Connexins and their channels in inflammation
Identifieur interne : 003865 ( Pmc/Corpus ); précédent : 003864; suivant : 003866Connexins and their channels in inflammation
Auteurs : Joost Willebrords ; Sara Crespo Yanguas ; Michaël Maes ; Elke Decrock ; Nan Wang ; Luc Leybaert ; Brenda R. Kwak ; Colin R. Green ; Bruno Cogliati ; Mathieu VinkenSource :
- Critical reviews in biochemistry and molecular biology [ 1040-9238 ] ; 2016.
Abstract
Inflammation may be caused by a variety of factors and is a hallmark of a
plethora of acute and chronic diseases. The purpose of inflammation is to
eliminate the initial cell injury trigger, to clear out dead cells from damaged
tissue and to initiate tissue regeneration. Despite the wealth of knowledge
regarding the involvement of cellular communication in inflammation, studies on
the role of connexin-based channels in this process have only begun to emerge in
the last few years. In this paper, a state-of-the-art overview of the effects of
inflammation on connexin signaling is provided.
Url:
DOI: 10.1080/10409238.2016.1204980
PubMed: 27387655
PubMed Central: 5584657
Links to Exploration step
PMC:5584657Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Connexins and their channels in inflammation</title>
<author><name sortKey="Willebrords, Joost" sort="Willebrords, Joost" uniqKey="Willebrords J" first="Joost" last="Willebrords">Joost Willebrords</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crespo Yanguas, Sara" sort="Crespo Yanguas, Sara" uniqKey="Crespo Yanguas S" first="Sara" last="Crespo Yanguas">Sara Crespo Yanguas</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michaël" last="Maes">Michaël Maes</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Decrock, Elke" sort="Decrock, Elke" uniqKey="Decrock E" first="Elke" last="Decrock">Elke Decrock</name>
<affiliation><nlm:aff id="A2">Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Nan" sort="Wang, Nan" uniqKey="Wang N" first="Nan" last="Wang">Nan Wang</name>
<affiliation><nlm:aff id="A2">Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leybaert, Luc" sort="Leybaert, Luc" uniqKey="Leybaert L" first="Luc" last="Leybaert">Luc Leybaert</name>
<affiliation><nlm:aff id="A2">Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kwak, Brenda R" sort="Kwak, Brenda R" uniqKey="Kwak B" first="Brenda R." last="Kwak">Brenda R. Kwak</name>
<affiliation><nlm:aff id="A3">Department of Pathology and Immunology and Division of Cardiology, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland; Brenda R. Kwak: Tel: +41 22 379 57 37</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Green, Colin R" sort="Green, Colin R" uniqKey="Green C" first="Colin R." last="Green">Colin R. Green</name>
<affiliation><nlm:aff id="A4">Department of Ophthalmology and New Zealand National Eye Centre, University of Auckland, New Zealand; Colin R. Green: Tel: +64 9 923 61 35</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cogliati, Bruno" sort="Cogliati, Bruno" uniqKey="Cogliati B" first="Bruno" last="Cogliati">Bruno Cogliati</name>
<affiliation><nlm:aff id="A5">Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, 05508-270 São Paulo, Brazil; Bruno Cogliati: Tel: +55 11 30 91 12 00</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vinken, Mathieu" sort="Vinken, Mathieu" uniqKey="Vinken M" first="Mathieu" last="Vinken">Mathieu Vinken</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27387655</idno>
<idno type="pmc">5584657</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584657</idno>
<idno type="RBID">PMC:5584657</idno>
<idno type="doi">10.1080/10409238.2016.1204980</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">003865</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003865</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Connexins and their channels in inflammation</title>
<author><name sortKey="Willebrords, Joost" sort="Willebrords, Joost" uniqKey="Willebrords J" first="Joost" last="Willebrords">Joost Willebrords</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Crespo Yanguas, Sara" sort="Crespo Yanguas, Sara" uniqKey="Crespo Yanguas S" first="Sara" last="Crespo Yanguas">Sara Crespo Yanguas</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michaël" last="Maes">Michaël Maes</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Decrock, Elke" sort="Decrock, Elke" uniqKey="Decrock E" first="Elke" last="Decrock">Elke Decrock</name>
<affiliation><nlm:aff id="A2">Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Nan" sort="Wang, Nan" uniqKey="Wang N" first="Nan" last="Wang">Nan Wang</name>
<affiliation><nlm:aff id="A2">Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Leybaert, Luc" sort="Leybaert, Luc" uniqKey="Leybaert L" first="Luc" last="Leybaert">Luc Leybaert</name>
<affiliation><nlm:aff id="A2">Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kwak, Brenda R" sort="Kwak, Brenda R" uniqKey="Kwak B" first="Brenda R." last="Kwak">Brenda R. Kwak</name>
<affiliation><nlm:aff id="A3">Department of Pathology and Immunology and Division of Cardiology, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland; Brenda R. Kwak: Tel: +41 22 379 57 37</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Green, Colin R" sort="Green, Colin R" uniqKey="Green C" first="Colin R." last="Green">Colin R. Green</name>
<affiliation><nlm:aff id="A4">Department of Ophthalmology and New Zealand National Eye Centre, University of Auckland, New Zealand; Colin R. Green: Tel: +64 9 923 61 35</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cogliati, Bruno" sort="Cogliati, Bruno" uniqKey="Cogliati B" first="Bruno" last="Cogliati">Bruno Cogliati</name>
<affiliation><nlm:aff id="A5">Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, 05508-270 São Paulo, Brazil; Bruno Cogliati: Tel: +55 11 30 91 12 00</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vinken, Mathieu" sort="Vinken, Mathieu" uniqKey="Vinken M" first="Mathieu" last="Vinken">Mathieu Vinken</name>
<affiliation><nlm:aff id="A1">Department of<italic>In Vitro</italic>
Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Critical reviews in biochemistry and molecular biology</title>
<idno type="ISSN">1040-9238</idno>
<idno type="eISSN">1549-7798</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Inflammation may be caused by a variety of factors and is a hallmark of a
plethora of acute and chronic diseases. The purpose of inflammation is to
eliminate the initial cell injury trigger, to clear out dead cells from damaged
tissue and to initiate tissue regeneration. Despite the wealth of knowledge
regarding the involvement of cellular communication in inflammation, studies on
the role of connexin-based channels in this process have only begun to emerge in
the last few years. In this paper, a state-of-the-art overview of the effects of
inflammation on connexin signaling is provided. <italic>Vice versa</italic>
, the
involvement of connexins and their channels in inflammation will be discussed by
relying on studies that use a variety of experimental tools, such as genetically
modified animals, small interfering RNA and connexin-based channel blockers. A
better understanding of the importance of connexin signaling in inflammation may
open up towards clinical perspectives.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8903774</journal-id>
<journal-id journal-id-type="pubmed-jr-id">3208</journal-id>
<journal-id journal-id-type="nlm-ta">Crit Rev Biochem Mol Biol</journal-id>
<journal-id journal-id-type="iso-abbrev">Crit. Rev. Biochem. Mol. Biol.</journal-id>
<journal-title-group><journal-title>Critical reviews in biochemistry and molecular biology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1040-9238</issn>
<issn pub-type="epub">1549-7798</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27387655</article-id>
<article-id pub-id-type="pmc">5584657</article-id>
<article-id pub-id-type="doi">10.1080/10409238.2016.1204980</article-id>
<article-id pub-id-type="manuscript">EMS73952</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Connexins and their channels in inflammation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Willebrords</surname>
<given-names>Joost</given-names>
</name>
<pmc-comment>joost.willebrords@vub.ac.be </pmc-comment>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Crespo Yanguas</surname>
<given-names>Sara</given-names>
</name>
<pmc-comment>sara.crespo.yanguas@vub.ac.be </pmc-comment>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Maes</surname>
<given-names>Michaël</given-names>
</name>
<pmc-comment>michael.mc.maes@vub.ac.be </pmc-comment>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Decrock</surname>
<given-names>Elke</given-names>
</name>
<pmc-comment>elke.decrock@ugent.be </pmc-comment>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Nan</given-names>
</name>
<pmc-comment>nan.wang@ugent.be </pmc-comment>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leybaert</surname>
<given-names>Luc</given-names>
</name>
<pmc-comment>luc.leybaert@ugent.be </pmc-comment>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kwak</surname>
<given-names>Brenda R.</given-names>
</name>
<pmc-comment>brenda.kwakchanson@unige.ch </pmc-comment>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Green</surname>
<given-names>Colin R.</given-names>
</name>
<pmc-comment>c.green@auckland.ac.nz </pmc-comment>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cogliati</surname>
<given-names>Bruno</given-names>
</name>
<pmc-comment>bcogliati@usp.br </pmc-comment>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vinken</surname>
<given-names>Mathieu</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of<italic>In Vitro</italic>
Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium; Joost Willebrords: + Tel: 32 2 477 45 87, Michaël Maes: Tel: +32 2 477 45 87, Sara Crespo Yanguas: Tel: +32 2 477 45 87</aff>
<aff id="A2"><label>2</label>
Department of Basic Medical Sciences, Physiology Group, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium; Elke Decrock: Tel: +32 9 332 39 73, Nan Wang: Tel: +32 9 332 39 38, Luc Leybaert: Tel: +32 9 332 33 66</aff>
<aff id="A3"><label>3</label>
Department of Pathology and Immunology and Division of Cardiology, University of Geneva, Rue Michel-Servet 1, CH-1211 Geneva, Switzerland; Brenda R. Kwak: Tel: +41 22 379 57 37</aff>
<aff id="A4"><label>4</label>
Department of Ophthalmology and New Zealand National Eye Centre, University of Auckland, New Zealand; Colin R. Green: Tel: +64 9 923 61 35</aff>
<aff id="A5"><label>5</label>
Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Av. Prof. Dr. Orlando Marques de Paiva 87, 05508-270 São Paulo, Brazil; Bruno Cogliati: Tel: +55 11 30 91 12 00</aff>
<author-notes><corresp id="CR1"><label>*</label>
Corresponding author: Mathieu Vinken:
<email>mathieu.vinken@vub.ac.be</email>
; Tel: +32 2 477 45 87</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>31</day>
<month>8</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub"><day>07</day>
<month>7</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><season>Nov-Dec</season>
<year>2016</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>05</day>
<month>9</month>
<year>2017</year>
</pub-date>
<volume>51</volume>
<issue>6</issue>
<fpage>413</fpage>
<lpage>439</lpage>
<pmc-comment>elocation-id from pubmed: 10.1080/10409238.2016.1204980</pmc-comment>
<abstract><p id="P1">Inflammation may be caused by a variety of factors and is a hallmark of a
plethora of acute and chronic diseases. The purpose of inflammation is to
eliminate the initial cell injury trigger, to clear out dead cells from damaged
tissue and to initiate tissue regeneration. Despite the wealth of knowledge
regarding the involvement of cellular communication in inflammation, studies on
the role of connexin-based channels in this process have only begun to emerge in
the last few years. In this paper, a state-of-the-art overview of the effects of
inflammation on connexin signaling is provided. <italic>Vice versa</italic>
, the
involvement of connexins and their channels in inflammation will be discussed by
relying on studies that use a variety of experimental tools, such as genetically
modified animals, small interfering RNA and connexin-based channel blockers. A
better understanding of the importance of connexin signaling in inflammation may
open up towards clinical perspectives.</p>
</abstract>
<kwd-group><kwd>Connexins</kwd>
<kwd>gap junctions</kwd>
<kwd>hemichannels</kwd>
<kwd>inflammation</kwd>
<kwd>cytokines</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003865 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 003865 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= LymphedemaV1 |flux= Pmc |étape= Corpus |type= RBID |clé= PMC:5584657 |texte= Connexins and their channels in inflammation }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:27387655" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a LymphedemaV1
This area was generated with Dilib version V0.6.31. |