Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial
Identifieur interne : 003888 ( Pmc/Corpus ); précédent : 003887; suivant : 003889Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial
Auteurs : K. M. Winters-Stone ; J. Dobek ; L. M. Nail ; J. A. Bennett ; M. C. Leo ; B. Torgrimson-Ojerio ; S.-W. Luoh ; A. SchwartzSource :
- Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA [ 0937-941X ] ; 2012.
Abstract
Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year.
Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause.
We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter).
There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck—POWIR, 0.004±0.093 g/cm2 vs. FLEX, −0.010±0.089 g/cm2;
Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.
Url:
DOI: 10.1007/s00198-012-2143-2
PubMed: 22996743
PubMed Central: 3856427
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial</title><author><name sortKey="Winters Stone, K M" sort="Winters Stone, K M" uniqKey="Winters Stone K" first="K. M." last="Winters-Stone">K. M. Winters-Stone</name></author><author><name sortKey="Dobek, J" sort="Dobek, J" uniqKey="Dobek J" first="J." last="Dobek">J. Dobek</name></author><author><name sortKey="Nail, L M" sort="Nail, L M" uniqKey="Nail L" first="L. M." last="Nail">L. M. Nail</name></author><author><name sortKey="Bennett, J A" sort="Bennett, J A" uniqKey="Bennett J" first="J. A." last="Bennett">J. A. Bennett</name></author><author><name sortKey="Leo, M C" sort="Leo, M C" uniqKey="Leo M" first="M. C." last="Leo">M. C. Leo</name></author><author><name sortKey="Torgrimson Ojerio, B" sort="Torgrimson Ojerio, B" uniqKey="Torgrimson Ojerio B" first="B." last="Torgrimson-Ojerio">B. Torgrimson-Ojerio</name></author><author><name sortKey="Luoh, S W" sort="Luoh, S W" uniqKey="Luoh S" first="S.-W." last="Luoh">S.-W. Luoh</name></author><author><name sortKey="Schwartz, A" sort="Schwartz, A" uniqKey="Schwartz A" first="A." last="Schwartz">A. Schwartz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22996743</idno><idno type="pmc">3856427</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856427</idno><idno type="RBID">PMC:3856427</idno><idno type="doi">10.1007/s00198-012-2143-2</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">003888</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003888</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial</title><author><name sortKey="Winters Stone, K M" sort="Winters Stone, K M" uniqKey="Winters Stone K" first="K. M." last="Winters-Stone">K. M. Winters-Stone</name></author><author><name sortKey="Dobek, J" sort="Dobek, J" uniqKey="Dobek J" first="J." last="Dobek">J. Dobek</name></author><author><name sortKey="Nail, L M" sort="Nail, L M" uniqKey="Nail L" first="L. M." last="Nail">L. M. Nail</name></author><author><name sortKey="Bennett, J A" sort="Bennett, J A" uniqKey="Bennett J" first="J. A." last="Bennett">J. A. Bennett</name></author><author><name sortKey="Leo, M C" sort="Leo, M C" uniqKey="Leo M" first="M. C." last="Leo">M. C. Leo</name></author><author><name sortKey="Torgrimson Ojerio, B" sort="Torgrimson Ojerio, B" uniqKey="Torgrimson Ojerio B" first="B." last="Torgrimson-Ojerio">B. Torgrimson-Ojerio</name></author><author><name sortKey="Luoh, S W" sort="Luoh, S W" uniqKey="Luoh S" first="S.-W." last="Luoh">S.-W. Luoh</name></author><author><name sortKey="Schwartz, A" sort="Schwartz, A" uniqKey="Schwartz A" first="A." last="Schwartz">A. Schwartz</name></author></analytic><series><title level="j">Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</title><idno type="ISSN">0937-941X</idno><idno type="eISSN">1433-2965</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Summary</title><p id="P1">Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year.</p></sec><sec id="S2"><title>Introduction</title><p id="P2">Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause.</p></sec><sec id="S3"><title>Methods</title><p id="P3">We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter).</p></sec><sec id="S4"><title>Results</title><p id="P4">There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck—POWIR, 0.004±0.093 g/cm<sup>2</sup> vs. FLEX, −0.010±0.089 g/cm<sup>2</sup>; <italic>p</italic><0.01; spine—POWIR, −0.003±0.114 g/cm<sup>2</sup> vs. FLEX, −0.020±0.110 g/cm<sup>2</sup>; <italic>p</italic>=0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; <italic>p</italic><0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (<italic>p</italic><0.03).</p></sec><sec id="S5"><title>Conclusion</title><p id="P5">Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9100105</journal-id><journal-id journal-id-type="pubmed-jr-id">2061</journal-id><journal-id journal-id-type="nlm-ta">Osteoporos Int</journal-id><journal-id journal-id-type="iso-abbrev">Osteoporos Int</journal-id><journal-title-group><journal-title>Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA</journal-title></journal-title-group><issn pub-type="ppub">0937-941X</issn><issn pub-type="epub">1433-2965</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22996743</article-id><article-id pub-id-type="pmc">3856427</article-id><article-id pub-id-type="doi">10.1007/s00198-012-2143-2</article-id><article-id pub-id-type="manuscript">NIHMS469447</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Impact + resistance training improves bone health and body composition in prematurely menopausal breast cancer survivors: a randomized controlled trial</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Winters-Stone</surname><given-names>K. M.</given-names></name><aff id="A1">School of Nursing, Oregon Health & Science University, Portland, OR, USA. Knight Cancer Center, Oregon Health & Science University, Portland, OR, USA. Oregon Health & Science University, 3455 SW US Veteran’s Hospital Rd, Mailcode: SN-ORD, Portland, OR 97239, USA</aff><email>wintersk@ohsu.edu</email></contrib><contrib contrib-type="author"><name><surname>Dobek</surname><given-names>J.</given-names></name><aff id="A2">School of Nursing, Oregon Health & Science University, Portland, OR, USA. School of Medicine, Oregon Health & Science University, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Nail</surname><given-names>L. M.</given-names></name><aff id="A3">School of Nursing, Oregon Health & Science University, Portland, OR, USA. Knight Cancer Center, Oregon Health & Science University, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>J. A.</given-names></name><aff id="A4">School of Nursing, Oregon Health & Science University, Portland, OR, USA. Knight Cancer Center, Oregon Health & Science University, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Leo</surname><given-names>M. C.</given-names></name><aff id="A5">Kaiser Permanente Center for Health Research, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Torgrimson-Ojerio</surname><given-names>B.</given-names></name><aff id="A6">School of Nursing, Oregon Health & Science University, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Luoh</surname><given-names>S.-W.</given-names></name><aff id="A7">Portland VA Medical Center, Portland, OR, USA</aff></contrib><contrib contrib-type="author"><name><surname>Schwartz</surname><given-names>A.</given-names></name><aff id="A8">Idaho State University, Pocatello, ID, USA</aff></contrib></contrib-group><pub-date pub-type="nihms-submitted"><day>21</day><month>11</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>21</day><month>9</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>5</month><year>2014</year></pub-date><volume>24</volume><issue>5</issue><elocation-id>10.1007/s00198-012-2143-2</elocation-id><permissions><copyright-statement>© International Osteoporosis Foundation and National Osteoporosis Foundation 2012</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><sec id="S1"><title>Summary</title><p id="P1">Our randomized controlled trial in prematurely menopausal breast cancer survivors showed that impact + resistance training prevented increases in percentage of body fat compared with controls and also improved BMD at the hip and prevented BMD loss at the spine among exercise-trained women who were menopausal for >1 year.</p></sec><sec id="S2"><title>Introduction</title><p id="P2">Cancer treatment-related menopause worsens bone health and body composition in breast cancer survivors (BCS). We investigated whether impact + resistance training could improve bone mineral density (BMD), reduce bone turnover, build muscle, and decrease fat mass in BCS with premature menopause.</p></sec><sec id="S3"><title>Methods</title><p id="P3">We conducted a randomized controlled trial in 71 BCS (mean age, 46.5 years) within 5 years of treatment-related menopause. Women were randomly assigned to one of two groups: (1) impact + resistance training (prevent osteoporosis with impact + resistance (POWIR)) or (2) exercise placebo (FLEX) 3×/week for 1 year. Outcomes were hip and spine BMD (in grams per square centimeter) and body composition (percent body fat (%BF) and lean and fat mass (in kilograms)) by DXA and bone turnover markers (serum osteocalcin (in nanograms per milliliter) and urinary deoxypryrodinoline (in nanomoles per milliliter).</p></sec><sec id="S4"><title>Results</title><p id="P4">There were no significant group × time interactions for bone outcomes when using an intent-to-treat approach on the full sample. In analyses restricted to BCS who were menopausal for ≥1 year, POWIR increased BMD at the hip and slowed BMD loss at the spine compared with FLEX (femoral neck—POWIR, 0.004±0.093 g/cm<sup>2</sup> vs. FLEX, −0.010±0.089 g/cm<sup>2</sup>; <italic>p</italic><0.01; spine—POWIR, −0.003±0.114 g/cm<sup>2</sup> vs. FLEX, −0.020±0.110 g/cm<sup>2</sup>; <italic>p</italic>=0.03). POWIR prevented increases in %BF (POWIR, 0.01 % vs. FLEX, 1.3 %; <italic>p</italic><0.04). Women with attendance to POWIR at ≥64 % had better improvements in %BF than women attending less often (<italic>p</italic><0.03).</p></sec><sec id="S5"><title>Conclusion</title><p id="P5">Impact + resistance training may effectively combat bone loss and worsening body composition from premature menopause in BCS.</p></sec></abstract><kwd-group><kwd>Chemotherapy</kwd><kwd>Neoplasm</kwd><kwd>Obesity</kwd><kwd>Osteoporosis</kwd><kwd>Physical activity</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source><award-id>R01 CA120123 || CA</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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