evidence suggests that these factors also may be important after the diagnosis of cancer and influence the course of disease, as well as overall health, well-being, and survival. Lifestyle and medical interventions that effectively modify these factors could potentially be harnessed as a means of cancer control. However, for such interventions to be maximally effective and sustainable, broad sweeping scientific discoveries ranging from molecular and cellular advances, to developments in delivering interventions on both individual and societal levels are needed. This review summarizes key discussion topics that were addressed in a recent Institute of Medicine Workshop entitled, “The Role of Obesity in Cancer Survival and Recurrence”; discussions included: 1) mechanisms associated with obesity and energy balance that influence cancer progression; 2) complexities of studying and interpreting energy balance in relation to cancer recurrence and survival; 3) associations between obesity and cancer risk, recurrence, and mortality; 4) interventions that promote weight loss, increased physical activity, and negative energy balance as a means of cancer control; and 5) future directions.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-journal-id">9200608</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2299</journal-id>
<journal-id journal-id-type="nlm-ta">Cancer Epidemiol Biomarkers Prev</journal-id>
<journal-id journal-id-type="iso-abbrev">Cancer Epidemiol. Biomarkers Prev.</journal-id>
<journal-title-group>
<journal-title>Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1055-9965</issn>
<issn pub-type="epub">1538-7755</issn>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">22695735</article-id>
<article-id pub-id-type="pmc">3415558</article-id>
<article-id pub-id-type="doi">10.1158/1055-9965.EPI-12-0485</article-id>
<article-id pub-id-type="manuscript">NIHMS395141</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>The Role of Obesity in Cancer Survival and Recurrence</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Demark-Wahnefried</surname>
<given-names>Wendy</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Platz</surname>
<given-names>Elizabeth A.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ligibel</surname>
<given-names>Jennifer A.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Blair</surname>
<given-names>Cindy K.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Courneya</surname>
<given-names>Kerry S.</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Meyerhardt</surname>
<given-names>Jeffrey A.</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ganz</surname>
<given-names>Patricia A.</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Rock</surname>
<given-names>Cheryl L.</given-names>
</name>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Schmitz</surname>
<given-names>Kathryn H.</given-names>
</name>
<xref ref-type="aff" rid="A7">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wadden</surname>
<given-names>Thomas</given-names>
</name>
<xref ref-type="aff" rid="A8">8</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Philip</surname>
<given-names>Errol J.</given-names>
</name>
<xref ref-type="aff" rid="A9">9</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wolfe</surname>
<given-names>Bruce</given-names>
</name>
<xref ref-type="aff" rid="A10">10</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Gapstur</surname>
<given-names>Susan M.</given-names>
</name>
<xref ref-type="aff" rid="A11">11</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ballard-Barbash</surname>
<given-names>Rachel</given-names>
</name>
<xref ref-type="aff" rid="A12">12</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>McTiernan</surname>
<given-names>Anne</given-names>
</name>
<xref ref-type="aff" rid="A13">13</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Minasian</surname>
<given-names>Lori</given-names>
</name>
<xref ref-type="aff" rid="A14">14</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Nebeling</surname>
<given-names>Linda</given-names>
</name>
<xref ref-type="aff" rid="A15">15</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Goodwin</surname>
<given-names>Pamela J.</given-names>
</name>
</contrib>
</contrib-group>
<aff id="A1">
<label>1</label>
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL</aff>
<aff id="A2">
<label>2</label>
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD</aff>
<aff id="A3">
<label>3</label>
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA</aff>
<aff id="A4">
<label>4</label>
Faculty of Physical Education and Recreation, University of Alberta, Edmonton, Canada</aff>
<aff id="A5">
<label>5</label>
Schools of Medicine and Public Health, University of California–Los Angeles, Los Angeles, CA</aff>
<aff id="A6">
<label>6</label>
Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA</aff>
<aff id="A7">
<label>7</label>
Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA</aff>
<aff id="A8">
<label>8</label>
Center for Weight and Eating Disorders, University of Pennsylvania, Philadelphia, PA</aff>
<aff id="A9">
<label>9</label>
Dept of Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Ctr, New York, NY</aff>
<aff id="A10">
<label>10</label>
Department of Surgery, Oregon Health and Science University, Portland, OR</aff>
<aff id="A11">
<label>11</label>
Epidemiology Research Program, American Cancer Society, Atlanta, GA</aff>
<aff id="A12">
<label>12</label>
Applied Research Program, National Cancer Institute (NCI), Bethesda, MD</aff>
<aff id="A13">
<label>13</label>
Fred Hutchinson Cancer Research Center, Seattle, WA</aff>
<aff id="A14">
<label>14</label>
Community Oncology and Prevention Trials Research Group, NCI, Bethesda, MD</aff>
<aff id="A15">
<label>15</label>
Behavioral Research Program, NCI, Bethesda, MD</aff>
<aff id="A16">
<label>16</label>
Dept. of Medicine, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada</aff>
<author-notes>
<corresp id="FN1">Correspondence: Wendy Demark-Wahnefried, PhD, RD, 1675 University Blvd, Room 346, Birmingham, AL 35294-3360, Phone: 205.975.4022/FAX: 205.975.2592/
<email>demark@uab.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>20</day>
<month>7</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub">
<day>13</day>
<month>6</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub">
<month>8</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>01</day>
<month>8</month>
<year>2013</year>
</pub-date>
<volume>21</volume>
<issue>8</issue>
<fpage>1244</fpage>
<lpage>1259</lpage>
<abstract>
<p id="P1">Obesity and components of energy imbalance, i.e., excessive energy intake and suboptimal levels of physical activity, are established risk factors for cancer incidence. Accumulating evidence suggests that these factors also may be important after the diagnosis of cancer and influence the course of disease, as well as overall health, well-being, and survival. Lifestyle and medical interventions that effectively modify these factors could potentially be harnessed as a means of cancer control. However, for such interventions to be maximally effective and sustainable, broad sweeping scientific discoveries ranging from molecular and cellular advances, to developments in delivering interventions on both individual and societal levels are needed. This review summarizes key discussion topics that were addressed in a recent Institute of Medicine Workshop entitled, “The Role of Obesity in Cancer Survival and Recurrence”; discussions included: 1) mechanisms associated with obesity and energy balance that influence cancer progression; 2) complexities of studying and interpreting energy balance in relation to cancer recurrence and survival; 3) associations between obesity and cancer risk, recurrence, and mortality; 4) interventions that promote weight loss, increased physical activity, and negative energy balance as a means of cancer control; and 5) future directions.</p>
</abstract>
<kwd-group>
<kwd>neoplasms</kwd>
<kwd>obesity</kwd>
<kwd>diet</kwd>
<kwd>physical activity</kwd>
<kwd>survival</kwd>
<kwd>recurrence</kwd>
</kwd-group>
<funding-group>
<award-group>
<funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R25 CA047888 || CA</award-id>
</award-group>
<award-group>
<funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>P30 CA013148 || CA</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>

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}}

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