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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial</title><author><name sortKey="Winters Stone, K M" sort="Winters Stone, K M" uniqKey="Winters Stone K" first="K. M." last="Winters-Stone">K. M. Winters-Stone</name></author><author><name sortKey="Dobek, J" sort="Dobek, J" uniqKey="Dobek J" first="J." last="Dobek">J. Dobek</name></author><author><name sortKey="Nail, L M" sort="Nail, L M" uniqKey="Nail L" first="L. M." last="Nail">L. M. Nail</name></author><author><name sortKey="Bennett, J A" sort="Bennett, J A" uniqKey="Bennett J" first="J. A." last="Bennett">J. A. Bennett</name></author><author><name sortKey="Leo, M C" sort="Leo, M C" uniqKey="Leo M" first="M. C." last="Leo">M. C. Leo</name></author><author><name sortKey="Torgrimson Ojerio, B" sort="Torgrimson Ojerio, B" uniqKey="Torgrimson Ojerio B" first="B." last="Torgrimson-Ojerio">B. Torgrimson-Ojerio</name></author><author><name sortKey="Luoh, S W" sort="Luoh, S W" uniqKey="Luoh S" first="S.-W." last="Luoh">S.-W. Luoh</name></author><author><name sortKey="Schwartz, A" sort="Schwartz, A" uniqKey="Schwartz A" first="A." last="Schwartz">A. Schwartz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22996743</idno><idno type="pmc">3856427</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856427</idno><idno type="RBID">PMC:3856427</idno><idno type="doi">10.1007/s00198-012-2143-2</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">003888</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003888</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial</title><author><name sortKey="Winters Stone, K M" sort="Winters Stone, K M" uniqKey="Winters Stone K" first="K. M." last="Winters-Stone">K. M. Winters-Stone</name></author><author><name sortKey="Dobek, J" sort="Dobek, J" uniqKey="Dobek J" first="J." last="Dobek">J. Dobek</name></author><author><name sortKey="Nail, L M" sort="Nail, L M" uniqKey="Nail L" first="L. M." last="Nail">L. M. Nail</name></author><author><name sortKey="Bennett, J A" sort="Bennett, J A" uniqKey="Bennett J" first="J. A." last="Bennett">J. A. Bennett</name></author><author><name sortKey="Leo, M C" sort="Leo, M C" uniqKey="Leo M" first="M. C." last="Leo">M. C. Leo</name></author><author><name sortKey="Torgrimson Ojerio, B" sort="Torgrimson Ojerio, B" uniqKey="Torgrimson Ojerio B" first="B." last="Torgrimson-Ojerio">B. Torgrimson-Ojerio</name></author><author><name sortKey="Luoh, S W" sort="Luoh, S W" uniqKey="Luoh S" first="S.-W." last="Luoh">S.-W. Luoh</name></author><author><name sortKey="Schwartz, A" sort="Schwartz, A" uniqKey="Schwartz A" first="A." last="Schwartz">A. Schwartz</name></author></analytic><series><title level="j">Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</title><idno type="ISSN">0937-941X</idno><idno type="eISSN">1433-2965</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Summary</title><p id="P1">Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year.</p></sec><sec id="S2"><title>Introduction</title><p id="P2">Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause.</p></sec><sec id="S3"><title>Methods</title><p id="P3">We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter).</p></sec><sec id="S4"><title>Results</title><p id="P4">There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck—POWIR, 0.004±0.093 g/cm<sup>2</sup> vs. FLEX, −0.010±0.089 g/cm<sup>2</sup>; <italic>p</italic><0.01; spine—POWIR, −0.003±0.114 g/cm<sup>2</sup> vs. FLEX, −0.020±0.110 g/cm<sup>2</sup>; <italic>p</italic>=0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; <italic>p</italic><0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (<italic>p</italic><0.03).</p></sec><sec id="S5"><title>Conclusion</title><p id="P5">Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9100105</journal-id><journal-id journal-id-type="pubmed-jr-id">2061</journal-id><journal-id journal-id-type="nlm-ta">Osteoporos Int</journal-id><journal-id journal-id-type="iso-abbrev">Osteoporos Int</journal-id><journal-title-group><journal-title>Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</journal-title></journal-title-group><issn pub-type="ppub">0937-941X</issn><issn pub-type="epub">1433-2965</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22996743</article-id><article-id pub-id-type="pmc">3856427</article-id><article-id pub-id-type="doi">10.1007/s00198-012-2143-2</article-id><article-id pub-id-type="manuscript">NIHMS469447</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Winters-Stone</surname><given-names>K. M.</given-names></name><aff id="A1">School of Nursing, Oregon Health & Science University, Portland, OR, USA. Knight Cancer Center, Oregon Health & Science University, Portland, OR, USA. Oregon Health & Science University, 3455 SW US Veteran’s Hospital Rd, Mailcode: SN-ORD, Portland, OR 97239, USA</aff><email>wintersk@ohsu.edu</email></contrib><contrib contrib-type="author"><name><surname>Dobek</surname><given-names>J.</given-names></name><aff id="A2">School of Nursing, Oregon Health & Science University, Portland, OR, USA. School of Medicine, Oregon Health & Science University, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Nail</surname><given-names>L. M.</given-names></name><aff id="A3">School of Nursing, Oregon Health & Science University, Portland, OR, USA. Knight Cancer Center, Oregon Health & Science University, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>J. A.</given-names></name><aff id="A4">School of Nursing, Oregon Health & Science University, Portland, OR, USA. Knight Cancer Center, Oregon Health & Science University, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Leo</surname><given-names>M. C.</given-names></name><aff id="A5">Kaiser Permanente Center for Health Research, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Torgrimson-Ojerio</surname><given-names>B.</given-names></name><aff id="A6">School of Nursing, Oregon Health & Science University, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Luoh</surname><given-names>S.-W.</given-names></name><aff id="A7">Portland VA Medical Center, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Schwartz</surname><given-names>A.</given-names></name><aff id="A8">Idaho State University, Pocatello, ID, USA</aff></contrib></contrib-group><pub-date pub-type="nihms-submitted"><day>21</day><month>11</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>21</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2014</year></pub-date><volume>24</volume><issue>5</issue><elocation-id>10.1007/s00198-012-2143-2</elocation-id><permissions><copyright-statement>© International Osteoporosis Foundation and National Osteoporosis Foundation 2012</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec id="S1"><title>Summary</title><p id="P1">Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year.</p></sec><sec id="S2"><title>Introduction</title><p id="P2">Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause.</p></sec><sec id="S3"><title>Methods</title><p id="P3">We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter).</p></sec><sec id="S4"><title>Results</title><p id="P4">There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck—POWIR, 0.004±0.093 g/cm<sup>2</sup> vs. FLEX, −0.010±0.089 g/cm<sup>2</sup>; <italic>p</italic><0.01; spine—POWIR, −0.003±0.114 g/cm<sup>2</sup> vs. FLEX, −0.020±0.110 g/cm<sup>2</sup>; <italic>p</italic>=0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; <italic>p</italic><0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (<italic>p</italic><0.03).</p></sec><sec id="S5"><title>Conclusion</title><p id="P5">Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.</p></sec></abstract><kwd-group><kwd>Chemotherapy</kwd><kwd>Neoplasm</kwd><kwd>Obesity</kwd><kwd>Osteoporosis</kwd><kwd>Physical activity</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA120123 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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